{"id":"https://openalex.org/W4409079319","doi":"https://doi.org/10.1158/1535-7163.28713798","title":"Supplemental Figure S3 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity","display_name":"Supplemental Figure S3 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity","publication_year":2025,"publication_date":"2025-04-02","ids":{"openalex":"https://openalex.org/W4409079319","doi":"https://doi.org/10.1158/1535-7163.28713798"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.28713798","doi":"https://doi.org/10.1158/1535-7163.28713798","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.28713798","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.28713798","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006903694","display_name":"Kinsey L. Nelson","orcid":"https://orcid.org/0000-0003-4292-7325","observed_orcids":["https://orcid.org/0000-0003-4292-7325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kinsey L. Nelson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4292-7325","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076451685","display_name":"Katherine A. Reil","orcid":"https://orcid.org/0000-0002-0255-6315","observed_orcids":["https://orcid.org/0000-0002-0255-6315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine A. Reil","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0255-6315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060389174","display_name":"Shingo Tsuji","orcid":"https://orcid.org/0000-0003-0598-3694","observed_orcids":["https://orcid.org/0000-0003-0598-3694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shingo Tsuji","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0598-3694","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113034451","display_name":"Amanda M. Parikh","orcid":"https://orcid.org/0009-0002-2391-3622","observed_orcids":["https://orcid.org/0009-0002-2391-3622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda M. Parikh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-2391-3622","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021979414","display_name":"Mikella Robinson","orcid":"https://orcid.org/0000-0001-6198-7185","observed_orcids":["https://orcid.org/0000-0001-6198-7185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikella Robinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6198-7185","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059436422","display_name":"Carrie Danielle House","orcid":"https://orcid.org/0000-0002-1870-5872","observed_orcids":["https://orcid.org/0000-0002-1870-5872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrie D. House","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1870-5872","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055383437","display_name":"Kathleen L. McGuire","orcid":"https://orcid.org/0000-0002-5357-3721","observed_orcids":["https://orcid.org/0000-0002-5357-3721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen L. McGuire","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5357-3721","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068096782","display_name":"Matthew J. Giacalone","orcid":"https://orcid.org/0000-0001-8979-115X","observed_orcids":["https://orcid.org/0000-0001-8979-115X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew J. Giacalone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8979-115X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.15000000596046448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.8230000138282776},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.9070000052452087},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.6970000267028809},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.4020000100135803},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.890999972820282},{"id":"https://openalex.org/keywords/mb49-cells","display_name":"MB49 cells","score":0.6869999766349792},{"id":"https://openalex.org/keywords/j774a-1-cells","display_name":"J774A.1 cells","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.8032299280166626},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6058928966522217},{"id":"https://openalex.org/C2776542497","wikidata":"https://www.wikidata.org/wiki/Q5266672","display_name":"Development (topology)","level":2,"score":0.4122105538845062},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.378821462392807},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3678061366081238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3196238875389099},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.268579363822937},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21193274855613708},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.12174978852272034},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10037243366241455},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.28713798","doi":"https://doi.org/10.1158/1535-7163.28713798","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.28713798","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/28713798","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplemental_Figure_S3_from_VAX014_Activates_Tumor-Intrinsic_STING_and_RIG-I_to_Promote_the_Development_of_Antitumor_Immunity/28713798","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.28713798","doi":"https://doi.org/10.1158/1535-7163.28713798","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.28713798","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404052715","https://openalex.org/W4406842676","https://openalex.org/W4415900118","https://openalex.org/W7125597573","https://openalex.org/W4361949415","https://openalex.org/W4392679522","https://openalex.org/W2122982861"],"abstract_inverted_index":{"Supplemental":[0],"Figure":[1],"S3.":[2],"VAX014":[3,33],"does":[4],"not":[5],"activate":[6],"endosomal":[7],"TLR3":[8,26],"in":[9,40,58,79,94],"MB49":[10,12,59,82,95],"cells.":[11],"or":[13,32],"J774A.1":[14,43,67],"cells":[15,44,60,83,96],"were":[16],"plated":[17],"(5.0":[18],"\u00d7":[19],"105":[20],"cells/well)":[21],"and":[22,56,92,114],"treated":[23,66],"with":[24,62],"the":[25,63,115,122],"agonist":[27],"Poly(I:C)":[28],"(0.65":[29],"\u03bcg/mL),":[30],"VAX-I":[31],"rBMCs":[34],"for":[35,125],"\u223c20":[36],"hours.":[37],"A)":[38],"IFN-\u03b2":[39,78],"supernatants":[41,64,80],"of":[42,54,81,90,110,121],"measured":[45,98],"via":[46],"ELISA":[47],"(n":[48,74,84,102],"=":[49,75,85,103],"3).":[50,86],"B)":[51],"Surface":[52,88],"expression":[53,89,120],"PD-L1":[55,91],"MHC-I":[57,93],"co-incubated":[61],"from":[65],"cells,":[68],"as":[69,97],"determined":[70],"by":[71,99],"flow":[72,100],"cytometry":[73,101],"3\u20136).":[76],"C)":[77],"D)":[87],"6).":[104],"Histograms":[105],"depict":[106],"mean":[107],"\u00b1":[108],"SEM":[109],"all":[111],"combined":[112],"experiments":[113],"dashed":[116],"lines":[117],"represent":[118],"baseline":[119],"untreated":[123],"control":[124],"each":[126],"cell":[127],"type.":[128]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-04-02T00:00:00"}