{"id":"https://openalex.org/W4408937901","doi":"https://doi.org/10.1158/2643-3230.bcd-23-0240","title":"Advancing CAR T-cell Therapies with Artificial Intelligence: Opportunities and Challenges","display_name":"Advancing CAR T-cell Therapies with Artificial Intelligence: Opportunities and Challenges","publication_year":2025,"publication_date":"2025-03-28","ids":{"openalex":"https://openalex.org/W4408937901","doi":"https://doi.org/10.1158/2643-3230.bcd-23-0240","pmid":"https://pubmed.ncbi.nlm.nih.gov/40152695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12050963"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3230.bcd-23-0240","doi":"https://doi.org/10.1158/2643-3230.bcd-23-0240","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2643-3230.bcd-23-0240","pdf_url":null,"source":{"id":"https://openalex.org/S4210239195","display_name":"Blood Cancer Discovery","issn_l":"2643-3230","issn":["2643-3230","2643-3249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12050963","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002886777","display_name":"Fabio Luciani","orcid":"https://orcid.org/0000-0003-0666-6324","observed_orcids":["https://orcid.org/0000-0003-0666-6324"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fabio Luciani","raw_affiliation_strings":["1Systems Immunology and Immunogenomics, School of Biomedical Sciences, UNSW Sydney, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-0666-6324","affiliations":[{"raw_affiliation_string":"1Systems Immunology and Immunogenomics, School of Biomedical Sciences, UNSW Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058250486","display_name":"Arman Safavi","orcid":"https://orcid.org/0000-0002-8803-0700","observed_orcids":["https://orcid.org/0000-0002-8803-0700"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Arman Safavi","raw_affiliation_strings":["1Systems Immunology and Immunogenomics, School of Biomedical Sciences, UNSW Sydney, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8803-0700","affiliations":[{"raw_affiliation_string":"1Systems Immunology and Immunogenomics, School of Biomedical Sciences, UNSW Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047130754","display_name":"Puneeth Guruprasad","orcid":"https://orcid.org/0000-0001-9615-1935","observed_orcids":["https://orcid.org/0000-0001-9615-1935"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puneeth Guruprasad","raw_affiliation_strings":["2Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","3Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0001-9615-1935","affiliations":[{"raw_affiliation_string":"2Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013489157","display_name":"Linhui Chen","orcid":"https://orcid.org/0009-0005-2054-4448","observed_orcids":["https://orcid.org/0009-0005-2054-4448"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linhui Chen","raw_affiliation_strings":["2Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","3Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":"https://orcid.org/0009-0005-2054-4448","affiliations":[{"raw_affiliation_string":"2Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088355904","display_name":"Marco Ruella","orcid":"https://orcid.org/0000-0003-4301-5811","observed_orcids":["https://orcid.org/0000-0003-4301-5811"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Ruella","raw_affiliation_strings":["2Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","3Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0003-4301-5811","affiliations":[{"raw_affiliation_string":"2Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"3Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.5494,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.99170025,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"6","issue":"3","first_page":"159","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/target-identification","display_name":"target identification","score":0.753000020980835},{"id":"https://openalex.org/keywords/vector-design","display_name":"vector design","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cell-manufacturing","display_name":"cell manufacturing","score":0.6060000061988831},{"id":"https://openalex.org/keywords/data-repositories","display_name":"data repositories","score":0.9319999814033508},{"id":"https://openalex.org/keywords/data-heterogeneity","display_name":"data heterogeneity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/patient-privacy","display_name":"patient privacy","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.6813146471977234},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6014703512191772},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4835922122001648},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4657258689403534},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.4339030086994171},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.38021203875541687},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.34930992126464844},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3226383328437805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23407462239265442},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.17957761883735657},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12848380208015442},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.12776196002960205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12732216715812683},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/2643-3230.bcd-23-0240","doi":"https://doi.org/10.1158/2643-3230.bcd-23-0240","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2643-3230.bcd-23-0240","pdf_url":null,"source":{"id":"https://openalex.org/S4210239195","display_name":"Blood Cancer Discovery","issn_l":"2643-3230","issn":["2643-3230","2643-3249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discovery","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11392031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12050963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40152695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40152695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cancer discovery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12050963","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12050963/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discov","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11392031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12050963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G635154192","display_name":null,"funder_award_id":"R01 FD008168","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"},{"id":"https://openalex.org/G9000875818","display_name":"Selective B Cell Depletion Using Engineered T Cells As A Curative Treatment For Acquired Thrombotic Thrombocytopenic Purpura","funder_award_id":"R01HL178849","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000876787","display_name":"MODULATION OF CD5 SIGNALING TO ENHANCE ADOPTIVE T-CELL THERAPIES FOR CANCER","funder_award_id":"R37CA262362","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904249","display_name":"Enhancing Chimeric Antigen Receptor T Cell Therapies for HematologicMalignancies: Beyond CART 19","funder_award_id":"P01CA214278","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2340435799","https://openalex.org/W3048184133","https://openalex.org/W3177828909","https://openalex.org/W4200231545","https://openalex.org/W4281724842","https://openalex.org/W4295454080","https://openalex.org/W4295512323","https://openalex.org/W4311887602","https://openalex.org/W4321480081","https://openalex.org/W4322494886","https://openalex.org/W4324044837","https://openalex.org/W4389048928","https://openalex.org/W4404577932"],"related_works":["https://openalex.org/W4405481661","https://openalex.org/W4281684141","https://openalex.org/W7165173110","https://openalex.org/W7221527896","https://openalex.org/W7154842774","https://openalex.org/W4395664113","https://openalex.org/W4412623243","https://openalex.org/W7207564983","https://openalex.org/W7133562241","https://openalex.org/W7130504538"],"abstract_inverted_index":{"Artificial":[0],"intelligence":[1,53],"could":[2],"enhance":[3],"chimeric":[4],"antigen":[5],"receptor":[6],"T-cell":[7],"therapy":[8],"outcomes":[9],"through":[10],"optimization":[11],"of":[12],"all":[13],"steps,":[14],"from":[15],"target":[16],"identification,":[17],"vector":[18],"design,":[19],"and":[20,59],"manufacturing":[21],"to":[22,51],"personalized":[23],"data-driven":[24],"clinical":[25],"decisions.":[26],"In":[27],"this":[28,35],"report,":[29],"we":[30],"highlight":[31],"steps":[32],"toward":[33],"unlocking":[34],"potential,":[36],"including":[37],"the":[38],"need":[39],"for":[40,48],"standardized,":[41],"comprehensive":[42],"data":[43,57],"repositories":[44],"as":[45,56],"a":[46],"way":[47],"addressing":[49],"barriers":[50],"artificial":[52],"learning,":[54],"such":[55],"heterogeneity":[58],"patient":[60],"privacy.":[61]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-29T00:00:00"}