{"id":"https://openalex.org/W4409308618","doi":"https://doi.org/10.1101/2025.04.07.647508","title":"Differential association of SARS-CoV-2 IgG responses with anti-OC43 IgG in a Senegalese cohort","display_name":"Differential association of SARS-CoV-2 IgG responses with anti-OC43 IgG in a Senegalese cohort","publication_year":2025,"publication_date":"2025-04-08","ids":{"openalex":"https://openalex.org/W4409308618","doi":"https://doi.org/10.1101/2025.04.07.647508"},"language":"en","primary_location":{"id":"doi:10.1101/2025.04.07.647508","doi":"https://doi.org/10.1101/2025.04.07.647508","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.07.647508","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/08/2025.04.07.647508.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/08/2025.04.07.647508.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024994689","display_name":"Rokhaya Faye","orcid":"https://orcid.org/0000-0003-2146-2784","observed_orcids":["https://orcid.org/0000-0003-2146-2784"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Rokhaya Faye","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055834862","display_name":"Adji Astou Mbow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Adji Astou Mbow","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059016469","display_name":"Billo Tall","orcid":"https://orcid.org/0009-0002-5689-7905","observed_orcids":["https://orcid.org/0009-0002-5689-7905"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Billo Tall","raw_affiliation_strings":["Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026525141","display_name":"Aboubacry Gaye","orcid":"https://orcid.org/0000-0002-8550-7737","observed_orcids":["https://orcid.org/0000-0002-8550-7737"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Aboubacry Gaye","raw_affiliation_strings":["Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005780424","display_name":"Amadou Moustapha Ndoye","orcid":"https://orcid.org/0009-0003-3592-0739","observed_orcids":["https://orcid.org/0009-0003-3592-0739"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Amadou Moustapha Ndoye","raw_affiliation_strings":["Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079166146","display_name":"Rokhaya Gueye","orcid":"https://orcid.org/0000-0003-1641-4112","observed_orcids":["https://orcid.org/0000-0003-1641-4112"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Rokhaya Gueye","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060172237","display_name":"Dieynaba Diallo","orcid":"https://orcid.org/0000-0002-3650-5815","observed_orcids":["https://orcid.org/0000-0002-3650-5815"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Dieynaba Diallo","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francine Ndebane Faye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Francine Ndebane Faye","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028909828","display_name":"Cheikh Talla","orcid":"https://orcid.org/0000-0003-0678-1226","observed_orcids":["https://orcid.org/0000-0003-0678-1226"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Cheikh Talla","raw_affiliation_strings":["Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040467803","display_name":"Ndongo Dia","orcid":"https://orcid.org/0000-0002-4051-3797","observed_orcids":["https://orcid.org/0000-0002-4051-3797"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Ndongo Dia","raw_affiliation_strings":["Institut Pasteur de Dakar, Virology Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Virology Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089384486","display_name":"B. Mbengue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Bababcar Mbengue","raw_affiliation_strings":["Universit\u00e9 Cheikh Anta Diop de Dakar, Service d\u2019Immunologie FMPO, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Cheikh Anta Diop de Dakar, Service d\u2019Immunologie FMPO, Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011841078","display_name":"St\u00e9phane Pelleau","orcid":"https://orcid.org/0000-0002-7070-2177","observed_orcids":["https://orcid.org/0000-0002-7070-2177"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Pelleau","raw_affiliation_strings":["Institut Pasteur, Infectious Disease Epidemiology and Analytics G5 Unit, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Infectious Disease Epidemiology and Analytics G5 Unit, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066808545","display_name":"Makhtar Niang","orcid":"https://orcid.org/0000-0003-0810-4595","observed_orcids":["https://orcid.org/0000-0003-0810-4595"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Makhtar Niang","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112773499","display_name":"Moussa Seydi","orcid":"https://orcid.org/0000-0002-0977-1085","observed_orcids":["https://orcid.org/0000-0002-0977-1085"]},"institutions":[{"id":"https://openalex.org/I4210139965","display_name":"Centre Hospitalier National Universitaire de Fann","ror":"https://ror.org/03yjk2s16","country_code":"SN","type":"healthcare","lineage":["https://openalex.org/I4210139965"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Moussa Seydi","raw_affiliation_strings":["Department of Infectious and Tropical diseases, Fann University Hospital, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious and Tropical diseases, Fann University Hospital, Dakar, Senegal","institution_ids":["https://openalex.org/I4210139965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111385117","display_name":"Amadou Alpha Sall","orcid":"https://orcid.org/0000-0002-1056-3662","observed_orcids":["https://orcid.org/0000-0002-1056-3662"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Amadou A. Sall","raw_affiliation_strings":["Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040211967","display_name":"Fabien Taieb","orcid":"https://orcid.org/0000-0002-0941-2859","observed_orcids":["https://orcid.org/0000-0002-0941-2859"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Fabien Ta\u00efeb","raw_affiliation_strings":["Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080293807","display_name":"Cheikh Loucoubar","orcid":"https://orcid.org/0000-0002-9582-4197","observed_orcids":["https://orcid.org/0000-0002-9582-4197"]},"institutions":[{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Cheikh Loucoubar","raw_affiliation_strings":["Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056258333","display_name":"Michael T. White","orcid":"https://orcid.org/0000-0002-7472-4138","observed_orcids":["https://orcid.org/0000-0002-7472-4138","https://orcid.org/0000-0001-7508-7882"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Micha\u00ebl White","raw_affiliation_strings":["Institut Pasteur, Infectious Disease Epidemiology and Analytics G5 Unit, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Infectious Disease Epidemiology and Analytics G5 Unit, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078560320","display_name":"Thomas Poiret","orcid":"https://orcid.org/0000-0003-1965-3522","observed_orcids":["https://orcid.org/0000-0003-1965-3522"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["SE","SN"],"is_corresponding":false,"raw_author_name":"Thomas Poiret","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","Karolinska Institute, Department of Medicine Huddinge (MedH), Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]},{"raw_affiliation_string":"Karolinska Institute, Department of Medicine Huddinge (MedH), Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074438842","display_name":"In\u00e8s Vigan-Womas","orcid":"https://orcid.org/0000-0001-7848-9297","observed_orcids":["https://orcid.org/0000-0001-7848-9297"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4210137838","display_name":"Institut Pasteur de Dakar","ror":"https://ror.org/02ysgwq33","country_code":"SN","type":"nonprofit","lineage":["https://openalex.org/I4210137838"]}],"countries":["FR","SN"],"is_corresponding":true,"raw_author_name":"In\u00e9s Vigan-Womas","raw_affiliation_strings":["Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","Institut Pasteur, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-7848-9297","affiliations":[{"raw_affiliation_string":"Institut Pasteur de Dakar, Immunophysiopathology and Infectious Diseases Department, Dakar, Senegal","institution_ids":["https://openalex.org/I4210137838"]},{"raw_affiliation_string":"Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5074438842"],"corresponding_institution_ids":["https://openalex.org/I157536573","https://openalex.org/I4210137838"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hcov-oc43","display_name":"HCoV-OC43","score":0.8209999799728394},{"id":"https://openalex.org/keywords/asymptomatic-covid-19","display_name":"asymptomatic COVID-19","score":0.8289999961853027},{"id":"https://openalex.org/keywords/symptomatic-covid-19","display_name":"symptomatic COVID-19","score":0.9240000247955322},{"id":"https://openalex.org/keywords/sars-cov-2-spike-protein","display_name":"SARS-CoV-2 spike protein","score":0.7620000243186951},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.6959999799728394},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.7459999918937683},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.3070000112056732},{"id":"https://openalex.org/keywords/sub-saharan-africa","display_name":"sub-Saharan Africa","score":0.7329999804496765},{"id":"https://openalex.org/keywords/senegal","display_name":"Senegal","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6136483550071716},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5768311023712158},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5047010183334351},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.48146525025367737},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4661971628665924},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.45344406366348267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4112429618835449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3939882814884186},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37605705857276917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1467995047569275},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.11644452810287476},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07828846573829651},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.04.07.647508","doi":"https://doi.org/10.1101/2025.04.07.647508","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.07.647508","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/08/2025.04.07.647508.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.04.07.647508","doi":"https://doi.org/10.1101/2025.04.07.647508","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.07.647508","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/08/2025.04.07.647508.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1150236008","display_name":"Institut Pasteur de Dakar - to connect local pathogen genomic surveillance to improved local immunological assessments and antibody discovery","funder_award_id":"INV-030776","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320321874","display_name":"Minist\u00e8re de l'Europe et des Affaires \u00c9trang\u00e8res","ror":"https://ror.org/00dfd1509"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409308618.pdf","grobid_xml":"https://content.openalex.org/works/W4409308618.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W2075603971","https://openalex.org/W3007859670","https://openalex.org/W3014721277","https://openalex.org/W3016746341","https://openalex.org/W3093667122","https://openalex.org/W3107068086","https://openalex.org/W3107476667","https://openalex.org/W3108357726","https://openalex.org/W3131755888","https://openalex.org/W3134324254","https://openalex.org/W3134489892","https://openalex.org/W3136275452","https://openalex.org/W3157116442","https://openalex.org/W3158186844","https://openalex.org/W3175182301","https://openalex.org/W3183356412","https://openalex.org/W3187037898","https://openalex.org/W3195467757","https://openalex.org/W4210279332","https://openalex.org/W4241518937","https://openalex.org/W4284887508","https://openalex.org/W4312071135","https://openalex.org/W4315475125","https://openalex.org/W4316468879","https://openalex.org/W4317939789","https://openalex.org/W4324133213","https://openalex.org/W4383058386","https://openalex.org/W4384025145","https://openalex.org/W4385299304","https://openalex.org/W4386546961","https://openalex.org/W4388732790","https://openalex.org/W4388948456","https://openalex.org/W4389750078","https://openalex.org/W4391256362","https://openalex.org/W4396588472","https://openalex.org/W4401243529"],"related_works":["https://openalex.org/W4384025145","https://openalex.org/W4311227533","https://openalex.org/W3134942922","https://openalex.org/W4220988106","https://openalex.org/W4406774786","https://openalex.org/W4313453925","https://openalex.org/W3190750829","https://openalex.org/W4398200272","https://openalex.org/W3129165862","https://openalex.org/W4404127347"],"abstract_inverted_index":{"Abstract":[0],"Numerous":[1],"studies":[2],"elucidated":[3],"the":[4,7,17,49,53,109,236,257,283,341,382,397],"kinetics":[5],"of":[6,19,52,62,238,285,362,384],"humoral":[8],"immune":[9,252,309,326,345,363],"response":[10],"post-SARS-CoV-2":[11],"infection.":[12],"However,":[13],"in":[14,46,185,199,225,280,316,330],"sub-Saharan":[15,391],"Africa,":[16],"evolution":[18,284],"SARS-CoV-2":[20,92,98,120,206,290,329,349],"IgG":[21,95,121,149,161,174,198,207,286],"antibody":[22,287,385],"responses":[23,288,310,327,346,386],"and":[24,99,155,171,196,214,222,270,350,365,374,407],"their":[25],"interaction":[26],"with":[27,65,179],"pre-existing":[28,219,351],"seasonal":[29,305,354],"human":[30],"coronavirus":[31,411],"(HCoVs:":[32],"OC43,":[33],"229E,":[34],"NL63,":[35],"HKU1)":[36],"immunity":[37,221,352],"remain":[38],"underexplored.":[39],"A":[40,60,188],"prospective":[41],"cohort":[42],"study":[43,203],"was":[44,191],"conducted":[45],"Senegal":[47],"during":[48],"first":[50],"year":[51],"COVID-19":[54,67,223,281,406],"pandemic":[55],"(March":[56],"to":[57,211,255,303,311,328,396],"December":[58],"2020).":[59],"total":[61],"204":[63,110],"patients":[64,144,158],"laboratory-confirmed":[66],"were":[68,71,86,101,122],"included.":[69],"Patients":[70],"classified":[72],"as":[73,323],"symptomatic":[74,186,200],"(n=157)":[75],"or":[76],"asymptomatic":[77,164],"(n=47)":[78],"based":[79],"on":[80,241,325,381],"clinical":[81],"presentation.":[82],"Plasma":[83],"samples":[84],"(n=705)":[85],"collected":[87],"over":[88,293,387],"6":[89,124,212],"months":[90,125,213],"from":[91,353],"positive":[93,189],"individuals.":[94],"levels":[96,150,162,175],"against":[97,151,245,289,405],"HCoVs":[100,240],"measured":[102],"using":[103],"a":[104,216,294,390],"multiplex":[105],"bead-based":[106],"assay.":[107],"Among":[108],"participants":[111],"included":[112],"(95":[113],"[46.6%]":[114],"female,":[115],"median":[116],"age,":[117],"44":[118],"[7\u201395]),":[119],"detectable":[123],"post-infection,":[126,178],"peaking":[127,181],"at":[128,140,182,401],"1":[129],"month":[130],"for":[131,135,167,209,260,265,370,409],"most":[132],"antigens,":[133],"except":[134],"Spike":[136],"(S),":[137],"which":[138],"peaked":[139],"3":[141,184],"months.":[142],"Elderly":[143],"(>60":[145],"years)":[146],"exhibited":[147],"higher":[148,160],"both":[152],"SARS-":[153],"CoV-2":[154],"HCoVs.":[156],"Symptomatic":[157],"had":[159],"than":[163],"individuals,":[165],"especially":[166],"WTS,":[168],"RBD,":[169],"S2,":[170],"N.":[172],"Anti-HCoV":[173],"remained":[176],"stable":[177],"OC43":[180],"week":[183],"patients.":[187,201],"correlation":[190],"found":[192],"between":[193,218,344],"anti-SARS-CoV-":[194],"2":[195],"anti-OC43":[197],"The":[202],"highlights":[204],"persistent":[205],"antibodies":[208],"up":[210],"suggests":[215],"link":[217],"HCoV-OC43":[220],"outcomes":[224],"Senegal.":[226],"These":[227,357],"findings":[228,358],"could":[229],"help":[230],"shape":[231],"future":[232,410],"vaccine":[233,272,376],"strategies,":[234],"considering":[235],"influence":[237,308],"circulating":[239,355],"long-":[242],"term":[243],"protection":[244,373],"SARS-CoV-2.":[246,312],"Author":[247],"summary":[248],"Understanding":[249],"how":[250,300],"our":[251,276,360,393],"system":[253],"responds":[254],"SARS-CoV-2,":[256],"virus":[258],"responsible":[259],"COVID-":[261],"19,":[262],"is":[263,320],"essential":[264],"guiding":[266],"public":[267],"health":[268],"countermeasures":[269],"informing":[271],"development":[273],"strategies.":[274,377],"In":[275],"study,":[277],"we":[278,298],"monitored,":[279],"patients,":[282],"structural":[291],"proteins":[292],"six-month":[295],"period.":[296],"Additionally,":[297],"examined":[299],"previous":[301],"exposure":[302],"common":[304],"coronaviruses":[306],"might":[307],"Conducting":[313],"this":[314,331],"research":[315,394],"an":[317],"African":[318],"context":[319],"particularly":[321],"important,":[322],"data":[324],"region":[332],"are":[333],"scarce.":[334],"Our":[335],"results":[336],"provide":[337],"valuable":[338],"insights":[339],"into":[340],"complex":[342],"interplay":[343],"elicited":[347],"by":[348],"coronaviruses.":[356],"enhance":[359],"understanding":[361],"memory":[364],"cross-reactivity,":[366],"two":[367],"critical":[368],"factors":[369],"assessing":[371],"long-term":[372],"optimizing":[375],"By":[378],"shedding":[379],"light":[380],"dynamics":[383],"time":[388],"within":[389],"population,":[392],"contributes":[395],"global":[398],"effort":[399],"aimed":[400],"developing":[402],"effective":[403],"interventions":[404],"preparing":[408],"outbreaks.":[412]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-04-10T00:00:00"}