{"id":"https://openalex.org/W4409304623","doi":"https://doi.org/10.1002/viw.20240075","title":"The effectiveness and safety of azvudine treatment in COVID\u201019 patients with kidney disease based on a multicenter retrospective cohort study","display_name":"The effectiveness and safety of azvudine treatment in COVID\u201019 patients with kidney disease based on a multicenter retrospective cohort study","publication_year":2025,"publication_date":"2025-04-09","ids":{"openalex":"https://openalex.org/W4409304623","doi":"https://doi.org/10.1002/viw.20240075"},"language":"en","primary_location":{"id":"doi:10.1002/viw.20240075","doi":"https://doi.org/10.1002/viw.20240075","is_oa":true,"landing_page_url":"https://doi.org/10.1002/viw.20240075","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240075","source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VIEW","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240075","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112112239","display_name":"Bo Yu","orcid":"https://orcid.org/0009-0001-6305-2014","observed_orcids":["https://orcid.org/0009-0001-6305-2014"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Yu","raw_affiliation_strings":["Department of Pharmacy The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"],"raw_orcid":"https://orcid.org/0009-0001-6305-2014","affiliations":[{"raw_affiliation_string":"Department of Pharmacy The First Affiliated Hospital of Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113115292","display_name":"Mengzhao Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengzhao Yang","raw_affiliation_strings":["Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101632989","display_name":"Jia Xin Yu","orcid":"https://orcid.org/0000-0002-3319-5997","observed_orcids":["https://orcid.org/0000-0002-3319-5997"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Yu","raw_affiliation_strings":["Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101536285","display_name":"Daming Wang","orcid":"https://orcid.org/0000-0001-5572-5090","observed_orcids":["https://orcid.org/0000-0001-5572-5090"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daming Wang","raw_affiliation_strings":["Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044782497","display_name":"Hong Luo","orcid":"https://orcid.org/0000-0002-9501-651X","observed_orcids":["https://orcid.org/0000-0002-9501-651X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Luo","raw_affiliation_strings":["Guangshan County People's Hospital, Guangshan County  Xinyang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangshan County People's Hospital, Guangshan County  Xinyang China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034552479","display_name":"Ming Cheng","orcid":"https://orcid.org/0000-0001-7098-6790","observed_orcids":["https://orcid.org/0000-0001-7098-6790"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Cheng","raw_affiliation_strings":["Department of Medical Information The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Information The First Affiliated Hospital of Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071884526","display_name":"Shixi Zhang","orcid":"https://orcid.org/0000-0001-6649-622X","observed_orcids":["https://orcid.org/0000-0001-6649-622X"]},"institutions":[{"id":"https://openalex.org/I4210109624","display_name":"Shangqiu First People's Hospital","ror":"https://ror.org/025gwsg11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shixi Zhang","raw_affiliation_strings":["Department of Infectious Diseases Shangqiu Municipal Hospital  Shangqiu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Shangqiu Municipal Hospital  Shangqiu China","institution_ids":["https://openalex.org/I4210109624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000388617","display_name":"Guotao Li","orcid":"https://orcid.org/0000-0001-9201-2700","observed_orcids":["https://orcid.org/0000-0001-9201-2700"]},"institutions":[{"id":"https://openalex.org/I4210125993","display_name":"Luoyang Central Hospital Affiliated to Zhengzhou University","ror":"https://ror.org/03cg5ap92","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guotao Li","raw_affiliation_strings":["Department of Infectious Diseases Luoyang Central Hospital Affiliated of Zhengzhou University  Luoyang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Luoyang Central Hospital Affiliated of Zhengzhou University  Luoyang China","institution_ids":["https://openalex.org/I4210125993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398723","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0003-1736-7880","observed_orcids":["https://orcid.org/0000-0003-1736-7880"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210143981","display_name":"Henan Provincial Chest Hospital","ror":"https://ror.org/04d3sf574","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Department of Clinical Laboratory Henan Provincial Chest Hospital Affiliated of Zhengzhou University  Zhengzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Henan Provincial Chest Hospital Affiliated of Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210143981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024382839","display_name":"Guowu Qian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guowu Qian","raw_affiliation_strings":["Department of Gastrointestinal Surgery Nanyang Central Hospital  Nanyang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery Nanyang Central Hospital  Nanyang China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058298924","display_name":"Donghua Zhang","orcid":"https://orcid.org/0000-0003-2959-9638","observed_orcids":["https://orcid.org/0000-0003-2959-9638"]},"institutions":[{"id":"https://openalex.org/I4210096186","display_name":"The Fifth People's Hospital of Anyang","ror":"https://ror.org/00ty48v44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096186"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donghua Zhang","raw_affiliation_strings":["Department of Infectious Diseases Anyang City Fifth People's Hospital  Anyang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases Anyang City Fifth People's Hospital  Anyang China","institution_ids":["https://openalex.org/I4210096186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103037806","display_name":"Silin Li","orcid":"https://orcid.org/0000-0002-4543-1141","observed_orcids":["https://orcid.org/0000-0002-4543-1141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silin Li","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine Fengqiu County People's Hospital  Xinxiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine Fengqiu County People's Hospital  Xinxiang China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003281764","display_name":"Zhigang Ren","orcid":"https://orcid.org/0000-0003-0798-3444","observed_orcids":["https://orcid.org/0000-0003-0798-3444"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhigang Ren","raw_affiliation_strings":["Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"],"raw_orcid":"https://orcid.org/0000-0003-0798-3444","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases State Key Laboratory of Antiviral Drugs Pingyuan Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091720132","display_name":"Quancheng Kan","orcid":"https://orcid.org/0000-0002-2998-4918","observed_orcids":["https://orcid.org/0000-0002-2998-4918"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quancheng Kan","raw_affiliation_strings":["Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou University  Zhengzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou University  Zhengzhou China","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003281764","https://openalex.org/A5091720132"],"corresponding_institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.732,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67050164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"6","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azvudine","display_name":"azvudine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9660000205039978},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.921999990940094},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7774744629859924},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7767835855484009},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6473158597946167},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5017035007476807},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4908323884010315},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.472507119178772},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.47182971239089966},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.45714524388313293},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.44741031527519226},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4322761297225952},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.42372697591781616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1822807788848877},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.11287656426429749},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.07729530334472656},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.06781059503555298}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/viw.20240075","doi":"https://doi.org/10.1002/viw.20240075","is_oa":true,"landing_page_url":"https://doi.org/10.1002/viw.20240075","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240075","source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VIEW","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:126447d8d6924e91a22d77d355a04525","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/126447d8d6924e91a22d77d355a04525","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"View, Vol 6, Iss 3, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/viw.20240075","doi":"https://doi.org/10.1002/viw.20240075","is_oa":true,"landing_page_url":"https://doi.org/10.1002/viw.20240075","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/VIW.20240075","source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VIEW","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7727370608","display_name":null,"funder_award_id":"2022YFC2303100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320322766","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21"},{"id":"https://openalex.org/F4320329504","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409304623.pdf","grobid_xml":"https://content.openalex.org/works/W4409304623.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2056365493","https://openalex.org/W2159798994","https://openalex.org/W2922315794","https://openalex.org/W2999535351","https://openalex.org/W3011605790","https://openalex.org/W3015539298","https://openalex.org/W3043552482","https://openalex.org/W3082374203","https://openalex.org/W3091853899","https://openalex.org/W3113301600","https://openalex.org/W3120938688","https://openalex.org/W4210736465","https://openalex.org/W4210845203","https://openalex.org/W4251567075","https://openalex.org/W4294043822","https://openalex.org/W4319769006","https://openalex.org/W4366993457","https://openalex.org/W4385407145","https://openalex.org/W4386165857","https://openalex.org/W4387603421"],"related_works":["https://openalex.org/W2953771978","https://openalex.org/W4391941342","https://openalex.org/W2809647437","https://openalex.org/W1503373895","https://openalex.org/W4382055447","https://openalex.org/W2056621076","https://openalex.org/W1969266547","https://openalex.org/W4210813419","https://openalex.org/W3021739776","https://openalex.org/W4200133826"],"abstract_inverted_index":{"Abstract":[0],"Kidney":[1],"disease":[2,27,71,79,114,153,182,232],"has":[3],"been":[4,30],"the":[5,122,133,148,191,216,220,239],"main":[6],"risk":[7,240],"factor":[8,175],"of":[9,19,68,106,136,151,166,173,193,207,224,241],"poor":[10],"prognosis":[11],"for":[12],"COVID\u201019":[13,23,49,228],"patients.":[14],"The":[15,163],"effectiveness":[16,221],"and":[17,37,62,76,93,112,147,180,222,233],"safety":[18,223],"azvudine":[20,75,100,210,225,236],"treatment":[21,85,226],"in":[22,41,51,176,227],"patients":[24,54,72,80,229],"with":[25,57,74,230],"kidney":[26,58,70,78,231],"have":[28],"not":[29],"reported.":[31],"Herein,":[32],"we":[33,97,214],"conducted":[34],"a":[35,66,250],"nine\u2010center":[36],"retrospective":[38,253],"cohort":[39,254],"study":[40],"China":[42],"(ClinicalTrials:":[43],"NCT06349655)":[44],"that":[45,99,132,235],"enrolled":[46],"32,864":[47],"hospitalized":[48],"patients,":[50],"which":[52],"4192":[53],"were":[55,88,187],"pre\u2010existed":[56],"disease.":[59],"After":[60],"exclusions":[61],"propensity":[63],"score":[64],"matching,":[65],"total":[67],"831":[69,77],"treated":[73,81],"without":[82,244],"any":[83],"anti\u2010viral":[84],"(normal":[86],"group)":[87],"selected.":[89],"Based":[90],"on":[91,199,249],"Kaplan\u2013Meier":[92],"Cox":[94,126],"regression":[95,129],"analysis,":[96],"found":[98],"administration":[101],"had":[102],"significantly":[103],"decreased":[104],"risks":[105],"all\u2010cause":[107,137,178,242],"death":[108,138,243],"(p":[109,116],"<":[110,145],"0.0001)":[111],"composite":[113,152,181],"progression":[115,154],"=":[117,161],"0.012)":[118],"as":[119],"compared":[120],"to":[121,189,218],"normal":[123],"group.":[124],"Multivariate":[125],"proportional":[127],"hazards":[128],"analysis":[130,165,197],"demonstrated":[131,203],"hazard":[134,149],"ratio":[135,150],"was":[139,155],"0.64":[140],"(95%":[141,157],"CI:":[142,158],"0.503\u20130.826,":[143],"p":[144,160],"0.001)":[146],"0.81":[156],"0.658\u20131.004,":[159],"0.05).":[162],"subgroup":[164],"different":[167],"characteristics":[168],"indicated":[169],"no":[170],"significant":[171,245],"influence":[172],"single":[174],"both":[177],"mortality":[179],"progression.":[183],"Five":[184],"sensitivity":[185],"analyses":[186],"employed":[188],"verify":[190],"robustness":[192],"our":[194],"results.":[195],"Safety":[196],"based":[198,248],"adverse":[200,246],"event":[201],"rate":[202,206],"an":[204],"increased":[205],"hypertriglyceridemia":[208],"after":[209],"administration.":[211],"In":[212],"conclusion,":[213],"are":[215],"first":[217],"report":[219],"demonstrate":[234],"could":[237],"reduce":[238],"events":[247],"large\u2010scale,":[251],"multicenter,":[252],"study.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}