{"id":"https://openalex.org/W4409033472","doi":"https://doi.org/10.1101/2025.03.26.645551","title":"Modeling Masticatory Myalgia to Headache-like Referred Pain Triggers Local Gene Plasticity at Referred Pain Sites","display_name":"Modeling Masticatory Myalgia to Headache-like Referred Pain Triggers Local Gene Plasticity at Referred Pain Sites","publication_year":2025,"publication_date":"2025-03-31","ids":{"openalex":"https://openalex.org/W4409033472","doi":"https://doi.org/10.1101/2025.03.26.645551","pmid":"https://pubmed.ncbi.nlm.nih.gov/40235966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996359"},"language":"en","primary_location":{"id":"doi:10.1101/2025.03.26.645551","doi":"https://doi.org/10.1101/2025.03.26.645551","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.03.26.645551","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996359","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047385433","display_name":"Anahit H. Hovhannisyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anahit H. Hovhannisyan","raw_affiliation_strings":["Center for Pain Therapeutics and Addiction Research, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","Department of Endodontics, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","UTHSCSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pain Therapeutics and Addiction Research, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Endodontics, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"UTHSCSA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090361072","display_name":"Jessica Aldape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Aldape","raw_affiliation_strings":["Department of Pharmacology and Physiology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229","UTHSCSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Physiology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"UTHSCSA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066246489","display_name":"Jennifer M. Mecklenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Mecklenburg","raw_affiliation_strings":["Center for Pain Therapeutics and Addiction Research, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","Department of Endodontics, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","UTHSCSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pain Therapeutics and Addiction Research, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Endodontics, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"UTHSCSA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071466302","display_name":"Jessie J. Alfaro","orcid":"https://orcid.org/0000-0001-5131-9175","observed_orcids":["https://orcid.org/0000-0001-5131-9175"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie Alfaro","raw_affiliation_strings":["Department of Pharmacology and Physiology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229","Integrated Biomedical Sciences (IBMS) Program, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 USA","UTHSCSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Physiology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Integrated Biomedical Sciences (IBMS) Program, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"UTHSCSA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004117781","display_name":"Yi Zou","orcid":"https://orcid.org/0000-0002-1742-9650","observed_orcids":["https://orcid.org/0000-0002-1742-9650"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zou","raw_affiliation_strings":["Departments of Molecular Medicine, The Long School of Medicine, UTHSCSA, San Antonio, Texas 78229","UTHSCSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Long School of Medicine, UTHSCSA, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"UTHSCSA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015534740","display_name":"Zhao Lai","orcid":"https://orcid.org/0000-0002-3543-5376","observed_orcids":["https://orcid.org/0000-0002-3543-5376"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhao Lai","raw_affiliation_strings":["Departments of Molecular Medicine, The Long School of Medicine, UTHSCSA, San Antonio, Texas 78229","Greehey Children\u2019s Cancer Research Institute, UTHSCSA, San Antonio, Texas 78229","Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio (UTHSCSA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Long School of Medicine, UTHSCSA, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Greehey Children\u2019s Cancer Research Institute, UTHSCSA, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio (UTHSCSA)","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028986244","display_name":"Wei Guo","orcid":"https://orcid.org/0000-0002-3899-8174","observed_orcids":["https://orcid.org/0000-0002-3899-8174"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Guo","raw_affiliation_strings":["Department of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA","University of Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"University of Maryland","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101968464","display_name":"Jiale Yang","orcid":"https://orcid.org/0000-0003-1923-7537","observed_orcids":["https://orcid.org/0000-0003-1923-7537"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiale Yang","raw_affiliation_strings":["Department of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA","University of Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"University of Maryland","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009758954","display_name":"Malin M Ernberg","orcid":"https://orcid.org/0000-0003-4152-5439","observed_orcids":["https://orcid.org/0000-0003-4152-5439"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Malin Ernberg","raw_affiliation_strings":["Division of Oral Rehabilitation, Department of Dental Medicine Karolinska Institutet, Huddinge, Sweden","Karolinska Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oral Rehabilitation, Department of Dental Medicine Karolinska Institutet, Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Karolinska Institute","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031267300","display_name":"Danilo Boada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Danilo Boada","raw_affiliation_strings":["Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157-1009","Wake Forest University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC 27157-1009","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Wake Forest University","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ke Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Ren","raw_affiliation_strings":["Department of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA","UT Health at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neural and Pain Sciences, School of Dentistry, & Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"UT Health at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033043600","display_name":"Armen N. Akopian","orcid":"https://orcid.org/0000-0002-1066-253X","observed_orcids":["https://orcid.org/0000-0002-1066-253X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Armen N. Akopian","raw_affiliation_strings":["Center for Pain Therapeutics and Addiction Research, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","Department of Endodontics, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","Department of Pharmacology and Physiology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229","Integrated Biomedical Sciences (IBMS) Program, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pain Therapeutics and Addiction Research, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Endodontics, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Pharmacology and Physiology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Integrated Biomedical Sciences (IBMS) Program, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5033043600"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.19460000097751617,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/referred-pain","display_name":"referred pain","score":0.9300000071525574},{"id":"https://openalex.org/keywords/myofascial-pain","display_name":"myofascial pain","score":0.9229999780654907},{"id":"https://openalex.org/keywords/masseter-muscle","display_name":"masseter muscle","score":0.9049999713897705},{"id":"https://openalex.org/keywords/temporalis-muscle","display_name":"temporalis muscle","score":0.9879999756813049},{"id":"https://openalex.org/keywords/collagenase-injection","display_name":"collagenase injection","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mechanical-hypersensitivity","display_name":"mechanical hypersensitivity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dura-mater","display_name":"dura mater","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nociceptive-signaling","display_name":"nociceptive signaling","score":0.734000027179718},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2778616394","wikidata":"https://www.wikidata.org/wiki/Q474959","display_name":"myalgia","level":2,"score":0.9068317413330078},{"id":"https://openalex.org/C193206974","wikidata":"https://www.wikidata.org/wiki/Q6785539","display_name":"Masticatory force","level":2,"score":0.7860788702964783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.730043888092041},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6584916710853577},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.5105055570602417},{"id":"https://openalex.org/C3018395897","wikidata":"https://www.wikidata.org/wiki/Q1132056","display_name":"Myofascial pain","level":2,"score":0.4866543412208557},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.4452805519104004},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.444494366645813},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2307358980178833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1932215690612793},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.08753180503845215},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.03.26.645551","doi":"https://doi.org/10.1101/2025.03.26.645551","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.03.26.645551","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40235966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40235966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11996359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996359","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11996359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996359","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000889884","display_name":"Craniofacial Oral-biology Student Training in Academic Research (COSTAR)","funder_award_id":"T32DE014318","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W65178175","https://openalex.org/W1763422598","https://openalex.org/W1977788367","https://openalex.org/W1988266685","https://openalex.org/W1989317478","https://openalex.org/W1993267237","https://openalex.org/W2034807464","https://openalex.org/W2035116914","https://openalex.org/W2037132368","https://openalex.org/W2065958734","https://openalex.org/W2074982329","https://openalex.org/W2108769534","https://openalex.org/W2123527164","https://openalex.org/W2129671987","https://openalex.org/W2155454962","https://openalex.org/W2161318011","https://openalex.org/W2237362523","https://openalex.org/W2320424277","https://openalex.org/W2404569828","https://openalex.org/W2418264195","https://openalex.org/W2594477225","https://openalex.org/W2614655465","https://openalex.org/W2779892652","https://openalex.org/W2801855483","https://openalex.org/W2803263912","https://openalex.org/W2807410584","https://openalex.org/W2889282452","https://openalex.org/W2906596360","https://openalex.org/W2917603343","https://openalex.org/W2938393175","https://openalex.org/W2953645345","https://openalex.org/W3014132388","https://openalex.org/W3087336676","https://openalex.org/W3109219358","https://openalex.org/W3138310504","https://openalex.org/W3178314683","https://openalex.org/W3183362976","https://openalex.org/W3196565731","https://openalex.org/W4200046914","https://openalex.org/W4226257134","https://openalex.org/W4236357753","https://openalex.org/W4283748306","https://openalex.org/W4317870726","https://openalex.org/W4377089077","https://openalex.org/W4379877408","https://openalex.org/W4389203185","https://openalex.org/W4389625806","https://openalex.org/W4390512299","https://openalex.org/W4399681891"],"related_works":["https://openalex.org/W7154465472","https://openalex.org/W4311580578","https://openalex.org/W4307970950","https://openalex.org/W2889282452","https://openalex.org/W4306641998","https://openalex.org/W2792642104","https://openalex.org/W2113977401","https://openalex.org/W2132861740","https://openalex.org/W2104353015","https://openalex.org/W2414948256"],"abstract_inverted_index":{"Patients":[0],"with":[1,72,196],"myofascial":[2],"pain":[3,35,41,97,183,229,248],"in":[4,65,104,136,153,166,174,179,184,200,208,245],"the":[5,47,58,105,117,145,155,158,175,185,201,209,215],"head":[6],"and":[7,12,37,68,111,139,157,187,203],"neck":[8],"area":[9,107],"report":[10],"widespread":[11],"referred":[13,34,40,48,172,182,228,247],"pain,":[14],"including":[15],"headache.":[16],"Existing":[17],"preclinical":[18],"models":[19,32],"fail":[20],"to":[21,29,43,169],"replicate":[22],"this":[23,246],"clinical":[24],"phenotype;":[25],"therefore,":[26],"we":[27],"aimed":[28],"develop":[30],"animal":[31],"mimicking":[33],"phenomenon":[36],"investigate":[38],"whether":[39,119],"leads":[42],"gene":[44,198],"plasticity":[45,199],"at":[46],"sites.":[49],"We":[50],"modeled":[51,230],"masticatory":[52,113],"myalgia":[53,173],"by":[54,100,191,231,237],"stimulation":[55,143,193,233],"of":[56,77,116,144],"either":[57],"masseter":[59],"(MM)":[60],"or":[61,89,91,122,126],"temporal":[62],"muscle":[63],"(TM)":[64],"mice.":[66],"MM":[67,87,156,176,186,202,210,222],"TM":[69,192,216,232],"were":[70],"stimulated":[71],"a":[73],"single":[74,90,121],"high-dose":[75],"injection":[76,213],"Collagenase-type":[78],"II":[79],"(Col),":[80],"repetitive":[81,85,92,123],"low-dose":[82],"Col":[83,124,212],"injections,":[84],"gentle":[86],"stimulation,":[88],"forceful":[93],"mouth":[94,127],"opening.":[95],"Referred":[96,161],"was":[98,177,194],"assessed":[99],"measuring":[101],"mechanical":[102,151],"hypersensitivity":[103,152],"periorbital":[106,159,188],"(representing":[108],"headache-like":[109,134,162],"behavior)":[110],"another":[112],"muscle.":[114],"Stimulation":[115],"MM,":[118],"through":[120],"injections":[125],"opening,":[128],"produced":[129],"inconsistent,":[130],"short-lasting":[131],"(1-2":[132],"days)":[133],"behavior":[135,163],"both":[137,154],"males":[138],"females.":[140],"In":[141],"contrast,":[142],"TM,":[146],"using":[147],"different":[148],"paradigms,":[149],"triggered":[150,190],"area.":[160],"lasted":[164],"longer":[165],"females":[167],"compared":[168],"males,":[170],"while":[171],"pronouncer":[178],"males.":[180],"The":[181],"areas":[189],"associated":[195],"significant":[197],"dura":[204],"mater.":[205],"Transcriptional":[206],"changes":[207],"following":[211],"into":[214],"resembled":[217],"those":[218],"observed":[219],"after":[220],"direct":[221],"injections.":[223],"Presented":[224],"data":[225],"imply":[226],"that":[227],"could":[234],"be":[235],"accounted":[236],"nociceptive":[238],"signaling":[239],"from":[240],"multiple":[241],"local":[242],"sites":[243],"involved":[244],"network.":[249]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-04-01T00:00:00"}
