{"id":"https://openalex.org/W4409105995","doi":"https://doi.org/10.3389/fendo.2025.1518760","title":"The outcomes of blastocyst versus cleavage stage embryo biopsy for preimplantation genetic testing for monogenic diseases","display_name":"The outcomes of blastocyst versus cleavage stage embryo biopsy for preimplantation genetic testing for monogenic diseases","publication_year":2025,"publication_date":"2025-04-03","ids":{"openalex":"https://openalex.org/W4409105995","doi":"https://doi.org/10.3389/fendo.2025.1518760","pmid":"https://pubmed.ncbi.nlm.nih.gov/40248147","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12003119"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2025.1518760","doi":"https://doi.org/10.3389/fendo.2025.1518760","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2025.1518760","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1518760/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1518760/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077676010","display_name":"Lilach Marom Haham","orcid":"https://orcid.org/0000-0001-8913-9495","observed_orcids":["https://orcid.org/0000-0001-8913-9495"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Lilach Marom Haham","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060916224","display_name":"Adva Aizer","orcid":"https://orcid.org/0000-0003-0820-8079","observed_orcids":["https://orcid.org/0000-0003-0820-8079"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Adva Aizer","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Almog Arad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Almog Arad","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061069816","display_name":"Jigal Haas","orcid":"https://orcid.org/0000-0001-5274-7358","observed_orcids":["https://orcid.org/0000-0001-5274-7358"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jigal Haas","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053462787","display_name":"Oshrit Lebovitz","orcid":"https://orcid.org/0000-0003-1171-110X","observed_orcids":["https://orcid.org/0000-0003-1171-110X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oshrit Lebovitz","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067644086","display_name":"Eran Zilberberg","orcid":"https://orcid.org/0000-0002-1172-6216","observed_orcids":["https://orcid.org/0000-0002-1172-6216"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eran Zilberberg","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046790813","display_name":"Ravit Nahum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ravit Nahum","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108593782","display_name":"Raoul Orvieto","orcid":"https://orcid.org/0000-0001-6511-1340","observed_orcids":["https://orcid.org/0000-0001-6511-1340"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Raoul Orvieto","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel","The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077676010"],"corresponding_institution_ids":["https://openalex.org/I2799810450"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.895,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.80657384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"16","issue":null,"first_page":"1518760","last_page":"1518760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preimplantation-genetic-testing-for-monogenic-disease","display_name":"preimplantation genetic testing for monogenic disease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/trophectoderm-biopsy","display_name":"trophectoderm biopsy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/blastomere-biopsy","display_name":"blastomere biopsy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/implantation-rate","display_name":"implantation rate","score":0.8489999771118164},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.7751020193099976},{"id":"https://openalex.org/C68760520","wikidata":"https://www.wikidata.org/wiki/Q882097","display_name":"Blastomere","level":4,"score":0.7211483120918274},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.6731473803520203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6146628260612488},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.547799289226532},{"id":"https://openalex.org/C2910541586","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Blastocyst Transfer","level":5,"score":0.4807176887989044},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4806865155696869},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4474659562110901},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.4405853748321533},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.3999794125556946},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32858604192733765},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3208169639110565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2514305114746094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2203347384929657},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.082998126745224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.058717042207717896},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002970","descriptor_name":"Cleavage Stage, Ovum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018873","descriptor_name":"Pregnancy Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019836","descriptor_name":"Preimplantation Diagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2025.1518760","doi":"https://doi.org/10.3389/fendo.2025.1518760","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2025.1518760","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1518760/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:40248147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40248147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12003119","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12003119/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:22c6f00d58c147a3a6dfcd4db9a805a2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/22c6f00d58c147a3a6dfcd4db9a805a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2025.1518760","doi":"https://doi.org/10.3389/fendo.2025.1518760","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2025.1518760","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1518760/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409105995.pdf","grobid_xml":"https://content.openalex.org/works/W4409105995.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1963813674","https://openalex.org/W1982008816","https://openalex.org/W1989267920","https://openalex.org/W2017042541","https://openalex.org/W2024790307","https://openalex.org/W2030226455","https://openalex.org/W2046377650","https://openalex.org/W2071101635","https://openalex.org/W2094448698","https://openalex.org/W2109376016","https://openalex.org/W2109682665","https://openalex.org/W2111504689","https://openalex.org/W2116073351","https://openalex.org/W2141408351","https://openalex.org/W2162610003","https://openalex.org/W2168404614","https://openalex.org/W2294435919","https://openalex.org/W2300021431","https://openalex.org/W2300553549","https://openalex.org/W2410021341","https://openalex.org/W2521161933","https://openalex.org/W2524056803","https://openalex.org/W2549689970","https://openalex.org/W2625867325","https://openalex.org/W2792005394","https://openalex.org/W2888365152","https://openalex.org/W2903585683","https://openalex.org/W2921136538","https://openalex.org/W2944821929","https://openalex.org/W2969927864","https://openalex.org/W3015739340","https://openalex.org/W3023243495","https://openalex.org/W3028230913","https://openalex.org/W3030030551","https://openalex.org/W3032037546","https://openalex.org/W3085319508","https://openalex.org/W3095950289","https://openalex.org/W3112157728","https://openalex.org/W3132261985","https://openalex.org/W3184184652","https://openalex.org/W4220678844","https://openalex.org/W4230249059","https://openalex.org/W4248477344","https://openalex.org/W4280556963","https://openalex.org/W4310082963","https://openalex.org/W4366673809"],"related_works":["https://openalex.org/W4390331348","https://openalex.org/W4393388495","https://openalex.org/W2788495610","https://openalex.org/W1982008816","https://openalex.org/W4400297425","https://openalex.org/W3184192390","https://openalex.org/W2983278776","https://openalex.org/W4399033502","https://openalex.org/W4411324454","https://openalex.org/W2111504689"],"abstract_inverted_index":{"In":[0,37],"recent":[1],"years,":[2],"the":[3,17,25,30,52,63,93,100,143,167,177,188,212,230],"application":[4,32],"of":[5,21,33,65,197],"blastocyst":[6,101,149],"biopsy":[7,23,49,91,105,150,157,173,200,214],"in":[8,99,114,158,187,216,220],"PGT":[9,34],"has":[10,50,151],"been":[11],"gradually":[12],"rising,":[13],"mainly":[14],"due":[15,56],"to":[16,39,57,169,210,222],"assumed":[18],"detrimental":[19],"effect":[20],"blastomere":[22,172],"on":[24],"embryo":[26],"implantation":[27,115],"potential":[28],"and":[29,97,102,201],"widespread":[31],"for":[35,45,62,90,199,233],"aneuploidy.":[36],"contrast":[38],"complete":[40],"chromosomal":[41],"testing":[42],"(CCT)":[43],"cycles,":[44],"which":[46,180],"trophectoderm":[47],"(TE)":[48],"become":[51],"well-established":[53],"preferred":[54,213],"method":[55],"higher":[58,152],"diagnostic":[59],"reliability,":[60],"evidences":[61],"purpose":[64],"PGT-M":[66,79],"are":[67,208],"still":[68],"lacking.":[69],"Therefore,":[70],"we":[71],"conducted":[72],"a":[73,194,224],"retrospective":[74],"cohort":[75],"study":[76,141],"including":[77],"147":[78],"cycles":[80],"with":[81],"at":[82,92],"least":[83],"eight":[84],"high":[85],"quality":[86],"embryos":[87,198],"(HQE)":[88],"suitable":[89],"cleavage":[94,103,155],"stage,":[95],"83":[96],"64":[98],"stage":[104,156],"groups,":[106],"respectively.":[107],"Our":[108],"results":[109],"showed":[110],"no":[111],"significant":[112],"differences":[113],"rates":[116,123],"(32.8%":[117],"vs.":[118,128,137],"33.6%,":[119],"p=0.9),":[120],"clinical":[121],"pregnancy":[122],"(CPR)":[124],"per":[125],"transfer":[126],"(30.3%":[127],"33.0%,":[129],"p=0.7),":[130],"as":[131,133],"well":[132],"cumulative":[134],"CPR":[135],"(46.2%":[136],"38.3%,":[138],"p=0.4).":[139],"This":[140],"is":[142,166],"largest":[144],"so":[145],"far,":[146],"demonstrating":[147],"that":[148,171,227],"cost-effectiveness":[153,186],"over":[154],"good":[159],"prognosis":[160,190,232],"patient":[161,191,218],"population.":[162],"Moreover,":[163],"our":[164],"data":[165],"first":[168],"show":[170],"does":[174],"not":[175],"compromise":[176],"reproductive":[178],"outcomes,":[179],"merits":[181],"further":[182],"investigation":[183],"regarding":[184],"its":[185],"poor":[189],"population,":[192],"having":[193],"small":[195],"number":[196],"transfer.":[202],"Further":[203],"large":[204],"prospective":[205],"randomized":[206],"studies":[207],"needed":[209],"elucidate":[211],"strategy":[215],"specific":[217],"populations":[219],"order":[221],"provide":[223],"tailored":[225],"treatment":[226],"will":[228],"ensure":[229],"best":[231],"each":[234],"patient.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-03T00:00:00"}