{"id":"https://openalex.org/W4409361968","doi":"https://doi.org/10.3390/ijms26083635","title":"Quantification of Urine and Plasma Levels of Extracellular Vesicles in a Cohort of Kidney Transplant Recipients and Chronic Kidney Disease Patients","display_name":"Quantification of Urine and Plasma Levels of Extracellular Vesicles in a Cohort of Kidney Transplant Recipients and Chronic Kidney Disease Patients","publication_year":2025,"publication_date":"2025-04-11","ids":{"openalex":"https://openalex.org/W4409361968","doi":"https://doi.org/10.3390/ijms26083635","pmid":"https://pubmed.ncbi.nlm.nih.gov/40332150","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12027010"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26083635","doi":"https://doi.org/10.3390/ijms26083635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26083635","pdf_url":"https://www.mdpi.com/1422-0067/26/8/3635/pdf?version=1744379992","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/8/3635/pdf?version=1744379992","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110930860","display_name":"Valentine Jacob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]},{"id":"https://openalex.org/I4401200268","display_name":"H\u00e9matopo\u00ef\u00e8se et immunologie","ror":"https://ror.org/03keztm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentine Jacob","raw_affiliation_strings":["HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","Laboratory of Histocompatibility, Amiens University Hospital, F-80000 Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"raw_affiliation_string":"Laboratory of Histocompatibility, Amiens University Hospital, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093347741","display_name":"Quentin de Berny","orcid":"https://orcid.org/0000-0003-4487-9101","observed_orcids":["https://orcid.org/0000-0003-4487-9101"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Quentin de Berny","raw_affiliation_strings":["Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0003-4487-9101","affiliations":[{"raw_affiliation_string":"Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003330441","display_name":"Fran\u00e7ois Brazier","orcid":"https://orcid.org/0000-0002-3898-4389","observed_orcids":["https://orcid.org/0000-0002-3898-4389"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Brazier","raw_affiliation_strings":["Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0002-3898-4389","affiliations":[{"raw_affiliation_string":"Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033157210","display_name":"Claire Presne","orcid":"https://orcid.org/0000-0002-9928-4351","observed_orcids":["https://orcid.org/0000-0002-9928-4351"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Presne","raw_affiliation_strings":["Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043460635","display_name":"Julien Lion","orcid":"https://orcid.org/0000-0002-7251-5332","observed_orcids":["https://orcid.org/0000-0002-7251-5332"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]},{"id":"https://openalex.org/I4401200268","display_name":"H\u00e9matopo\u00ef\u00e8se et immunologie","ror":"https://ror.org/03keztm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Lion","raw_affiliation_strings":["HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","Laboratory of Histocompatibility, Amiens University Hospital, F-80000 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0002-7251-5332","affiliations":[{"raw_affiliation_string":"HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"raw_affiliation_string":"Laboratory of Histocompatibility, Amiens University Hospital, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004132295","display_name":"Hakim Ouled\u2010Haddou","orcid":"https://orcid.org/0000-0002-3342-1288","observed_orcids":["https://orcid.org/0000-0002-3342-1288"]},"institutions":[{"id":"https://openalex.org/I4401200268","display_name":"H\u00e9matopo\u00ef\u00e8se et immunologie","ror":"https://ror.org/03keztm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hakim Ouled-Haddou","raw_affiliation_strings":["HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0002-3342-1288","affiliations":[{"raw_affiliation_string":"HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041591151","display_name":"Val\u00e9rie Metzinger\u2010Le Meuth","orcid":"https://orcid.org/0000-0003-1718-5083","observed_orcids":["https://orcid.org/0000-0003-1718-5083"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091279","display_name":"Universit\u00e9 Sorbonne Paris Nord","ror":"https://ror.org/0199hds37","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210091279"]},{"id":"https://openalex.org/I4210134185","display_name":"Laboratoire de Recherche Vasculaire Translationnelle","ror":"https://ror.org/032q95r88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210091279","https://openalex.org/I4210134185"]},{"id":"https://openalex.org/I4401200268","display_name":"H\u00e9matopo\u00ef\u00e8se et immunologie","ror":"https://ror.org/03keztm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Metzinger-Le Meuth","raw_affiliation_strings":["HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","INSERM UMRS 1148, Laboratory for Vascular Translational Science (LVTS), UFR SMBH, University of Sorbonne Paris Nord, F-93000 Bobigny, France"],"raw_orcid":"https://orcid.org/0000-0003-1718-5083","affiliations":[{"raw_affiliation_string":"HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"raw_affiliation_string":"INSERM UMRS 1148, Laboratory for Vascular Translational Science (LVTS), UFR SMBH, University of Sorbonne Paris Nord, F-93000 Bobigny, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210091279","https://openalex.org/I4210134185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057090299","display_name":"Gabriel J. Choukroun","orcid":"https://orcid.org/0000-0003-0772-5656","observed_orcids":["https://orcid.org/0000-0003-0772-5656"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gabriel Choukroun","raw_affiliation_strings":["Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology Dialysis Transplantation, Amiens University Hospital, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061051387","display_name":"Laurent Metzinger","orcid":"https://orcid.org/0000-0002-7636-8480","observed_orcids":["https://orcid.org/0000-0002-7636-8480"]},"institutions":[{"id":"https://openalex.org/I4401200268","display_name":"H\u00e9matopo\u00ef\u00e8se et immunologie","ror":"https://ror.org/03keztm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Metzinger","raw_affiliation_strings":["HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0002-7636-8480","affiliations":[{"raw_affiliation_string":"HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013758593","display_name":"Nicolas Guillaume","orcid":"https://orcid.org/0000-0003-2573-5989","observed_orcids":["https://orcid.org/0000-0003-2573-5989","https://orcid.org/0009-0001-7009-7915"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]},{"id":"https://openalex.org/I4401200268","display_name":"H\u00e9matopo\u00ef\u00e8se et immunologie","ror":"https://ror.org/03keztm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nicolas Guillaume","raw_affiliation_strings":["HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","Laboratory of Histocompatibility, Amiens University Hospital, F-80000 Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEMATIM UR-UPJV 4666, C.U.R.S, University of Picardie Jules Verne, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"raw_affiliation_string":"Laboratory of Histocompatibility, Amiens University Hospital, F-80000 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013758593"],"corresponding_institution_ids":["https://openalex.org/I4210096553","https://openalex.org/I4401200268","https://openalex.org/I4647051"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.3641,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.77344139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"8","first_page":"3635","last_page":"3635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.6859999895095825},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kidney-allograft-rejection","display_name":"renal allograft rejection","score":0.9710000157356262},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.8009999990463257},{"id":"https://openalex.org/keywords/t-cell-mediated-rejection","display_name":"T cell-mediated rejection","score":0.949999988079071},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.6320000290870667},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.890999972820282},{"id":"https://openalex.org/keywords/podocalyxin","display_name":"podocalyxin","score":0.8840000033378601},{"id":"https://openalex.org/keywords/aquaporin-1","display_name":"aquaporin-1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.7590000033378601},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cd41","display_name":"CD41","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endothelial-vesicles","display_name":"endothelial vesicles","score":0.7670000195503235},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.8320000171661377},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7590464949607849},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6212738752365112},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6066732406616211},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5574084520339966},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5432471036911011},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.49799394607543945},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.49308034777641296},{"id":"https://openalex.org/C2779458710","wikidata":"https://www.wikidata.org/wiki/Q1088059","display_name":"Chronic allograft nephropathy","level":4,"score":0.4761088788509369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45611733198165894},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4499109089374542},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4002082943916321},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3670695424079895},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35124391317367554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23942577838897705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11679482460021973},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.08847379684448242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms26083635","doi":"https://doi.org/10.3390/ijms26083635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26083635","pdf_url":"https://www.mdpi.com/1422-0067/26/8/3635/pdf?version=1744379992","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:40332150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40332150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12027010","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12027010/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05037018v1","doi":null,"is_oa":false,"landing_page_url":"https://u-picardie.hal.science/hal-05037018","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, 2025, 26 (8), pp.3635. ⟨10.3390/ijms26083635⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms26083635","doi":"https://doi.org/10.3390/ijms26083635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26083635","pdf_url":"https://www.mdpi.com/1422-0067/26/8/3635/pdf?version=1744379992","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409361968.pdf","grobid_xml":"https://content.openalex.org/works/W4409361968.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2003343932","https://openalex.org/W2052145861","https://openalex.org/W2058976564","https://openalex.org/W2061069563","https://openalex.org/W2086272179","https://openalex.org/W2129062330","https://openalex.org/W2136347227","https://openalex.org/W2159041173","https://openalex.org/W2170852633","https://openalex.org/W2270829764","https://openalex.org/W2394755025","https://openalex.org/W2549968482","https://openalex.org/W2751238393","https://openalex.org/W2766519372","https://openalex.org/W2781097765","https://openalex.org/W2791168161","https://openalex.org/W2793691042","https://openalex.org/W2888556650","https://openalex.org/W2912814500","https://openalex.org/W2982944631","https://openalex.org/W3016677386","https://openalex.org/W3033808786","https://openalex.org/W3148740053","https://openalex.org/W3195251730","https://openalex.org/W3196186912","https://openalex.org/W4294953533","https://openalex.org/W4312113831","https://openalex.org/W4379185069","https://openalex.org/W4387019600","https://openalex.org/W4391649568","https://openalex.org/W4392980187"],"related_works":["https://openalex.org/W3202017350","https://openalex.org/W4409320359","https://openalex.org/W7204016922","https://openalex.org/W7171315641","https://openalex.org/W4296380771","https://openalex.org/W4403835328","https://openalex.org/W4296794346","https://openalex.org/W7170119100","https://openalex.org/W4402796687","https://openalex.org/W2774718115"],"abstract_inverted_index":{"Extracellular":[0],"vesicles":[1],"(EVs)":[2],"have":[3],"a":[4,99,159],"key":[5],"role":[6],"in":[7,193],"intercellular":[8],"communication.":[9],"We":[10,22,35,61],"hypothesized":[11],"that":[12],"EVs":[13,44,141,164,171],"are":[14],"biomarkers":[15,180,190],"of":[16,42,93,102,140,163,181,191],"nephropathy":[17,192],"or":[18,59],"kidney":[19,27,31,182],"allograft":[20,111,116,131,183],"rejection.":[21,184],"screened":[23],"patients":[24,64],"with":[25,65,84,119,124,130,134,156],"chronic":[26],"disease":[28,117],"(CKD)":[29],"and":[30,39,46,70,113,128,146,152,176],"transplant":[32],"(KT)":[33],"recipients.":[34],"measured":[36],"the":[37,76,85,94,105],"urine":[38,78,161],"plasma":[40,138],"levels":[41,139],"total":[43,77],"overall":[45],"EV":[47,79],"subpopulations":[48,95],"(positive":[49],"for":[50],"podocalyxin,":[51],"aquaporin-1,":[52],"CD133,":[53],"CD144,":[54],"CD19,":[55],"CD3,":[56],"CD16,":[57],"CD56,":[58],"CD41).":[60],"included":[62],"92":[63],"CKD,":[66,75],"70":[67],"KT":[68,106],"recipients,":[69,107],"33":[71],"healthy":[72],"volunteers.":[73],"In":[74],"concentration":[80],"was":[81,96],"correlated":[82],"positively":[83],"estimated":[86],"glomerular":[87],"filtration":[88],"rate":[89],"(eGFR),":[90],"but":[91],"none":[92],"identified":[97],"as":[98],"potential":[100],"biomarker":[101],"nephropathy.":[103],"Among":[104],"30":[108],"had":[109,115,136,158],"good":[110],"function":[112],"40":[114],"(13":[118],"antibody-mediated":[120],"rejections":[121],"(ABMR),":[122],"12":[123],"T-cell-mediated":[125],"rejection":[126],"(TCMR),":[127],"15":[129],"dysfunction).":[132],"Patients":[133,155],"ABMR":[135],"low":[137,160],"derived":[142,165,172],"from":[143,166,173],"B-cells,":[144,174],"T-cells,":[145,175],"endothelium":[147,167,177],"(p":[148,168],"=":[149,169],"0.003,":[150],"0.009,":[151],"0.005,":[153],"respectively).":[154],"TCMR":[157],"level":[162],"0.05).":[170],"might":[178],"be":[179],"However,":[185],"we":[186],"did":[187],"not":[188],"identify":[189],"CKD.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-12T00:00:00"}