{"id":"https://openalex.org/W4409178751","doi":"https://doi.org/10.1186/s40001-025-02466-x","title":"Identification of thyroid cancer biomarkers using WGCNA and machine learning","display_name":"Identification of thyroid cancer biomarkers using WGCNA and machine learning","publication_year":2025,"publication_date":"2025-04-05","ids":{"openalex":"https://openalex.org/W4409178751","doi":"https://doi.org/10.1186/s40001-025-02466-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/40186253"},"language":"en","primary_location":{"id":"doi:10.1186/s40001-025-02466-x","doi":"https://doi.org/10.1186/s40001-025-02466-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40001-025-02466-x","pdf_url":"https://eurjmedres.biomedcentral.com/counter/pdf/10.1186/s40001-025-02466-x","source":{"id":"https://openalex.org/S64516541","display_name":"European journal of medical research","issn_l":"0949-2321","issn":["0949-2321","2047-783X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://eurjmedres.biomedcentral.com/counter/pdf/10.1186/s40001-025-02466-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024878217","display_name":"Gaofeng Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaofeng Hu","raw_affiliation_strings":["Wenzhou Medical University, Wenzhou, Zhejiang, China","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068686920","display_name":"Wenyuan Niu","orcid":"https://orcid.org/0000-0002-8745-6136","observed_orcids":["https://orcid.org/0000-0002-8745-6136"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyuan Niu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiaming Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaming Ge","raw_affiliation_strings":["Wenzhou Medical University, Wenzhou, Zhejiang, China","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100967347","display_name":"Jie Xuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Xuan","raw_affiliation_strings":["Wenzhou Medical University, Wenzhou, Zhejiang, China","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101565056","display_name":"Yanyang Liu","orcid":"https://orcid.org/0000-0003-2754-473X","observed_orcids":["https://orcid.org/0000-0003-2754-473X"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyang Liu","raw_affiliation_strings":["Wenzhou Medical University, Wenzhou, Zhejiang, China","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070159436","display_name":"Mengjia Li","orcid":"https://orcid.org/0009-0000-7935-6453","observed_orcids":["https://orcid.org/0009-0000-7935-6453"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengjia Li","raw_affiliation_strings":["Wenzhou Medical University, Wenzhou, Zhejiang, China","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104186952","display_name":"Huize Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huize Shen","raw_affiliation_strings":["School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051590699","display_name":"Shang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shang Ma","raw_affiliation_strings":["Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. 1226609433@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. 1226609433@qq.com","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102023105","display_name":"Yuanqiang Li","orcid":"https://orcid.org/0000-0002-8262-2983","observed_orcids":["https://orcid.org/0000-0002-8262-2983"]},"institutions":[{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanqiang Li","raw_affiliation_strings":["Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. yuanqiangli@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. yuanqiangli@hotmail.com","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100747697","display_name":"Qinglin Li","orcid":"https://orcid.org/0000-0001-8469-0923","observed_orcids":["https://orcid.org/0000-0001-8469-0923"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qinglin Li","raw_affiliation_strings":["Wenzhou Medical University, Wenzhou, Zhejiang, China. qinglin200886@126.com","Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. qinglin200886@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University, Wenzhou, Zhejiang, China. qinglin200886@126.com","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. qinglin200886@126.com","institution_ids":["https://openalex.org/I4210098734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051590699","https://openalex.org/A5100747697","https://openalex.org/A5102023105"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210098734"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":4.7094,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.95454078,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"30","issue":"1","first_page":"244","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7149999737739563},{"id":"https://openalex.org/keywords/p4ha2","display_name":"P4HA2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7519999742507935},{"id":"https://openalex.org/keywords/gene-co-expression-modules","display_name":"gene co-expression modules","score":0.8529999852180481},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.746999979019165},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6060000061988831},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6759305000305176},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5215675234794617},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.46395984292030334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4618026614189148},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44434884190559387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43768852949142456},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4267534017562866},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41153645515441895},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.34846585988998413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2607145309448242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.232459157705307},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s40001-025-02466-x","doi":"https://doi.org/10.1186/s40001-025-02466-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40001-025-02466-x","pdf_url":"https://eurjmedres.biomedcentral.com/counter/pdf/10.1186/s40001-025-02466-x","source":{"id":"https://openalex.org/S64516541","display_name":"European journal of medical research","issn_l":"0949-2321","issn":["0949-2321","2047-783X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medical Research","raw_type":"journal-article"},{"id":"pmid:40186253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40186253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medical research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10784934","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11971869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11971869","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11971869","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Med Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d86273d85b4642788b3b8019f3e9c710","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d86273d85b4642788b3b8019f3e9c710","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Medical Research, Vol 30, Iss 1, Pp 1-22 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40001-025-02466-x","doi":"https://doi.org/10.1186/s40001-025-02466-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40001-025-02466-x","pdf_url":"https://eurjmedres.biomedcentral.com/counter/pdf/10.1186/s40001-025-02466-x","source":{"id":"https://openalex.org/S64516541","display_name":"European journal of medical research","issn_l":"0949-2321","issn":["0949-2321","2047-783X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6377777338","display_name":null,"funder_award_id":"82474317","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7971389741","display_name":null,"funder_award_id":"82173346","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8814535677","display_name":"\u80bf\u7624\u653e\u7597\u201c\u706b\u6bd2\u201d\u7684\u4e2d\u533b\u836f\u9632\u6cbb\u7814\u7a76","funder_award_id":"LR24H270001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338469","display_name":"Science and Technology Program of Zhejiang Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409178751.pdf","grobid_xml":"https://content.openalex.org/works/W4409178751.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1966327575","https://openalex.org/W1982654262","https://openalex.org/W1985987855","https://openalex.org/W2025657174","https://openalex.org/W2033998652","https://openalex.org/W2050550559","https://openalex.org/W2052925947","https://openalex.org/W2059964515","https://openalex.org/W2063378268","https://openalex.org/W2066555341","https://openalex.org/W2067786443","https://openalex.org/W2069347512","https://openalex.org/W2083969794","https://openalex.org/W2101777703","https://openalex.org/W2109095774","https://openalex.org/W2135046866","https://openalex.org/W2169733686","https://openalex.org/W2177870565","https://openalex.org/W2256062582","https://openalex.org/W2295598076","https://openalex.org/W2749751126","https://openalex.org/W2787048720","https://openalex.org/W2787288868","https://openalex.org/W2901182680","https://openalex.org/W2911964244","https://openalex.org/W2914759403","https://openalex.org/W2972865130","https://openalex.org/W3082276399","https://openalex.org/W3093415007","https://openalex.org/W3100082769","https://openalex.org/W3107851253","https://openalex.org/W3114486788","https://openalex.org/W3134188460","https://openalex.org/W3161551694","https://openalex.org/W3171067218","https://openalex.org/W3172768376","https://openalex.org/W3186346887","https://openalex.org/W3187445484","https://openalex.org/W3187656047","https://openalex.org/W3194401451","https://openalex.org/W3200393353","https://openalex.org/W4200095605","https://openalex.org/W4211038303","https://openalex.org/W4211247697","https://openalex.org/W4220681411","https://openalex.org/W4220893037","https://openalex.org/W4253609270","https://openalex.org/W4281254526","https://openalex.org/W4282915448","https://openalex.org/W4285389657","https://openalex.org/W4292478882","https://openalex.org/W4308388279","https://openalex.org/W4319601558","https://openalex.org/W4323928489","https://openalex.org/W4362576241","https://openalex.org/W4363646550","https://openalex.org/W4366245601","https://openalex.org/W4382651879","https://openalex.org/W4385986528","https://openalex.org/W4386572711","https://openalex.org/W4387861003","https://openalex.org/W4390689782","https://openalex.org/W4391671392","https://openalex.org/W4392371692","https://openalex.org/W4392754631","https://openalex.org/W4392777513","https://openalex.org/W4393176990","https://openalex.org/W4393935425","https://openalex.org/W4395037778","https://openalex.org/W4396690071","https://openalex.org/W4396971202","https://openalex.org/W4398255319","https://openalex.org/W4399916883","https://openalex.org/W4400265791","https://openalex.org/W4402491674","https://openalex.org/W4405263688","https://openalex.org/W4405320279","https://openalex.org/W4407909720"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W939259490","https://openalex.org/W2898732673","https://openalex.org/W4250761926","https://openalex.org/W2323904043","https://openalex.org/W2510890708","https://openalex.org/W2410053581","https://openalex.org/W2383658677"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"incidence":[2],"of":[3],"thyroid":[4,143,177],"cancer":[5,144,178],"(TC)":[6],"is":[7,26],"increasing":[8],"in":[9,176],"China,":[10],"largely":[11],"due":[12],"to":[13,160],"overdiagnosis":[14],"from":[15,40],"widespread":[16],"screening":[17],"and":[18,31,47,66,77,107,122,133,154],"improved":[19],"ultrasound":[20],"technology.":[21],"Identifying":[22],"precise":[23],"TC":[24,35,119],"biomarkers":[25],"crucial":[27],"for":[28,152,172],"accurate":[29],"diagnosis":[30,153],"effective":[32],"treatment.":[33,155],"METHODS:":[34],"patient":[36],"data":[37],"were":[38,43,80,92],"obtained":[39],"TCGA.":[41],"DEGs":[42],"analyzed":[44,81],"using":[45,82],"DESeq2,":[46],"WGCNA":[48],"identified":[49,61,137],"gene":[50],"modules":[51],"associated":[52,101],"with":[53,64,102],"TC.":[54],"Machine":[55],"learning":[56],"algorithms":[57],"(XGBoost,":[58],"LASSO,":[59],"RF)":[60],"key":[62,86,141],"biomarkers,":[63],"ROC":[65],"AUC":[67],">":[68],"0.95":[69],"indicating":[70],"strong":[71],"diagnostic":[72,163],"performance.":[73],"Immune":[74],"cell":[75,120],"infiltration":[76],"biomarker":[78],"correlation":[79],"CIBERSORT.":[83],"RESULTS:":[84],"Four":[85],"genes":[87],"(P4HA2,":[88],"TFF3,":[89],"RPS6KA5,":[90],"EYA1)":[91],"found":[93],"as":[94,139],"potential":[95,142,159],"biomarkers.":[96],"High":[97],"P4HA2":[98,116,138,156],"expression":[99],"was":[100],"suppressed":[103],"anti-tumor":[104],"immune":[105],"responses":[106],"promoted":[108],"disease":[109],"progression.":[110],"In":[111],"vitro":[112],"studies":[113],"showed":[114],"that":[115],"upregulation":[117],"increased":[118],"growth":[121],"migration,":[123],"while":[124],"its":[125],"suppression":[126],"reduced":[127],"these":[128],"activities.":[129],"CONCLUSION:":[130],"Through":[131],"bioinformatics":[132],"experimental":[134],"validation,":[135],"we":[136],"a":[140,162],"biomarker.":[145],"This":[146],"finding":[147],"provides":[148],"new":[149],"molecular":[150],"targets":[151],"has":[157],"the":[158],"be":[161],"or":[164],"therapeutic":[165],"target,":[166],"which":[167],"could":[168],"have":[169],"significant":[170],"implications":[171],"improving":[173],"clinical":[174],"outcomes":[175],"patients.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}