{"id":"https://openalex.org/W4409410562","doi":"https://doi.org/10.1038/s41598-025-96597-0","title":"Comparison of flow cytometry and heterotrophic plate count methods for dialysis water microbial monitoring","display_name":"Comparison of flow cytometry and heterotrophic plate count methods for dialysis water microbial monitoring","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409410562","doi":"https://doi.org/10.1038/s41598-025-96597-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/40229402","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11997118"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-96597-0","doi":"https://doi.org/10.1038/s41598-025-96597-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-96597-0","pdf_url":"https://www.nature.com/articles/s41598-025-96597-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-96597-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102892185","display_name":"Rui Lucena","orcid":"https://orcid.org/0009-0009-2333-8956","observed_orcids":["https://orcid.org/0009-0009-2333-8956"]},"institutions":[{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]},{"id":"https://openalex.org/I90589149","display_name":"Fresenius Medical Care (Germany)","ror":"https://ror.org/04sk0bj73","country_code":"DE","type":"company","lineage":["https://openalex.org/I90589149"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rui Lucena","raw_affiliation_strings":["Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany. rui.lucena@freseniusmedicalcare.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany. rui.lucena@freseniusmedicalcare.com","institution_ids":["https://openalex.org/I4210108778","https://openalex.org/I90589149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038363388","display_name":"Juliane Feurle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]},{"id":"https://openalex.org/I90589149","display_name":"Fresenius Medical Care (Germany)","ror":"https://ror.org/04sk0bj73","country_code":"DE","type":"company","lineage":["https://openalex.org/I90589149"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juliane Feurle","raw_affiliation_strings":["Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany","institution_ids":["https://openalex.org/I4210108778","https://openalex.org/I90589149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102770680","display_name":"C\u00e9lia Gil","orcid":"https://orcid.org/0000-0001-9362-6579","observed_orcids":["https://orcid.org/0000-0001-9362-6579","https://orcid.org/0000-0002-1883-6119"]},"institutions":[{"id":"https://openalex.org/I4210122709","display_name":"Hospital de Santa Cruz","ror":"https://ror.org/02r581p42","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210122709"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"C\u00e9lia Gil","raw_affiliation_strings":["Unidade Local de Sa\u00fade Lisboa Ocidental, Hospital Santa Cruz (Nephrology Department); Medical Director Nephrocare Alverca Dialysis Clinic, Portugal, NephroCare Alverca, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidade Local de Sa\u00fade Lisboa Ocidental, Hospital Santa Cruz (Nephrology Department); Medical Director Nephrocare Alverca Dialysis Clinic, Portugal, NephroCare Alverca, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210122709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039333052","display_name":"An\u00edbal Ferreira","orcid":"https://orcid.org/0000-0002-3300-6033","observed_orcids":["https://orcid.org/0000-0002-3300-6033"]},"institutions":[{"id":"https://openalex.org/I4210095157","display_name":"Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9","ror":"https://ror.org/00k6r3f30","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210095157"]},{"id":"https://openalex.org/I4210134891","display_name":"Hospital Curry Cabral","ror":"https://ror.org/0353kya20","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210095157","https://openalex.org/I4210134891"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"An\u00edbal Ferreira","raw_affiliation_strings":["Nova Medical School Lisboa, Nephrology Department of Hospital Curry Cabral - ULS S\u00e3o Jos\u00e9, NephroCare Carregado, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nova Medical School Lisboa, Nephrology Department of Hospital Curry Cabral - ULS S\u00e3o Jos\u00e9, NephroCare Carregado, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210095157","https://openalex.org/I4210134891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108916145","display_name":"Pedro Ponce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403386540","display_name":"Nephrocare Portugal SA (Portugal)","ror":"https://ror.org/03j99jp33","country_code":"PT","type":"company","lineage":["https://openalex.org/I4403386540"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Ponce","raw_affiliation_strings":["Country Medical Director NephroCare Portugal, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Country Medical Director NephroCare Portugal, Lisbon, Portugal","institution_ids":["https://openalex.org/I4403386540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054201980","display_name":"Bernard Canaud","orcid":"https://orcid.org/0000-0001-6854-2816","observed_orcids":["https://orcid.org/0000-0001-6854-2816"]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Canaud","raw_affiliation_strings":["Nephrology Department, School of Medicine, and Foundation Ch. Mion, Montpellier University, AIDER-Sant\u00e9, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, School of Medicine, and Foundation Ch. Mion, Montpellier University, AIDER-Sant\u00e9, Montpellier, France","institution_ids":["https://openalex.org/I19894307"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5102892185"],"corresponding_institution_ids":["https://openalex.org/I4210108778","https://openalex.org/I90589149"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.2019,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.85284616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"12809","last_page":"12809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dialysis-water","display_name":"dialysis water","score":0.8790000081062317},{"id":"https://openalex.org/keywords/microbiological-surveillance","display_name":"microbiological monitoring","score":0.9020000100135803},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.9909999966621399},{"id":"https://openalex.org/keywords/heterotrophic-plate-count","display_name":"heterotrophic plate count","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/water-disinfection","display_name":"water disinfection","score":0.652999997138977},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.6980000138282776},{"id":"https://openalex.org/keywords/method-comparison","display_name":"method comparison","score":0.527999997138977},{"id":"https://openalex.org/keywords/rapid-microbial-detection","display_name":"rapid microbial detection","score":0.5950000286102295},{"id":"https://openalex.org/keywords/patient-safety","display_name":"patient safety","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C3019970041","wikidata":"https://www.wikidata.org/wiki/Q1949855","display_name":"Plate count","level":3,"score":0.6518197059631348},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.6352319121360779},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6225285530090332},{"id":"https://openalex.org/C35195898","wikidata":"https://www.wikidata.org/wiki/Q159344","display_name":"Heterotroph","level":3,"score":0.5918695330619812},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35535186529159546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3471529483795166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3009570240974426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21064594388008118},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17609113454818726},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1080661416053772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014871","descriptor_name":"Water Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015314","descriptor_name":"Dialysis Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-025-96597-0","doi":"https://doi.org/10.1038/s41598-025-96597-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-96597-0","pdf_url":"https://www.nature.com/articles/s41598-025-96597-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:10809126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11997118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40229402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40229402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11997118","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11997118/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:dcf7ad0a3d5742998b183cd69b10db27","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dcf7ad0a3d5742998b183cd69b10db27","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)","raw_type":"article"},{"id":"pmh:oai:run.unl.pt:10362/182840","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/pages/publications/105003096489","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-96597-0","doi":"https://doi.org/10.1038/s41598-025-96597-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-96597-0","pdf_url":"https://www.nature.com/articles/s41598-025-96597-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.9090999960899353,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409410562.pdf","grobid_xml":"https://content.openalex.org/works/W4409410562.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W25710973","https://openalex.org/W1653680695","https://openalex.org/W1968663049","https://openalex.org/W1974673614","https://openalex.org/W1980587414","https://openalex.org/W1982689275","https://openalex.org/W1983196591","https://openalex.org/W1983441017","https://openalex.org/W1994464134","https://openalex.org/W2014846618","https://openalex.org/W2025561883","https://openalex.org/W2037560033","https://openalex.org/W2040678203","https://openalex.org/W2075282644","https://openalex.org/W2086653027","https://openalex.org/W2090038789","https://openalex.org/W2095078025","https://openalex.org/W2103152121","https://openalex.org/W2106728690","https://openalex.org/W2114210543","https://openalex.org/W2122672654","https://openalex.org/W2155518106","https://openalex.org/W2159421987","https://openalex.org/W2164979928","https://openalex.org/W2171726535","https://openalex.org/W2308454942","https://openalex.org/W2418517571","https://openalex.org/W2467532039","https://openalex.org/W2777844500","https://openalex.org/W2904137410","https://openalex.org/W2949783524","https://openalex.org/W3013569997","https://openalex.org/W4226190825","https://openalex.org/W4281780016"],"related_works":["https://openalex.org/W4415549494","https://openalex.org/W2096560498","https://openalex.org/W4402910798","https://openalex.org/W2568998128","https://openalex.org/W1830654224","https://openalex.org/W2586171209","https://openalex.org/W3106721028","https://openalex.org/W7120907381","https://openalex.org/W3161648063","https://openalex.org/W2090220850"],"abstract_inverted_index":{"Water":[0],"is":[1,92,231],"an":[2,156],"essential":[3],"component":[4],"of":[5,27,53,62,69,80,112,135,150,173,198,220],"renal":[6],"replacement":[7],"therapy":[8],"by":[9],"dialysis.":[10],"Haemodialysis":[11],"patients":[12],"undergoing":[13],"4-hour":[14],"dialysis":[15,28,36,55,64,70,87,151,158,182,199,224,247,250],"sessions,":[16],"thrice":[17],"weekly,":[18],"may":[19],"be":[20,73,235],"exposed":[21],"to":[22,50,58,76,168,214,237],"more":[23],"than":[24,193],"360":[25],"L":[26],"fluid":[29],"per":[30],"week.":[31],"Dialysis":[32],"water":[33,71,85,114,152,183,248],"and":[34,57,86,100,139,166,208,242,249],"ultrapure":[35],"fluids":[37,88,225,251],"have":[38],"been":[39],"established":[40],"as":[41,127,176],"a":[42,117,128,177],"prerequisite":[43],"for":[44,181,195,246],"online":[45],"convective":[46],"therapies":[47],"(namely":[48],"haemodiafiltration),":[49],"improve":[51],"biocompatibility":[52],"the":[54,63,78,81,109,113,133,148,170,216,228],"system":[56],"reduce":[59],"inflammation":[60],"profile":[61],"patients.":[65],"The":[66],"microbial":[67,89,110,153,184,196],"quality":[68,90,154,252],"should":[72],"monitored":[74],"regularly":[75],"demonstrate":[77],"effectiveness":[79],"disinfection":[82],"protocol.":[83],"Current":[84],"assessment":[91],"typically":[93],"done":[94],"via":[95],"heterotrophic":[96],"plate":[97],"counts":[98,104],"(HPC)":[99],"endotoxins":[101],"analysis.":[102],"Plate":[103],"methodology":[105],"provides":[106,132],"information":[107],"on":[108],"content":[111],"only":[115],"after":[116],"considerable":[118],"incubation":[119],"time":[120],"(typically":[121],"7":[122],"days).":[123],"Flow":[124],"cytometry":[125],"(FCM),":[126],"rapid":[129],"alternative":[130,179],"method,":[131],"possibility":[134],"real-time":[136],"corrective":[137,204],"actions":[138],"greater":[140],"patient":[141],"safety.":[142],"In":[143],"this":[144],"study,":[145],"we":[146],"compared":[147],"outcomes":[149],"in":[155,223],"existing":[157],"clinic,":[159],"using":[160,254],"two":[161],"different":[162],"measurement":[163],"methods,":[164],"HPC":[165,194],"FCM,":[167],"test":[169],"possible":[171,217],"benefits":[172],"applying":[174],"FCM":[175,189,221,229],"valid":[178],"method":[180,222,230],"monitoring.":[185,226],"We":[186],"conclude":[187],"that":[188],"offers":[190],"higher":[191],"sensitivity":[192],"monitoring":[197],"water,":[200],"potentially":[201],"enabling":[202],"earlier":[203],"actions.":[205],"More":[206],"extensive":[207],"larger":[209],"studies":[210],"are":[211],"needed,":[212],"namely,":[213],"evaluate":[215],"added":[218],"value":[219],"If":[227],"confirmed,":[232],"it":[233],"will":[234],"necessary":[236],"establish":[238],"maximum":[239],"allowable":[240],"levels":[241,245],"typical":[243],"action":[244],"when":[253],"FCM.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-14T00:00:00"}
