{"id":"https://openalex.org/W4408961846","doi":"https://doi.org/10.1186/s12957-025-03717-1","title":"Targeting NETO2 suppresses cell proliferation, invasion, and migration and inactivates the STAT3/C-MYC pathway in hepatocellular carcinoma","display_name":"Targeting NETO2 suppresses cell proliferation, invasion, and migration and inactivates the STAT3/C-MYC pathway in hepatocellular carcinoma","publication_year":2025,"publication_date":"2025-03-29","ids":{"openalex":"https://openalex.org/W4408961846","doi":"https://doi.org/10.1186/s12957-025-03717-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/40158169"},"language":"en","primary_location":{"id":"doi:10.1186/s12957-025-03717-1","doi":"https://doi.org/10.1186/s12957-025-03717-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12957-025-03717-1","pdf_url":null,"source":{"id":"https://openalex.org/S180997207","display_name":"World Journal of Surgical Oncology","issn_l":"1477-7819","issn":["1477-7819"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12957-025-03717-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016889500","display_name":"Na Shun Meng He","orcid":"https://orcid.org/0000-0002-9307-6818","observed_orcids":["https://orcid.org/0000-0002-9307-6818"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Shun Meng He","raw_affiliation_strings":["Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072631261","display_name":"Xinghua Wu","orcid":"https://orcid.org/0000-0003-2547-9540","observed_orcids":["https://orcid.org/0000-0003-2547-9540"]},"institutions":[{"id":"https://openalex.org/I4210110441","display_name":"Second Affiliated Hospital of Inner Mongolia Medical University","ror":"https://ror.org/01y07zp44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinghua Wu","raw_affiliation_strings":["Electromyography Center, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electromyography Center, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010030, China","institution_ids":["https://openalex.org/I4210110441"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Chen","raw_affiliation_strings":["Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017062696","display_name":"Xinyi Yun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Yun","raw_affiliation_strings":["Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055959674","display_name":"Shun Yao","orcid":"https://orcid.org/0000-0003-1727-4078","observed_orcids":["https://orcid.org/0000-0003-1727-4078"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Yao","raw_affiliation_strings":["Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039169614","display_name":"Haibo Yu","orcid":"https://orcid.org/0000-0003-1506-2346","observed_orcids":["https://orcid.org/0000-0003-1506-2346"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai Yu","raw_affiliation_strings":["Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China. yuhai110920@163.com","Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China. yuhai110920@163.com","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"Minimally Invasive Intervention Department, Peking University Cancer Hospital Inner Mongolia Hospital, No. 42 Zhaowuda Road, Saihan District, Hohhot, 100020, China","institution_ids":["https://openalex.org/I4210093964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039169614"],"corresponding_institution_ids":["https://openalex.org/I4210093964"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.9658,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.72839107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"23","issue":"1","first_page":"107","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neto2","display_name":"NETO2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8140000104904175},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.6959999799728394},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.8176907896995544},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7662807703018188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7305943965911865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.710845947265625},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.6547677516937256},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5247024297714233},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4602903127670288},{"id":"https://openalex.org/C3017392945","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatic carcinoma","level":3,"score":0.4598653316497803},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38911527395248413},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38567739725112915},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29093796014785767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1798461377620697},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1452242136001587},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06821724772453308}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12957-025-03717-1","doi":"https://doi.org/10.1186/s12957-025-03717-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12957-025-03717-1","pdf_url":null,"source":{"id":"https://openalex.org/S180997207","display_name":"World Journal of Surgical Oncology","issn_l":"1477-7819","issn":["1477-7819"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:40158169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40158169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of surgical oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11954197","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11954197","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World J Surg Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f8c462287f6b4acda744d688b048d657","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f8c462287f6b4acda744d688b048d657","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Surgical Oncology, Vol 23, Iss 1, Pp 1-9 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12957-025-03717-1","doi":"https://doi.org/10.1186/s12957-025-03717-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12957-025-03717-1","pdf_url":null,"source":{"id":"https://openalex.org/S180997207","display_name":"World Journal of Surgical Oncology","issn_l":"1477-7819","issn":["1477-7819"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W2023944340","https://openalex.org/W2127712585","https://openalex.org/W2149366664","https://openalex.org/W2237809442","https://openalex.org/W2485812469","https://openalex.org/W2809238544","https://openalex.org/W2912485591","https://openalex.org/W2948097715","https://openalex.org/W2983258509","https://openalex.org/W3111887387","https://openalex.org/W3113268733","https://openalex.org/W3168097989","https://openalex.org/W3198364422","https://openalex.org/W3201657639","https://openalex.org/W3208805822","https://openalex.org/W3213277274","https://openalex.org/W3217225427","https://openalex.org/W4294838953","https://openalex.org/W4305014082","https://openalex.org/W4318595810","https://openalex.org/W4318927412","https://openalex.org/W4362717256","https://openalex.org/W4382808892","https://openalex.org/W4390528241","https://openalex.org/W4391581754","https://openalex.org/W4391671392","https://openalex.org/W4392111283","https://openalex.org/W4393935425"],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W4238067486","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W2578490996","https://openalex.org/W1967934156","https://openalex.org/W2362937100","https://openalex.org/W2350945165"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuropilin":[1],"and":[2,34,45,50,76,84,89,103,125,150,189,199,209,226,238,240],"tolloid-like":[3],"2":[4],"(NETO2)":[5],"facilitates":[6],"the":[7,27,38,112,134,145,163,215,242],"progression":[8],"of":[9,29,147],"various":[10],"cancers,":[11],"but":[12,175,213],"its":[13,35],"role":[14],"in":[15,32,81,101,121,130,172,180,197,224],"hepatocellular":[16],"carcinoma":[17],"(HCC)":[18],"is":[19,248],"not":[20,137,177],"known.":[21],"This":[22],"study":[23],"aimed":[24],"to":[25,127],"assess":[26],"potential":[28,250],"targeting":[30],"NETO2":[31,56,63,74,231,247],"HCC":[33,42,234,253],"relationship":[36],"with":[37,52,66],"STAT3/C-MYC":[39,243],"pathway.":[40],"METHODS:":[41],"cells":[43,68,132,153,174],"(Huh7":[44],"MHCC-97":[46,85,104,122,151,181,200,227],"H)":[47],"were":[48,79,192,211],"cultured":[49],"transfected":[51],"control":[53,59],"siRNA":[54,57],"(siCtrl),":[55],"(siNETO2),":[58],"overexpression":[60,64],"(oeCtrl),":[61],"or":[62],"(oeNETO2),":[65],"non-transfected":[67],"used":[69],"as":[70],"blank":[71],"controls.":[72],"RESULTS:":[73],"mRNA":[75],"protein":[77],"expressions":[78,191],"reduced":[80,168,220],"both":[82],"Huh7":[83,102,131,149,173,198,225],"H":[86,105,123,152,182,201,228],"cells.":[87,106,183,202,229],"EdU":[88],"CCK-8":[90],"assays":[91],"indicated":[92],"that":[93,111,144,162,187,206,214,246],"cell":[94,113,164,207,216,235],"proliferation":[95,208],"was":[96,116,136,167,176,219],"decreased":[97,154,193],"after":[98,118,155,169,194,221],"siNETO2":[99,119,156,170,195],"transfection":[100,120,171,196,223],"TUNEL":[107],"assay":[108,142,160],"found":[109],"revealed":[110,143,161,186,205],"apoptosis":[114,217],"rate":[115,166,218],"greater":[117,129],"cells,":[124],"tended":[126],"be":[128],"(but":[133],"difference":[135],"statistically":[138],"significant).":[139],"Transwell":[140],"invasion":[141,210],"number":[146],"invasive":[148],"transfection.":[157],"Cell":[158],"scratch":[159],"migration":[165,239],"significantly":[178],"different":[179],"Western":[184],"blotting":[185],"p-STAT3":[188],"C-MYC":[190],"Overexpression":[203],"experiments":[204],"promoted":[212],"oeNETO2":[222],"CONCLUSION:":[230],"knockdown":[232],"suppresses":[233],"proliferation,":[236],"invasion,":[237],"inactivates":[241],"pathway,":[244],"suggesting":[245],"a":[249],"target":[251],"for":[252],"treatment.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
