{"id":"https://openalex.org/W4409411615","doi":"https://doi.org/10.1227/neu.0000000000003451","title":"Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases: An International, Multicenter, Single-Arm Phase II Trial","display_name":"Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases: An International, Multicenter, Single-Arm Phase II Trial","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409411615","doi":"https://doi.org/10.1227/neu.0000000000003451","pmid":"https://pubmed.ncbi.nlm.nih.gov/40227031"},"language":"en","primary_location":{"id":"doi:10.1227/neu.0000000000003451","doi":"https://doi.org/10.1227/neu.0000000000003451","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003451","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068458176","display_name":"Randa Higazy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Randa Higazy","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034169058","display_name":"Dianna Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dianna Li","raw_affiliation_strings":["Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012023189","display_name":"Ruth Lau","orcid":"https://orcid.org/0000-0002-8640-2339","observed_orcids":["https://orcid.org/0000-0002-8640-2339"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ruth Lau","raw_affiliation_strings":["Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113886283","display_name":"Barbara\u2010Ann Millar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Barbara-Ann Millar","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069616282","display_name":"Normand Laperri\u00e8re","orcid":"https://orcid.org/0000-0001-8930-9650","observed_orcids":["https://orcid.org/0000-0001-8930-9650"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Normand Laperriere","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087189944","display_name":"Alejandro Berl\u00edn","orcid":"https://orcid.org/0000-0002-1880-6905","observed_orcids":["https://orcid.org/0000-0002-1880-6905"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alejandro Berlin","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112292402","display_name":"Tatiana Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tatiana Conrad","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102011670","display_name":"Enrique Gutierrez-Valencia","orcid":"https://orcid.org/0000-0002-3524-2339","observed_orcids":["https://orcid.org/0000-0002-3524-2339"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Enrique Gutierrez-Valencia","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072584423","display_name":"Gelareh Mohammed Zadeh","orcid":"https://orcid.org/0000-0002-6637-4502","observed_orcids":["https://orcid.org/0000-0002-6637-4502","https://orcid.org/0009-0009-2002-5313"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gelareh Zadeh","raw_affiliation_strings":["Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108772048","display_name":"Mark Bernstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark Bernstein","raw_affiliation_strings":["Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068763367","display_name":"Aristotelis Kalyvas","orcid":"https://orcid.org/0000-0002-0222-488X","observed_orcids":["https://orcid.org/0000-0002-0222-488X"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aristotelis Kalyvas","raw_affiliation_strings":["Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031270256","display_name":"Julian Spears","orcid":"https://orcid.org/0000-0002-4111-6929","observed_orcids":["https://orcid.org/0000-0002-4111-6929"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julian Spears","raw_affiliation_strings":["Division of Neurosurgery, St Michael's Hospital, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, St Michael's Hospital, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1297363086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002463670","display_name":"Daniel Zips","orcid":"https://orcid.org/0000-0001-5779-9675","observed_orcids":["https://orcid.org/0000-0001-5779-9675"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Zips","raw_affiliation_strings":["Department of Radiation Oncology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006454522","display_name":"Peter Vajkoczy","orcid":"https://orcid.org/0000-0003-4350-392X","observed_orcids":["https://orcid.org/0000-0003-4350-392X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Vajkoczy","raw_affiliation_strings":["Department of Neurosurgery, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052242253","display_name":"Carolin Senger","orcid":"https://orcid.org/0000-0001-7700-4657","observed_orcids":["https://orcid.org/0000-0001-7700-4657"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Senger","raw_affiliation_strings":["Department of Radiation Oncology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079543964","display_name":"G\u00fcliz Acker","orcid":"https://orcid.org/0000-0002-8946-6426","observed_orcids":["https://orcid.org/0000-0002-8946-6426"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"G\u00fcliz Acker","raw_affiliation_strings":["Department of Neurosurgery, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany","Department of Radiation Oncology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Radiation Oncology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany;","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075561360","display_name":"Paul N. Kongkham","orcid":"https://orcid.org/0000-0002-1047-9305","observed_orcids":["https://orcid.org/0000-0002-1047-9305"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Paul Kongkham","raw_affiliation_strings":["Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061702922","display_name":"David Benjamin Shultz","orcid":"https://orcid.org/0000-0001-8242-6555","observed_orcids":["https://orcid.org/0000-0001-8242-6555"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David B. Shultz","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5061702922","https://openalex.org/A5075561360","https://openalex.org/A5079543964"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I2802654988","https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":1.1744,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77049766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"97","issue":"4","first_page":"793","last_page":"800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9290000200271606},{"id":"https://openalex.org/keywords/single-fraction-radiosurgery","display_name":"single-fraction radiosurgery","score":0.8619999885559082},{"id":"https://openalex.org/keywords/radiation-necrosis","display_name":"radiation necrosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/local-failure","display_name":"local failure","score":0.6840000152587891},{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/intracranial-progression-free-survival","display_name":"intracranial progression-free survival","score":0.8889999985694885},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9309999942779541},{"id":"https://openalex.org/keywords/large-brain-metastases","display_name":"large brain metastases","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9752775430679321},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.7954497337341309},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5631712675094604},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4612862169742584},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.41135287284851074},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.36088424921035767},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.18798062205314636}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016634","descriptor_name":"Radiosurgery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016634","descriptor_name":"Radiosurgery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016634","descriptor_name":"Radiosurgery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016634","descriptor_name":"Radiosurgery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1227/neu.0000000000003451","doi":"https://doi.org/10.1227/neu.0000000000003451","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003451","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:40227031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40227031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5099999904632568}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311559","display_name":"Princess Margaret Cancer Foundation","ror":"https://ror.org/00ctsa544"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1985351938","https://openalex.org/W2015902877","https://openalex.org/W2067407840","https://openalex.org/W2100595880","https://openalex.org/W2103148512","https://openalex.org/W2106059936","https://openalex.org/W2153140684","https://openalex.org/W2168888547","https://openalex.org/W2492450141","https://openalex.org/W2529551570","https://openalex.org/W2562107065","https://openalex.org/W2725029513","https://openalex.org/W2726463501","https://openalex.org/W2780638065","https://openalex.org/W2917491088","https://openalex.org/W2921683643","https://openalex.org/W3165649268","https://openalex.org/W3198647633","https://openalex.org/W3211928495","https://openalex.org/W4200190043","https://openalex.org/W4206276742","https://openalex.org/W4224981127","https://openalex.org/W4308744601","https://openalex.org/W4376133388","https://openalex.org/W4379768904","https://openalex.org/W4385666595","https://openalex.org/W4387472888","https://openalex.org/W4388035759","https://openalex.org/W4395064604"],"related_works":["https://openalex.org/W2077579868","https://openalex.org/W1490990766","https://openalex.org/W2620592657","https://openalex.org/W3032177237","https://openalex.org/W72122836","https://openalex.org/W2476392803","https://openalex.org/W4292594305","https://openalex.org/W2049714445","https://openalex.org/W2397473359","https://openalex.org/W2318466862"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"Previous":[3],"reports":[4],"have":[5],"suggested":[6],"that":[7],"neoadjuvant":[8,44],"stereotactic":[9],"radiosurgery":[10],"(SRS)":[11],"for":[12,46,261],"brain":[13],"metastases":[14],"(BrMets)":[15],"mitigates":[16],"the":[17,79,109,131,150,215,236,251],"elevated":[18],"risks":[19],"of":[20,42,104,126,238,255],"radiation":[21,265],"necrosis":[22],"(RN)":[23],"and":[24,57,71,123,136,143,190,214,235],"meningeal":[25,239],"recurrence":[26],"associated":[27,246],"with":[28,51,73,82,94,247],"adjuvant":[29],"SRS.":[30,96,249],"We":[31],"report":[32],"treatment":[33],"outcomes":[34],"from":[35],"a":[36,83,258],"multicenter":[37],"phase":[38],"II":[39],"trial":[40],"(NCT03368625)":[41],"single-fraction":[43,74],"SRS":[45,75],"large":[47],"BrMets.":[48],"METHODS:":[49],"Patients":[50],"1":[52,177,191],"index":[53,80,110,132],"BrMet":[54],"requiring":[55,64],"resection":[56,65],"up":[58],"to":[59],"9":[60],"nonindex":[61],"BrMets":[62],"not":[63],"were":[66,92,148],"recruited":[67],"across":[68],"3":[69],"centers":[70],"treated":[72],"(14-21":[76],"Gy)":[77],"targeting":[78],"lesion":[81],"2-mm":[84],"margin,":[85],"followed":[86],"by":[87],"surgical":[88],"resection.":[89],"Nonindex":[90],"lesions":[91],"targeted":[93],"definitive":[95],"The":[97,203],"primary":[98],"end":[99,113],"point":[100],"was":[101,154,207,220,241],"1-year":[102,124,253],"rate":[103,254],"grade":[105,163],"2+":[106,164],"RN":[107,234],"affecting":[108,130],"lesion.":[111],"Secondary":[112],"points":[114],"included":[115],"median":[116,151,204],"overall":[117,205],"survival,":[118,122],"2-year":[119,216],"intracranial":[120,217],"progression-free":[121,218],"rates":[125,245],"local":[127],"failure":[128,240],"(LF)":[129],"lesion,":[133],"leptomeningeal":[134,181],"disease,":[135],"pachymeningeal":[137,194],"disease.":[138],"RESULTS:":[139],"Between":[140],"April":[141],"2018":[142],"November":[144],"2022,":[145],"35":[146],"patients":[147,161,167,231],"enrolled;":[149],"follow-up":[152],"period":[153],"11.8":[155],"months":[156,209],"(IQR:":[157],"6.14,":[158],"15.9).":[159],"No":[160],"developed":[162,179,193],"RN.":[165],"Six":[166],"experienced":[168,232],"LF":[169,256],"(1-year":[170,183,196],"rate:":[171,184,197],"18.0%":[172],"[95%":[173,186,199],"CI:":[174,187,200,211,223],"7.03,":[175],"32.9]);":[176],"patient":[178,192],"classic":[180],"disease":[182,195],"2.9%":[185],"0.21,":[188],"12.9]),":[189],"3.2%":[198],"0.22,":[201],"14.6]).":[202],"survival":[206,219],"13.8":[208],"(95%":[210,222],"8.15,":[212],"22.4),":[213],"29.5%":[221],"13.8,":[224],"63.1).":[225],"CONCLUSION:":[226],"In":[227],"this":[228],"study,":[229],"no":[230],"symptomatic":[233],"incidence":[237],"lower":[242],"than":[243],"historical":[244],"postoperative":[248],"However,":[250],"high":[252],"suggests":[257],"potential":[259],"benefit":[260],"higher":[262],"or":[263,267],"fractionated":[264],"doses":[266],"larger":[268],"clinical":[269],"target":[270],"volume":[271],"margins.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}