{"id":"https://openalex.org/W4409124166","doi":"https://doi.org/10.1186/s12872-025-04647-2","title":"Liver biomarkers as predictors of prognosis in heart failure with preserved ejection fraction: a systematic review and meta-analysis","display_name":"Liver biomarkers as predictors of prognosis in heart failure with preserved ejection fraction: a systematic review and meta-analysis","publication_year":2025,"publication_date":"2025-04-02","ids":{"openalex":"https://openalex.org/W4409124166","doi":"https://doi.org/10.1186/s12872-025-04647-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/40175926","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11963275"},"language":"en","primary_location":{"id":"doi:10.1186/s12872-025-04647-2","doi":"https://doi.org/10.1186/s12872-025-04647-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-025-04647-2","pdf_url":null,"source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4409124166"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12872-025-04647-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106989351","display_name":"Parham Dastjerdi","orcid":"https://orcid.org/0009-0007-3386-7697","observed_orcids":["https://orcid.org/0009-0007-3386-7697"]},"institutions":[{"id":"https://openalex.org/I4403928369","display_name":"Cardiovascular Diseases Research Institute","ror":"https://ror.org/01ktv1m31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parham Dastjerdi","raw_affiliation_strings":["Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0009-0007-3386-7697","affiliations":[{"raw_affiliation_string":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928369","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058444074","display_name":"Mehrdad Mahalleh","orcid":"https://orcid.org/0000-0002-6210-2112","observed_orcids":["https://orcid.org/0000-0002-6210-2112"]},"institutions":[{"id":"https://openalex.org/I4403928369","display_name":"Cardiovascular Diseases Research Institute","ror":"https://ror.org/01ktv1m31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrdad Mahalleh","raw_affiliation_strings":["Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-6210-2112","affiliations":[{"raw_affiliation_string":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928369","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106989352","display_name":"Hedieh Shayesteh","orcid":"https://orcid.org/0009-0002-8450-4662","observed_orcids":["https://orcid.org/0009-0002-8450-4662"]},"institutions":[{"id":"https://openalex.org/I4403928369","display_name":"Cardiovascular Diseases Research Institute","ror":"https://ror.org/01ktv1m31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hedieh Shayesteh","raw_affiliation_strings":["Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0009-0002-8450-4662","affiliations":[{"raw_affiliation_string":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928369","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061127745","display_name":"Mohammad Sadeq Najafi","orcid":"https://orcid.org/0000-0002-5041-6798","observed_orcids":["https://orcid.org/0000-0002-5041-6798"]},"institutions":[{"id":"https://openalex.org/I4403928369","display_name":"Cardiovascular Diseases Research Institute","ror":"https://ror.org/01ktv1m31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Sadeq Najafi","raw_affiliation_strings":["Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-5041-6798","affiliations":[{"raw_affiliation_string":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928369","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059490349","display_name":"Roozbeh Narimani Javid","orcid":"https://orcid.org/0000-0002-9134-8787","observed_orcids":["https://orcid.org/0000-0002-9134-8787"]},"institutions":[{"id":"https://openalex.org/I4403928369","display_name":"Cardiovascular Diseases Research Institute","ror":"https://ror.org/01ktv1m31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Roozbeh Narimani-Javid","raw_affiliation_strings":["Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-9134-8787","affiliations":[{"raw_affiliation_string":"Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928369","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035253498","display_name":"Mohadese Dashtkoohi","orcid":"https://orcid.org/0000-0003-3579-4181","observed_orcids":["https://orcid.org/0000-0003-3579-4181"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohadese Dashtkoohi","raw_affiliation_strings":["Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0003-3579-4181","affiliations":[{"raw_affiliation_string":"Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Seyed Ali Mofidi","orcid":"https://orcid.org/0000-0002-7849-3760","observed_orcids":["https://orcid.org/0000-0002-7849-3760"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Ali Mofidi","raw_affiliation_strings":["Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-7849-3760","affiliations":[{"raw_affiliation_string":"Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026322926","display_name":"Kaveh Hosseini","orcid":"https://orcid.org/0000-0001-5676-3099","observed_orcids":["https://orcid.org/0000-0001-5676-3099"]},"institutions":[{"id":"https://openalex.org/I4403928369","display_name":"Cardiovascular Diseases Research Institute","ror":"https://ror.org/01ktv1m31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kaveh Hosseini","raw_affiliation_strings":["Cardiac Primary Prevention Research Center, Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran","Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0001-5676-3099","affiliations":[{"raw_affiliation_string":"Cardiac Primary Prevention Research Center, Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"raw_affiliation_string":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928369","https://openalex.org/I70640408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063096603","display_name":"Masih Tajdini","orcid":"https://orcid.org/0000-0002-5286-9897","observed_orcids":["https://orcid.org/0000-0002-5286-9897"]},"institutions":[{"id":"https://openalex.org/I4401041623","display_name":"Tehran Heart Center","ror":"https://ror.org/042f28677","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4401041623","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I4403928369","display_name":"Cardiovascular Diseases Research Institute","ror":"https://ror.org/01ktv1m31","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Masih Tajdini","raw_affiliation_strings":["Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. masihtajdini@gmail.com"],"raw_orcid":"https://orcid.org/0000-0002-5286-9897","affiliations":[{"raw_affiliation_string":"Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. masihtajdini@gmail.com","institution_ids":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063096603"],"corresponding_institution_ids":["https://openalex.org/I4401041623","https://openalex.org/I4403928369","https://openalex.org/I70640408"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":2.2022,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.88980924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"25","issue":"1","first_page":"244","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":1.0},{"id":"https://openalex.org/keywords/liver-function-biomarkers","display_name":"liver function biomarkers","score":0.8119999766349792},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.6909999847412109},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.6570000052452087},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8759999871253967},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8930000066757202},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.953000009059906},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8050221800804138},{"id":"https://openalex.org/C555175668","wikidata":"https://www.wikidata.org/wiki/Q539690","display_name":"Angiology","level":2,"score":0.7990930080413818},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7204958200454712},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7077326774597168},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6611419916152954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6338189244270325},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6281554698944092},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.6159143447875977}],"mesh":[{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12872-025-04647-2","doi":"https://doi.org/10.1186/s12872-025-04647-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-025-04647-2","pdf_url":null,"source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11963275","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11963275/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11963275/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovasc Disord","raw_type":"Text"},{"id":"pmid:40175926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40175926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cardiovascular disorders","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e1024758af0844f78cca76638fb864b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e1024758af0844f78cca76638fb864b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cardiovascular Disorders, Vol 25, Iss 1, Pp 1-16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12872-025-04647-2","doi":"https://doi.org/10.1186/s12872-025-04647-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-025-04647-2","pdf_url":null,"source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409124166.pdf","grobid_xml":"https://content.openalex.org/works/W4409124166.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W98412749","https://openalex.org/W1976113377","https://openalex.org/W1985850316","https://openalex.org/W2007496527","https://openalex.org/W2068489677","https://openalex.org/W2073069044","https://openalex.org/W2074713275","https://openalex.org/W2082977560","https://openalex.org/W2218389985","https://openalex.org/W2341568598","https://openalex.org/W2586816621","https://openalex.org/W2607242643","https://openalex.org/W2612219720","https://openalex.org/W2641443785","https://openalex.org/W2735428440","https://openalex.org/W2765613816","https://openalex.org/W2791740573","https://openalex.org/W2954654225","https://openalex.org/W2967381667","https://openalex.org/W2973163536","https://openalex.org/W2973749867","https://openalex.org/W2990724953","https://openalex.org/W2991912917","https://openalex.org/W3005476393","https://openalex.org/W3012527193","https://openalex.org/W3044676930","https://openalex.org/W3096816297","https://openalex.org/W3112039339","https://openalex.org/W3113344507","https://openalex.org/W3124681093","https://openalex.org/W3127757965","https://openalex.org/W3128153022","https://openalex.org/W3130980188","https://openalex.org/W3133934719","https://openalex.org/W3160483611","https://openalex.org/W3164461722","https://openalex.org/W3176215832","https://openalex.org/W3181806673","https://openalex.org/W3184799482","https://openalex.org/W3185104145","https://openalex.org/W3198000254","https://openalex.org/W3205457161","https://openalex.org/W3211067229","https://openalex.org/W3215648480","https://openalex.org/W3216858231","https://openalex.org/W4200049150","https://openalex.org/W4220888479","https://openalex.org/W4223427030","https://openalex.org/W4229334845","https://openalex.org/W4280622706","https://openalex.org/W4284670427","https://openalex.org/W4289929142","https://openalex.org/W4306969913","https://openalex.org/W4322754104","https://openalex.org/W4378717948","https://openalex.org/W4379508906","https://openalex.org/W4386837158","https://openalex.org/W4391034573","https://openalex.org/W4392465237","https://openalex.org/W4393005658","https://openalex.org/W4405459021"],"related_works":["https://openalex.org/W4380149037","https://openalex.org/W3160483611","https://openalex.org/W2990724953","https://openalex.org/W7166044262","https://openalex.org/W7135048044","https://openalex.org/W7149441111","https://openalex.org/W2755187720","https://openalex.org/W3130980188","https://openalex.org/W3217461941","https://openalex.org/W4394095364"],"abstract_inverted_index":{"BACKGROUND:":[0],"Heart":[1],"failure":[2,13],"with":[3,15,84,137,188],"preserved":[4],"ejection":[5],"fraction":[6],"(HFpEF)":[7],"accounts":[8],"for":[9,76,182,196,235],"50%":[10],"of":[11,50,66,70,81,95,131,141,147,194,205],"heart":[12,96],"cases,":[14],"increasing":[16],"prevalence":[17],"due":[18],"to":[19,45,202],"aging":[20],"and":[21,27,35,42,72,110,166],"risk":[22,140,236],"factors":[23],"such":[24],"as":[25,231],"hypertension":[26],"obesity.":[28],"Liver":[29],"dysfunction":[30],"is":[31],"common":[32],"in":[33,59,87,144,216,238],"HFpEF":[34,60],"may":[36,199,229],"impact":[37],"prognosis.":[38],"This":[39],"systematic":[40,64],"review":[41],"meta-analysis":[43,146],"aimed":[44],"evaluate":[46],"the":[47,79,115,128,167,191,203],"prognostic":[48,225],"value":[49],"liver":[51,82,220],"function":[52,221],"markers":[53,83,198,222],"(albumin,":[54],"bilirubin,":[55],"AST,":[56,183],"ALT,":[57,184],"ALP)":[58],"patients.":[61],"METHODS:":[62],"A":[63],"search":[65],"PubMed,":[67],"Embase,":[68],"Web":[69],"Science,":[71],"Scopus":[73],"was":[74,92,112,134],"conducted":[75],"studies":[77,120,149,195],"assessing":[78],"association":[80,168],"adverse":[85,142,189],"outcomes":[86,143,215],"HFpEF.":[88,239],"The":[89],"primary":[90],"outcome":[91],"a":[93,107,138,145,232],"composite":[94],"failure-related":[97],"hospitalization":[98],"or":[99,186],"death.":[100],"Hazard":[101],"ratios":[102],"(HR)":[103],"were":[104,124,180],"pooled":[105],"using":[106,114],"random-effects":[108],"model,":[109],"heterogeneity":[111,161],"assessed":[113],"I\u00b2":[116,155],"statistic.":[117],"RESULTS:":[118],"Twenty":[119],"involving":[121],"30,623":[122],"patients":[123],"included.":[125],"Serum":[126,227],"albumin,":[127],"main":[129],"marker":[130,234],"our":[132],"study,":[133],"significantly":[135],"associated":[136],"reduced":[139],"16":[148],"(HR":[150,171],"0.71,":[151],"95%":[152,173],"CI:":[153,174],"0.61-0.83;":[154],"=":[156,164],"87%).":[157],"After":[158],"excluding":[159],"outliers,":[160],"decreased":[162],"(I\u00b2":[163],"23%),":[165],"remained":[169],"significant":[170,178],"0.75,":[172],"0.69-0.82).":[175],"Although":[176],"no":[177],"associations":[179],"found":[181],"ALP,":[185],"bilirubin":[187],"outcomes,":[190],"limited":[192,224],"number":[193],"these":[197],"have":[200],"contributed":[201],"lack":[204],"statistical":[206],"significance.":[207],"CONCLUSION:":[208],"Higher":[209],"serum":[210],"albumin":[211,228],"levels":[212],"predict":[213],"better":[214],"HFpEF,":[217],"while":[218],"other":[219],"showed":[223],"utility.":[226],"serve":[230],"valuable":[233],"stratification":[237]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-04-03T00:00:00"}