{"id":"https://openalex.org/W4408995541","doi":"https://doi.org/10.1016/j.bbi.2025.03.030","title":"CCL25 in the cerebrospinal fluid is negatively correlated with fatigue in chronic pain patients","display_name":"CCL25 in the cerebrospinal fluid is negatively correlated with fatigue in chronic pain patients","publication_year":2025,"publication_date":"2025-03-31","ids":{"openalex":"https://openalex.org/W4408995541","doi":"https://doi.org/10.1016/j.bbi.2025.03.030","pmid":"https://pubmed.ncbi.nlm.nih.gov/40158641"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbi.2025.03.030","doi":"https://doi.org/10.1016/j.bbi.2025.03.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbi.2025.03.030","pdf_url":null,"source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbi.2025.03.030","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5099037929","display_name":"Alexander H.C. Rosenstr\u00f6m","orcid":"https://orcid.org/0000-0002-2104-1595","observed_orcids":["https://orcid.org/0000-0002-2104-1595"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Alexander H.C. Rosenstr\u00f6m","raw_affiliation_strings":["Department of Surgical Sciences, Clinical Pain Research, Uppsala University, Akademiska sjukhuset, ing\u00e5ng 70, 1tr, 751 85 Uppsala, Sweden. Electronic address: alexander.rosenstrom@uu.se"],"raw_orcid":"https://orcid.org/0000-0002-2104-1595","affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Clinical Pain Research, Uppsala University, Akademiska sjukhuset, ing\u00e5ng 70, 1tr, 751 85 Uppsala, Sweden. Electronic address: alexander.rosenstrom@uu.se","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044018957","display_name":"Aisha Siddiqah Ahmed","orcid":"https://orcid.org/0000-0002-8483-5309","observed_orcids":["https://orcid.org/0000-0002-8483-5309"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Aisha Siddiqah Ahmed","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, Solna (L8:03), 171 76 Stockholm, Sweden. Electronic address: aisha.ahmed@ki.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, Solna (L8:03), 171 76 Stockholm, Sweden. Electronic address: aisha.ahmed@ki.se","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067486651","display_name":"Alex Bersellini Farinotti","orcid":"https://orcid.org/0000-0002-3607-1332","observed_orcids":["https://orcid.org/0000-0002-3607-1332"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Alex Bersellini Farinotti","raw_affiliation_strings":["Department of Physiology and Pharmacology, Karolinska Institute, Karolinska Institutet, Dept. of Physiology and Pharmacology, 171 77 Stockholm, Sweden. Electronic address: alex.bersellini.farinotti@ki.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska Institute, Karolinska Institutet, Dept. of Physiology and Pharmacology, 171 77 Stockholm, Sweden. Electronic address: alex.bersellini.farinotti@ki.se","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076627508","display_name":"Kim Kultima","orcid":"https://orcid.org/0000-0002-0680-1410","observed_orcids":["https://orcid.org/0000-0002-0680-1410"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kim Kultima","raw_affiliation_strings":["Department of Physiology and Pharmacology, Karolinska Institute, Karolinska Institutet, Dept. of Physiology and Pharmacology, 171 77 Stockholm, Sweden; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Ing\u00e5ng 40, 5 tr, 751 85 Uppsala, Sweden. Electronic address: kim.kultima@medsci.uu.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska Institute, Karolinska Institutet, Dept. of Physiology and Pharmacology, 171 77 Stockholm, Sweden; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Ing\u00e5ng 40, 5 tr, 751 85 Uppsala, Sweden. Electronic address: kim.kultima@medsci.uu.se","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1342360035","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045553815","display_name":"Svante Berg","orcid":"https://orcid.org/0000-0003-3090-6690","observed_orcids":["https://orcid.org/0000-0003-3090-6690"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Svante Berg","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, Solna (L8:03), 171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, Solna (L8:03), 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003868980","display_name":"Martin F. Bjurstr\u00f6m","orcid":"https://orcid.org/0000-0001-5463-7742","observed_orcids":["https://orcid.org/0000-0001-5463-7742"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Martin F. Bjurstr\u00f6m","raw_affiliation_strings":["Department of Surgical Sciences, Clinical Pain Research, Uppsala University, Akademiska sjukhuset, ing\u00e5ng 70, 1tr, 751 85 Uppsala, Sweden. Electronic address: martin.flores.bjurstrom@uu.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Clinical Pain Research, Uppsala University, Akademiska sjukhuset, ing\u00e5ng 70, 1tr, 751 85 Uppsala, Sweden. Electronic address: martin.flores.bjurstrom@uu.se","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070089176","display_name":"Camilla I. Svensson","orcid":"https://orcid.org/0000-0001-7980-4631","observed_orcids":["https://orcid.org/0000-0001-7980-4631"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Camilla I. Svensson","raw_affiliation_strings":["Department of Physiology and Pharmacology, Karolinska Institute, Karolinska Institutet, Dept. of Physiology and Pharmacology, 171 77 Stockholm, Sweden. Electronic address: camilla.svensson@ki.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Karolinska Institute, Karolinska Institutet, Dept. of Physiology and Pharmacology, 171 77 Stockholm, Sweden. Electronic address: camilla.svensson@ki.se","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087218277","display_name":"Eva Kosek","orcid":"https://orcid.org/0000-0003-0488-8177","observed_orcids":["https://orcid.org/0000-0003-0488-8177"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eva Kosek","raw_affiliation_strings":["Department of Surgical Sciences, Clinical Pain Research, Uppsala University, Akademiska sjukhuset, ing\u00e5ng 70, 1tr, 751 85 Uppsala, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Karolinska Institutet, Nobels v\u00e4g 9, 171 77 Stockholm, Sweden. Electronic address: eva.kosek@ki.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Clinical Pain Research, Uppsala University, Akademiska sjukhuset, ing\u00e5ng 70, 1tr, 751 85 Uppsala, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Karolinska Institutet, Nobels v\u00e4g 9, 171 77 Stockholm, Sweden. Electronic address: eva.kosek@ki.se","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1342360035","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5099037929"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1342360035"],"apc_list":{"value":5680,"currency":"USD","value_usd":5680},"apc_paid":{"value":5680,"currency":"USD","value_usd":5680},"fwci":1.5483,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.78298283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"128","issue":null,"first_page":"54","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccl25","display_name":"CCL25","score":0.996999979019165},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-cytokines","display_name":"cerebrospinal fluid cytokines","score":0.925000011920929},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.8090000152587891},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neuroimmune-activation","display_name":"neuroimmune activation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lumbar-disc-herniation","display_name":"lumbar disc herniation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/csf-serum-albumin-quotient","display_name":"CSF/serum albumin quotient","score":0.8109999895095825},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.38100001215934753},{"id":"https://openalex.org/keywords/preoperative-biomarkers","display_name":"preoperative biomarkers","score":0.527999997138977},{"id":"https://openalex.org/keywords/rest-pain","display_name":"rest pain","score":0.4620000123977661},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.4230000078678131},{"id":"https://openalex.org/keywords/multiplex-proteomics","display_name":"multiplex proteomics","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7244691252708435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5757149457931519},{"id":"https://openalex.org/C3020395016","wikidata":"https://www.wikidata.org/wiki/Q5113974","display_name":"Chronic fatigue","level":3,"score":0.41465047001838684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3673999309539795},{"id":"https://openalex.org/C2779566273","wikidata":"https://www.wikidata.org/wiki/Q209733","display_name":"Chronic fatigue syndrome","level":2,"score":0.06354469060897827}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007405","descriptor_name":"Intervertebral Disc Displacement","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbi.2025.03.030","doi":"https://doi.org/10.1016/j.bbi.2025.03.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbi.2025.03.030","pdf_url":null,"source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},{"id":"pmid:40158641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40158641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, behavior, and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:uu-555367","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-555367","pdf_url":"https://uu.diva-portal.org/smash/get/diva2:1954862/FULLTEXT01","source":{"id":"https://openalex.org/S7407055280","display_name":"H\u00f6gskolan Kristianstad Publikationer","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.bbi.2025.03.030","doi":"https://doi.org/10.1016/j.bbi.2025.03.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbi.2025.03.030","pdf_url":null,"source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G158165936","display_name":null,"funder_award_id":"K2013-52X-22199-01-3","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G1581701","display_name":null,"funder_award_id":"542-2013-8373","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7948776125","display_name":"Beyond inflammation - exploring novel pain-generating mechanisms of antibodies in painful autoimmune disease","funder_award_id":"2013-08373","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8141751699","display_name":null,"funder_award_id":"K2013-52X-22199-01-3","funder_id":"https://openalex.org/F4320322570","funder_display_name":"Stockholms L\u00e4ns Landsting"},{"id":"https://openalex.org/G855275999","display_name":null,"funder_award_id":"602919","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320313744","display_name":"Australian Society of Antimicrobials","ror":"https://ror.org/038yc5y48"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322570","display_name":"Stockholms L\u00e4ns Landsting","ror":"https://ror.org/02zrae794"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323741","display_name":"Magnus Bergvalls Stiftelse","ror":"https://ror.org/040ya8k73"},{"id":"https://openalex.org/F4320324797","display_name":"Reumatikerf\u00f6rbundet","ror":"https://ror.org/00zps9v98"},{"id":"https://openalex.org/F4320325656","display_name":"Landstinget i Uppsala l\u00e4n","ror":"https://ror.org/01dv86r63"},{"id":"https://openalex.org/F4320328597","display_name":"Region Uppsala","ror":null},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F5923432838","display_name":"IEEE Computational Intelligence Society","ror":"https://ror.org/02r5b6694"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408995541.pdf","grobid_xml":"https://content.openalex.org/works/W4408995541.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W646218571","https://openalex.org/W1747462596","https://openalex.org/W1985990153","https://openalex.org/W1986884477","https://openalex.org/W1987138256","https://openalex.org/W1991834652","https://openalex.org/W1993258961","https://openalex.org/W2005220900","https://openalex.org/W2005396232","https://openalex.org/W2008751223","https://openalex.org/W2010084870","https://openalex.org/W2031692056","https://openalex.org/W2036764069","https://openalex.org/W2043791447","https://openalex.org/W2047074480","https://openalex.org/W2061538346","https://openalex.org/W2065028487","https://openalex.org/W2075860873","https://openalex.org/W2090466892","https://openalex.org/W2118890208","https://openalex.org/W2123255618","https://openalex.org/W2126795224","https://openalex.org/W2151487996","https://openalex.org/W2159520551","https://openalex.org/W2166151683","https://openalex.org/W2415750758","https://openalex.org/W2592360091","https://openalex.org/W2758808222","https://openalex.org/W2766923756","https://openalex.org/W2800140348","https://openalex.org/W2804353711","https://openalex.org/W2883942034","https://openalex.org/W2892426195","https://openalex.org/W2944592785","https://openalex.org/W2965210273","https://openalex.org/W3045030121","https://openalex.org/W3086002846","https://openalex.org/W3137781904","https://openalex.org/W3165802878","https://openalex.org/W3194107711","https://openalex.org/W4211159180","https://openalex.org/W4308834893","https://openalex.org/W4320494335","https://openalex.org/W4383873629","https://openalex.org/W4399398674","https://openalex.org/W4400702245","https://openalex.org/W6799443407"],"related_works":["https://openalex.org/W7221838881","https://openalex.org/W2324611432","https://openalex.org/W4399398674","https://openalex.org/W2036764069","https://openalex.org/W2048655054","https://openalex.org/W2075860873","https://openalex.org/W4400702245","https://openalex.org/W1992548080","https://openalex.org/W2924889950","https://openalex.org/W7204645047"],"abstract_inverted_index":{"\u2022":[0,8,18,34,47],"Two-thirds":[1],"of":[2,56,123,128,151,192,195,225,339,347,374,418,437,448,463,486,509,520,559,591,608],"cytokines":[3,21,100,176,325,341,351,378,474,603],"correlate":[4,79],"with":[5,38,42,80,113,184,189,210,230,382,402,427,606],"BBB":[6,144,196,319,331,449],"permeability.":[7,133],"Chronic":[9,61],"pain":[10,23,43,49,62,115,120,357,393,413,442,613,648],"patients":[11,112,152,209],"report":[12],"both":[13,30,356,388,502,574,632],"disturbed":[14,489],"sleep":[15,45,73,185,237,368,400,480],"and":[16,22,32,52,72,75,139,198,218,247,271,288,321,330,342,360,370,376,392,412,455,479,498,504,513,544,571,576,610,614,634,639,649],"fatigue.":[17,60,362,560,592],"Correlations":[19],"between":[20,318,367,472,495,569],"or":[24,44,164,180,187,477],"fatigue":[25,71,248,383,497,572,615],"are":[26,182,511,604,641],"mostly":[27],"negative":[28,555,567],"in":[29,58,101,111,137,148,174,177,269,387,440,475,501,515,533,573],"serum":[31,138,179,270,375,476,503],"CSF.":[33],"CSF-CCL25":[35,53],"is":[36,63,465,538,545],"associated":[37,183,605,650],"fatigue,":[39,188,426],"but":[40],"not":[41],"disturbance.":[46],"Depression,":[48],"at":[50,358],"rest":[51,359,395],"explain":[54],"47%":[55],"variability":[57],"general":[59,361,425,496],"often":[64],"accompanied":[65],"by":[66],"other":[67],"symptoms":[68,77],"such":[69],"as":[70,141,143,540,552],"disturbance,":[74,481],"these":[76,124,206],"all":[78,212,305],"neuroimmune":[81,91,581],"activation.":[82],"However,":[83],"their":[84,521],"relation":[85],"to":[86,107,117,265,304,309,336,343,355,410,456,529,549,557,597,617,626],"one":[87],"another":[88],"on":[89,96,222,451,460,588,647],"a":[90,97,149,231,289,421,457,483,541,553],"axis":[92],"remains":[93],"elusive.":[94],"Based":[95],"recent":[98],"review,":[99],"the":[102,126,178,193,223,252,337,344,446,516,546,566,589],"cerebrospinal":[103],"fluid":[104],"(CSF)":[105],"seem":[106,616],"be":[108,203,564,627],"generally":[109],"upregulated":[110],"chronic":[114,441],"compared":[116],"controls,":[118],"disregarding":[119],"type.":[121],"Some":[122],"have":[125,584,618],"possilibity":[127],"altering":[129],"blood\u2013brain":[130],"barrier":[131],"(BBB)":[132],"Therefore,":[134],"cytokine":[135,267,453,499,543,548,621],"levels":[136,346,417,462,500],"CSF,":[140,272,517],"well":[142],"permeability,":[145,197],"were":[146,172,215,220,283,352,365,380,396,469,506],"measured":[147,229,250,278],"cohort":[150],"suffering":[153],"from":[154],"either":[155],"degenerative":[156],"disc":[157,161],"disease":[158],"(DDD),":[159],"lumbar":[160],"herniation":[162],"(LDH)":[163],"osteoarthritis":[165],"(OA).":[166],"In":[167,408,433,491],"this":[168,434],"exploratory":[169,435],"study,":[170],"we":[171],"interested":[173],"whether":[175,199],"CSF":[181,219,345,377,416,478,505],"disturbance":[186,238,369,401,624],"special":[190],"consideration":[191],"effect":[194,312,587],"functional":[200,385,523],"clusters":[201,386],"can":[202],"found":[204,366,528],"among":[205],"cytokines.":[207,349,371],"One-hundred-twenty":[208],"DDD/LDH/OA,":[211],"awaiting":[213,444],"surgery,":[214,445],"included.":[216],"Blood":[217],"collected":[221],"day":[224],"surgery.":[226],"Pain":[227],"was":[228,239,249,263,277,296,302,315,333,420],"visual":[232],"analog":[233],"scale":[234],"0\u2013100":[235],"mm,":[236],"assessed":[240],"using":[241,251,279,631],"Pittsburgh":[242],"Sleep":[243,623],"Quality":[244],"Index":[245],"(PSQI),":[246],"Multidimensional":[253],"Fatigue":[254],"Inventory":[255],"(MFI).":[256],"A":[257],"92-protein":[258],"multiplex":[259],"panel":[260],"(OLINK,":[261],"Sweden)":[262],"used":[264,284],"analyze":[266],"expression":[268],"respectively.":[273],"CSF-serum":[274,328],"albumin":[275],"quotient":[276],"ELISA.":[280],"Non-parametric":[281],"statistics":[282],"for":[285,399,644],"univariate":[286,575],"analyses,":[287],"false":[290],"discovery":[291],"rate":[292],"(FDR)":[293],"<":[294],"0.10":[295],"considered":[297],"statistically":[298],"significant.":[299],"Bonferroni":[300],"correction":[301],"applied":[303],"multivariable":[306],"protein":[307],"analyses":[308,373,578],"obtain":[310],"conservative":[311],"estimates.":[313],"There":[314],"an":[316,403,428,585],"association":[317],"permeability":[320,332],"serum-CSF":[322,452],"dynamics:":[323],"thirty-one":[324],"showed":[326],"significant":[327,422,554],"correlation,":[329],"significantly":[334,488],"correlated":[335,354,381],"quotients":[338],"35":[340],"11":[348],"Several":[350],"negatively":[353],"No":[363],"correlations":[364],"Network":[372],"that":[379,580,600,612],"revealed":[384],"compartments.":[389],"Anxiety,":[390],"depression,":[391],"during":[394,414],"important":[397],"regressors":[398],"R":[404,429],"2":[405,430],"=":[406,431],"0.41.":[407],"addition":[409],"depression":[411],"rest,":[415],"CCL25":[419,514,537,570,638],"regressor":[423],"regarding":[424],"0.47.":[432],"study":[436,594],"immune":[438],"profiles":[439],"cohorts":[443],"importance":[447],"dynamics":[450],"dynamics,":[454],"lesser":[458],"extent":[459],"central":[461],"cytokines,":[464],"highlighted.":[466],"Surprisingly,":[467],"there":[468],"no":[470],"associations":[471,494],"any":[473],"despite":[482],"high":[484],"prevalence":[485],"clinically":[487],"sleep.":[490],"contrast,":[492],"several":[493],"found.":[507],"Cytokines":[508],"note":[510],"CXCL11":[512,525,640],"especially":[518],"because":[519],"direct":[522],"association.":[524],"has":[526],"been":[527],"exert":[530],"neuroprotective":[531],"effects":[532],"animal":[534],"models,":[535],"while":[536],"known":[539],"proinflammatory":[542],"only":[547],"fall":[550],"out":[551],"contributor":[556],"degree":[558,590],"While":[561],"causality":[562],"cannot":[563],"addressed,":[565,629],"correlation":[568],"multivariate":[577],"implies":[579],"activity":[582],"might":[583],"ameliorating":[586],"This":[593],"further":[595,628],"adds":[596],"existing":[598],"evidence":[599],"centrally":[601],"acting":[602],"severity":[607],"symptomatology,":[609],"highlights":[611],"slightly":[619],"different":[620],"profiles.":[622],"needs":[625],"ideally":[630],"subjective":[633],"objective":[635],"assessment":[636],"methods.":[637],"interesting":[642],"biomarkers":[643],"future":[645],"research":[646],"symptoms.":[651]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-31T00:00:00"}
