{"id":"https://openalex.org/W4409367669","doi":"https://doi.org/10.1002/cbdv.202500162","title":"Nature\u2010Inspired Anticancer Agents: The Synergy of Phytochemicals and Synthetic Analogs (2019\u20132024)","display_name":"Nature\u2010Inspired Anticancer Agents: The Synergy of Phytochemicals and Synthetic Analogs (2019\u20132024)","publication_year":2025,"publication_date":"2025-04-11","ids":{"openalex":"https://openalex.org/W4409367669","doi":"https://doi.org/10.1002/cbdv.202500162","pmid":"https://pubmed.ncbi.nlm.nih.gov/40213994"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.202500162","doi":"https://doi.org/10.1002/cbdv.202500162","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202500162","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biodiversity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101578090","display_name":"Aman Aman","orcid":"https://orcid.org/0009-0002-6101-7079","observed_orcids":["https://orcid.org/0009-0002-6101-7079"]},"institutions":[{"id":"https://openalex.org/I4210092982","display_name":"Indo Soviet Friendship College of Pharmacy","ror":"https://ror.org/00fd30e02","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210092982"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aman Rai","raw_affiliation_strings":["Department of Pharmaceutical Chemistry ISF College of Pharmacy  Moga India","ISF College of Pharmacy Pharmaceutical Chemistry  Moga 142001 Moga INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry ISF College of Pharmacy  Moga India","institution_ids":["https://openalex.org/I4210092982"]},{"raw_affiliation_string":"ISF College of Pharmacy Pharmaceutical Chemistry  Moga 142001 Moga INDIA","institution_ids":["https://openalex.org/I4210092982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078763625","display_name":"Rohit Bhatia","orcid":"https://orcid.org/0000-0003-4194-8749","observed_orcids":["https://orcid.org/0000-0003-4194-8749"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rohit Bhatia","raw_affiliation_strings":["Chitkara College of Pharmacy Chitkara University  Rajpura India","Chitkara College of Pharmacy Pharmaceutical Chemistry  Rajpura 140401 Rajpura INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy Chitkara University  Rajpura India","institution_ids":["https://openalex.org/I74319210"]},{"raw_affiliation_string":"Chitkara College of Pharmacy Pharmaceutical Chemistry  Rajpura 140401 Rajpura INDIA","institution_ids":["https://openalex.org/I74319210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061757758","display_name":"Rajesh K. Singh","orcid":"https://orcid.org/0000-0002-5943-3498","observed_orcids":["https://orcid.org/0000-0002-5943-3498"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rajesh K. Singh","raw_affiliation_strings":["Department of Pharmaceutical Chemistry Shivalik College of Pharmacy  Rupnagar India","Shivalik College of Pharmacy Pharmaceutical Chemistry  Mojowal 140126 Nangal, Rupnagar INDIA"],"raw_orcid":"https://orcid.org/0000-0002-5943-3498","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry Shivalik College of Pharmacy  Rupnagar India","institution_ids":[]},{"raw_affiliation_string":"Shivalik College of Pharmacy Pharmaceutical Chemistry  Mojowal 140126 Nangal, Rupnagar INDIA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061757758"],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.4994,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.52564103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"22","issue":"9","first_page":"e202500162","last_page":"e202500162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1543000042438507,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.9959999918937683},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.9549999833106995},{"id":"https://openalex.org/keywords/synthetic-analogues","display_name":"synthetic analogues","score":0.9580000042915344},{"id":"https://openalex.org/keywords/vinca-alkaloids","display_name":"vinca alkaloids","score":0.9160000085830688},{"id":"https://openalex.org/keywords/curcuminoids","display_name":"curcuminoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":1.0},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9819999933242798},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.7459999918937683},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7319999933242798},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5932319164276123},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5646785497665405},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.5361565947532654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4632730484008789},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4342602491378784},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4175609350204468},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.36200371384620667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23336291313171387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22012054920196533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17096644639968872},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbdv.202500162","doi":"https://doi.org/10.1002/cbdv.202500162","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202500162","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biodiversity","raw_type":"journal-article"},{"id":"pmid:40213994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40213994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W1199874813","https://openalex.org/W1983375287","https://openalex.org/W2027010220","https://openalex.org/W2096482056","https://openalex.org/W2339407404","https://openalex.org/W2795063553","https://openalex.org/W2795464319","https://openalex.org/W2884498481","https://openalex.org/W2899961157","https://openalex.org/W2905654463","https://openalex.org/W2909558076","https://openalex.org/W2913969183","https://openalex.org/W2947077617","https://openalex.org/W2954822414","https://openalex.org/W2980136515","https://openalex.org/W2988476950","https://openalex.org/W2994638756","https://openalex.org/W2995338836","https://openalex.org/W3001733563","https://openalex.org/W3009846392","https://openalex.org/W3027456772","https://openalex.org/W3044624338","https://openalex.org/W3047607890","https://openalex.org/W3092757803","https://openalex.org/W3104569476","https://openalex.org/W3109391596","https://openalex.org/W3116160946","https://openalex.org/W3118901993","https://openalex.org/W3120689400","https://openalex.org/W3142545326","https://openalex.org/W3194239922","https://openalex.org/W3216146155","https://openalex.org/W4200307603","https://openalex.org/W4214706655","https://openalex.org/W4214834050","https://openalex.org/W4220728834","https://openalex.org/W4220737061","https://openalex.org/W4221131605","https://openalex.org/W4223637031","https://openalex.org/W4223913756","https://openalex.org/W4224021011","https://openalex.org/W4226442636","https://openalex.org/W4229051551","https://openalex.org/W4280505267","https://openalex.org/W4283119423","https://openalex.org/W4283787529","https://openalex.org/W4283800761","https://openalex.org/W4283837173","https://openalex.org/W4285005135","https://openalex.org/W4286449000","https://openalex.org/W4289526272","https://openalex.org/W4306638484","https://openalex.org/W4310788330","https://openalex.org/W4310946789","https://openalex.org/W4311029059","https://openalex.org/W4311287841","https://openalex.org/W4312138835","https://openalex.org/W4312140587","https://openalex.org/W4313518491","https://openalex.org/W4313530184","https://openalex.org/W4313644742","https://openalex.org/W4313877579","https://openalex.org/W4315433173","https://openalex.org/W4315754639","https://openalex.org/W4315795920","https://openalex.org/W4319296680","https://openalex.org/W4320496937","https://openalex.org/W4321605991","https://openalex.org/W4322709348","https://openalex.org/W4323313981","https://openalex.org/W4323568104","https://openalex.org/W4323653639","https://openalex.org/W4327682531","https://openalex.org/W4361280612","https://openalex.org/W4365513375","https://openalex.org/W4366828409","https://openalex.org/W4367047812","https://openalex.org/W4367054947","https://openalex.org/W4367838943","https://openalex.org/W4372279758","https://openalex.org/W4372317384","https://openalex.org/W4379966834","https://openalex.org/W4380874738","https://openalex.org/W4381735716","https://openalex.org/W4381930471","https://openalex.org/W4382182645","https://openalex.org/W4383535411","https://openalex.org/W4383742253","https://openalex.org/W4384068003","https://openalex.org/W4384131373","https://openalex.org/W4384807165","https://openalex.org/W4384924298","https://openalex.org/W4385009748","https://openalex.org/W4385186834","https://openalex.org/W4385349893","https://openalex.org/W4385459133","https://openalex.org/W4385483118","https://openalex.org/W4385765152","https://openalex.org/W4385771485","https://openalex.org/W4387515819","https://openalex.org/W4391724694","https://openalex.org/W6633658626"],"related_works":["https://openalex.org/W3003697872","https://openalex.org/W7130698539","https://openalex.org/W7162944615","https://openalex.org/W4223588456","https://openalex.org/W4413302419","https://openalex.org/W4415725591","https://openalex.org/W4416814311","https://openalex.org/W7138857458","https://openalex.org/W4281762377","https://openalex.org/W4308666272"],"abstract_inverted_index":{"Cancer":[0],"remains":[1],"one":[2],"of":[3,28,38,119,170],"the":[4,35,39,151,167],"most":[5],"formidable":[6],"global":[7],"health":[8],"challenges,":[9],"marked":[10],"by":[11,34,70],"uncontrolled":[12],"cell":[13],"growth":[14],"and":[15,31,63,82,96,121,138,148,157,172,180],"division.":[16],"Despite":[17],"medical":[18],"advancements,":[19],"traditional":[20],"treatments":[21],"often":[22],"fall":[23],"short":[24],"due":[25],"to":[26,94],"issues":[27],"specificity,":[29],"resistance,":[30],"toxicity,":[32],"compounded":[33],"complex":[36],"pathophysiology":[37],"disease.":[40],"In":[41],"this":[42,164],"context,":[43],"natural":[44,98],"products,":[45],"particularly":[46],"phytochemicals,":[47],"have":[48,65],"emerged":[49],"as":[50,56,115],"promising":[51],"anticancer":[52,68],"agents.":[53],"Compounds":[54],"such":[55,114],"vinca":[57],"alkaloids,":[58],"curcuminoids,":[59],"flavonoids,":[60],"terpenoids,":[61],"polyphenols,":[62],"others":[64],"demonstrated":[66],"potent":[67],"properties":[69],"targeting":[71],"key":[72],"molecular":[73],"pathways,":[74],"including":[75],"protein":[76],"kinases,":[77],"aromatase,":[78],"EGFR,":[79],"TNF-\u03b1,":[80],"HER-2,":[81],"caspases.":[83],"This":[84],"review":[85],"explores":[86],"recent":[87],"advancements":[88],"in":[89,150,175],"phytochemical":[90],"research":[91],"from":[92],"2019":[93],"2024":[95],"includes":[97],"product-inspired":[99],"synthetic":[100],"derivatives":[101,174],"with":[102,161],"enhanced":[103],"therapeutic":[104,178],"potential.":[105],"A":[106],"comprehensive":[107],"literature":[108],"survey":[109],"was":[110],"conducted":[111],"using":[112],"databases":[113],"PubMed,":[116],"Scopus,":[117],"Web":[118],"Science,":[120],"Google":[122],"Scholar.":[123],"Keywords":[124],"used":[125],"included":[126],"\"phytochemicals,\"":[127],"\"natural":[128],"products,\"":[129],"\"cancer,\"":[130],"\"anticancer":[131],"agents,\"":[132],"\"kinase":[133],"inhibitors,\"":[134],"\"EGFR,\"":[135],"\"HER2,\"":[136],"\"aromatase,\"":[137],"\"synthetic":[139],"analogs.\"":[140],"Articles":[141],"were":[142],"selected":[143],"based":[144],"on":[145],"relevance,":[146,163],"recency,":[147],"impact":[149],"field.":[152],"By":[153],"providing":[154],"mechanistic":[155],"insights":[156],"highlighting":[158],"novel":[159],"compounds":[160],"clinical":[162],"work":[165],"underscores":[166],"critical":[168],"role":[169],"phytochemicals":[171],"their":[173],"addressing":[176],"current":[177],"limitations":[179],"shaping":[181],"future":[182],"cancer":[183],"treatments.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-12T00:00:00"}
