{"id":"https://openalex.org/W4408977708","doi":"https://doi.org/10.1111/hepr.14189","title":"Neutrophil\u2010to\u2010lymphocyte ratio at the start of the second course of durvalumab plus tremelimumab therapy predicts therapeutic efficacy in patients with advanced hepatocellular carcinoma: A multicenter analysis","display_name":"Neutrophil\u2010to\u2010lymphocyte ratio at the start of the second course of durvalumab plus tremelimumab therapy predicts therapeutic efficacy in patients with advanced hepatocellular carcinoma: A multicenter analysis","publication_year":2025,"publication_date":"2025-03-28","ids":{"openalex":"https://openalex.org/W4408977708","doi":"https://doi.org/10.1111/hepr.14189","pmid":"https://pubmed.ncbi.nlm.nih.gov/40317623"},"language":"en","primary_location":{"id":"doi:10.1111/hepr.14189","doi":"https://doi.org/10.1111/hepr.14189","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hepr.14189","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/hepr.14189","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091721791","display_name":"Takanori Suzuki","orcid":"https://orcid.org/0000-0002-8940-2393","observed_orcids":["https://orcid.org/0000-0002-8940-2393"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Suzuki","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786576","display_name":"Kentaro Matsuura","orcid":"https://orcid.org/0009-0005-0163-3971","observed_orcids":["https://orcid.org/0009-0005-0163-3971"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kentaro Matsuura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0009-0005-0163-3971","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112304862","display_name":"Satoshi Sobue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103227","display_name":"Kasugai Municipal Hospital","ror":"https://ror.org/019ekef14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103227"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Sobue","raw_affiliation_strings":["Department of Gastroenterology, Kasugai Municipal Hospital, Kasugai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Kasugai Municipal Hospital, Kasugai, Japan","institution_ids":["https://openalex.org/I4210103227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109237904","display_name":"Daisuke Kato","orcid":"https://orcid.org/0009-0000-1767-2389","observed_orcids":["https://orcid.org/0009-0000-1767-2389"]},"institutions":[{"id":"https://openalex.org/I4210153328","display_name":"Japanese Red Cross Nagoya Daini Hospital","ror":"https://ror.org/043pqsk20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210153328"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Kato","raw_affiliation_strings":["Department of Gastroenterology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4210153328"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katsumi Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153328","display_name":"Japanese Red Cross Nagoya Daini Hospital","ror":"https://ror.org/043pqsk20","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210153328"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsumi Hayashi","raw_affiliation_strings":["Department of Gastroenterology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4210153328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045091020","display_name":"Hiromu Kondo","orcid":"https://orcid.org/0000-0002-1277-6821","observed_orcids":["https://orcid.org/0000-0002-1277-6821"]},"institutions":[{"id":"https://openalex.org/I4405284444","display_name":"Nagoya City University East Medical Center","ror":"https://ror.org/03jrv0f64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284444"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromu Kondo","raw_affiliation_strings":["Department of Gastroenterology, Nagoya City East Medical Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nagoya City East Medical Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4405284444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046575716","display_name":"Kaiki Anbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095909","display_name":"Toyokawa City Hospital","ror":"https://ror.org/00rsqd019","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095909"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaiki Anbe","raw_affiliation_strings":["Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan","institution_ids":["https://openalex.org/I4210095909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083451186","display_name":"Tsutomu Mizoshita","orcid":"https://orcid.org/0000-0003-0460-5288","observed_orcids":["https://orcid.org/0000-0003-0460-5288"]},"institutions":[{"id":"https://openalex.org/I4210095909","display_name":"Toyokawa City Hospital","ror":"https://ror.org/00rsqd019","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095909"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Mizoshita","raw_affiliation_strings":["Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Toyokawa City Hospital, Toyokawa, Japan","institution_ids":["https://openalex.org/I4210095909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054698219","display_name":"Kohei Okayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Okayama","raw_affiliation_strings":["Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100861068","display_name":"Fumihiro Okumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091314","display_name":"Gifu Prefectural Tajimi Hospital","ror":"https://ror.org/00jy2zq62","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091314"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihiro Okumura","raw_affiliation_strings":["Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Gifu Prefectural Tajimi Hospital, Gifu, Japan","institution_ids":["https://openalex.org/I4210091314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007300762","display_name":"Yoshihide Kimura","orcid":"https://orcid.org/0000-0003-4801-8384","observed_orcids":["https://orcid.org/0000-0003-4801-8384"]},"institutions":[{"id":"https://openalex.org/I4405283410","display_name":"Nagoya City University West Medical Center","ror":"https://ror.org/01mjfcx54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283410"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihide Kimura","raw_affiliation_strings":["Department of Gastroenterology, Nagoya City University West Medical Center, Nagoya, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4801-8384","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Nagoya City University West Medical Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4405283410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002154290","display_name":"Atsushi Ozasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284505","display_name":"Asahi Rosai Hospital","ror":"https://ror.org/03pb0nd05","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210135681","https://openalex.org/I4405284505"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Ozasa","raw_affiliation_strings":["Department of Gastroenterology, Asahi Rousai Hospital, Owariasahi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Asahi Rousai Hospital, Owariasahi, Japan","institution_ids":["https://openalex.org/I4405284505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030283533","display_name":"Hiroki Inada","orcid":"https://orcid.org/0000-0002-3456-6921","observed_orcids":["https://orcid.org/0000-0002-3456-6921"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Inada","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3456-6921","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049936220","display_name":"Takayuki Tokunaga","orcid":"https://orcid.org/0000-0002-3631-4525","observed_orcids":["https://orcid.org/0000-0002-3631-4525"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Tokunaga","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3631-4525","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004634738","display_name":"Satoshi Narahara","orcid":"https://orcid.org/0000-0001-8647-9486","observed_orcids":["https://orcid.org/0000-0001-8647-9486"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Narahara","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8647-9486","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068438828","display_name":"Hayato Kawamura","orcid":"https://orcid.org/0000-0002-7679-4279","observed_orcids":["https://orcid.org/0000-0002-7679-4279"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hayato Kawamura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kei Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Fujiwara","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020203707","display_name":"Shunsuke Nojiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Nojiri","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047369080","display_name":"Hiromi Kataoka","orcid":"https://orcid.org/0000-0001-9491-0723","observed_orcids":["https://orcid.org/0000-0001-9491-0723"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Kataoka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009887722","display_name":"Yasuhito Tanaka","orcid":"https://orcid.org/0000-0002-2473-6966","observed_orcids":["https://orcid.org/0000-0002-2473-6966","https://orcid.org/0000-0002-7658-3690"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Tanaka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2473-6966","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5102786576"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":4.0897,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.95020901,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"55","issue":"6","first_page":"883","last_page":"895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.4262999892234802,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9940000176429749},{"id":"https://openalex.org/keywords/durvalumab","display_name":"durvalumab","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tremelimumab","display_name":"tremelimumab","score":1.0},{"id":"https://openalex.org/keywords/unresectable-hepatocellular-carcinoma","display_name":"unresectable hepatocellular carcinoma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8270000219345093},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8930000066757202},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.8949999809265137},{"id":"https://openalex.org/keywords/des-gamma-carboxy-prothrombin","display_name":"PIVKA-II","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8581497669219971},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7527213096618652},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7135694026947021},{"id":"https://openalex.org/C2777742743","wikidata":"https://www.wikidata.org/wiki/Q19904005","display_name":"Durvalumab","level":5,"score":0.7017262578010559},{"id":"https://openalex.org/C2778650287","wikidata":"https://www.wikidata.org/wiki/Q7838098","display_name":"Tremelimumab","level":5,"score":0.6925904154777527},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5542534589767456},{"id":"https://openalex.org/C2778963024","wikidata":"https://www.wikidata.org/wiki/Q17132454","display_name":"Neutrophil to lymphocyte ratio","level":3,"score":0.496185839176178},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4416901767253876},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.42323732376098633},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.41183626651763916},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.36372217535972595},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31023135781288147},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.24419590830802917},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21086817979812622},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.11785075068473816},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/hepr.14189","doi":"https://doi.org/10.1111/hepr.14189","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hepr.14189","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},{"id":"pmid:40317623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40317623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology research : the official journal of the Japan Society of Hepatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/hepr.14189","doi":"https://doi.org/10.1111/hepr.14189","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hepr.14189","pdf_url":null,"source":{"id":"https://openalex.org/S110399111","display_name":"Hepatology Research","issn_l":"1386-6346","issn":["1386-6346","1872-034X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4359795407","display_name":"Development of biomarkers to predict the efficacy of cancer immunotherapy for unresectable hepatocellular carcinoma","funder_award_id":"23K07359","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320319384","display_name":"Ichihara International Scholarship Foundation","ror":"https://ror.org/00hqy1s77"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1971837077","https://openalex.org/W1974402264","https://openalex.org/W1994003134","https://openalex.org/W2009780857","https://openalex.org/W2019607817","https://openalex.org/W2028319026","https://openalex.org/W2043017894","https://openalex.org/W2047945295","https://openalex.org/W2070199947","https://openalex.org/W2085852125","https://openalex.org/W2096998441","https://openalex.org/W2119190881","https://openalex.org/W2121960517","https://openalex.org/W2147172608","https://openalex.org/W2560499218","https://openalex.org/W2761031851","https://openalex.org/W2782319564","https://openalex.org/W2787358630","https://openalex.org/W2809889937","https://openalex.org/W2894822321","https://openalex.org/W2925462527","https://openalex.org/W2934884265","https://openalex.org/W2990882781","https://openalex.org/W2998700378","https://openalex.org/W3006581633","https://openalex.org/W3025022288","https://openalex.org/W3198596994","https://openalex.org/W3199751602","https://openalex.org/W3205595708","https://openalex.org/W4205601742","https://openalex.org/W4205676771","https://openalex.org/W4213062169","https://openalex.org/W4213154232","https://openalex.org/W4281645619","https://openalex.org/W4294904355","https://openalex.org/W4310961831","https://openalex.org/W4316506182","https://openalex.org/W4318754607","https://openalex.org/W4390103740","https://openalex.org/W4393935425","https://openalex.org/W4400157588","https://openalex.org/W4401020887","https://openalex.org/W4401656441","https://openalex.org/W4402135362","https://openalex.org/W4402830581","https://openalex.org/W6922222858","https://openalex.org/W6959427619"],"related_works":["https://openalex.org/W4411307390","https://openalex.org/W4318754607","https://openalex.org/W4416308031","https://openalex.org/W4407827765","https://openalex.org/W3026716772","https://openalex.org/W4294904355","https://openalex.org/W4412084447","https://openalex.org/W7131829708","https://openalex.org/W4409290018","https://openalex.org/W6986540282"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Durvalumab":[3],"plus":[4,32],"tremelimumab":[5],"(Dur/Tre)":[6],"therapy":[7,34,55],"is":[8,243],"expected":[9],"to":[10,114,122,166],"have":[11],"good":[12],"therapeutic":[13,45],"efficacy":[14],"for":[15,42,77,245],"patients":[16,37,61,71,143,170,250],"with":[17,62,73,171,187,199,236,252],"unresectable":[18],"hepatocellular":[19],"carcinoma":[20],"(u-HCC).":[21],"We":[22],"previously":[23],"reported":[24],"that":[25,214],"the":[26,44,51,105,117,127,130,138,152,158,161,180],"neutrophil-to-lymphocyte":[27],"ratio":[28,225],"(NLR)":[29],"during":[30,53],"atezolizumab":[31],"bevacizumab":[33],"in":[35,60,169,248],"u-HCC":[36,70,249],"was":[38,184],"a":[39,146,192],"useful":[40,244],"marker":[41],"predicting":[43,246],"response.":[46],"Therefore,":[47],"we":[48],"investigated":[49],"whether":[50],"NLR":[52,156],"Dur/Tre":[54,74,134,253],"could":[56],"predict":[57],"treatment":[58],"outcomes":[59],"u-HCC.":[63],"DESIGN:":[64],"The":[65,155,240],"present":[66],"study":[67],"included":[68],"64":[69,139],"treated":[72,251],"and":[75,97,110,116,119,179,223],"evaluated":[76],"their":[78],"initial":[79,153],"response":[80],"by":[81],"dynamic":[82],"computed":[83],"tomography":[84],"or":[85],"magnetic":[86],"resonance":[87],"imaging":[88],"at":[89,126,151,157],"least":[90],"once":[91],"until":[92],"December":[93],"2024.":[94],"Alpha-fetoprotein":[95],"(AFP)":[96],"des-gamma-carboxyprothrombin":[98],"(DCP)":[99],"ratios":[100,121],"were":[101,112,124,233],"defined":[102],"as":[103],"follows:":[104],"pretreatment":[106,123],"levels":[107],"of":[108,129,133,160],"AFP":[109,118,224],"DCP":[111,120],"set":[113],"1,":[115],"calculated":[125],"start":[128,159],"second":[131,162],"course":[132,163],"therapy.":[135,254],"RESULTS:":[136],"Of":[137],"HCC":[140],"patients,":[141],"34":[142],"(53%)":[144],"achieved":[145],"disease":[147,175],"control":[148],"rate":[149],"(non-PD)":[150],"evaluation.":[154],"(NLR-2c)":[164],"tended":[165],"be":[167],"lower":[168],"non-PD":[172],"than":[173,197],"progressive":[174],"(p":[176],"=":[177,209,231],"0.133),":[178],"optimal":[181],"cutoff":[182],"value":[183,242],"5.75.":[185],"Patients":[186],"NLR-2c":[188,200,215,241],"\u2265":[189,216,226],"5.75":[190,202,217],"had":[191],"shorter":[193],"progression-free":[194],"survival":[195],"(PFS)":[196],"those":[198],"<":[201,221],"(median:":[203],"1.7":[204],"vs.":[205],"5.5":[206],"months,":[207],"p":[208,220,230],"0.002).":[210],"Multivariate":[211],"analysis":[212],"showed":[213],"(HR":[218,228],"4.66;":[219],"0.001)":[222],"0.933":[227],"4.32;":[229],"0.004)":[232],"significantly":[234],"associated":[235],"poor":[237],"PFS.":[238],"CONCLUSIONS:":[239],"PFS":[247]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-03-30T00:00:00"}
