{"id":"https://openalex.org/W4409304872","doi":"https://doi.org/10.37547/ijmscr/volume05issue03-09","title":"The study of acute toxity and efficacy evaluation of bioactive compounds for constipation","display_name":"The study of acute toxity and efficacy evaluation of bioactive compounds for constipation","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4409304872","doi":"https://doi.org/10.37547/ijmscr/volume05issue03-09"},"language":"en","primary_location":{"id":"doi:10.37547/ijmscr/volume05issue03-09","doi":"https://doi.org/10.37547/ijmscr/volume05issue03-09","is_oa":true,"landing_page_url":"https://doi.org/10.37547/ijmscr/volume05issue03-09","pdf_url":"https://theusajournals.com/index.php/ijmscr/article/download/5054/4720/5823","source":{"id":"https://openalex.org/S4387279703","display_name":"International Journal of Medical Sciences And Clinical Research","issn_l":"2771-2265","issn":["2771-2265"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences And Clinical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://theusajournals.com/index.php/ijmscr/article/download/5054/4720/5823","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117091208","display_name":"Nufuzakhan Adilova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164592","display_name":"Tashkent Medical Academy","ror":"https://ror.org/05sgw3s08","country_code":"UZ","type":"education","lineage":["https://openalex.org/I4210164592","https://openalex.org/I4405267534"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Nufuzakhan Adilova","raw_affiliation_strings":["Tashkent Medical Academy , Tashkent , Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tashkent Medical Academy , Tashkent , Uzbekistan","institution_ids":["https://openalex.org/I4210164592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117091209","display_name":"Malika Foziljonova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malika Foziljonova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117091210","display_name":"Zilola Abdujalilova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zilola Abdujalilova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117091211","display_name":"Abdusattor Tojiboyev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdusattor Tojiboyev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5117091212","display_name":"Jasurbek Kholmatov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jasurbek Kholmatov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"3","first_page":"46","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.9269999861717224},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.968999981880188},{"id":"https://openalex.org/keywords/laxative-efficacy","display_name":"laxative efficacy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/intestinal-motility","display_name":"intestinal motility","score":0.9570000171661377},{"id":"https://openalex.org/keywords/stool-frequency","display_name":"stool frequency","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.49799999594688416},{"id":"https://openalex.org/keywords/safety-profile","display_name":"safety profile","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.7584940195083618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47135868668556213},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.450031042098999},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3800796568393707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24889326095581055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.37547/ijmscr/volume05issue03-09","doi":"https://doi.org/10.37547/ijmscr/volume05issue03-09","is_oa":true,"landing_page_url":"https://doi.org/10.37547/ijmscr/volume05issue03-09","pdf_url":"https://theusajournals.com/index.php/ijmscr/article/download/5054/4720/5823","source":{"id":"https://openalex.org/S4387279703","display_name":"International Journal of Medical Sciences And Clinical Research","issn_l":"2771-2265","issn":["2771-2265"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences And Clinical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.37547/ijmscr/volume05issue03-09","doi":"https://doi.org/10.37547/ijmscr/volume05issue03-09","is_oa":true,"landing_page_url":"https://doi.org/10.37547/ijmscr/volume05issue03-09","pdf_url":"https://theusajournals.com/index.php/ijmscr/article/download/5054/4720/5823","source":{"id":"https://openalex.org/S4387279703","display_name":"International Journal of Medical Sciences And Clinical Research","issn_l":"2771-2265","issn":["2771-2265"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences And Clinical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409304872.pdf","grobid_xml":"https://content.openalex.org/works/W4409304872.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2065238108"],"related_works":["https://openalex.org/W7201832130","https://openalex.org/W4389996658","https://openalex.org/W2399714041","https://openalex.org/W4242005194","https://openalex.org/W7202168978","https://openalex.org/W2809551393","https://openalex.org/W2971607770","https://openalex.org/W4412682983","https://openalex.org/W3089094282","https://openalex.org/W2401607467"],"abstract_inverted_index":{"Constipation":[0],"is":[1],"a":[2,87],"prevalent":[3],"gastrointestinal":[4],"disorder":[5],"that":[6,73],"significantly":[7],"impacts":[8],"patients'":[9],"quality":[10],"of":[11,24,31,46],"life.":[12],"The":[13,50],"present":[14],"study":[15],"aims":[16],"to":[17,42,98],"evaluate":[18],"the":[19,29,47,74],"acute":[20],"toxicity":[21,34],"and":[22,57,66,81,103],"efficacy":[23,52],"selected":[25],"bioactive":[26,48],"compounds":[27,76],"for":[28,90],"treatment":[30],"constipation.":[32],"Acute":[33],"was":[35,53],"assessed":[36],"using":[37],"standardized":[38],"in":[39],"vivo":[40],"models":[41],"determinethe":[43],"safety":[44,79,102],"profile":[45],"compounds.":[49],"therapeutic":[51],"evaluated":[54],"through":[55],"pharmacodynamic":[56],"biochemical":[58],"analyses,":[59],"focusing":[60],"on":[61],"bowel":[62],"motility,":[63],"stool":[64],"frequency,":[65],"intestinal":[67],"microbiota":[68],"modulation.":[69],"Preliminary":[70],"findings":[71],"suggest":[72],"tested":[75],"exhibit":[77],"favorable":[78],"margins":[80],"potent":[82],"laxative":[83],"effects,":[84],"potentially":[85],"offering":[86],"novel":[88],"approach":[89],"constipation":[91],"management.":[92],"Further":[93],"clinical":[94],"studies":[95],"are":[96],"required":[97],"validate":[99],"their":[100],"long-term":[101],"effectiveness.":[104]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-10T00:00:00"}