{"id":"https://openalex.org/W4409130243","doi":"https://doi.org/10.4103/jcrt.jcrt_388_24","title":"Epigenetics and cancer stem cells\u2014The world of cancer genesis: A review","display_name":"Epigenetics and cancer stem cells\u2014The world of cancer genesis: A review","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4409130243","doi":"https://doi.org/10.4103/jcrt.jcrt_388_24","pmid":"https://pubmed.ncbi.nlm.nih.gov/40214347"},"language":"en","primary_location":{"id":"doi:10.4103/jcrt.jcrt_388_24","doi":"https://doi.org/10.4103/jcrt.jcrt_388_24","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jcrt.jcrt_388_24","pdf_url":null,"source":{"id":"https://openalex.org/S53738828","display_name":"Journal of Cancer Research and Therapeutics","issn_l":"1998-4138","issn":["1998-4138","0973-1482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/jcrt.jcrt_388_24","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078124491","display_name":"Neema Tiwari","orcid":"https://orcid.org/0000-0002-6273-7679","observed_orcids":["https://orcid.org/0000-0002-6273-7679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neema Tiwari","raw_affiliation_strings":["Department of Pathology, Super Specialty Paediatric Hospital and Post Graduate Teaching Institute, Noida, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Super Specialty Paediatric Hospital and Post Graduate Teaching Institute, Noida, Uttar Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055925753","display_name":"Jyoti Mishra","orcid":"https://orcid.org/0009-0002-9467-5481","observed_orcids":["https://orcid.org/0009-0002-9467-5481"]},"institutions":[{"id":"https://openalex.org/I2801491316","display_name":"Government of Uttar Pradesh","ror":"https://ror.org/00hx1yw75","country_code":"IN","type":"government","lineage":["https://openalex.org/I2801491316"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jyoti Mishra","raw_affiliation_strings":["Department of Pathology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India","institution_ids":["https://openalex.org/I2801491316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103573177","display_name":"Natasha Singh","orcid":"https://orcid.org/0000-0003-3074-8303","observed_orcids":["https://orcid.org/0000-0003-3074-8303"]},"institutions":[{"id":"https://openalex.org/I2801491316","display_name":"Government of Uttar Pradesh","ror":"https://ror.org/00hx1yw75","country_code":"IN","type":"government","lineage":["https://openalex.org/I2801491316"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Natasha Singh","raw_affiliation_strings":["Department of Pathology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India","institution_ids":["https://openalex.org/I2801491316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101659107","display_name":"S. K. Mishra","orcid":"https://orcid.org/0000-0001-8522-0106","observed_orcids":["https://orcid.org/0000-0001-8522-0106","https://orcid.org/0000-0002-1647-3625","https://orcid.org/0009-0005-0921-6806"]},"institutions":[{"id":"https://openalex.org/I2801491316","display_name":"Government of Uttar Pradesh","ror":"https://ror.org/00hx1yw75","country_code":"IN","type":"government","lineage":["https://openalex.org/I2801491316"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjay Kumar Mishra","raw_affiliation_strings":["Department of Surgery, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India","institution_ids":["https://openalex.org/I2801491316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041962030","display_name":"Monal Trisal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Monal Trisal","raw_affiliation_strings":["Department of Pathology, Hamdard Institute of Medical Science and Research, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hamdard Institute of Medical Science and Research, New Delhi, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055287980","display_name":"Shailza Verma","orcid":"https://orcid.org/0009-0009-5426-1840","observed_orcids":["https://orcid.org/0009-0009-5426-1840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shailza Verma","raw_affiliation_strings":["Department of Biochemistry, Nagaland Institute of Medical Science and Research, Kohima, Nagaland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagaland Institute of Medical Science and Research, Kohima, Nagaland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041962030"],"corresponding_institution_ids":["https://openalex.org/I19716509"],"apc_list":null,"apc_paid":null,"fwci":0.1416,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12023645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"21","issue":"1","first_page":"5","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":1.0},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cancer-genesis","display_name":"cancer genesis","score":0.5740000009536743},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.847000002861023},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.5210000276565552},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7618988752365112},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7498772144317627},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7466927766799927},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6587880253791809},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5438116788864136},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5341030359268188},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48292800784111023},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4678550362586975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.453251451253891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38790363073349},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3343275189399719},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3290467858314514},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2301328182220459},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.17143219709396362},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.061974138021469116},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4103/jcrt.jcrt_388_24","doi":"https://doi.org/10.4103/jcrt.jcrt_388_24","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jcrt.jcrt_388_24","pdf_url":null,"source":{"id":"https://openalex.org/S53738828","display_name":"Journal of Cancer Research and Therapeutics","issn_l":"1998-4138","issn":["1998-4138","0973-1482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Therapeutics","raw_type":"journal-article"},{"id":"pmid:40214347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40214347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and therapeutics","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.4103/jcrt.jcrt_388_24","doi":"https://doi.org/10.4103/jcrt.jcrt_388_24","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jcrt.jcrt_388_24","pdf_url":null,"source":{"id":"https://openalex.org/S53738828","display_name":"Journal of Cancer Research and Therapeutics","issn_l":"1998-4138","issn":["1998-4138","0973-1482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1967358345","https://openalex.org/W1989958716","https://openalex.org/W1990757263","https://openalex.org/W1994599132","https://openalex.org/W2001144553","https://openalex.org/W2001544973","https://openalex.org/W2002032609","https://openalex.org/W2010653264","https://openalex.org/W2023427658","https://openalex.org/W2028025998","https://openalex.org/W2029231546","https://openalex.org/W2051935450","https://openalex.org/W2069717852","https://openalex.org/W2072348418","https://openalex.org/W2090982381","https://openalex.org/W2096083625","https://openalex.org/W2100621969","https://openalex.org/W2104666893","https://openalex.org/W2117692326","https://openalex.org/W2121604817","https://openalex.org/W2128338098","https://openalex.org/W2137162822","https://openalex.org/W2138784667","https://openalex.org/W2141410747","https://openalex.org/W2141437534","https://openalex.org/W2153382986","https://openalex.org/W2158207797","https://openalex.org/W2167319166","https://openalex.org/W2170210082","https://openalex.org/W2896629991","https://openalex.org/W2935942593","https://openalex.org/W3159642248"],"related_works":["https://openalex.org/W2417456692","https://openalex.org/W2030317722","https://openalex.org/W2586020508","https://openalex.org/W1974883791","https://openalex.org/W2148635782","https://openalex.org/W2096330673","https://openalex.org/W2379915430","https://openalex.org/W4377098663","https://openalex.org/W2038700261","https://openalex.org/W159288766"],"abstract_inverted_index":{"ABSTRACT:":[0],"The":[1],"major":[2],"cause":[3],"of":[4,81,96,110,116,122],"sickness":[5],"and":[6,37,52,65,98,106,132,142],"mortality":[7],"in":[8,21,85,113,144],"affluent":[9],"nations":[10],"is":[11,27,48],"cancer.":[12,30,45,63,145],"Cancer":[13],"cases":[14],"are":[15,43,60],"rapidly":[16],"outpacing":[17],"infectious":[18],"illness":[19],"burdens":[20],"emerging":[22],"nations.":[23],"No":[24],"age":[25],"group":[26],"resistant":[28],"to":[29,56,89,93,138],"Children":[31],"as":[32,34,39,41],"young":[33,50],"six":[35],"months":[36],"seniors":[38],"old":[40],"95":[42],"contracting":[44],"What's":[46],"surprising":[47],"that":[49,124],"individuals":[51],"those":[53],"not":[54],"exposed":[55],"viruses":[57],"or":[58],"tobacco":[59],"also":[61],"getting":[62],"Mutations":[64],"chromosomal":[66],"instability":[67],"have":[68],"a":[69],"crucial":[70],"impact.":[71],"An":[72],"intriguing":[73],"academic":[74],"debate":[75],"will":[76],"center":[77],"on":[78],"the":[79,82,94,101,107,114,136],"function":[80],"epigenetic":[83],"landscape":[84],"cancer":[86,97,102],"cells":[87,131],"compared":[88],"normal":[90],"cells,":[91],"leading":[92],"start":[95],"development":[99],"(including":[100],"stem":[103,130],"cell":[104],"concept),":[105],"possible":[108],"application":[109],"this":[111],"information":[112],"creation":[115],"more":[117],"effective":[118],"therapies.":[119],"Important":[120],"aspects":[121],"carcinogenesis":[123,143],"must":[125],"be":[126],"fully":[127],"addressed":[128],"include":[129],"epigenetics,":[133],"which":[134],"hold":[135],"key":[137],"therapeutic":[139],"response,":[140],"chemoresistance,":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-04-04T00:00:00"}
