{"id":"https://openalex.org/W4409150402","doi":"https://doi.org/10.1038/s44341-025-00015-5","title":"Premetastatic niche mechanics and organotropism in breast cancer","display_name":"Premetastatic niche mechanics and organotropism in breast cancer","publication_year":2025,"publication_date":"2025-04-03","ids":{"openalex":"https://openalex.org/W4409150402","doi":"https://doi.org/10.1038/s44341-025-00015-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/40191104","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11968405"},"language":"en","primary_location":{"id":"doi:10.1038/s44341-025-00015-5","doi":"https://doi.org/10.1038/s44341-025-00015-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44341-025-00015-5","pdf_url":"https://www.nature.com/articles/s44341-025-00015-5.pdf","source":{"id":"https://openalex.org/S4404127002","display_name":"npj Biological Physics and Mechanics.","issn_l":"3004-863X","issn":["3004-863X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Biological Physics and Mechanics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s44341-025-00015-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049067553","display_name":"Sarah Libring","orcid":"https://orcid.org/0000-0001-8336-5862","observed_orcids":["https://orcid.org/0000-0001-8336-5862"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Libring","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035287010","display_name":"Cynthia A. Reinhart\u2010King","orcid":"https://orcid.org/0000-0001-6959-3914","observed_orcids":["https://orcid.org/0000-0001-6959-3914"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cynthia A. Reinhart-King","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX USA","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035287010"],"corresponding_institution_ids":["https://openalex.org/I74775410"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.4465,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.39867932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"11","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.33250001072883606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pre-metastatic-niche","display_name":"pre-metastatic niche","score":0.996999979019165},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7419999837875366},{"id":"https://openalex.org/keywords/organotropism","display_name":"organotropism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/extracellular-matrix-mechanics","display_name":"extracellular matrix mechanics","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cancer-cell-mechanics","display_name":"cancer cell mechanics","score":0.9629999995231628},{"id":"https://openalex.org/keywords/biomechanics","display_name":"biomechanics","score":0.8389999866485596},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6683340072631836},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.6235353946685791},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38829949498176575},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35471615195274353},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33213651180267334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31190991401672363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23875826597213745},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1153038740158081}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/s44341-025-00015-5","doi":"https://doi.org/10.1038/s44341-025-00015-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44341-025-00015-5","pdf_url":"https://www.nature.com/articles/s44341-025-00015-5.pdf","source":{"id":"https://openalex.org/S4404127002","display_name":"npj Biological Physics and Mechanics.","issn_l":"3004-863X","issn":["3004-863X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Biological Physics and Mechanics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11968405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11968405","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11968405/pdf/44341_2025_Article_15.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Biol Phys Mech","raw_type":"Text"},{"id":"pmid:40191104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40191104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj biological physics and mechanics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s44341-025-00015-5","doi":"https://doi.org/10.1038/s44341-025-00015-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44341-025-00015-5","pdf_url":"https://www.nature.com/articles/s44341-025-00015-5.pdf","source":{"id":"https://openalex.org/S4404127002","display_name":"npj Biological Physics and Mechanics.","issn_l":"3004-863X","issn":["3004-863X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Biological Physics and Mechanics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3965370516","display_name":"Sorting and characterization of cancer cells based on metabolic phenotype","funder_award_id":"R21CA271715","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4757568329","display_name":null,"funder_award_id":"CA264734","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G863871099","display_name":"Matrix Accumulation in the Metastatic Niche","funder_award_id":"F99CA264734","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000889886","display_name":"Characterizing CAFs in Metastasis as a Function of Breast Cancer Cell Phenotype","funder_award_id":"K00CA264734","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409150402.pdf","grobid_xml":"https://content.openalex.org/works/W4409150402.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W929324999","https://openalex.org/W1504879193","https://openalex.org/W1963700430","https://openalex.org/W1966070297","https://openalex.org/W1975553175","https://openalex.org/W1975859224","https://openalex.org/W1977753771","https://openalex.org/W1982659560","https://openalex.org/W1983487545","https://openalex.org/W1989095124","https://openalex.org/W2002355437","https://openalex.org/W2006073003","https://openalex.org/W2007196889","https://openalex.org/W2012247886","https://openalex.org/W2018000782","https://openalex.org/W2019922483","https://openalex.org/W2026815880","https://openalex.org/W2034580741","https://openalex.org/W2051753177","https://openalex.org/W2055801606","https://openalex.org/W2062889854","https://openalex.org/W2070687651","https://openalex.org/W2081148792","https://openalex.org/W2084699749","https://openalex.org/W2101335366","https://openalex.org/W2103310208","https://openalex.org/W2104801060","https://openalex.org/W2105524728","https://openalex.org/W2106572080","https://openalex.org/W2115436106","https://openalex.org/W2116413963","https://openalex.org/W2135139969","https://openalex.org/W2137485628","https://openalex.org/W2141952014","https://openalex.org/W2145990138","https://openalex.org/W2146530991","https://openalex.org/W2154706646","https://openalex.org/W2159744630","https://openalex.org/W2160191376","https://openalex.org/W2163802608","https://openalex.org/W2167105148","https://openalex.org/W2283853409","https://openalex.org/W2295392753","https://openalex.org/W2413902698","https://openalex.org/W2417406783","https://openalex.org/W2418074144","https://openalex.org/W2518854129","https://openalex.org/W2557127393","https://openalex.org/W2561101222","https://openalex.org/W2572990295","https://openalex.org/W2593027881","https://openalex.org/W2729826160","https://openalex.org/W2739216777","https://openalex.org/W2753779930","https://openalex.org/W2769814280","https://openalex.org/W2770338041","https://openalex.org/W2781993335","https://openalex.org/W2789838322","https://openalex.org/W2800590229","https://openalex.org/W2802799856","https://openalex.org/W2809029138","https://openalex.org/W2886751286","https://openalex.org/W2899471886","https://openalex.org/W2901236694","https://openalex.org/W2936086509","https://openalex.org/W2943993922","https://openalex.org/W2945139835","https://openalex.org/W2945547824","https://openalex.org/W2952510751","https://openalex.org/W2952632971","https://openalex.org/W2957274573","https://openalex.org/W2971818215","https://openalex.org/W2982740884","https://openalex.org/W3000294122","https://openalex.org/W3005976568","https://openalex.org/W3016522056","https://openalex.org/W3021717500","https://openalex.org/W3024031448","https://openalex.org/W3032315001","https://openalex.org/W3045954925","https://openalex.org/W3047473202","https://openalex.org/W3048522594","https://openalex.org/W3088377134","https://openalex.org/W3088720415","https://openalex.org/W3092007298","https://openalex.org/W3092324811","https://openalex.org/W3109961441","https://openalex.org/W3114415956","https://openalex.org/W3137174059","https://openalex.org/W3176452841","https://openalex.org/W3186706555","https://openalex.org/W3186968522","https://openalex.org/W3189505974","https://openalex.org/W3196913683","https://openalex.org/W3210747018","https://openalex.org/W4213224911","https://openalex.org/W4225005528","https://openalex.org/W4281619645","https://openalex.org/W4283272429","https://openalex.org/W4308060033","https://openalex.org/W4309468395","https://openalex.org/W4311291416","https://openalex.org/W4312089822","https://openalex.org/W4313382384","https://openalex.org/W4317914696","https://openalex.org/W4318559896","https://openalex.org/W4365142107","https://openalex.org/W4366772265","https://openalex.org/W4372046965","https://openalex.org/W4378469717","https://openalex.org/W4378806274","https://openalex.org/W4379537203","https://openalex.org/W4385620091","https://openalex.org/W4386118979","https://openalex.org/W4387118569","https://openalex.org/W4388035151","https://openalex.org/W4389145640","https://openalex.org/W4389639261","https://openalex.org/W4390034797","https://openalex.org/W4394012741"],"related_works":["https://openalex.org/W4415764406","https://openalex.org/W7112423130","https://openalex.org/W7205010684","https://openalex.org/W3137174059","https://openalex.org/W7039325368","https://openalex.org/W7157575192","https://openalex.org/W146285696","https://openalex.org/W3122478428","https://openalex.org/W2021506809","https://openalex.org/W4391004461"],"abstract_inverted_index":{"Numerous":[0],"physical":[1,50],"and":[2,19,25,44,52],"mechanical":[3],"changes":[4],"occur":[5],"in":[6,33,35],"the":[7,13,16,21,56],"premetastatic":[8,17,41],"niche.":[9],"Here,":[10],"we":[11],"review":[12],"mechanics":[14,28],"of":[15],"niche":[18,42],"how":[20],"altered":[22],"extracellular":[23],"matrix":[24],"cancer":[26],"cell":[27,46],"may":[29],"play":[30],"a":[31],"role":[32],"organotropism":[34],"breast":[36],"cancer.":[37],"Future":[38],"research":[39],"into":[40],"development":[43],"organotropic":[45],"behavior":[47],"should":[48],"address":[49],"alterations":[51,61],"biomechanical":[53],"effects":[54],"to":[55],"same":[57],"rigor":[58],"that":[59],"biochemical":[60],"are":[62],"studied.":[63]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-04-05T00:00:00"}