{"id":"https://openalex.org/W4409410459","doi":"https://doi.org/10.1016/j.ceb.2025.102513","title":"Is macropinocytosis more than just a passive gulp?","display_name":"Is macropinocytosis more than just a passive gulp?","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409410459","doi":"https://doi.org/10.1016/j.ceb.2025.102513","pmid":"https://pubmed.ncbi.nlm.nih.gov/40220735"},"language":"en","primary_location":{"id":"doi:10.1016/j.ceb.2025.102513","doi":"https://doi.org/10.1016/j.ceb.2025.102513","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ceb.2025.102513","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ceb.2025.102513","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008915275","display_name":"Roberta Palmulli","orcid":"https://orcid.org/0000-0003-2271-3186","observed_orcids":["https://orcid.org/0000-0003-2271-3186"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roberta Palmulli","raw_affiliation_strings":["Department of Biochemistry, Sanger Building, 80 Tennis Court Road, University of Cambridge, Cambridge, CB2 1GA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sanger Building, 80 Tennis Court Road, University of Cambridge, Cambridge, CB2 1GA, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012953918","display_name":"Laura M. Machesky","orcid":"https://orcid.org/0000-0002-7592-9856","observed_orcids":["https://orcid.org/0000-0002-7592-9856"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Laura M. Machesky","raw_affiliation_strings":["Department of Biochemistry, Sanger Building, 80 Tennis Court Road, University of Cambridge, Cambridge, CB2 1GA, UK. Electronic address: lmm202@cam.ac.uk"],"raw_orcid":"https://orcid.org/0000-0002-7592-9856","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Sanger Building, 80 Tennis Court Road, University of Cambridge, Cambridge, CB2 1GA, UK. Electronic address: lmm202@cam.ac.uk","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012953918"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":1.1258,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"94","issue":null,"first_page":"102513","last_page":"102513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":1.0},{"id":"https://openalex.org/keywords/nutrient-uptake","display_name":"nutrient uptake","score":0.6520000100135803},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4359999895095825},{"id":"https://openalex.org/keywords/drug-delivery-to-tumor-cells","display_name":"drug delivery to tumor cells","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C40017333","wikidata":"https://www.wikidata.org/wiki/Q321362","display_name":"Pinocytosis","level":4,"score":0.9803156852722168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6548285484313965},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6441700458526611},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6416406035423279},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5457907319068909},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.47724080085754395},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4487242102622986},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.41804760694503784},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41003239154815674},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3389054536819458},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.30390387773513794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25409016013145447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20066547393798828},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010873","descriptor_name":"Pinocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010873","descriptor_name":"Pinocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ceb.2025.102513","doi":"https://doi.org/10.1016/j.ceb.2025.102513","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ceb.2025.102513","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},{"id":"pmid:40220735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40220735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/382784","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/382784","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.ceb.2025.102513","doi":"https://doi.org/10.1016/j.ceb.2025.102513","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ceb.2025.102513","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G592875827","display_name":null,"funder_award_id":"DRCRPG-Nov22/100017","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1829589101","https://openalex.org/W1985381440","https://openalex.org/W2037555314","https://openalex.org/W2129917557","https://openalex.org/W2170019668","https://openalex.org/W2236601877","https://openalex.org/W2523259950","https://openalex.org/W2562415513","https://openalex.org/W2726164542","https://openalex.org/W2755806464","https://openalex.org/W2802856655","https://openalex.org/W2890876012","https://openalex.org/W2900606149","https://openalex.org/W2903777652","https://openalex.org/W2925187261","https://openalex.org/W3009504922","https://openalex.org/W3093671468","https://openalex.org/W3136422153","https://openalex.org/W3156078793","https://openalex.org/W3164982115","https://openalex.org/W3168700739","https://openalex.org/W3174041342","https://openalex.org/W3183081365","https://openalex.org/W3211557894","https://openalex.org/W4212856044","https://openalex.org/W4225497948","https://openalex.org/W4225620021","https://openalex.org/W4225797147","https://openalex.org/W4226129018","https://openalex.org/W4280541491","https://openalex.org/W4283700010","https://openalex.org/W4293581925","https://openalex.org/W4302010997","https://openalex.org/W4309293674","https://openalex.org/W4311743311","https://openalex.org/W4320709152","https://openalex.org/W4323652588","https://openalex.org/W4324309218","https://openalex.org/W4377982219","https://openalex.org/W4382241920","https://openalex.org/W4383558966","https://openalex.org/W4385897908","https://openalex.org/W4386609029","https://openalex.org/W4388486354","https://openalex.org/W4390909477","https://openalex.org/W4391567746","https://openalex.org/W4394797242","https://openalex.org/W4396706052","https://openalex.org/W4399577232","https://openalex.org/W4400677736","https://openalex.org/W4404102029","https://openalex.org/W4405307058"],"related_works":["https://openalex.org/W1986257842","https://openalex.org/W3142747831","https://openalex.org/W3185753590","https://openalex.org/W2158302952","https://openalex.org/W4238726741","https://openalex.org/W1970012363","https://openalex.org/W2034357005","https://openalex.org/W2043944480","https://openalex.org/W4200586734","https://openalex.org/W2105006553"],"abstract_inverted_index":{"Macropinocytosis":[0],"is":[1,81],"known":[2],"as":[3,27],"nonselective":[4],"drinking":[5],"of":[6,12,16,31,93],"the":[7,29,76,84],"cellular":[8],"milieu":[9],"for":[10,41],"scavenging":[11],"nutrients":[13,32],"and":[14,55,62,83,115,123],"uptake":[15,30,106],"extracellular":[17],"fluids.":[18],"It":[19],"has":[20],"recently":[21],"gained":[22],"attention":[23],"in":[24,70,107,110],"cancer":[25],"research,":[26],"targeting":[28],"or":[33,72,103],"chemotherapeutic":[34],"particles":[35],"by":[36],"tumor":[37],"cells":[38,88],"holds":[39],"promise":[40],"new":[42],"therapeutic":[43],"interventions.":[44],"Macropinocytic":[45],"cups":[46,54],"form":[47],"from":[48],"actin-based":[49],"protrusions":[50],"that":[51,87,101],"coalesce":[52],"into":[53,57],"collapse":[56],"large":[58],"vesicles":[59],"containing":[60],"cargoes":[61,90],"transmembrane":[63],"receptors,":[64],"which":[65],"can":[66],"then":[67],"be":[68,113],"degraded":[69],"lysosomes":[71],"recycled":[73],"back":[74],"to":[75],"plasma":[77],"membrane.":[78],"How":[79],"macropinocytosis":[80,108],"triggered":[82],"various":[85],"ways":[86],"utilize":[89],"are":[91],"topics":[92],"much":[94],"interest.":[95],"Here,":[96],"we":[97],"discuss":[98],"emerging":[99],"evidence":[100],"cargo":[102],"membrane":[104],"receptor":[105,121],"may":[109,116],"some":[111],"cases":[112],"selective":[114],"substantially":[117],"alter":[118],"cell":[119],"surface":[120],"trafficking":[122],"display.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}