{"id":"https://openalex.org/W4409255672","doi":"https://doi.org/10.1016/j.omton.2025.200982","title":"hsa-miR-5688 inhibits FOXC1-OCT4/SOX2 feedforward loop that drives chemoresistance in breast cancer stem cells","display_name":"hsa-miR-5688 inhibits FOXC1-OCT4/SOX2 feedforward loop that drives chemoresistance in breast cancer stem cells","publication_year":2025,"publication_date":"2025-04-08","ids":{"openalex":"https://openalex.org/W4409255672","doi":"https://doi.org/10.1016/j.omton.2025.200982","pmid":"https://pubmed.ncbi.nlm.nih.gov/40330903"},"language":"en","primary_location":{"id":"doi:10.1016/j.omton.2025.200982","doi":"https://doi.org/10.1016/j.omton.2025.200982","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2025.200982","pdf_url":null,"source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omton.2025.200982","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031629589","display_name":"Apratim Dutta","orcid":"https://orcid.org/0000-0002-9643-5396","observed_orcids":["https://orcid.org/0000-0002-9643-5396"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Apratim Dutta","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026211558","display_name":"Sourio Chakraborty","orcid":"https://orcid.org/0000-0003-4925-2754","observed_orcids":["https://orcid.org/0000-0003-4925-2754"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sourio Chakraborty","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035740598","display_name":"Apoorva Bhattacharya","orcid":"https://orcid.org/0000-0001-5016-8918","observed_orcids":["https://orcid.org/0000-0001-5016-8918"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Apoorva Bhattacharya","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004991238","display_name":"Udit Basak","orcid":"https://orcid.org/0000-0001-9632-8614","observed_orcids":["https://orcid.org/0000-0001-9632-8614"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Udit Basak","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070276956","display_name":"Subhadip Pati","orcid":"https://orcid.org/0000-0002-8878-0915","observed_orcids":["https://orcid.org/0000-0002-8878-0915"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhadip Pati","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060335899","display_name":"Sumon Mukherjee","orcid":"https://orcid.org/0000-0003-2175-0348","observed_orcids":["https://orcid.org/0000-0003-2175-0348"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumon Mukherjee","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039373871","display_name":"Deblina Guha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deblina Guha","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068985380","display_name":"Shruti Banerjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shruti Banerjee","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058524504","display_name":"Nibedita Ray Chaudhuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nibedita Ray Chaudhuri","raw_affiliation_strings":["Unified Academic Campus, Bose Institute, HCGJ+4X5, EN Block, Sector V, Bidhannagar, Kolkata, West Bengal 700091, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unified Academic Campus, Bose Institute, HCGJ+4X5, EN Block, Sector V, Bidhannagar, Kolkata, West Bengal 700091, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010185785","display_name":"Diptendra Kumar Sarkar","orcid":"https://orcid.org/0000-0002-9702-5620","observed_orcids":["https://orcid.org/0000-0002-9702-5620"]},"institutions":[{"id":"https://openalex.org/I4210100047","display_name":"Institute of Post Graduate Medical Education and Research","ror":"https://ror.org/00ysvbp68","country_code":"IN","type":"education","lineage":["https://openalex.org/I226431899","https://openalex.org/I4210100047"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Diptendra Sarkar","raw_affiliation_strings":["Department of Surgery, IPGMER and SSKM Hospital, Kolkata 700020, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, IPGMER and SSKM Hospital, Kolkata 700020, India","institution_ids":["https://openalex.org/I4210100047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090802552","display_name":"Kuladip Jana","orcid":"https://orcid.org/0000-0003-4748-253X","observed_orcids":["https://orcid.org/0000-0003-4748-253X"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kuladip Jana","raw_affiliation_strings":["Unified Academic Campus, Bose Institute, HCGJ+4X5, EN Block, Sector V, Bidhannagar, Kolkata, West Bengal 700091, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unified Academic Campus, Bose Institute, HCGJ+4X5, EN Block, Sector V, Bidhannagar, Kolkata, West Bengal 700091, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021647592","display_name":"Gaurisankar Sa","orcid":"https://orcid.org/0000-0002-5322-3481","observed_orcids":["https://orcid.org/0000-0002-5322-3481"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gaurisankar Sa","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026320911","display_name":"Shubhra Ghosh Dastidar","orcid":"https://orcid.org/0000-0002-0692-8139","observed_orcids":["https://orcid.org/0000-0002-0692-8139"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubhra Ghosh Dastidar","raw_affiliation_strings":["Unified Academic Campus, Bose Institute, HCGJ+4X5, EN Block, Sector V, Bidhannagar, Kolkata, West Bengal 700091, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unified Academic Campus, Bose Institute, HCGJ+4X5, EN Block, Sector V, Bidhannagar, Kolkata, West Bengal 700091, India","institution_ids":["https://openalex.org/I152754861"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102008653","display_name":"Tanya Das","orcid":"https://orcid.org/0000-0002-9583-0693","observed_orcids":["https://orcid.org/0000-0002-9583-0693"]},"institutions":[{"id":"https://openalex.org/I152754861","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88","country_code":"IN","type":"facility","lineage":["https://openalex.org/I152754861"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Tanya Das","raw_affiliation_strings":["Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India"],"raw_orcid":"https://orcid.org/0000-0002-9583-0693","affiliations":[{"raw_affiliation_string":"Centenary Building, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India","institution_ids":["https://openalex.org/I152754861"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102008653"],"corresponding_institution_ids":["https://openalex.org/I152754861"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.7233,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69189415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"33","issue":"2","first_page":"200982","last_page":"200982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.08340000361204147,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxc1","display_name":"FOXC1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9200000166893005},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":1.0},{"id":"https://openalex.org/keywords/feedforward-loop","display_name":"feed-forward loop","score":0.7990000247955322},{"id":"https://openalex.org/keywords/breast-cancer-stem-cells","display_name":"breast cancer stem cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8809999823570251},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.6499999761581421},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.6859999895095825},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.4860000014305115},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6169999837875366},{"id":"https://openalex.org/keywords/pluripotency-factors","display_name":"pluripotency factors","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.7240064740180969},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5845847725868225},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5240378975868225},{"id":"https://openalex.org/C2779184190","wikidata":"https://www.wikidata.org/wiki/Q1269627","display_name":"Amendment","level":2,"score":0.48784518241882324},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4654252231121063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46373215317726135},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4371607303619385},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36432379484176636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35262903571128845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30565279722213745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30293816328048706},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.2691355347633362},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.2111372947692871},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14037886261940002},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10889971256256104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10748216509819031},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08767443895339966}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.omton.2025.200982","doi":"https://doi.org/10.1016/j.omton.2025.200982","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2025.200982","pdf_url":null,"source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},{"id":"pmid:40330903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40330903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10864031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12051596","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12051596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12051596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mol Ther Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fcf5fdde338a44c3859d712d8db04fd4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fcf5fdde338a44c3859d712d8db04fd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Oncology, Vol 33, Iss 2, Pp 200982- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omton.2025.200982","doi":"https://doi.org/10.1016/j.omton.2025.200982","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2025.200982","pdf_url":null,"source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2669494524","display_name":null,"funder_award_id":"EMR/2016/003607","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G3188192925","display_name":null,"funder_award_id":"BT/ PR40174 /BTIS/137/45/2022","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G7214140750","display_name":null,"funder_award_id":"HRD/Head/IES/2023","funder_id":"https://openalex.org/F4320320720","funder_display_name":"Indian Council of Medical Research"}],"funders":[{"id":"https://openalex.org/F4320318273","display_name":"Irish Endocrine Society","ror":"https://ror.org/01tvt4378"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"},{"id":"https://openalex.org/F4320329061","display_name":"Bose Institute","ror":"https://ror.org/01a5mqy88"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W968982197","https://openalex.org/W1548456890","https://openalex.org/W1600841976","https://openalex.org/W1842991947","https://openalex.org/W1933629402","https://openalex.org/W1967621223","https://openalex.org/W1982225414","https://openalex.org/W1983307326","https://openalex.org/W1992621857","https://openalex.org/W1993749140","https://openalex.org/W2000481222","https://openalex.org/W2000865770","https://openalex.org/W2003776328","https://openalex.org/W2020324446","https://openalex.org/W2023427658","https://openalex.org/W2039109621","https://openalex.org/W2044601473","https://openalex.org/W2053538195","https://openalex.org/W2063373713","https://openalex.org/W2068164877","https://openalex.org/W2071100938","https://openalex.org/W2071628605","https://openalex.org/W2074808378","https://openalex.org/W2102627944","https://openalex.org/W2103339395","https://openalex.org/W2111786713","https://openalex.org/W2113841300","https://openalex.org/W2116261578","https://openalex.org/W2116504531","https://openalex.org/W2118278569","https://openalex.org/W2127438438","https://openalex.org/W2130979840","https://openalex.org/W2137005750","https://openalex.org/W2141549067","https://openalex.org/W2144045727","https://openalex.org/W2146143823","https://openalex.org/W2148114118","https://openalex.org/W2151001058","https://openalex.org/W2163107106","https://openalex.org/W2171398108","https://openalex.org/W2226316051","https://openalex.org/W2292253123","https://openalex.org/W2303257969","https://openalex.org/W2407558248","https://openalex.org/W2521569068","https://openalex.org/W2523603169","https://openalex.org/W2612204980","https://openalex.org/W2624576378","https://openalex.org/W2736520162","https://openalex.org/W2757262038","https://openalex.org/W2769426045","https://openalex.org/W2791923388","https://openalex.org/W2793379119","https://openalex.org/W2802173235","https://openalex.org/W2884244088","https://openalex.org/W2890949684","https://openalex.org/W2923618138","https://openalex.org/W2946459547","https://openalex.org/W2969263349","https://openalex.org/W2980389467","https://openalex.org/W3010385922","https://openalex.org/W3011208491","https://openalex.org/W3016049324","https://openalex.org/W3016077210","https://openalex.org/W3019281170","https://openalex.org/W3021909056","https://openalex.org/W3045616570","https://openalex.org/W3094021014","https://openalex.org/W3112413337","https://openalex.org/W3115798578","https://openalex.org/W3129607550","https://openalex.org/W3162350134","https://openalex.org/W3183577306","https://openalex.org/W3204917837","https://openalex.org/W3215596355","https://openalex.org/W4210969254","https://openalex.org/W4220771632","https://openalex.org/W4367669123","https://openalex.org/W4389244966","https://openalex.org/W6770792585","https://openalex.org/W7073725586"],"related_works":["https://openalex.org/W2083646121","https://openalex.org/W2513022266","https://openalex.org/W2980552249","https://openalex.org/W3154835059","https://openalex.org/W2136551967","https://openalex.org/W1982432361","https://openalex.org/W1951644923","https://openalex.org/W3008610168","https://openalex.org/W3159036808","https://openalex.org/W2150479858"],"abstract_inverted_index":{"Inherently":[0],"chemotherapy-resistant":[1],"breast":[2,41,83,184,200],"cancer":[3,201],"stem":[4],"cells":[5],"(CSCs)":[6],"are":[7],"responsible":[8],"for":[9,196],"tumor":[10],"initiation,":[11],"metastasis,":[12],"and":[13,19,52,64,98,107,135,145,159,170,188],"relapse.":[14],"CSCs":[15,42,167],"\"acquire\"":[16],"more":[17],"resistance":[18,132,182],"stemness":[20,96,158],"upon":[21],"chemotherapy,":[22],"thereby":[23],"making":[24],"relapse-free":[25,197],"survival":[26,198],"extremely":[27],"challenging.":[28],"Here,":[29],"we":[30,174],"describe":[31],"a":[32,67,116,176,192],"novel":[33],"role":[34],"of":[35,40,48,87,95,105,115,125,137,151,157,164,199],"FOXC1":[36,58,73,89],"in":[37,72,82,109,121,133,143,154,183],"\"acquired":[38],"resistance\"":[39],"during":[43],"chemotherapy.":[44],"Putative":[45],"binding":[46,90],"sites":[47,91],"pluripotency":[49],"factors":[50],"OCT4":[51,78,106],"SOX2,":[53],"but":[54],"not":[55],"NANOG,":[56],"on":[57,92],"promoter,":[59],"were":[60],"demonstrated":[61],"by":[62,66,140],"JASPAR":[63],"validated":[65],"docking":[68],"experiment.":[69],"Significant":[70],"decline":[71],"expression":[74],"was":[75],"noticed":[76],"after":[77],"or":[79],"SOX2":[80,108],"ablation":[81],"CSCs.":[84,122],"Contrastingly,":[85],"presence":[86],"putative":[88],"the":[93,113,138,149],"promoters":[94],"genes":[97],"drug-resistance":[99],"marker":[100],"ABCG2,":[101],"along":[102],"with":[103],"downregulation":[104,136],"FOXC1-ablated":[110],"CSCs,":[111,134,185],"indicated":[112],"existence":[114],"feedforward":[117],"FOXC1-OCT4/SOX2":[118],"transactivation":[119],"loop":[120,153],"Chemotherapy-induced":[123],"upregulation":[124],"FOXC1,":[126],"stemness,":[127],"as":[128,130,191],"well":[129],"drug":[131,160],"same":[139],"prior":[141],"FOXC1-ablation":[142],"in-vitro":[144],"in-vivo":[146],"models,":[147],"endorsed":[148],"contribution":[150],"this":[152],"chemo-induced":[155],"acquisition":[156],"resistance.":[161],"Finally,":[162],"over-expression":[163],"hsa-miR-5688":[165,190],"sensitized":[166],"toward":[168],"chemotherapy":[169],"decelerated":[171],"recurrence.":[172],"Accordingly,":[173],"demonstrate":[175],"hitherto":[177],"unknown":[178],"mechanism":[179],"underpinning":[180],"chemotherapy-induced":[181],"causing":[186],"relapse":[187],"identified":[189],"potential":[193],"therapeutic":[194],"candidate":[195],"patients.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-04-09T00:00:00"}