{"id":"https://openalex.org/W4409216632","doi":"https://doi.org/10.1590/1980-5764-dn-2024-0204","title":"Advancements in the treatment of Alzheimer's disease: a comprehensive review","display_name":"Advancements in the treatment of Alzheimer's disease: a comprehensive review","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4409216632","doi":"https://doi.org/10.1590/1980-5764-dn-2024-0204","pmid":"https://pubmed.ncbi.nlm.nih.gov/40195966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11975295"},"language":"en","primary_location":{"id":"doi:10.1590/1980-5764-dn-2024-0204","doi":"https://doi.org/10.1590/1980-5764-dn-2024-0204","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1980-5764-dn-2024-0204","pdf_url":"https://www.scielo.br/j/dn/a/h6d5q4GywcGLXFTZpDrTf7S/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2736711785","display_name":"Dementia & Neuropsychologia","issn_l":"1980-5764","issn":["1980-5764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312171","host_organization_name":"Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento","host_organization_lineage":["https://openalex.org/P4310312171"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia & Neuropsychologia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/dn/a/h6d5q4GywcGLXFTZpDrTf7S/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117060201","display_name":"Srushti Rajanna","orcid":"https://orcid.org/0009-0003-2005-3433","observed_orcids":["https://orcid.org/0009-0003-2005-3433"]},"institutions":[{"id":"https://openalex.org/I4405281066","display_name":"East West College of Pharmacy","ror":"https://ror.org/03tfnrx97","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405281066"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Srushti Rajanna","raw_affiliation_strings":["East West College of Pharmacy,  India"],"raw_orcid":"https://orcid.org/0009-0003-2005-3433","affiliations":[{"raw_affiliation_string":"East West College of Pharmacy,  India","institution_ids":["https://openalex.org/I4405281066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117060202","display_name":"Prajwal Pradeep Gundale","orcid":"https://orcid.org/0009-0004-3634-7839","observed_orcids":["https://orcid.org/0009-0004-3634-7839"]},"institutions":[{"id":"https://openalex.org/I4405281066","display_name":"East West College of Pharmacy","ror":"https://ror.org/03tfnrx97","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405281066"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Prajwal Pradeep Gundale","raw_affiliation_strings":["East West College of Pharmacy,  India"],"raw_orcid":"https://orcid.org/0009-0004-3634-7839","affiliations":[{"raw_affiliation_string":"East West College of Pharmacy,  India","institution_ids":["https://openalex.org/I4405281066"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5117060203","display_name":"Apoorva Dev Mahadevaiah","orcid":"https://orcid.org/0000-0002-5094-4443","observed_orcids":["https://orcid.org/0000-0002-5094-4443"]},"institutions":[{"id":"https://openalex.org/I4405281066","display_name":"East West College of Pharmacy","ror":"https://ror.org/03tfnrx97","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405281066"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Apoorva Dev Mahadevaiah","raw_affiliation_strings":["East West College of Pharmacy,  India"],"raw_orcid":"https://orcid.org/0000-0002-5094-4443","affiliations":[{"raw_affiliation_string":"East West College of Pharmacy,  India","institution_ids":["https://openalex.org/I4405281066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5117060202"],"corresponding_institution_ids":["https://openalex.org/I4405281066"],"apc_list":null,"apc_paid":null,"fwci":1.7809,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8507177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"19","issue":null,"first_page":"e20240204","last_page":"e20240204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/symptomatic-treatment","display_name":"symptomatic treatment","score":0.9610000252723694},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lifestyle-intervention","display_name":"lifestyle intervention","score":0.8809999823570251},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9340000152587891},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.8579999804496765},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.9350000023841858},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":1.0},{"id":"https://openalex.org/keywords/neuroprotective-agents","display_name":"neuroprotective agents","score":0.8809999823570251},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6755620837211609},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6563687920570374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6150928139686584},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6111515164375305},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5149572491645813},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.49651724100112915},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4568827748298645},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4164811968803406},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3601057231426239},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3031335473060608},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.26010653376579285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1311456263065338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11255118250846863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0722241997718811},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1590/1980-5764-dn-2024-0204","doi":"https://doi.org/10.1590/1980-5764-dn-2024-0204","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1980-5764-dn-2024-0204","pdf_url":"https://www.scielo.br/j/dn/a/h6d5q4GywcGLXFTZpDrTf7S/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2736711785","display_name":"Dementia & Neuropsychologia","issn_l":"1980-5764","issn":["1980-5764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312171","host_organization_name":"Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento","host_organization_lineage":["https://openalex.org/P4310312171"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia & Neuropsychologia","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:10787855","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11975295","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40195966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40195966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia & neuropsychologia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11975295","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11975295/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dement Neuropsychol","raw_type":"Text"},{"id":"pmh:oai:redalyc.org:339581871011","doi":null,"is_oa":true,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=339581871011","pdf_url":"https://www.redalyc.org/journal/3395/339581871011/339581871011.pdf","source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dementia & Neuropsychologia (Brasil) Vol.19","raw_type":"rese\u00f1a"},{"id":"pmh:oai:doaj.org/article:12f43ef9ff484af7b876aa4111cf7c9d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/12f43ef9ff484af7b876aa4111cf7c9d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dementia & Neuropsychologia, Vol 19 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/1980-5764-dn-2024-0204","doi":"https://doi.org/10.1590/1980-5764-dn-2024-0204","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1980-5764-dn-2024-0204","pdf_url":"https://www.scielo.br/j/dn/a/h6d5q4GywcGLXFTZpDrTf7S/?lang=en&format=pdf","source":{"id":"https://openalex.org/S2736711785","display_name":"Dementia & Neuropsychologia","issn_l":"1980-5764","issn":["1980-5764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-20","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312171","host_organization_name":"Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento","host_organization_lineage":["https://openalex.org/P4310312171"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Neurologia Cognitiva e do Comportamento"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia & Neuropsychologia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409216632.pdf","grobid_xml":"https://content.openalex.org/works/W4409216632.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1994067502","https://openalex.org/W2010925911","https://openalex.org/W2052742260","https://openalex.org/W2085907924","https://openalex.org/W2090523774","https://openalex.org/W2090968981","https://openalex.org/W2108216694","https://openalex.org/W2130983640","https://openalex.org/W2161737267","https://openalex.org/W2330649365","https://openalex.org/W2415242066","https://openalex.org/W2510806376","https://openalex.org/W2604612717","https://openalex.org/W2617072792","https://openalex.org/W2737900099","https://openalex.org/W2771307084","https://openalex.org/W2772872651","https://openalex.org/W2784892576","https://openalex.org/W2787612390","https://openalex.org/W2798054687","https://openalex.org/W2802659348","https://openalex.org/W2802724927","https://openalex.org/W2883286350","https://openalex.org/W2884982789","https://openalex.org/W2895816045","https://openalex.org/W2918884175","https://openalex.org/W2988412209","https://openalex.org/W2996134840","https://openalex.org/W3009441391","https://openalex.org/W3009833354","https://openalex.org/W3009893408","https://openalex.org/W3045828365","https://openalex.org/W3045997188","https://openalex.org/W3099128996","https://openalex.org/W3113707451","https://openalex.org/W3137380811","https://openalex.org/W3137826907","https://openalex.org/W3149199574","https://openalex.org/W3156104410","https://openalex.org/W3159116119","https://openalex.org/W3167556772","https://openalex.org/W3184418928","https://openalex.org/W3199353075","https://openalex.org/W4200292583","https://openalex.org/W4205897663","https://openalex.org/W4210516473","https://openalex.org/W4225741213","https://openalex.org/W4226454711","https://openalex.org/W4281724038","https://openalex.org/W4285132881","https://openalex.org/W4310461604","https://openalex.org/W4360591479","https://openalex.org/W4362554996","https://openalex.org/W4365810791","https://openalex.org/W4378219872","https://openalex.org/W4384522480","https://openalex.org/W4386070073","https://openalex.org/W4387259038","https://openalex.org/W4389617681","https://openalex.org/W4390908313"],"related_works":["https://openalex.org/W4401344568","https://openalex.org/W4401849135","https://openalex.org/W4406845594","https://openalex.org/W4412846673","https://openalex.org/W4416344689","https://openalex.org/W4410286862","https://openalex.org/W7117646188","https://openalex.org/W4415668658","https://openalex.org/W4407240990","https://openalex.org/W4367396619"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,78,87],"(AD)":[2],"is":[3,46],"a":[4],"progressive":[5],"neurodegenerative":[6],"disorder":[7],"characterized":[8],"by":[9],"cognitive":[10],"decline,":[11],"memory":[12],"loss,":[13],"and":[14,39,56,77,116],"behavioral":[15],"changes.":[16],"Despite":[17],"being":[18],"the":[19,47],"most":[20],"common":[21],"cause":[22],"of":[23,69,94],"dementia,":[24],"effective":[25,61],"treatments":[26],"have":[27,33],"been":[28],"elusive.":[29],"However,":[30],"recent":[31],"years":[32],"witnessed":[34],"significant":[35],"advancements":[36,45],"in":[37],"understanding":[38],"treating":[40],"Alzheimer's.":[41],"Key":[42],"to":[43,53],"these":[44,95],"shift":[48],"toward":[49],"targeted":[50],"therapies":[51],"tailored":[52],"individual":[54],"genetic":[55],"biomarker":[57,107],"profiles,":[58],"promising":[59],"more":[60],"outcomes":[62],"while":[63],"minimizing":[64],"side":[65],"effects.":[66],"The":[67],"integration":[68],"advanced":[70],"neuroimaging":[71],"techniques":[72],"has":[73],"revolutionized":[74],"early":[75],"diagnosis":[76],"monitoring,":[79],"enabling":[80],"proactive":[81],"intervention":[82],"strategies":[83],"that":[84],"may":[85],"alter":[86],"trajectories.":[88],"This":[89],"review":[90],"provides":[91],"an":[92],"overview":[93],"advancements,":[96],"focusing":[97],"on":[98],"disease-modifying":[99],"therapies,":[100,104],"symptomatic":[101],"treatments,":[102],"combination":[103],"lifestyle":[105],"interventions,":[106],"development,":[108],"innovative":[109],"drug":[110],"delivery":[111],"systems,":[112],"immunotherapy,":[113],"gene":[114],"therapy,":[115],"neuroprotective":[117],"agents.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-04-07T00:00:00"}