{"id":"https://openalex.org/W4409127161","doi":"https://doi.org/10.1101/2025.04.01.646614","title":"Impact of Cesarean Delivery on Reward Behavior and Neurodevelopment in Adult Prairie Vole Offspring","display_name":"Impact of Cesarean Delivery on Reward Behavior and Neurodevelopment in Adult Prairie Vole Offspring","publication_year":2025,"publication_date":"2025-04-03","ids":{"openalex":"https://openalex.org/W4409127161","doi":"https://doi.org/10.1101/2025.04.01.646614","pmid":"https://pubmed.ncbi.nlm.nih.gov/40236166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996564"},"language":"en","primary_location":{"id":"doi:10.1101/2025.04.01.646614","doi":"https://doi.org/10.1101/2025.04.01.646614","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.01.646614","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2025.04.01.646614","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034102353","display_name":"Katelyn Rogers","orcid":"https://orcid.org/0009-0002-1727-7017","observed_orcids":["https://orcid.org/0009-0002-1727-7017"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Rogers","raw_affiliation_strings":["Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA"],"raw_orcid":"https://orcid.org/0009-0002-1727-7017","affiliations":[{"raw_affiliation_string":"Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emily Kiernan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Kiernan","raw_affiliation_strings":["Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051458337","display_name":"Miranda E. Partie","orcid":"https://orcid.org/0000-0002-1072-7612","observed_orcids":["https://orcid.org/0000-0002-1072-7612"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miranda Partie","raw_affiliation_strings":["Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA"],"raw_orcid":"https://orcid.org/0000-0002-1072-7612","affiliations":[{"raw_affiliation_string":"Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006999592","display_name":"William M. Kenkel","orcid":"https://orcid.org/0000-0002-0271-1071","observed_orcids":["https://orcid.org/0000-0002-0271-1071"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Kenkel","raw_affiliation_strings":["Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA"],"raw_orcid":"https://orcid.org/0000-0002-0271-1071","affiliations":[{"raw_affiliation_string":"Department of Psychological & Brain Sciences, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006999592"],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.3495999872684479,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cesarean-section","display_name":"cesarean section","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vaginal-delivery","display_name":"vaginal delivery","score":0.7860000133514404},{"id":"https://openalex.org/keywords/prairie-voles","display_name":"Microtus ochrogaster","score":0.9290000200271606},{"id":"https://openalex.org/keywords/food-reward","display_name":"food reward","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.6150000095367432},{"id":"https://openalex.org/keywords/mesolimbic-pathway","display_name":"mesolimbic system","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.7699999809265137},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dopamine-dysregulation","display_name":"dopamine dysregulation","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8843162655830383},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.6874310374259949},{"id":"https://openalex.org/C35124327","wikidata":"https://www.wikidata.org/wiki/Q5159285","display_name":"Conditioned place preference","level":3,"score":0.6727198362350464},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5223478078842163},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5115209817886353},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4989902973175049},{"id":"https://openalex.org/C143661069","wikidata":"https://www.wikidata.org/wiki/Q670713","display_name":"Reward system","level":2,"score":0.4850537180900574},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4635182321071625},{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.4389716684818268},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.4273848235607147},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39873358607292175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36054861545562744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35299748182296753},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.32462918758392334},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23142078518867493},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17634999752044678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13398799300193787},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.07595938444137573},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1101/2025.04.01.646614","doi":"https://doi.org/10.1101/2025.04.01.646614","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.01.646614","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40236166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40236166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10808616","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996564","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11996564","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996564","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.04.01.646614","doi":"https://doi.org/10.1101/2025.04.01.646614","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.01.646614","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1541979437","https://openalex.org/W1951724000","https://openalex.org/W1967384560","https://openalex.org/W1977792249","https://openalex.org/W1980557031","https://openalex.org/W1993305928","https://openalex.org/W2001457444","https://openalex.org/W2005576024","https://openalex.org/W2007298889","https://openalex.org/W2008857744","https://openalex.org/W2010129023","https://openalex.org/W2013863661","https://openalex.org/W2018328822","https://openalex.org/W2025440394","https://openalex.org/W2040795654","https://openalex.org/W2094347090","https://openalex.org/W2098989477","https://openalex.org/W2099540110","https://openalex.org/W2103545875","https://openalex.org/W2114821999","https://openalex.org/W2137787282","https://openalex.org/W2142683796","https://openalex.org/W2168638573","https://openalex.org/W2170919042","https://openalex.org/W2314347989","https://openalex.org/W2334183236","https://openalex.org/W2343236286","https://openalex.org/W2394618499","https://openalex.org/W2514219021","https://openalex.org/W2897287107","https://openalex.org/W2950742841","https://openalex.org/W2973274899","https://openalex.org/W3113363310","https://openalex.org/W3210165062","https://openalex.org/W3215919632","https://openalex.org/W4206716946","https://openalex.org/W4220719633","https://openalex.org/W4319062737","https://openalex.org/W4391796230"],"related_works":["https://openalex.org/W4416897240","https://openalex.org/W1967384560","https://openalex.org/W3166920315","https://openalex.org/W2057676490","https://openalex.org/W2018328822","https://openalex.org/W1964801651","https://openalex.org/W2036501066","https://openalex.org/W2120962478","https://openalex.org/W3209284627","https://openalex.org/W2593436602"],"abstract_inverted_index":{"Accumulating":[0],"clinical":[1],"evidence":[2],"has":[3,59,237],"shown":[4,60],"that":[5,47,61,233,248],"birth":[6,91],"by":[7,235],"Cesarean":[8],"section":[9],"(CS)":[10],"is":[11],"associated":[12],"with":[13],"a":[14,88,143,150,190],"higher":[15,73],"incidence":[16],"of":[17,22,66,79,90,142,221,258],"disorders":[18],"involving":[19],"the":[20,69,75,84,109,162,172,224,243],"dysregulation":[21],"dopamine":[23],"(DA),":[24],"such":[25,101],"as":[26,87,102],"attention":[27],"deficit-hyperactivity":[28],"disorder,":[29,32],"autism":[30],"spectrum":[31],"and":[33,54,72,111,146,152,181,227,247],"obesity,":[34],"compared":[35,198],"to":[36,98,107,115,131,139,148,155,199],"vaginal":[37],"delivery":[38,234],"(VD).":[39],"The":[40],"mesolimbic":[41],"(ML)":[42],"system":[43,86],"encompasses":[44],"DAergic":[45],"neurons":[46],"modulate":[48],"reward":[49,117,245,256],"processes":[50],"underlying":[51],"learning,":[52],"motivation,":[53],"food":[55,116,255],"intake.":[56],"Previous":[57],"research":[58],"there":[62],"are":[63],"lower":[64,191,219],"levels":[65,220],"DA":[67],"in":[68,74,83,118,161,169,205,223,242,260],"prefrontal":[70],"cortex":[71],"nucleus":[76],"accumbens":[77],"(NAc)":[78],"CS":[80,93,119,179,185,216,236,249],"offspring.":[81,122],"Alterations":[82],"ML-DA":[85],"consequence":[89],"via":[92],"may":[94],"impact":[95],"behavioral":[96,110],"response":[97,145,206],"rewarding":[99],"stimuli,":[100],"food.":[103],"Thus,":[104],"we":[105],"aimed":[106],"ascertain":[108],"neurodevelopmental":[112,239],"outcomes":[113],"relevant":[114],"prairie":[120,186],"vole":[121,187],"This":[123],"study":[124],"utilized":[125],"conditioned":[126,144,173],"place":[127],"preference":[128,170],"(CPP)":[129],"testing":[130,177,197],"assess":[132,140],"learning":[133],"using":[134],"context-dependent":[135],"conditioning,":[136],"operant":[137],"conditioning":[138],"acquisition":[141],"motivation":[147,253],"receive":[149],"reinforcer,":[151],"immunohistochemistry":[153],"(IHC)":[154],"stain":[156],"for":[157,171],"tyrosine":[158],"hydroxylase":[159],"(TH)":[160],"NAc.":[163],"Behavioral":[164],"results":[165,214],"showed":[166,215],"no":[167,203],"difference":[168,204],"chamber":[174],"during":[175,195,207],"CPP":[176],"between":[178],"offspring":[180,188,217,250],"their":[182],"VD":[183,200],"counterparts.":[184],"had":[189,218],"average":[192],"break":[193],"point":[194],"progressive-ratio":[196],"offspring,":[201],"but":[202],"fixed-ratio":[208],"1":[209],"or":[210],"3":[211],"testing.":[212],"IHC":[213],"TH-immunoreactivity":[222],"NAc":[225],"core":[226],"shell.":[228],"These":[229],"findings":[230],"further":[231],"support":[232],"long-term":[238],"effects,":[240],"specifically":[241],"brain's":[244],"system,":[246],"have":[251],"decreased":[252],"toward":[254],"independent":[257],"deficits":[259],"learning.":[261]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-04-04T00:00:00"}
