{"id":"https://openalex.org/W4408960834","doi":"https://doi.org/10.1161/circulationaha.125.074545","title":"Oral Semaglutide and Cardiovascular Outcomes in People With Type 2 Diabetes, According to SGLT2i Use: Prespecified Analyses of the SOUL Randomized Trial","display_name":"Oral Semaglutide and Cardiovascular Outcomes in People With Type 2 Diabetes, According to SGLT2i Use: Prespecified Analyses of the SOUL Randomized Trial","publication_year":2025,"publication_date":"2025-03-29","ids":{"openalex":"https://openalex.org/W4408960834","doi":"https://doi.org/10.1161/circulationaha.125.074545","pmid":"https://pubmed.ncbi.nlm.nih.gov/40156843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12144549"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.125.074545","doi":"https://doi.org/10.1161/circulationaha.125.074545","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.125.074545","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1161/circulationaha.125.074545","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019976194","display_name":"Nikolaus Marx","orcid":"https://orcid.org/0000-0001-6141-634X","observed_orcids":["https://orcid.org/0000-0001-6141-634X"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nikolaus Marx","raw_affiliation_strings":["Department of Internal Medicine I, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University, University Hospital Aachen, Germany (N.M.)","Department of Internal Medicine I, RWTH Aachen University, University Hospital Aachen, Aachen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6141-634X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University, University Hospital Aachen, Germany (N.M.)","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"Department of Internal Medicine I, RWTH Aachen University, University Hospital Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039316946","display_name":"John Eric Deanfield","orcid":"https://orcid.org/0000-0001-8806-6052","observed_orcids":["https://orcid.org/0000-0001-8806-6052"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John E. Deanfield","raw_affiliation_strings":["Institute of Cardiovascular Sciences, University College London, United Kingdom (J.E.D.)","Institute of Cardiovascular Sciences, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University College London, United Kingdom (J.E.D.)","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043842967","display_name":"Johannes F.E. Mann","orcid":"https://orcid.org/0000-0002-3154-5332","observed_orcids":["https://orcid.org/0000-0002-3154-5332"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes F.E. Mann","raw_affiliation_strings":["Friedrich Alexander University of Erlangen, Germany (J.F.E.M.)","Kuratorium f\u00fcr Heimdialyse Kidney Center, Munich, Germany (J.F.E.M.)","KfH Kidney Center, Munich, Germany. Friedrich Alexander University of Erlangen, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich Alexander University of Erlangen, Germany (J.F.E.M.)","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Kuratorium f\u00fcr Heimdialyse Kidney Center, Munich, Germany (J.F.E.M.)","institution_ids":[]},{"raw_affiliation_string":"KfH Kidney Center, Munich, Germany. Friedrich Alexander University of Erlangen, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022712557","display_name":"Rosario Arechavaleta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130040446","display_name":"Universidad Aut\u00f3noma de Guadalajara","ror":"https://ror.org/05ppk0267","country_code":"MX","type":"education","lineage":["https://openalex.org/I130040446"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rosario Arechavaleta","raw_affiliation_strings":["Department of Endocrinology, Universidad Autonoma de Guadalajara, Jalisco, Mexico (R.A.)","Department of Endocrinology, Universidad Autonoma de Guadalajara, Jalisco, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Universidad Autonoma de Guadalajara, Jalisco, Mexico (R.A.)","institution_ids":["https://openalex.org/I130040446"]},{"raw_affiliation_string":"Department of Endocrinology, Universidad Autonoma de Guadalajara, Jalisco, Mexico","institution_ids":["https://openalex.org/I130040446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080463002","display_name":"Stephen Charles Bain","orcid":"https://orcid.org/0000-0001-8519-4964","observed_orcids":["https://orcid.org/0000-0001-8519-4964"]},"institutions":[{"id":"https://openalex.org/I39586589","display_name":"Swansea University","ror":"https://ror.org/053fq8t95","country_code":"GB","type":"education","lineage":["https://openalex.org/I39586589"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen C. Bain","raw_affiliation_strings":["School of Medicine, Swansea University, United Kingdom (S.C.B.)","School of Medicine, Swansea University, Swansea, UK"],"raw_orcid":"https://orcid.org/0000-0001-8519-4964","affiliations":[{"raw_affiliation_string":"School of Medicine, Swansea University, United Kingdom (S.C.B.)","institution_ids":["https://openalex.org/I39586589"]},{"raw_affiliation_string":"School of Medicine, Swansea University, Swansea, UK","institution_ids":["https://openalex.org/I39586589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065730535","display_name":"HARPREET SINGH BAJAJ","orcid":"https://orcid.org/0000-0002-1461-1465","observed_orcids":["https://orcid.org/0000-0002-1461-1465"]},"institutions":[{"id":"https://openalex.org/I4210112039","display_name":"LMC Diabetes & Endocrinology (Canada)","ror":"https://ror.org/01cakqh38","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210112039"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Harpreet S. Bajaj","raw_affiliation_strings":["LMC Diabetes and Endocrinology, Brampton, Canada (H.S.B.)","LMC Diabetes and Endocrinology, Brampton, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1461-1465","affiliations":[{"raw_affiliation_string":"LMC Diabetes and Endocrinology, Brampton, Canada (H.S.B.)","institution_ids":["https://openalex.org/I4210112039"]},{"raw_affiliation_string":"LMC Diabetes and Endocrinology, Brampton, Ontario, Canada","institution_ids":["https://openalex.org/I4210112039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061075697","display_name":"Katrine Bayer Tanggaard","orcid":"https://orcid.org/0000-0001-8086-5757","observed_orcids":["https://orcid.org/0000-0001-8086-5757"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Katrine Bayer Tanggaard","raw_affiliation_strings":["Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","Novo Nordisk A/S, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013839934","display_name":"Andreas L. Birkenfeld","orcid":"https://orcid.org/0000-0003-1407-9023","observed_orcids":["https://orcid.org/0000-0003-1407-9023"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I4210160326","display_name":"German Center for Diabetes Research","ror":"https://ror.org/04qq88z54","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210160326","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas L. Birkenfeld","raw_affiliation_strings":["Department of Diabetology, Endocrinology and Nephrology, University Hospital T\u00fcbingen, Germany (A.L.B.)","Institute for Diabetes Research and Metabolic Diseases, Helmholtz Munich, German Center for Diabetes Research (A.L.B.)","Department of Diabetology, Endocrinology and Nephrology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany and Institute for Diabetes Research and Metabolic Diseases, Helmholtz Munich, German Center for Diabetes Research, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1407-9023","affiliations":[{"raw_affiliation_string":"Department of Diabetology, Endocrinology and Nephrology, University Hospital T\u00fcbingen, Germany (A.L.B.)","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"Institute for Diabetes Research and Metabolic Diseases, Helmholtz Munich, German Center for Diabetes Research (A.L.B.)","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210160326"]},{"raw_affiliation_string":"Department of Diabetology, Endocrinology and Nephrology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany and Institute for Diabetes Research and Metabolic Diseases, Helmholtz Munich, German Center for Diabetes Research, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210160326","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040182038","display_name":"John B. Buse","orcid":"https://orcid.org/0000-0002-9723-3876","observed_orcids":["https://orcid.org/0000-0002-9723-3876","https://orcid.org/0000-0001-6894-4110"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. Buse","raw_affiliation_strings":["University of North Carolina School of Medicine, Chapel Hill (J.B.B.)","University of North Carolina School of Medicine, Chapel Hill, NC"],"raw_orcid":"https://orcid.org/0000-0002-9723-3876","affiliations":[{"raw_affiliation_string":"University of North Carolina School of Medicine, Chapel Hill (J.B.B.)","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"University of North Carolina School of Medicine, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024082712","display_name":"\u017daklina Davicevic-Elez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Zaklina Davicevic-Elez","raw_affiliation_strings":["Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","Novo Nordisk A/S, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077027153","display_name":"Cyrus V Desouza","orcid":"https://orcid.org/0000-0001-6660-0568","observed_orcids":["https://orcid.org/0000-0001-6660-0568"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cyrus Desouza","raw_affiliation_strings":["Division of Diabetes, Endocrinology, and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, Omaha (C.D.)","Division of Diabetes, Endocrinology, and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":"https://orcid.org/0000-0001-6660-0568","affiliations":[{"raw_affiliation_string":"Division of Diabetes, Endocrinology, and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, Omaha (C.D.)","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Division of Diabetes, Endocrinology, and Metabolism, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090993994","display_name":"Scott S. Emerson","orcid":"https://orcid.org/0000-0002-2695-0165","observed_orcids":["https://orcid.org/0000-0002-2695-0165"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott S. Emerson","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle (S.S.E.)","Department of Biostatistics, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle (S.S.E.)","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114035153","display_name":"Mads D.M. Engelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mads D.M. Engelmann","raw_affiliation_strings":["Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","Novo Nordisk A/S, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004099465","display_name":"G. Kees Hovingh","orcid":"https://orcid.org/0000-0002-8145-1676","observed_orcids":["https://orcid.org/0000-0002-8145-1676"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"G. Kees Hovingh","raw_affiliation_strings":["Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","Novo Nordisk A/S, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005006476","display_name":"Silvio E. Inzucchi","orcid":"https://orcid.org/0000-0003-1254-6636","observed_orcids":["https://orcid.org/0000-0003-1254-6636"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvio E. Inzucchi","raw_affiliation_strings":["Section of Endocrinology, Yale University School of Medicine, New Haven, CT (S.E.I.)","Section of Endocrinology, Yale University School of Medicine, New Haven, CT"],"raw_orcid":"https://orcid.org/0000-0003-1254-6636","affiliations":[{"raw_affiliation_string":"Section of Endocrinology, Yale University School of Medicine, New Haven, CT (S.E.I.)","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Section of Endocrinology, Yale University School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018432247","display_name":"Pardeep S. Jhund","orcid":"https://orcid.org/0000-0003-4306-5317","observed_orcids":["https://orcid.org/0000-0003-4306-5317"]},"institutions":[{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pardeep S. Jhund","raw_affiliation_strings":["British Heart Foundation, Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom (P.S.J.)","British Heart Foundation, Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK"],"raw_orcid":"https://orcid.org/0000-0003-4306-5317","affiliations":[{"raw_affiliation_string":"British Heart Foundation, Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom (P.S.J.)","institution_ids":["https://openalex.org/I32003884","https://openalex.org/I7882870"]},{"raw_affiliation_string":"British Heart Foundation, Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I32003884","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025608840","display_name":"Sharon L. Mulvagh","orcid":"https://orcid.org/0000-0002-7377-4053","observed_orcids":["https://orcid.org/0000-0002-7377-4053"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sharon L. Mulvagh","raw_affiliation_strings":["Department of Medicine, Division of Cardiology, Dalhousie University, Halifax, Nova Scotia, Canada (S.L.M.)","Department of Medicine, Division of Cardiology, Dalhousie University, Halifax, Nova Scotia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7377-4053","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, Dalhousie University, Halifax, Nova Scotia, Canada (S.L.M.)","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, Dalhousie University, Halifax, Nova Scotia, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018561083","display_name":"Rodica Pop\u2010Busui","orcid":"https://orcid.org/0000-0002-2042-1350","observed_orcids":["https://orcid.org/0000-0002-2042-1350"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodica Pop-Busui","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland (R.P.-B.)","Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, OR"],"raw_orcid":"https://orcid.org/0000-0002-2042-1350","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland (R.P.-B.)","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072011562","display_name":"Neil R Poulter","orcid":"https://orcid.org/0000-0002-6292-997X","observed_orcids":["https://orcid.org/0000-0002-6292-997X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil R. Poulter","raw_affiliation_strings":["Imperial Clinical Trials Unit, Imperial College London, United Kingdom (N.R.P.)","Imperial Clinical Trials Unit, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-6292-997X","affiliations":[{"raw_affiliation_string":"Imperial Clinical Trials Unit, Imperial College London, United Kingdom (N.R.P.)","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Imperial Clinical Trials Unit, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110231477","display_name":"S\u00f8ren Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren Rasmussen","raw_affiliation_strings":["Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","Novo Nordisk A/S, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark (K.B.-T., Z.D.-E., M.D.M.E., G.K.H., S.R.)","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074833626","display_name":"Shih\u2010Te Tu","orcid":"https://orcid.org/0000-0002-1202-7409","observed_orcids":["https://orcid.org/0000-0002-1202-7409","https://orcid.org/0000-0002-7749-2723"]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Te Tu","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Taiwan (S.-T.T.)","Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Taiwan (S.-T.T.)","institution_ids":["https://openalex.org/I4210159511"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071945904","display_name":"Darren K. McGuire","orcid":"https://orcid.org/0000-0002-6412-7989","observed_orcids":["https://orcid.org/0000-0002-6412-7989"]},"institutions":[{"id":"https://openalex.org/I1286960001","display_name":"Parkland Health & Hospital System","ror":"https://ror.org/04rt7ps04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286960001"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren K. McGuire","raw_affiliation_strings":["Clinic for Cardiology, Angiology, and Intensive Care Medicine, University of Texas Southwestern Medical Center, and Parkland Health and Hospital System, Dallas (D.K.M.)","Clinic for Cardiology, Angiology, and Intensive Care Medicine, University of Texas Southwestern Medical Center, and Parkland Health and Hospital System, Dallas, TX"],"raw_orcid":"https://orcid.org/0000-0002-6412-7989","affiliations":[{"raw_affiliation_string":"Clinic for Cardiology, Angiology, and Intensive Care Medicine, University of Texas Southwestern Medical Center, and Parkland Health and Hospital System, Dallas (D.K.M.)","institution_ids":["https://openalex.org/I1286960001","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Clinic for Cardiology, Angiology, and Intensive Care Medicine, University of Texas Southwestern Medical Center, and Parkland Health and Hospital System, Dallas, TX","institution_ids":["https://openalex.org/I1286960001","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":null,"display_name":"on behalf of the SOUL Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"on behalf of the SOUL Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":24,"corresponding_author_ids":["https://openalex.org/A5019976194"],"corresponding_institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"],"apc_list":null,"apc_paid":null,"fwci":41.7487,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.99868599,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"151","issue":"23","first_page":"1639","last_page":"1650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.925000011920929},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.6010000109672546},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8659999966621399},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.5130000114440918},{"id":"https://openalex.org/keywords/soul-trial","display_name":"SOUL trial","score":0.7839999794960022},{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.777999997138977},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.7419999837875366},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.9359999895095825},{"id":"https://openalex.org/keywords/renal-safety","display_name":"renal safety","score":0.38199999928474426},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.699999988079071},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9553720951080322},{"id":"https://openalex.org/C2909862629","wikidata":"https://www.wikidata.org/wiki/Q27261089","display_name":"Semaglutide","level":5,"score":0.9516228437423706},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7835137844085693},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6282706260681152},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5143943428993225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4318333864212036},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34304121136665344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21587282419204712},{"id":"https://openalex.org/C2781308992","wikidata":"https://www.wikidata.org/wiki/Q2526479","display_name":"Liraglutide","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000099194","descriptor_name":"Semaglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D004763","descriptor_name":"Glucagon-Like Peptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004763","descriptor_name":"Glucagon-Like Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004763","descriptor_name":"Glucagon-Like Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1161/circulationaha.125.074545","doi":"https://doi.org/10.1161/circulationaha.125.074545","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.125.074545","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12144549","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12144549","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Text"},{"id":"pmid:40156843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40156843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:cronfa.swan.ac.uk:cronfa69195","doi":null,"is_oa":true,"landing_page_url":"https://cronfa.swan.ac.uk/Record/cronfa69195","pdf_url":"https://cronfa.swan.ac.uk/Record/cronfa69195/Download/69195__34454__c4bd09f72a8a43f78a57b73af30fd582.pdf","source":{"id":"https://openalex.org/S4306401612","display_name":"Cronfa (Swansea University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39586589","host_organization_name":"Swansea University","host_organization_lineage":["https://openalex.org/I39586589"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/0b046e7d-a054-47fe-a010-1b8b94b870a6","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/0b046e7d-a054-47fe-a010-1b8b94b870a6","pdf_url":"https://pure.amsterdamumc.nl/ws/files/142427855/Oral-semaglutide-and-cardiovascular-outcomes-in-people-with-type-2-diabetes-according-to-sglt2i-use.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publications.rwth-aachen.de:1030929","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-255267%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Circulation : an official journal of the American Heart Association 151(23), 1639-1650 (2025). doi:10.1161/CIRCULATIONAHA.125.074545","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.125.074545","doi":"https://doi.org/10.1161/circulationaha.125.074545","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.125.074545","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000873915","display_name":"NIDDK Diabetic Foot Consortium Clinical Research Unit","funder_award_id":"U01DK119083","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000916325","display_name":"Yale Diabetes Research Center","funder_award_id":"P30DK045735","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408960834.pdf","grobid_xml":"https://content.openalex.org/works/W4408960834.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2009187570","https://openalex.org/W2114823464","https://openalex.org/W2128034658","https://openalex.org/W2146264128","https://openalex.org/W2425644022","https://openalex.org/W2519510391","https://openalex.org/W2626446274","https://openalex.org/W2894746763","https://openalex.org/W2900413769","https://openalex.org/W2948612418","https://openalex.org/W2956532717","https://openalex.org/W3092379111","https://openalex.org/W3177365549","https://openalex.org/W3195404919","https://openalex.org/W3205211596","https://openalex.org/W3214731876","https://openalex.org/W4200148796","https://openalex.org/W4308183941","https://openalex.org/W4353021269","https://openalex.org/W4362522003","https://openalex.org/W4385409351","https://openalex.org/W4386151915","https://openalex.org/W4389560873","https://openalex.org/W4398781461","https://openalex.org/W4399940216","https://openalex.org/W4402066452","https://openalex.org/W4405187747","https://openalex.org/W4408960945"],"related_works":["https://openalex.org/W7023540709","https://openalex.org/W4410099718","https://openalex.org/W4417221678","https://openalex.org/W4400026323","https://openalex.org/W4408960945","https://openalex.org/W4206445899","https://openalex.org/W2519510391","https://openalex.org/W4417181847","https://openalex.org/W4410805012","https://openalex.org/W4385409351"],"abstract_inverted_index":{"BACKGROUND:":[0],"Both":[1],"GLP-1":[2],"(glucagon-like":[3],"peptide-1)":[4],"receptor":[5],"agonists":[6],"and":[7,22,42,61,89,194,274],"SGLT2":[8],"(sodium-glucose":[9],"cotransporter-2)":[10],"inhibitors":[11],"(SGLT2i)":[12],"improve":[13],"cardiovascular":[14,23,41,63,112,116,224,266],"outcomes":[15,268],"in":[16,149,203,240],"people":[17],"with":[18,57,253],"type":[19,58],"2":[20,59],"diabetes":[21,60],"or":[24,72,121,254],"chronic":[25,66],"kidney":[26,67],"disease.":[27],"However,":[28],"there":[29,174],"are":[30],"limited":[31],"data":[32],"about":[33],"the":[34,97,129,143,146,150,241],"effect":[35],"of":[36,83,94,131,140,145,177,182,196,200,221,238,243,250,270],"combining":[37],"these":[38],"agents":[39],"on":[40],"safety":[43],"outcomes.":[44],"METHODS:":[45],"The":[46,103,246],"SOUL":[47],"trial":[48,98,152],"(Semaglutide":[49],"Cardiovascular":[50],"Outcomes":[51],"Trial;":[52],"NCT03914326)":[53],"randomized":[54],"9650":[55],"participants":[56,76,204],"atherosclerotic":[62],"disease":[64,68],"and/or":[65],"to":[69,80,108,278],"oral":[70,158,244,251],"semaglutide":[71,159,252,262],"placebo.":[73],"As":[74],"prespecified,":[75],"were":[77,175,258],"analyzed":[78],"according":[79],"baseline":[81,209],"use":[82,93,230,233],"SGLT2i":[84,95,171,207,229,257,272],"(yes,":[85,99],"n=2596;":[86],"no,":[87,101],"n=7054),":[88],"subsequently":[90],"for":[91,157],"any":[92,227],"during":[96],"n=4718;":[100],"n=4932).":[102],"primary":[104,147,185],"outcome":[105,148,186],"was":[106,125,154],"time":[107],"first":[109],"major":[110,222,264],"adverse":[111,133,223,247,265],"event,":[113],"defined":[114],"as":[115],"death,":[117],"nonfatal":[118,122],"myocardial":[119],"infarction,":[120],"stroke.":[123],"Safety":[124],"evaluated":[126],"by":[127,226],"comparing":[128],"incidence":[130],"serious":[132],"events.":[134],"RESULTS:":[135],"Over":[136],"a":[137],"mean":[138],"follow-up":[139],"47.5\u00b110.9":[141],"months,":[142],"risk":[144],"overall":[151],"population":[153],"14%":[155],"lower":[156],"versus":[160,180,198,231],"placebo":[161],"(hazard":[162,188,210],"ratio,":[163,189,211],"0.86;":[164],"95%":[165,191,213],"CI,":[166,192,214],"0.77\u20130.96).":[167],"In":[168],"those":[169],"taking":[170,206],"at":[172,208],"baseline,":[173],"143":[176],"1296":[178],"(semaglutide)":[179],"158":[181],"1300":[183],"(placebo)":[184],"events":[187,225],"0.89;":[190],"0.71\u20131.11);":[193],"436":[195],"3529":[197],"510":[199],"3525,":[201],"respectively,":[202],"not":[205],"0.84;":[212],"0.74\u20130.95;":[215],"P":[216],"-interaction,":[217],"0.66).":[218],"An":[219],"analysis":[220],"in-trial":[228],"no":[232,236],"also":[234],"showed":[235],"evidence":[237],"heterogeneity":[239],"effects":[242],"semaglutide.":[245],"event":[248,267],"profiles":[249],"without":[255],"concomitant":[256,271],"similar.":[259],"CONCLUSIONS:":[260],"Oral":[261],"reduced":[263],"independently":[269],"treatment,":[273],"this":[275],"combination":[276],"appeared":[277],"be":[279],"safe.":[280],"REGISTRATION:":[281],"URL:":[282],"https://www.clinicaltrials.gov":[283],";":[284],"Unique":[285],"identifier:":[286],"NCT03914326.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":54},{"year":2025,"cited_by_count":22}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-03-29T00:00:00"}
