{"id":"https://openalex.org/W4409108534","doi":"https://doi.org/10.1530/etj-25-0039","title":"High-dose versus low-dose block-and-replace treatment for a first episode of Graves\u2019 disease","display_name":"High-dose versus low-dose block-and-replace treatment for a first episode of Graves\u2019 disease","publication_year":2025,"publication_date":"2025-04-01","ids":{"openalex":"https://openalex.org/W4409108534","doi":"https://doi.org/10.1530/etj-25-0039","pmid":"https://pubmed.ncbi.nlm.nih.gov/40172327"},"language":"en","primary_location":{"id":"doi:10.1530/etj-25-0039","doi":"https://doi.org/10.1530/etj-25-0039","is_oa":true,"landing_page_url":"https://doi.org/10.1530/etj-25-0039","pdf_url":"https://etj.bioscientifica.com/downloadpdf/view/journals/etj/aop/etj-25-0039/etj-25-0039.pdf","source":{"id":"https://openalex.org/S2764859698","display_name":"European Thyroid Journal","issn_l":"2235-0640","issn":["2235-0640","2235-0802"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Thyroid Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://etj.bioscientifica.com/downloadpdf/view/journals/etj/aop/etj-25-0039/etj-25-0039.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116884347","display_name":"Arnaud Smolders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Arnaud Smolders","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","A Smolders, Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]},{"raw_affiliation_string":"A Smolders, Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028653799","display_name":"Aglaia Kyrilli","orcid":"https://orcid.org/0000-0002-9896-4419","observed_orcids":["https://orcid.org/0000-0002-9896-4419"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Aglaia Kyrilli","raw_affiliation_strings":["Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles 2 , ,","A Kyrilli, Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles 2 , ,","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]},{"raw_affiliation_string":"A Kyrilli, Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032726062","display_name":"Stefan Matei Constantinescu","orcid":"https://orcid.org/0000-0003-2665-9455","observed_orcids":["https://orcid.org/0000-0003-2665-9455"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Stefan Matei Constantinescu","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","S Constantinescu, Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2665-9455","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]},{"raw_affiliation_string":"S Constantinescu, Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009626422","display_name":"Bernard Corvilain","orcid":"https://orcid.org/0000-0001-7240-5953","observed_orcids":["https://orcid.org/0000-0001-7240-5953"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bernard Corvilain","raw_affiliation_strings":["Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles 2 , ,","B Corvilain, Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles 2 , ,","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]},{"raw_affiliation_string":"B Corvilain, Department of Endocrinology, Hopital Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022369973","display_name":"Chantal Daumerie","orcid":"https://orcid.org/0000-0002-1411-3247","observed_orcids":["https://orcid.org/0000-0002-1411-3247"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Chantal Daumerie","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","C Daumerie, Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]},{"raw_affiliation_string":"C Daumerie, Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015429326","display_name":"Maria\u2010Cristina Burlacu","orcid":"https://orcid.org/0000-0002-8437-3933","observed_orcids":["https://orcid.org/0000-0002-8437-3933"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maria-Cristina Burlacu","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","M Burlacu, Department of Endocrinology and Nutrition, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-8437-3933","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain 1 , ,","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]},{"raw_affiliation_string":"M Burlacu, Department of Endocrinology and Nutrition, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073","https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2064,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79743469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"14","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.9760000109672546},{"id":"https://openalex.org/keywords/levothyroxine-dose","display_name":"levothyroxine dose","score":0.800000011920929},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.8690000176429749},{"id":"https://openalex.org/keywords/graves-ophthalmopathy","display_name":"Graves' ophthalmopathy","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9526763558387756},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7907811403274536},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6740760207176208},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5864002704620361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.57066410779953},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.5550433397293091},{"id":"https://openalex.org/C2775883008","wikidata":"https://www.wikidata.org/wiki/Q773449","display_name":"Levothyroxine","level":3,"score":0.504574179649353},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4985177516937256},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4662439227104187},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4572943449020386},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.38742595911026}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1530/etj-25-0039","doi":"https://doi.org/10.1530/etj-25-0039","is_oa":true,"landing_page_url":"https://doi.org/10.1530/etj-25-0039","pdf_url":"https://etj.bioscientifica.com/downloadpdf/view/journals/etj/aop/etj-25-0039/etj-25-0039.pdf","source":{"id":"https://openalex.org/S2764859698","display_name":"European Thyroid Journal","issn_l":"2235-0640","issn":["2235-0640","2235-0802"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Thyroid Journal","raw_type":"journal-article"},{"id":"pmid:40172327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40172327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European thyroid journal","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10830747","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12020463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12020463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12020463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur Thyroid J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:64dc6bc637eb466e9a562420f173c881","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/64dc6bc637eb466e9a562420f173c881","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Thyroid Journal, Vol 14, Iss 2 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1530/etj-25-0039","doi":"https://doi.org/10.1530/etj-25-0039","is_oa":true,"landing_page_url":"https://doi.org/10.1530/etj-25-0039","pdf_url":"https://etj.bioscientifica.com/downloadpdf/view/journals/etj/aop/etj-25-0039/etj-25-0039.pdf","source":{"id":"https://openalex.org/S2764859698","display_name":"European Thyroid Journal","issn_l":"2235-0640","issn":["2235-0640","2235-0802"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Thyroid Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409108534.pdf","grobid_xml":"https://content.openalex.org/works/W4409108534.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1199524426","https://openalex.org/W1964538666","https://openalex.org/W1984094434","https://openalex.org/W1992061501","https://openalex.org/W2038860718","https://openalex.org/W2043410596","https://openalex.org/W2134134791","https://openalex.org/W2149372001","https://openalex.org/W2167716419","https://openalex.org/W2510464317","https://openalex.org/W2884675353","https://openalex.org/W3033610368","https://openalex.org/W3090259806","https://openalex.org/W3092514617","https://openalex.org/W3115990831","https://openalex.org/W4393991184"],"related_works":["https://openalex.org/W3024886683","https://openalex.org/W1560976911","https://openalex.org/W3160226296","https://openalex.org/W2998226874","https://openalex.org/W2083256140","https://openalex.org/W2081588773","https://openalex.org/W4224115610","https://openalex.org/W2360693916","https://openalex.org/W2761289376","https://openalex.org/W2505565526"],"abstract_inverted_index":{"Objective:":[0],"The":[1,96],"optimal":[2],"treatment":[3],"with":[4,33,65,80,247],"antithyroid":[5],"drugs":[6],"(ATDs)":[7],"for":[8,39,47],"a":[9,205,224,248],"first":[10,206,249],"episode":[11,250],"of":[12,24,98,159,208,211,216,229,251],"Graves'":[13],"disease":[14,57],"(GD)":[15],"remains":[16],"controversial.":[17],"Methods:":[18],"Retrospective,":[19],"two":[20],"academic":[21],"centres":[22],"study":[23],"newly":[25],"diagnosed":[26],"GD":[27,252],"between":[28,103],"1990":[29],"and":[30,44,73,105,189,214,259],"2022,":[31],"treated":[32],"ATD":[34,53,67,82,176,258],"in":[35,93,154,245],"block-and-replace":[36],"(B+R)":[37],"regimen":[38],"at":[40,48,113,122,131],"least":[41,49],"12":[42,123],"months":[43,235],"followed":[45],"up":[46,254],"1":[50],"year":[51],"after":[52,223],"discontinuation":[54],"or":[55,157],"until":[56],"relapse.":[58],"Sixty":[59],"patients":[60,75,213,218,246],"received":[61,76,173],"high-dose":[62,265],"B+R":[63,78,266],"(HD)":[64],"fixed":[66],"dose":[68,83,177,192,263],"maintained":[69],"during":[70,85],"the":[71,86,155],"study,":[72],"60":[74],"low-dose":[77],"(LD)":[79],"lower":[81,175,190],"adjusted":[84],"study.":[87],"Results:":[88],"Baseline":[89],"characteristics":[90],"were":[91,151],"similar":[92,242],"both":[94],"groups.":[95],"point-prevalence":[97],"euthyroidism":[99],"was":[100],"not":[101],"different":[102],"HD":[104,139,212],"LD":[106,142,172,217],"(38":[107],"vs":[108,117,126,140,167,181,196,232],"47%,":[109],"P":[110,119,128,169,186,201],"=":[111,120,129,144,170,221,237],"0.460":[112],"6":[114],"months,":[115,124,133,137],"69":[116],"82%,":[118],"0.194":[121],"70":[125],"78%,":[127,168],"0.370":[130],"18":[132,136],"respectively).":[134],"At":[135],"27%":[138],"38%":[141],"(P":[143,220,236],"0.242)":[145],"had":[146],"thyroid":[147],"eye":[148],"disease.":[149],"There":[150],"no":[152],"differences":[153],"number":[156],"type":[158],"ATD-related":[160],"adverse":[161],"events":[162],"(AE)":[163],"(no":[164],"AE":[165],"73":[166],"0.707).":[171],"mean":[174],"(15.3":[178],"\u00b1":[179,183,194,198],"4.2":[180],"30.0":[182],"0.0":[184],"mg/day,":[185],"<":[187,202],"0.001)":[188],"levothyroxine":[191,262],"(72.6":[193],"16.7":[195],"100.6":[197],"24.5":[199],"\u03bcg/day,":[200],"0.001).":[203],"After":[204],"course":[207],"ATD,":[209],"63%":[210],"60%":[215],"relapsed":[219],"0.707)":[222],"median":[225],"time":[226],"(interquartile":[227],"range)":[228],"11.0":[230],"(18)":[231],"7.0":[233],"(19)":[234],"0.109).":[238],"Conclusion:":[239],"We":[240],"observed":[241],"relapse":[243],"rates":[244],"receiving":[253],"to":[255],"50%":[256],"less":[257,261],"30%":[260],"than":[264],"regimen.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}