{"id":"https://openalex.org/W4408985809","doi":"https://doi.org/10.1016/j.bbagen.2025.130799","title":"EZH2-induced histone methylation in the Nrf2 promoter region mediates pyroptosis in inflammatory cardiomyocyte injury","display_name":"EZH2-induced histone methylation in the Nrf2 promoter region mediates pyroptosis in inflammatory cardiomyocyte injury","publication_year":2025,"publication_date":"2025-03-30","ids":{"openalex":"https://openalex.org/W4408985809","doi":"https://doi.org/10.1016/j.bbagen.2025.130799","pmid":"https://pubmed.ncbi.nlm.nih.gov/40157552"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbagen.2025.130799","doi":"https://doi.org/10.1016/j.bbagen.2025.130799","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbagen.2025.130799","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003286262","display_name":"Xiaozhou Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaozhou Yao","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Junru Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junru Ji","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424598","display_name":"Dandan Chen","orcid":"https://orcid.org/0000-0002-7690-4837","observed_orcids":["https://orcid.org/0000-0002-7690-4837"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Chen","raw_affiliation_strings":["Department of Critical Care Medicine, Haikou Hospital, Xiangya Medical College, Central South University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Haikou Hospital, Xiangya Medical College, Central South University, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034179594","display_name":"Yike Zhu","orcid":"https://orcid.org/0000-0002-5761-0243","observed_orcids":["https://orcid.org/0000-0002-5761-0243"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yike Zhu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081546606","display_name":"Xingjun Cai","orcid":"https://orcid.org/0000-0003-0874-1877","observed_orcids":["https://orcid.org/0000-0003-0874-1877"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xingjun Cai","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China. Electronic address: caixingjun6535@hainmc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, China. Electronic address: caixingjun6535@hainmc.edu.cn","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081546606"],"corresponding_institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"],"apc_list":{"value":3310,"currency":"USD","value_usd":3310},"apc_paid":null,"fwci":0.7208,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61539813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"1869","issue":"6","first_page":"130799","last_page":"130799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":1.0},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/septic-cardiomyopathy","display_name":"septic cardiomyopathy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.7310000061988831},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9160000085830688},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.847000002861023},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.878000020980835},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.9018359184265137},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.8441668748855591},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5908838510513306},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5862876176834106},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5026569366455078},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5022766590118408},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49025943875312805},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.4845694601535797},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.44854986667633057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3791792392730713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3474145233631134},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3159360885620117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24072405695915222},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18287184834480286},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1490544080734253},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11464828252792358},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.10201740264892578}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbagen.2025.130799","doi":"https://doi.org/10.1016/j.bbagen.2025.130799","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbagen.2025.130799","pdf_url":null,"source":{"id":"https://openalex.org/S4210238601","display_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","issn_l":"0304-4165","issn":["0304-4165","1872-8006"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - General Subjects","raw_type":"journal-article"},{"id":"pmid:40157552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40157552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta. General subjects","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2062927905","https://openalex.org/W2075611712","https://openalex.org/W2144589352","https://openalex.org/W2787149302","https://openalex.org/W2913506254","https://openalex.org/W2973106464","https://openalex.org/W2989676031","https://openalex.org/W2995540455","https://openalex.org/W3164944391","https://openalex.org/W3180985662","https://openalex.org/W3202438914","https://openalex.org/W3213338109","https://openalex.org/W4200088585","https://openalex.org/W4220826972","https://openalex.org/W4280502300","https://openalex.org/W4281771719","https://openalex.org/W4283163798","https://openalex.org/W4310786888","https://openalex.org/W4311253795","https://openalex.org/W4320034464","https://openalex.org/W4321494634","https://openalex.org/W4364321697","https://openalex.org/W4381251725","https://openalex.org/W4385192197"],"related_works":["https://openalex.org/W4397009316","https://openalex.org/W4200088585","https://openalex.org/W3138772270","https://openalex.org/W4294992511","https://openalex.org/W7134806368","https://openalex.org/W4401103230","https://openalex.org/W7057076512","https://openalex.org/W4386214080","https://openalex.org/W3179194742","https://openalex.org/W7152093456"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-03-31T00:00:00"}
