{"id":"https://openalex.org/W4408947653","doi":"https://doi.org/10.3389/froh.2025.1520195","title":"Case Report: Virtual surgery and 3D printing in a medication-related osteonecrosis of the jaws (MRONJ) pathological mandibular fracture","display_name":"Case Report: Virtual surgery and 3D printing in a medication-related osteonecrosis of the jaws (MRONJ) pathological mandibular fracture","publication_year":2025,"publication_date":"2025-03-28","ids":{"openalex":"https://openalex.org/W4408947653","doi":"https://doi.org/10.3389/froh.2025.1520195","pmid":"https://pubmed.ncbi.nlm.nih.gov/40226834"},"language":"en","primary_location":{"id":"doi:10.3389/froh.2025.1520195","doi":"https://doi.org/10.3389/froh.2025.1520195","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2025.1520195","pdf_url":null,"source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/froh.2025.1520195","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047915946","display_name":"Giorgio Lo Giudice","orcid":"https://orcid.org/0000-0001-9944-1073","observed_orcids":["https://orcid.org/0000-0001-9944-1073"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I246010334","display_name":"Universit\u00e0 degli Studi di Enna Kore","ror":"https://ror.org/04vd28p53","country_code":"IT","type":"education","lineage":["https://openalex.org/I246010334"]},{"id":"https://openalex.org/I4210139630","display_name":"Azienda Ospedaliera Universitaria Policlinico \"G. Martino\"","ror":"https://ror.org/03tf96d34","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210139630"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giorgio Lo Giudice","raw_affiliation_strings":["Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy","Department of Medicine and Surgery, University of Enna \"Kore\", Enna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I4210139630"]},{"raw_affiliation_string":"Department of Medicine and Surgery, University of Enna \"Kore\", Enna, Italy","institution_ids":["https://openalex.org/I246010334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025274078","display_name":"Alessandro Calvo","orcid":"https://orcid.org/0000-0001-6026-8728","observed_orcids":["https://orcid.org/0000-0001-6026-8728"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I4210139630","display_name":"Azienda Ospedaliera Universitaria Policlinico \"G. Martino\"","ror":"https://ror.org/03tf96d34","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210139630"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Calvo","raw_affiliation_strings":["Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I4210139630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015359128","display_name":"Emanuele Magaudda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I4210139630","display_name":"Azienda Ospedaliera Universitaria Policlinico \"G. Martino\"","ror":"https://ror.org/03tf96d34","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210139630"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuele Magaudda","raw_affiliation_strings":["Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I4210139630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085203024","display_name":"Francesco Saverio De Ponte","orcid":"https://orcid.org/0000-0002-9255-4152","observed_orcids":["https://orcid.org/0000-0002-9255-4152"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I4210139630","display_name":"Azienda Ospedaliera Universitaria Policlinico \"G. Martino\"","ror":"https://ror.org/03tf96d34","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210139630"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Saverio De Ponte","raw_affiliation_strings":["Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Maxillo-Facial Surgery Unit, University Hospital \"G. Martino\", University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I4210139630"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023796922","display_name":"Enrico Nastro Siniscalchi","orcid":"https://orcid.org/0000-0002-4424-0917","observed_orcids":["https://orcid.org/0000-0002-4424-0917"]},"institutions":[{"id":"https://openalex.org/I246010334","display_name":"Universit\u00e0 degli Studi di Enna Kore","ror":"https://ror.org/04vd28p53","country_code":"IT","type":"education","lineage":["https://openalex.org/I246010334"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Nastro Siniscalchi","raw_affiliation_strings":["Department of Medicine and Surgery, University of Enna \"Kore\", Enna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Surgery, University of Enna \"Kore\", Enna, Italy","institution_ids":["https://openalex.org/I246010334"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047915946"],"corresponding_institution_ids":["https://openalex.org/I112862951","https://openalex.org/I246010334","https://openalex.org/I4210139630"],"apc_list":{"value":2550,"currency":"CHF","value_usd":3077},"apc_paid":{"value":2550,"currency":"CHF","value_usd":3077},"fwci":0.4818,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52535326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"6","issue":null,"first_page":"1520195","last_page":"1520195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11562","display_name":"Facial Trauma and Fracture Management","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medication-related-osteonecrosis-of-the-jaw","display_name":"medication-related osteonecrosis of the jaw","score":0.9589999914169312},{"id":"https://openalex.org/keywords/virtual-surgery","display_name":"virtual surgery","score":0.8169999718666077},{"id":"https://openalex.org/keywords/3d-printing","display_name":"3D printing","score":0.9869999885559082},{"id":"https://openalex.org/keywords/computer-aided-design-and-manufacturing","display_name":"computer-aided design and manufacturing","score":0.8489999771118164},{"id":"https://openalex.org/keywords/surgical-planning","display_name":"surgical planning","score":0.6610000133514404},{"id":"https://openalex.org/keywords/titanium-reconstruction-plate","display_name":"titanium reconstruction plate","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sequestrectomy","display_name":"sequestrectomy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bone-debridement","display_name":"bone debridement","score":0.8019999861717224},{"id":"https://openalex.org/keywords/fracture-containment","display_name":"fracture containment","score":0.6029999852180481},{"id":"https://openalex.org/keywords/mandibular-model","display_name":"mandibular model","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.7186716794967651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7065526247024536},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.38558024168014526},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.3437497615814209},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32696235179901123},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10971832275390625}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/froh.2025.1520195","doi":"https://doi.org/10.3389/froh.2025.1520195","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2025.1520195","pdf_url":null,"source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},{"id":"pmid:40226834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40226834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oral health","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:11985856","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11985856","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Oral Health","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:34b977b751f04941b38a6897d800365a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/34b977b751f04941b38a6897d800365a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oral Health, Vol 6 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/froh.2025.1520195","doi":"https://doi.org/10.3389/froh.2025.1520195","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2025.1520195","pdf_url":null,"source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1668313609","https://openalex.org/W1989040196","https://openalex.org/W2026616100","https://openalex.org/W2058889454","https://openalex.org/W2083194651","https://openalex.org/W2086539666","https://openalex.org/W2107318775","https://openalex.org/W2127080901","https://openalex.org/W2133709814","https://openalex.org/W2169315979","https://openalex.org/W2512781651","https://openalex.org/W2769325014","https://openalex.org/W2794598757","https://openalex.org/W2963368473","https://openalex.org/W3023467101","https://openalex.org/W3084100243","https://openalex.org/W3199758240","https://openalex.org/W3216420966","https://openalex.org/W4206700516","https://openalex.org/W4206781950","https://openalex.org/W4210659489","https://openalex.org/W4213264012","https://openalex.org/W4296918589","https://openalex.org/W4308720341","https://openalex.org/W4313478792","https://openalex.org/W4317734525","https://openalex.org/W4323841997","https://openalex.org/W4381617514","https://openalex.org/W4389486141","https://openalex.org/W4391605492","https://openalex.org/W4393002840","https://openalex.org/W4400279901","https://openalex.org/W4402038045"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,113,136],"use":[2],"of":[3,14,59,66,74,84,97,101,108,126,144,176],"anatomical":[4],"models,":[5,42],"guides,":[6],"and":[7,16,25,30,99,106,139,155,163,184,187],"surgical":[8,48,95,158],"templates":[9],"allows":[10],"for":[11,122,132,190],"increased":[12,174],"precision":[13,175],"interventions":[15],"reduced":[17,157,178],"operative":[18,186],"times.":[19],"Thanks":[20],"to":[21,39,46,149],"computer-aided":[22,26],"design":[23],"(CAD)":[24],"manufacturing":[27],"(CAM)":[28],"technologies":[29],"rapid":[31],"prototyping":[32,165],"through":[33],"3D":[34],"printing,":[35],"it":[36],"is":[37],"possible":[38],"obtain":[40],"accurate":[41],"which":[43],"are":[44],"useful":[45],"defining":[47],"planning":[49],"in":[50,78,170],"the":[51,57,67,75,82,109,123,127,145,182,191],"maxillofacial":[52],"district.":[53],"Methods:":[54],"We":[55],"present":[56],"case":[58],"a":[60,63,93,120,156,167],"patient":[61],"with":[62,147,181],"pathological":[64],"fracture":[65,110,133],"mandibular":[68,115,151],"body":[69],"affected":[70],"by":[71],"medication-related":[72],"osteonecrosis":[73],"jaws":[76],"(MRONJ)":[77],"stage":[79],"III.":[80],"Through":[81],"manipulation":[83],"virtual":[85,94],"models":[86],"obtained":[87],"from":[88],"thin-layer":[89],"Computed":[90],"Tomography":[91],"(CT),":[92],"intervention":[96],"sequestrectomy":[98],"debridement":[100],"necrotic":[102],"bone":[103],"tissue,":[104],"reduction":[105],"containment":[107],"was":[111,117],"performed.":[112],"resulting":[114],"model":[116,146],"used":[118,131],"as":[119],"template":[121],"preoperative":[124],"modeling":[125],"titanium":[128],"reconstruction":[129],"plate":[130],"containment.":[134],"Results:":[135],"intraoperative":[137],"result":[138],"follow-up":[140],"demonstrated":[141],"good":[142],"accuracy":[143],"respect":[148],"post-operative":[150],"dynamics,":[152],"condylar-fossa":[153],"position":[154],"time.":[159],"Discussion:":[160],"Virtual":[161],"surgery":[162],"3D-printed":[164],"represent":[166],"feasible":[168],"technique":[169],"MRONJ":[171],"patients,":[172],"allowing":[173],"interventions,":[177],"risks":[179],"associated":[180],"operation,":[183],"improved":[185],"recovery":[188],"times":[189],"patient.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
