{"id":"https://openalex.org/W4409237484","doi":"https://doi.org/10.25303/294rjce026038","title":"LC\u2013MS/MS characterization of stress degradation products of Ripretinib along with development and validation of a stability-indicating HPLC method for quantification of Ripretinib","display_name":"LC\u2013MS/MS characterization of stress degradation products of Ripretinib along with development and validation of a stability-indicating HPLC method for quantification of Ripretinib","publication_year":2025,"publication_date":"2025-02-28","ids":{"openalex":"https://openalex.org/W4409237484","doi":"https://doi.org/10.25303/294rjce026038"},"language":"en","primary_location":{"id":"doi:10.25303/294rjce026038","doi":"https://doi.org/10.25303/294rjce026038","is_oa":false,"landing_page_url":"https://doi.org/10.25303/294rjce026038","pdf_url":null,"source":{"id":"https://openalex.org/S176032342","display_name":"Research Journal of Chemistry and Environment","issn_l":"0972-0626","issn":["0972-0626","2278-4527"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Chemistry and Environment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001615347","display_name":"Sambasiva Rao Tummala","orcid":"https://orcid.org/0000-0001-6686-7318","observed_orcids":["https://orcid.org/0000-0001-6686-7318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sambasiva Rao Tummala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104991452","display_name":"Naveena Gorrepati","orcid":"https://orcid.org/0000-0003-2586-3673","observed_orcids":["https://orcid.org/0000-0003-2586-3673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naveena Gorrepati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117066940","display_name":"Acharyulu P.S. Narayanam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Acharyulu P.S. Narayanam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014660745","display_name":"K. Rambabu","orcid":"https://orcid.org/0000-0003-4558-345X","observed_orcids":["https://orcid.org/0000-0003-4558-345X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Rambabu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089634422","display_name":"Haritha Potluri","orcid":"https://orcid.org/0000-0001-6534-4929","observed_orcids":["https://orcid.org/0000-0001-6534-4929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haritha Potluri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03747305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"4","first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ripretinib","display_name":"ripretinib","score":0.9869999885559082},{"id":"https://openalex.org/keywords/degradation-products","display_name":"degradation products","score":0.8289999961853027},{"id":"https://openalex.org/keywords/stress-degradation","display_name":"stress degradation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.8190000057220459},{"id":"https://openalex.org/keywords/green-analytical-method","display_name":"green analytical method","score":0.6990000009536743},{"id":"https://openalex.org/keywords/naphthyridine-derivatives","display_name":"naphthyridine derivatives","score":0.6330000162124634},{"id":"https://openalex.org/keywords/acid-hydrolysis","display_name":"acid hydrolysis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/alkaline-hydrolysis","display_name":"alkaline hydrolysis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/peroxide-degradation","display_name":"peroxide degradation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/impurity-characterization","display_name":"impurity characterization","score":0.38499999046325684},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.47099998593330383},{"id":"https://openalex.org/keywords/hplc-method-validation","display_name":"HPLC method validation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/pharmaceutical-impurities","display_name":"drug impurities","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6092485785484314},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5317173004150391},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5084561109542847},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.49564874172210693},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.47586768865585327},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18787524104118347},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1258639693260193},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11522442102432251},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25303/294rjce026038","doi":"https://doi.org/10.25303/294rjce026038","is_oa":false,"landing_page_url":"https://doi.org/10.25303/294rjce026038","pdf_url":null,"source":{"id":"https://openalex.org/S176032342","display_name":"Research Journal of Chemistry and Environment","issn_l":"0972-0626","issn":["0972-0626","2278-4527"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Chemistry and Environment","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W2026391790"],"abstract_inverted_index":{"The":[0,45,80,149,193],"green":[1,32],"analytical":[2],"HPLC":[3],"methods":[4,13],"are":[5],"highly":[6],"effective":[7],"for":[8,53,67,122,220],"quantifying":[9],"drugs":[10],"because":[11],"these":[12],"reduce":[14],"the":[15,68,208,216],"usage":[16],"of":[17,31,57,72,76,83,147,151,210],"harmful":[18],"chemicals":[19],"and":[20,36,61,70,98,114,134,154,169,185,199,223],"generate":[21],"less":[22],"waste":[23],"leading":[24],"to":[25,142,206],"minimal":[26],"environmental":[27],"influence.":[28],"Various":[29],"compositions":[30],"solvents":[33],"including":[34],"ethanol":[35,97],"water":[37],"with":[38,96],"buffers":[39],"were":[40,51,120,204],"utilized":[41,205],"as":[42,139,160,166,172,176,180,188],"mobile":[43],"phase.":[44],"conditions":[46],"that":[47,215],"produce":[48],"acceptable":[49],"results":[50,119],"studied":[52],"valuation":[54],"in":[55,102,104,131],"terms":[56],"linearity,":[58],"accuracy,":[59],"precision":[60],"sensitivity.":[62],"This":[63,212],"method":[64,81,217],"was":[65],"applied":[66],"sepration":[69],"characterization":[71],"degradation":[73],"products":[74],"(DPs)":[75],"ripretinib":[77],"using":[78],"LCMS/MS.":[79],"comprises":[82],"Ascentis":[84],"Express":[85],"C18":[86],"(2.1":[87],"mm":[88],"\u00d7":[89],"100":[90],"mm,":[91],"2.7":[92],"micron)":[93],"column":[94],"along":[95],"0.01%":[99],"formic":[100],"acid":[101],"water,":[103],"65:45":[105],"(v/v)":[106],"at":[107,110],"pH":[108],"4.3":[109],"0.7":[111],"mL/min":[112],"flow":[113],"261":[115],"nm":[116],"wavelength.":[117],"Acceptable":[118],"obtained":[121],"Ripretinib.":[123],"A":[124],"stress":[125],"test":[126],"revealed":[127],"six":[128],"different":[129],"DPs":[130],"acid,":[132],"base":[133],"peroxide":[135],"breakdown":[136],"tests,":[137],"labelled":[138],"DP":[140,158,164,170,174,178,186],"1":[141,159],"6":[143,187],"based":[144],"on":[145],"order":[146],"elution.":[148],"applicability":[150],"MSn":[152],"studies":[153],"mass":[155],"fragmentation":[156],"confirms":[157],"7-amino-3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1":[161],"H)-one":[162],"1-oxide,":[163],"2":[165],"1-[5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorop":[167],"henyl]urea":[168],"3":[171],"7-amino-3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one,":[173],"4":[175],"3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one,":[177],"5":[179],"{4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihyd":[181],"ro-1,6-naphthyridin-3-yl]-2-fluorophenyl}carbamic":[182],"ac":[183],"id":[184],"3-(2-bromo-4-fluoro-5-(3-phenylureido":[189],")phenyl)-1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1":[190],",6-naphthyridine":[191],"1-oxide.":[192],"GAPI":[194],"(Green":[195],"Analytical":[196],"Procedure":[197],"Index)":[198],"AGREE":[200],"(Analytical":[201],"GREEnness)":[202],"tools":[203],"assesses":[207],"greenness":[209],"method.":[211],"study":[213],"found":[214],"works":[218],"well":[219],"measuring":[221],"Ripretinib":[222],"characterized":[224],"its":[225],"DPs.":[226]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}