{"id":"https://openalex.org/W4409181237","doi":"https://doi.org/10.1002/adhm.202405159","title":"Development of Akkermansia Muciniphila Membrane\u2010Coated Mesoporous Silica Nanoparticles with a Cerium Oxide Core for Inflammatory Bowel Disease Treatment","display_name":"Development of Akkermansia Muciniphila Membrane\u2010Coated Mesoporous Silica Nanoparticles with a Cerium Oxide Core for Inflammatory Bowel Disease Treatment","publication_year":2025,"publication_date":"2025-04-03","ids":{"openalex":"https://openalex.org/W4409181237","doi":"https://doi.org/10.1002/adhm.202405159","pmid":"https://pubmed.ncbi.nlm.nih.gov/40181608"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.202405159","doi":"https://doi.org/10.1002/adhm.202405159","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.202405159","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081087117","display_name":"Nianhua Zhang","orcid":"https://orcid.org/0009-0001-2850-4505","observed_orcids":["https://orcid.org/0009-0001-2850-4505"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nianhua Zhang","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","Henan Institute of Advanced Technology Zhengzhou University  Zhengzhou 450001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Henan Institute of Advanced Technology Zhengzhou University  Zhengzhou 450001 China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437262","display_name":"Xu Zhang","orcid":"https://orcid.org/0000-0002-8098-8893","observed_orcids":["https://orcid.org/0000-0002-8098-8893","https://orcid.org/0000-0003-3407-5353","https://orcid.org/0000-0003-4179-9552"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zhang","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015871451","display_name":"Jiulong Li","orcid":"https://orcid.org/0000-0002-8816-7539","observed_orcids":["https://orcid.org/0000-0002-8816-7539"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiulong Li","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014748429","display_name":"Baoyi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoyi Li","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328287","display_name":"Shuai Wang","orcid":"https://orcid.org/0000-0002-4159-8518","observed_orcids":["https://orcid.org/0000-0002-4159-8518"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Wang","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","Henan Institute of Advanced Technology Zhengzhou University  Zhengzhou 450001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Henan Institute of Advanced Technology Zhengzhou University  Zhengzhou 450001 China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101610570","display_name":"Xiao Liu","orcid":"https://orcid.org/0009-0006-9942-8454","observed_orcids":["https://orcid.org/0009-0006-9942-8454"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Liu","raw_affiliation_strings":["Department of Gastroenterology Beijing Hospital Institute of Geriatric Medicine Chinese Academy of Medical Sciences National Center of Gerontology  Beijing 100730 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Beijing Hospital Institute of Geriatric Medicine Chinese Academy of Medical Sciences National Center of Gerontology  Beijing 100730 China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623489","display_name":"Huan Meng","orcid":"https://orcid.org/0000-0001-8844-3938","observed_orcids":["https://orcid.org/0000-0001-8844-3938"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huan Meng","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066978333","display_name":"Motao Zhu","orcid":"https://orcid.org/0000-0002-6619-0412","observed_orcids":["https://orcid.org/0000-0002-6619-0412"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Motao Zhu","raw_affiliation_strings":["CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China"],"raw_orcid":"https://orcid.org/0000-0002-6619-0412","affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biomedical Effects of Nanomaterials &amp; Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology  Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066978333","https://openalex.org/A5100623489","https://openalex.org/A5101610570"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I200296433","https://openalex.org/I4210119648","https://openalex.org/I4210141483"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":2.6851,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.89742171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"14","issue":"13","first_page":"e2405159","last_page":"e2405159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cerium-oxide-nanoparticles","display_name":"cerium oxide nanoparticles","score":0.8679999709129333},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7519999742507935},{"id":"https://openalex.org/keywords/oral-nanomedicine","display_name":"oral nanomedicine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6340000033378601},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8809999823570251},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.6150000095367432},{"id":"https://openalex.org/keywords/gastrointestinal-stability","display_name":"gastrointestinal stability","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2775941767","wikidata":"https://www.wikidata.org/wiki/Q15020908","display_name":"Akkermansia muciniphila","level":3,"score":0.8741551041603088},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5445424318313599},{"id":"https://openalex.org/C2780657402","wikidata":"https://www.wikidata.org/wiki/Q1055570","display_name":"Cerium oxide","level":3,"score":0.5362023711204529},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4923797845840454},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.45921823382377625},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.44019991159439087},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43742215633392334},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4235600233078003},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39007803797721863},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.33398205041885376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3198676109313965},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.31209906935691833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22208398580551147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22201001644134521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21774417161941528},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2082979679107666},{"id":"https://openalex.org/C2779851234","wikidata":"https://www.wikidata.org/wiki/Q50690","display_name":"Oxide","level":2,"score":0.20203468203544617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19370132684707642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10508283972740173},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07571923732757568}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000086102","descriptor_name":"Akkermansia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000086102","descriptor_name":"Akkermansia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000086102","descriptor_name":"Akkermansia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002563","descriptor_name":"Cerium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.202405159","doi":"https://doi.org/10.1002/adhm.202405159","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.202405159","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:40181608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40181608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1184612529","display_name":null,"funder_award_id":"32271452","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2377703127","display_name":null,"funder_award_id":"2022YFA 1206100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5087455472","display_name":null,"funder_award_id":"Z230008","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G7055946863","display_name":null,"funder_award_id":"32271449","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7457567685","display_name":null,"funder_award_id":"82204300","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7805729697","display_name":"\u7279\u5f02\u4f5c\u7528\u4e8e\u8010\u836f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684shRNA/\u836f\u7269\u53cc\u8f7d\u4f20\u9012\u7cfb\u7edf\u7684\u7814\u7a76","funder_award_id":"51773188","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8822704909","display_name":null,"funder_award_id":"32201158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1981461721","https://openalex.org/W2106865732","https://openalex.org/W2182578492","https://openalex.org/W2185905005","https://openalex.org/W2536753757","https://openalex.org/W2612519086","https://openalex.org/W2751128104","https://openalex.org/W2755496239","https://openalex.org/W2782098908","https://openalex.org/W2925222192","https://openalex.org/W2938339574","https://openalex.org/W2956175090","https://openalex.org/W3001866303","https://openalex.org/W3006764495","https://openalex.org/W3011629259","https://openalex.org/W3012095940","https://openalex.org/W3034743752","https://openalex.org/W3084862659","https://openalex.org/W3088281850","https://openalex.org/W3092547488","https://openalex.org/W3092965070","https://openalex.org/W3111020316","https://openalex.org/W3121177439","https://openalex.org/W3193349356","https://openalex.org/W3194581126","https://openalex.org/W3198451146","https://openalex.org/W3203912303","https://openalex.org/W3210873457","https://openalex.org/W3213425375","https://openalex.org/W4220900172","https://openalex.org/W4225145919","https://openalex.org/W4225405274","https://openalex.org/W4283521992","https://openalex.org/W4288052200","https://openalex.org/W4293339940","https://openalex.org/W4308373573","https://openalex.org/W4319027029","https://openalex.org/W4360999039","https://openalex.org/W4379742493","https://openalex.org/W4381715620","https://openalex.org/W4387562943","https://openalex.org/W4387661616","https://openalex.org/W4389051433","https://openalex.org/W4390355844","https://openalex.org/W4392044449","https://openalex.org/W4396641000","https://openalex.org/W6600529467","https://openalex.org/W6601198272","https://openalex.org/W6836901418"],"related_works":["https://openalex.org/W2768863811","https://openalex.org/W2550575759","https://openalex.org/W2160883824","https://openalex.org/W3044312527","https://openalex.org/W2165743023","https://openalex.org/W2913895512","https://openalex.org/W4386954332","https://openalex.org/W3213237956","https://openalex.org/W2173139831","https://openalex.org/W3196421357"],"abstract_inverted_index":{"Abstract":[0],"While":[1],"convenient":[2],"for":[3,11,32,109],"patient":[4],"compliance,":[5],"the":[6,20,27,99,129,160,166],"efficacy":[7],"of":[8,26,39,146,170],"oral":[9,68],"treatments":[10],"inflammatory":[12],"bowel":[13],"disease":[14],"(IBD)":[15],"is":[16,107],"often":[17],"compromised":[18],"by":[19,155],"dynamic":[21],"and":[22,54,119,168,176],"harsh":[23],"chemical":[24],"environment":[25],"gastrointestinal":[28],"tract,":[29],"presenting":[30],"challenges":[31],"effective":[33],"therapeutic":[34],"management.":[35],"The":[36,144],"pathological":[37],"complexity":[38],"IBD":[40,142,186],"frequently":[41],"involves":[42],"multiple":[43],"factors":[44],"such":[45],"as":[46],"oxidative":[47],"stress,":[48],"immune":[49],"dysregulation,":[50],"gut":[51,172],"microbiome":[52],"abnormality,":[53],"inadequate":[55],"drug":[56],"bioavailability,":[57],"among":[58],"others.":[59],"To":[60],"address":[61],"these":[62],"challenges,":[63],"this":[64],"project":[65,126],"develops":[66],"an":[67,84],"nanomedicine":[69],"platform":[70],"based":[71],"on":[72],"mesoporous":[73],"silica":[74],"nanoparticles":[75,149],"with":[76,83],"a":[77,93,140],"cerium":[78,147],"oxide":[79,148],"core,":[80],"further":[81,153],"coated":[82],"outer":[85],"membrane":[86],"(OM)":[87],"derived":[88],"from":[89],"Akkermansia":[90],"muciniphila":[91],"(Akk),":[92],"beneficial":[94,171],"bacteria":[95],"naturally":[96],"present":[97],"in":[98,139,184],"human":[100],"gut.":[101],"This":[102,125],"novel":[103],"nanocomplex,":[104],"termed":[105],"\u201cOM\u2010CeMeso,\u201d":[106],"evaluated":[108],"its":[110],"enhanced":[111],"stability,":[112],"reactive":[113],"oxygen":[114],"species":[115],"(ROS)":[116],"scavenging":[117],"capacity,":[118],"ability":[120],"to":[121,180],"restore":[122],"microbiota":[123],"homeostasis.":[124],"demonstrates":[127],"that":[128],"silica\u2010based":[130],"nanomaterials\u2019":[131],"acid\u2010resistant":[132],"yet":[133],"base\u2010degradable":[134],"properties":[135],"significantly":[136],"improved":[137],"stability":[138],"murine":[141,185],"model.":[143],"incorporation":[145],"(CeO2":[150],"NPs)":[151],"added":[152],"benefits":[154],"enhancing":[156],"ROS":[157],"scavenging.":[158],"Notably,":[159],"Akk\u2010derived":[161],"OM":[162],"coat":[163],"also":[164],"increases":[165],"diversity":[167],"abundance":[169],"microbiota.":[173],"These":[174],"complementary":[175],"integrated":[177],"functions":[178],"lead":[179],"significant":[181],"symptom":[182],"alleviation":[183],"models":[187],"while":[188],"avoiding":[189],"any":[190],"unwanted":[191],"toxicity.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
