{"id":"https://openalex.org/W4408992012","doi":"https://doi.org/10.3344/kjp.24316","title":"Physicochemical stability of mixtures of non-steroidal anti-inflammatory drugs such as ketorolac and diclofenac and antiemetics such as ondansetron and ramosetron: an in vitro study","display_name":"Physicochemical stability of mixtures of non-steroidal anti-inflammatory drugs such as ketorolac and diclofenac and antiemetics such as ondansetron and ramosetron: an in vitro study","publication_year":2025,"publication_date":"2025-03-31","ids":{"openalex":"https://openalex.org/W4408992012","doi":"https://doi.org/10.3344/kjp.24316","pmid":"https://pubmed.ncbi.nlm.nih.gov/40159937"},"language":"en","primary_location":{"id":"doi:10.3344/kjp.24316","doi":"https://doi.org/10.3344/kjp.24316","is_oa":true,"landing_page_url":"https://doi.org/10.3344/kjp.24316","pdf_url":null,"source":{"id":"https://openalex.org/S155381918","display_name":"The Korean journal of pain","issn_l":"1226-2579","issn":["1226-2579","2005-9159","2093-0569"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4360969335","host_organization_name":"The Korean Pain Society","host_organization_lineage":["https://openalex.org/P4360969335"],"host_organization_lineage_names":["The Korean Pain Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.3344/kjp.24316","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029249440","display_name":"Chung Hun Lee","orcid":"https://orcid.org/0000-0003-1557-3832","observed_orcids":["https://orcid.org/0000-0003-1557-3832"]},"institutions":[{"id":"https://openalex.org/I2799980853","display_name":"Korea University Medical Center","ror":"https://ror.org/02cs2sd33","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853"]},{"id":"https://openalex.org/I4405258752","display_name":"Korea University Guro Hospital","ror":"https://ror.org/0154bb690","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405258752"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Chung Hun Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Korea University Medical Center, Guro Hospital, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1557-3832","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Korea University Medical Center, Guro Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I2799980853","https://openalex.org/I4405258752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029249440"],"corresponding_institution_ids":["https://openalex.org/I2799980853","https://openalex.org/I4405258752"],"apc_list":null,"apc_paid":null,"fwci":0.3652,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4802859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"38","issue":"2","first_page":"103","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.5116999745368958,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.5116999745368958,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14189","display_name":"Intravenous Infusion Technology and Safety","score":0.2793000042438507,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketorolac","display_name":"ketorolac","score":0.9509999752044678},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":1.0},{"id":"https://openalex.org/keywords/ondansetron","display_name":"ondansetron","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ramosetron","display_name":"ramosetron","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antiemetics","display_name":"antiemetics","score":0.9620000123977661},{"id":"https://openalex.org/keywords/crystallization","display_name":"crystallization","score":0.6579999923706055},{"id":"https://openalex.org/keywords/concurrent-administration","display_name":"concurrent administration","score":0.5320000052452087},{"id":"https://openalex.org/keywords/postoperative-analgesia","display_name":"postoperative analgesia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/physicochemical-stability","display_name":"physicochemical stability","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2777170512","wikidata":"https://www.wikidata.org/wiki/Q410011","display_name":"Ondansetron","level":3,"score":0.928213357925415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.870685338973999},{"id":"https://openalex.org/C2778446825","wikidata":"https://www.wikidata.org/wiki/Q2014797","display_name":"Ketorolac","level":3,"score":0.8354721069335938},{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.6630896925926208},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6201324462890625},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39170902967453003},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.2665989100933075},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.14349955320358276}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3344/kjp.24316","doi":"https://doi.org/10.3344/kjp.24316","is_oa":true,"landing_page_url":"https://doi.org/10.3344/kjp.24316","pdf_url":null,"source":{"id":"https://openalex.org/S155381918","display_name":"The Korean journal of pain","issn_l":"1226-2579","issn":["1226-2579","2005-9159","2093-0569"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4360969335","host_organization_name":"The Korean Pain Society","host_organization_lineage":["https://openalex.org/P4360969335"],"host_organization_lineage_names":["The Korean Pain Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Pain","raw_type":"journal-article"},{"id":"pmid:40159937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40159937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean journal of pain","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11965992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11965992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Korean J Pain","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3344/kjp.24316","doi":"https://doi.org/10.3344/kjp.24316","is_oa":true,"landing_page_url":"https://doi.org/10.3344/kjp.24316","pdf_url":null,"source":{"id":"https://openalex.org/S155381918","display_name":"The Korean journal of pain","issn_l":"1226-2579","issn":["1226-2579","2005-9159","2093-0569"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4360969335","host_organization_name":"The Korean Pain Society","host_organization_lineage":["https://openalex.org/P4360969335"],"host_organization_lineage_names":["The Korean Pain Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4099999964237213}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8773122307","display_name":null,"funder_award_id":"K2313831","funder_id":"https://openalex.org/F4320316534","funder_display_name":"Korea University Guro Hospital"}],"funders":[{"id":"https://openalex.org/F4320316534","display_name":"Korea University Guro Hospital","ror":"https://ror.org/0154bb690"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W108396684","https://openalex.org/W1530524113","https://openalex.org/W1560748056","https://openalex.org/W1972778639","https://openalex.org/W1977910461","https://openalex.org/W2000224002","https://openalex.org/W2024620479","https://openalex.org/W2027825742","https://openalex.org/W2042199528","https://openalex.org/W2056498253","https://openalex.org/W2068529604","https://openalex.org/W2070755089","https://openalex.org/W2077863292","https://openalex.org/W2093006946","https://openalex.org/W2106285700","https://openalex.org/W2107496267","https://openalex.org/W2116069772","https://openalex.org/W2128387037","https://openalex.org/W2133116774","https://openalex.org/W2168350311","https://openalex.org/W2182137555","https://openalex.org/W2283682236","https://openalex.org/W2302180520","https://openalex.org/W2317888114","https://openalex.org/W2407531659","https://openalex.org/W2616475523","https://openalex.org/W2801890765","https://openalex.org/W2829125350","https://openalex.org/W3000536604","https://openalex.org/W3003592987","https://openalex.org/W3012315867","https://openalex.org/W3014575817","https://openalex.org/W3165449086","https://openalex.org/W3200634546","https://openalex.org/W4211036686","https://openalex.org/W4214619856","https://openalex.org/W4283383079","https://openalex.org/W4309470623","https://openalex.org/W4380576532","https://openalex.org/W4393392657","https://openalex.org/W4394740364"],"related_works":["https://openalex.org/W2018474001","https://openalex.org/W2076387453","https://openalex.org/W117411119","https://openalex.org/W2087105640","https://openalex.org/W1974935839","https://openalex.org/W3170356931","https://openalex.org/W3124276291","https://openalex.org/W2235423361","https://openalex.org/W2025384147","https://openalex.org/W2764110634"],"abstract_inverted_index":{"Background:":[0],"Drugs":[1],"administered":[2],"intravenously":[3],"during":[4],"the":[5,12,17,74,79,109,124,140,148,155,195,201],"postoperative":[6],"period":[7],"can":[8],"mix":[9],"before":[10],"entering":[11],"bloodstream.":[13],"This":[14],"study":[15],"assessed":[16,71],"stability":[18,169],"of":[19,21,91,117,127,159,184,197,203],"mixtures":[20,69,116,183],"non-steroidal":[22],"anti-inflammatory":[23],"drugs":[24],"(ketorolac":[25],"and":[26,28,31,73,95,104,121,143,163,167,188],"diclofenac)":[27],"antiemetics":[29],"(ondansetron":[30],"ramosetron)":[32],"to":[33,172,194],"determine":[34],"their":[35,177],"suitability":[36],"for":[37,65,153,170],"concurrent":[38,178],"administration.":[39],"Methods:":[40],"Ketorolac":[41],"or":[42,48,93,101,119,161,186],"diclofenac":[43,94,120,162,187],"was":[44,57,76],"combined":[45],"with":[46],"ondansetron":[47,122,189],"ramosetron":[49,96,164],"at":[50,63],"a":[51,60,132],"1:1":[52],"volume":[53],"ratio.":[54],"Each":[55],"mixture":[56],"stored":[58],"in":[59,139],"propylene":[61],"syringe":[62],"24\u00b0C":[64],"2":[66,173],"hours.":[67],"The":[68],"were":[70,82,136],"visually,":[72],"pH":[75,102,141],"measured.":[77],"Additionally,":[78],"drug":[80,110,149,205],"concentrations":[81,111,150],"determined":[83],"using":[84],"high-performance":[85],"liquid":[86],"chromatography":[87],"(HPLC).":[88],"Results:":[89],"Mixtures":[90,158],"ketorolac":[92,118,160,185],"showed":[97],"no":[98,137],"crystal":[99],"formation":[100,126,196],"changes,":[103],"HPLC":[105,144],"analysis":[106,145],"confirmed":[107],"that":[108,147,176],"remained":[112,151,206],"stable.":[113,207],"In":[114],"contrast,":[115],"exhibited":[123],"visible":[125],"10-50":[128],"\u03bcm":[129],"crystals":[130],"under":[131],"microscope.":[133],"However,":[134],"there":[135],"changes":[138],"levels,":[142],"indicated":[146],"stable":[152],"both":[154],"mixtures.":[156],"Conclusions:":[157],"demonstrated":[165],"physical":[166],"chemical":[168],"up":[171],"hours,":[174],"indicating":[175],"use":[179],"is":[180],"feasible.":[181],"Conversely,":[182],"should":[190],"be":[191],"avoided":[192],"due":[193],"crystals,":[198],"even":[199],"though":[200],"concentration":[202],"each":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
