{"id":"https://openalex.org/W4409009682","doi":"https://doi.org/10.1134/s1070428024602966","title":"Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment","display_name":"Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4409009682","doi":"https://doi.org/10.1134/s1070428024602966"},"language":"en","primary_location":{"id":"doi:10.1134/s1070428024602966","doi":"https://doi.org/10.1134/s1070428024602966","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1070428024602966","pdf_url":null,"source":{"id":"https://openalex.org/S73388172","display_name":"Russian Journal of Organic Chemistry","issn_l":"0022-3271","issn":["0022-3271","1070-4280","1608-3393","3034-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102004145","display_name":"A. S. Avagyan","orcid":"https://orcid.org/0000-0002-7148-3666","observed_orcids":["https://orcid.org/0000-0002-7148-3666"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":true,"raw_author_name":"A. S. Avagyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0002-7148-3666","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000342858","display_name":"S. O. Vardanyan","orcid":"https://orcid.org/0000-0003-4582-7629","observed_orcids":["https://orcid.org/0000-0003-4582-7629"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"S. O. Vardanyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0003-4582-7629","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065609653","display_name":"A. B. Sargsyan","orcid":"https://orcid.org/0000-0001-7115-9164","observed_orcids":["https://orcid.org/0000-0001-7115-9164"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"A. B. Sargsyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0001-7115-9164","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008078725","display_name":"H. \u0410. Panosyan","orcid":"https://orcid.org/0000-0001-8311-6276","observed_orcids":["https://orcid.org/0000-0001-8311-6276"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"H. A. Panosyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0001-8311-6276","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. S. Mkrtchyan","orcid":"https://orcid.org/0000-0002-1807-8610","observed_orcids":["https://orcid.org/0000-0002-1807-8610"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"G. S. Mkrtchyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0002-1807-8610","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098699057","display_name":"H. E. Tumajyan","orcid":"https://orcid.org/0000-0003-2151-4767","observed_orcids":["https://orcid.org/0000-0003-2151-4767"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"H. E. Tumajyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0003-2151-4767","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061543540","display_name":"Rafayel E. Muradyan","orcid":"https://orcid.org/0000-0002-4110-9454","observed_orcids":["https://orcid.org/0000-0002-4110-9454"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"R. E. Muradyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0002-4110-9454","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068322137","display_name":"Asya A. Aghekyan","orcid":"https://orcid.org/0000-0001-6151-4951","observed_orcids":["https://orcid.org/0000-0001-6151-4951"]},"institutions":[{"id":"https://openalex.org/I4210087551","display_name":"A. Mnjoyan Institute of Fine Organic Chemistry","ror":"https://ror.org/00588h422","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I4405279534","display_name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry","ror":"https://ror.org/01mepsb32","country_code":"AM","type":"facility","lineage":["https://openalex.org/I4405279534","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"A. A. Aghekyan","raw_affiliation_strings":["Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia"],"raw_orcid":"https://orcid.org/0000-0001-6151-4951","affiliations":[{"raw_affiliation_string":"Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia","institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102004145"],"corresponding_institution_ids":["https://openalex.org/I4210087551","https://openalex.org/I4405279534","https://openalex.org/I99064381"],"apc_list":null,"apc_paid":null,"fwci":0.2672,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31969439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"61","issue":"1","first_page":"73","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-3-4-oxadiazoles","display_name":"1,3,4-oxadiazoles","score":0.9810000061988831},{"id":"https://openalex.org/keywords/1-4-benzodioxane","display_name":"1,4-benzodioxane","score":0.925000011920929},{"id":"https://openalex.org/keywords/antiarrhythmic-activity","display_name":"antiarrhythmic activity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/diacylhydrazines","display_name":"diacylhydrazines","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hydrazides","display_name":"hydrazides","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hydrazine-hydrate","display_name":"hydrazine hydrate","score":0.9319999814033508},{"id":"https://openalex.org/keywords/2-5-disubstituted-oxadiazoles","display_name":"2,5-disubstituted oxadiazoles","score":0.8270000219345093},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9362685084342957},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.817417562007904},{"id":"https://openalex.org/C2779448499","wikidata":"https://www.wikidata.org/wiki/Q1227206","display_name":"Oxadiazole","level":2,"score":0.6289503574371338},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38761836290359497},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38139888644218445},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22706788778305054},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.11767295002937317},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.042067527770996094}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1070428024602966","doi":"https://doi.org/10.1134/s1070428024602966","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1070428024602966","pdf_url":null,"source":{"id":"https://openalex.org/S73388172","display_name":"Russian Journal of Organic Chemistry","issn_l":"0022-3271","issn":["0022-3271","1070-4280","1608-3393","3034-6304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Organic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1987659588","https://openalex.org/W2071591226","https://openalex.org/W3018761095","https://openalex.org/W3087651260","https://openalex.org/W3111258657","https://openalex.org/W4246506623"],"related_works":["https://openalex.org/W2012710083","https://openalex.org/W4404148499","https://openalex.org/W2517870426","https://openalex.org/W7131644190","https://openalex.org/W2073919267","https://openalex.org/W2766884340","https://openalex.org/W3160486156","https://openalex.org/W3015458952","https://openalex.org/W2315020583","https://openalex.org/W2162861884"],"abstract_inverted_index":{"Abstract":[0],"The":[1,50],"reaction":[2],"of":[3,22,33,43],"previously":[4],"reported":[5],"4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carbonyl":[6,34],"chloride":[7,35],"with":[8,36,47],"hydrazine":[9],"hydrate":[10],"gave":[11],"symmetrical":[12],"diacylhydrazine":[13],"which":[14],"was":[15],"cyclized":[16],"to":[17],"2,5-bis[4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-yl]-1,3,4-oxadiazole":[18],"by":[19,30,41],"the":[20,31,44],"action":[21],"phosphoryl":[23,48],"chloride.":[24,49],"Unsymmetrical":[25],"2,5-disubstituted":[26],"1,3,4-oxadiazoles":[27],"were":[28,53],"synthesized":[29,51],"condensation":[32],"various":[37],"acid":[38],"hydrazides,":[39],"followed":[40],"cyclization":[42],"resulting":[45],"diacylhydrazines":[46],"compounds":[52],"evaluated":[54],"for":[55],"their":[56],"antiarrhythmic":[57],"activity.":[58]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-31T00:00:00"}
