{"id":"https://openalex.org/W4409408339","doi":"https://doi.org/10.12677/acm.2025.1541078","title":"The Advances in the Application of Remimazolam in Elderly Patients","display_name":"The Advances in the Application of Remimazolam in Elderly Patients","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4409408339","doi":"https://doi.org/10.12677/acm.2025.1541078"},"language":"en","primary_location":{"id":"doi:10.12677/acm.2025.1541078","doi":"https://doi.org/10.12677/acm.2025.1541078","is_oa":true,"landing_page_url":"https://doi.org/10.12677/acm.2025.1541078","pdf_url":"https://pdf.hanspub.org/acm2025154_1848103248.pdf","source":{"id":"https://openalex.org/S2764671007","display_name":"Advances in Clinical Medicine","issn_l":"2161-8712","issn":["2161-8712","2161-8720"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697029","host_organization_name":"Hans Publishers","host_organization_lineage":["https://openalex.org/P4322697029"],"host_organization_lineage_names":["Hans Publishers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pdf.hanspub.org/acm2025154_1848103248.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117133437","display_name":"\u5175 \u6c88","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u5175 \u6c88","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5117133437"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11442565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"04","first_page":"1447","last_page":"1452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remimazolam","display_name":"remimazolam","score":0.9959999918937683},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9169999957084656},{"id":"https://openalex.org/keywords/geriatric-anesthesia","display_name":"geriatric anesthesia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.984000027179718},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anesthetic-drug-selection","display_name":"anesthetic drug selection","score":0.656000018119812},{"id":"https://openalex.org/keywords/postoperative-recovery","display_name":"postoperative recovery","score":0.8629999756813049},{"id":"https://openalex.org/keywords/surgical-safety","display_name":"surgical safety","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9578179121017456}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12677/acm.2025.1541078","doi":"https://doi.org/10.12677/acm.2025.1541078","is_oa":true,"landing_page_url":"https://doi.org/10.12677/acm.2025.1541078","pdf_url":"https://pdf.hanspub.org/acm2025154_1848103248.pdf","source":{"id":"https://openalex.org/S2764671007","display_name":"Advances in Clinical Medicine","issn_l":"2161-8712","issn":["2161-8712","2161-8720"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697029","host_organization_name":"Hans Publishers","host_organization_lineage":["https://openalex.org/P4322697029"],"host_organization_lineage_names":["Hans Publishers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Clinical Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12677/acm.2025.1541078","doi":"https://doi.org/10.12677/acm.2025.1541078","is_oa":true,"landing_page_url":"https://doi.org/10.12677/acm.2025.1541078","pdf_url":"https://pdf.hanspub.org/acm2025154_1848103248.pdf","source":{"id":"https://openalex.org/S2764671007","display_name":"Advances in Clinical Medicine","issn_l":"2161-8712","issn":["2161-8712","2161-8720"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697029","host_organization_name":"Hans Publishers","host_organization_lineage":["https://openalex.org/P4322697029"],"host_organization_lineage_names":["Hans Publishers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/5","display_name":"Gender equality"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409408339.pdf","grobid_xml":"https://content.openalex.org/works/W4409408339.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2017305411","https://openalex.org/W2324884202","https://openalex.org/W2484729923","https://openalex.org/W2924995552","https://openalex.org/W3134131256","https://openalex.org/W3179504841","https://openalex.org/W3200356088","https://openalex.org/W3216309176","https://openalex.org/W4200265687","https://openalex.org/W4205602991","https://openalex.org/W4290548145","https://openalex.org/W4298086912","https://openalex.org/W4366290780","https://openalex.org/W4372335816","https://openalex.org/W4379473281","https://openalex.org/W4381194162","https://openalex.org/W4393190458","https://openalex.org/W4399056698","https://openalex.org/W4400306200","https://openalex.org/W4400995654","https://openalex.org/W4401934568","https://openalex.org/W4404485078","https://openalex.org/W4405902910","https://openalex.org/W4405904514","https://openalex.org/W4406083077","https://openalex.org/W4407290896","https://openalex.org/W4407371439"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"\u968f\u7740\u4eba\u53e3\u7684\u8001\u9f84\u5316\u52a0\u5feb\uff0c\u8001\u5e74\u60a3\u8005\u624b\u672f\u9700\u6c42\u9010\u5e74\u589e\u52a0\u3002\u4f46\u8001\u5e74\u60a3\u8005\u5e38\u5e38\u5b58\u5728\u673a\u4f53\u529f\u80fd\u8870\u9000\uff0c\u5bf9\u9ebb\u9189\u548c\u624b\u672f\u7684\u8010\u53d7\u6027\u8f83\u5dee\u3002\u56e0\u6b64\uff0c\u9009\u62e9\u5408\u9002\u7684\u9ebb\u9189\u836f\u7269\u5bf9\u8001\u5e74\u60a3\u8005\u7684\u624b\u672f\u5b89\u5168\u548c\u672f\u540e\u6062\u590d\u81f3\u5173\u91cd\u8981\u3002\u745e\u9a6c\u5511\u4ed1\u662f\u4e00\u79cd\u65b0\u578b\u7684\u82ef\u4e8c\u6c2e\u44ec\u7c7b\u836f\u7269\uff0c\u5177\u6709\u8d77\u6548\u5feb\u4ee3\u8c22\u5feb\u4e14\u4ee3\u8c22\u4ea7\u7269\u65e0\u6d3b\u6027\u7684\u836f\u7406\u5b66\u7279\u70b9\uff0c\u8fd1\u5e74\u5728\u8001\u5e74\u60a3\u8005\u9ebb\u9189\u4e2d\u7684\u5e94\u7528\u7814\u7a76\u9010\u6e10\u589e\u52a0\u3002\u672c\u6587\u5c31\u745e\u9a6c\u5511\u4ed1\u7684\u4f5c\u7528\u673a\u5236\u4e0e\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u5bf9\u8001\u5e74\u60a3\u8005\u673a\u4f53\u7684\u5f71\u54cd\u548c\u5728\u8001\u5e74\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u5e94\u7528\u4f5c\u4e00\u7efc\u8ff0\uff0c\u4e3a\u5176\u4e34\u5e8a\u9ebb\u9189\u5e94\u7528\u63d0\u4f9b\u53c2\u8003\u3002With":[0],"the":[1,5,7,47,64,86,112],"accelerated":[2],"aging":[3],"of":[4,53,67,88,102,105,115],"population,":[6],"demand":[8],"for":[9,46,132],"surgical":[10,37,48],"procedures":[11],"among":[12],"elderly":[13,20,54,91,116],"patients":[14,21,92],"continues":[15],"to":[16,33,128],"rise":[17],"annually.":[18],"However,":[19],"often":[22],"experience":[23],"age-related":[24],"decline":[25],"in":[26,83,90,93,122],"physiological":[27,113],"functions,":[28],"demonstrating":[29],"significantly":[30],"reduced":[31],"tolerance":[32],"both":[34],"anesthesia":[35,89,135],"and":[36,50,70,72,107,118],"interventions.":[38],"Therefore,":[39],"choosing":[40],"appropriate":[41],"anesthetic":[42],"drugs":[43],"is":[44,57],"crucial":[45],"safety":[49],"postoperative":[51],"recovery":[52],"patients.":[55],"Remimazolam":[56],"a":[58,80,99],"new-type":[59],"benzodiazepine":[60],"drug,":[61],"which":[62],"has":[63,78],"pharmacological":[65],"characteristics":[66],"rapid":[68],"onset":[69],"metabolism,":[71],"its":[73,109,119],"metabo-lites":[74],"are":[75],"inactive.":[76],"There":[77],"been":[79],"gradual":[81],"increase":[82],"research":[84],"on":[85,111],"use":[87],"recent":[94],"years.":[95],"This":[96],"article":[97],"provides":[98],"comprehensive":[100],"review":[101],"remimazolam\u2019s":[103],"mechanism":[104],"action":[106],"pharmacokinetics,":[108],"impact":[110],"systems":[114],"patients,":[117],"clinical":[120,134],"applications":[121],"geriatric":[123],"populations.":[124],"The":[125],"synthesis":[126],"aims":[127],"offer":[129],"evidence-based":[130],"references":[131],"optimizing":[133],"practices":[136],"involving":[137],"this":[138],"agent.":[139]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}