{"id":"https://openalex.org/W4409079499","doi":"https://doi.org/10.1158/1535-7163.28713780","title":"Supplemental Figure S9 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity","display_name":"Supplemental Figure S9 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity","publication_year":2025,"publication_date":"2025-04-02","ids":{"openalex":"https://openalex.org/W4409079499","doi":"https://doi.org/10.1158/1535-7163.28713780"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.28713780","doi":"https://doi.org/10.1158/1535-7163.28713780","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.28713780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.28713780","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006903694","display_name":"Kinsey L. Nelson","orcid":"https://orcid.org/0000-0003-4292-7325","observed_orcids":["https://orcid.org/0000-0003-4292-7325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kinsey L. Nelson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4292-7325","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076451685","display_name":"Katherine A. Reil","orcid":"https://orcid.org/0000-0002-0255-6315","observed_orcids":["https://orcid.org/0000-0002-0255-6315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine A. Reil","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0255-6315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060389174","display_name":"Shingo Tsuji","orcid":"https://orcid.org/0000-0003-0598-3694","observed_orcids":["https://orcid.org/0000-0003-0598-3694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shingo Tsuji","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0598-3694","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113034451","display_name":"Amanda M. Parikh","orcid":"https://orcid.org/0009-0002-2391-3622","observed_orcids":["https://orcid.org/0009-0002-2391-3622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda M. Parikh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-2391-3622","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021979414","display_name":"Mikella Robinson","orcid":"https://orcid.org/0000-0001-6198-7185","observed_orcids":["https://orcid.org/0000-0001-6198-7185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikella Robinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6198-7185","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059436422","display_name":"Carrie Danielle House","orcid":"https://orcid.org/0000-0002-1870-5872","observed_orcids":["https://orcid.org/0000-0002-1870-5872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrie D. House","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1870-5872","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055383437","display_name":"Kathleen L. McGuire","orcid":"https://orcid.org/0000-0002-5357-3721","observed_orcids":["https://orcid.org/0000-0002-5357-3721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen L. McGuire","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5357-3721","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068096782","display_name":"Matthew J. Giacalone","orcid":"https://orcid.org/0000-0001-8979-115X","observed_orcids":["https://orcid.org/0000-0001-8979-115X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew J. Giacalone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8979-115X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.2632000148296356,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.20679999887943268,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.9599999785423279},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ifnar1","display_name":"IFNAR1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mb49-cells","display_name":"MB49 cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.8730723857879639},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6214406490325928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34506756067276},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33039629459381104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32623666524887085},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.30555403232574463},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2129005491733551},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1891602873802185},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.05265873670578003}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.28713780","doi":"https://doi.org/10.1158/1535-7163.28713780","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.28713780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/28713780","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplemental_Figure_S9_from_VAX014_Activates_Tumor-Intrinsic_STING_and_RIG-I_to_Promote_the_Development_of_Antitumor_Immunity/28713780","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.28713780","doi":"https://doi.org/10.1158/1535-7163.28713780","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.28713780","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404052715","https://openalex.org/W2482020736","https://openalex.org/W2148482462","https://openalex.org/W4408290575","https://openalex.org/W6939176927","https://openalex.org/W4389057442"],"abstract_inverted_index":{"Supplemental":[0],"Figure":[1,112],"S9.":[2],"MB49":[3,57,67],"STING":[4,58,106],"KO":[5,23,59,107],"clones":[6],"still":[7],"respond":[8],"to":[9],"IFN-\u03b2":[10],"by":[11,29,72],"upregulating":[12],"PD-L1":[13,53],"and":[14,39,54,87],"MHC-I.":[15],"A)":[16],"Surface":[17,50],"expression":[18,51,93],"of":[19,33,52,83,95],"IFNAR1":[20],"in":[21,56,111],"MB49STING":[22],"(STING":[24],"KO)":[25],"cells":[26,60],"as":[27,70],"analyzed":[28],"flow":[30,73],"cytometry.":[31],"MFI":[32],"unstained":[34],"control":[35,43],"was":[36,44],"subtracted":[37],"out":[38],"a":[40],"secondary":[41],"antibody":[42],"included":[45],"(n":[46,75],"=":[47,76,101],"3).":[48,77],"B)":[49],"MHC-I":[55],"\u00b1":[61,81],"IFNAR":[62],"blockade":[63],"co-incubated":[64],"with":[65],"VAX014-treated":[66],"WT":[68],"supernatants":[69],"determined":[71],"cytometry":[74],"Histograms":[78],"depict":[79],"mean":[80],"SEM":[82],"all":[84],"combined":[85],"experiments":[86],"dashed":[88],"lines":[89],"represent":[90],"the":[91,96],"baseline":[92],"value":[94],"corresponding":[97],"untreated":[98],"control.":[99],"ns":[100],"not":[102],"significant.":[103],"#indicates":[104],"which":[105],"clone":[108],"is":[109],"represented":[110],"3.":[113]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-04-02T00:00:00"}