{"id":"https://openalex.org/W4408929072","doi":"https://doi.org/10.3390/cimb47040232","title":"Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction","display_name":"Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction","publication_year":2025,"publication_date":"2025-03-27","ids":{"openalex":"https://openalex.org/W4408929072","doi":"https://doi.org/10.3390/cimb47040232","pmid":"https://pubmed.ncbi.nlm.nih.gov/40699631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12025420"},"language":"en","primary_location":{"id":"doi:10.3390/cimb47040232","doi":"https://doi.org/10.3390/cimb47040232","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb47040232","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cimb47040232","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015082880","display_name":"Habibe Y\u0131lmaz","orcid":"https://orcid.org/0000-0003-1106-0458","observed_orcids":["https://orcid.org/0000-0003-1106-0458"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]},{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB","TR"],"is_corresponding":true,"raw_author_name":"Habibe Y\u0131lmaz","raw_affiliation_strings":["Academic Unit of Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham NG7 2UH, UK","Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Trakya University, Edirne 22030, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Trakya University, Edirne 22030, T\u00fcrkiye","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011130143","display_name":"Ulvi Bayraktutan","orcid":"https://orcid.org/0000-0001-6922-0237","observed_orcids":["https://orcid.org/0000-0001-6922-0237"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ulvi Bayraktutan","raw_affiliation_strings":["Academic Unit of Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham NG7 2UH, UK"],"raw_orcid":"https://orcid.org/0000-0001-6922-0237","affiliations":[{"raw_affiliation_string":"Academic Unit of Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011130143","https://openalex.org/A5015082880"],"corresponding_institution_ids":["https://openalex.org/I12387023","https://openalex.org/I142263535"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":3.4031,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.9453125,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"47","issue":"4","first_page":"232","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.11240000277757645,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":1.0},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9610000252723694},{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.9869999885559082},{"id":"https://openalex.org/keywords/perivascular-spaces","display_name":"perivascular spaces","score":0.890999972820282},{"id":"https://openalex.org/keywords/cerebral-microbleeds","display_name":"cerebral microbleeds","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.4909999966621399},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.5720000267028809},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.5770000219345093},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.597000002861023},{"id":"https://openalex.org/keywords/phosphodiesterase-inhibitors","display_name":"phosphodiesterase inhibitors","score":0.984000027179718},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tetracycline-antibiotics","display_name":"tetracycline antibiotics","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antianginal-drugs","display_name":"antianginal drugs","score":0.7170000076293945},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5609999895095825},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8886376619338989},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7698873281478882},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6212606430053711},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5650578141212463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5610349178314209},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3983355760574341},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3563893735408783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26110512018203735},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15433254837989807}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/cimb47040232","doi":"https://doi.org/10.3390/cimb47040232","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb47040232","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12025420","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12025420","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Issues Mol Biol","raw_type":"Text"},{"id":"pmid:40699631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40699631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:47005369","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/47005369","pdf_url":"https://nottingham-repository.worktribe.com/preview/47005368/CIMB%20cSVD.pdf","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:acikerisim.trakya.edu.tr:20.500.14551/28605","doi":null,"is_oa":true,"landing_page_url":"https://doi.org10.3390/cimb47040232","pdf_url":null,"source":{"id":"https://openalex.org/S4306401406","display_name":"Trakya University's Institutional Open Access System (Trakya University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12387023","host_organization_name":"Trakya University","host_organization_lineage":["https://openalex.org/I12387023"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review Article"},{"id":"pmh:oai:doaj.org/article:a55acfb729fd42f3aee64cc9a3bdcc27","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a55acfb729fd42f3aee64cc9a3bdcc27","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Issues in Molecular Biology, Vol 47, Iss 4, p 232 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cimb47040232","doi":"https://doi.org/10.3390/cimb47040232","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb47040232","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":173,"referenced_works":["https://openalex.org/W112845398","https://openalex.org/W157346227","https://openalex.org/W188652514","https://openalex.org/W1537538750","https://openalex.org/W1565215438","https://openalex.org/W1608849851","https://openalex.org/W1731560702","https://openalex.org/W1772460577","https://openalex.org/W1915802091","https://openalex.org/W1933028486","https://openalex.org/W1966805395","https://openalex.org/W1972486690","https://openalex.org/W1972859449","https://openalex.org/W1973393911","https://openalex.org/W1979490323","https://openalex.org/W1981175423","https://openalex.org/W1989797372","https://openalex.org/W1990985580","https://openalex.org/W2009267056","https://openalex.org/W2018847226","https://openalex.org/W2026629342","https://openalex.org/W2026989717","https://openalex.org/W2027941039","https://openalex.org/W2033218230","https://openalex.org/W2035185226","https://openalex.org/W2035700338","https://openalex.org/W2040979266","https://openalex.org/W2042808393","https://openalex.org/W2047075745","https://openalex.org/W2048890924","https://openalex.org/W2051164530","https://openalex.org/W2057164916","https://openalex.org/W2063449407","https://openalex.org/W2068731335","https://openalex.org/W2071179731","https://openalex.org/W2073054137","https://openalex.org/W2074875228","https://openalex.org/W2075069825","https://openalex.org/W2077166140","https://openalex.org/W2078246734","https://openalex.org/W2079835998","https://openalex.org/W2084256007","https://openalex.org/W2085907924","https://openalex.org/W2090538970","https://openalex.org/W2094038819","https://openalex.org/W2097576923","https://openalex.org/W2101175089","https://openalex.org/W2102743559","https://openalex.org/W2104901197","https://openalex.org/W2111079150","https://openalex.org/W2113617025","https://openalex.org/W2114862320","https://openalex.org/W2118634615","https://openalex.org/W2122477279","https://openalex.org/W2127553032","https://openalex.org/W2148131629","https://openalex.org/W2148463229","https://openalex.org/W2151780486","https://openalex.org/W2158586724","https://openalex.org/W2160347316","https://openalex.org/W2168113652","https://openalex.org/W2169070397","https://openalex.org/W2181851876","https://openalex.org/W2263138261","https://openalex.org/W2277219084","https://openalex.org/W2316875009","https://openalex.org/W2339284835","https://openalex.org/W2527017317","https://openalex.org/W2544891436","https://openalex.org/W2551038843","https://openalex.org/W2554560091","https://openalex.org/W2560319914","https://openalex.org/W2568867359","https://openalex.org/W2604585470","https://openalex.org/W2616063679","https://openalex.org/W2684375425","https://openalex.org/W2737274080","https://openalex.org/W2743010525","https://openalex.org/W2795390956","https://openalex.org/W2801388762","https://openalex.org/W2884982525","https://openalex.org/W2888824643","https://openalex.org/W2889223700","https://openalex.org/W2911246644","https://openalex.org/W2928956234","https://openalex.org/W2943101143","https://openalex.org/W2947924379","https://openalex.org/W2950636079","https://openalex.org/W2981239143","https://openalex.org/W2981759230","https://openalex.org/W2989828646","https://openalex.org/W3004393628","https://openalex.org/W3006204378","https://openalex.org/W3007815224","https://openalex.org/W3008073336","https://openalex.org/W3009338790","https://openalex.org/W3009656198","https://openalex.org/W3012637180","https://openalex.org/W3016832090","https://openalex.org/W3038948962","https://openalex.org/W3044828938","https://openalex.org/W3049352209","https://openalex.org/W3092086456","https://openalex.org/W3092867708","https://openalex.org/W3093078669","https://openalex.org/W3094552695","https://openalex.org/W3097942751","https://openalex.org/W3104682194","https://openalex.org/W3111623592","https://openalex.org/W3113948922","https://openalex.org/W3118158112","https://openalex.org/W3119202142","https://openalex.org/W3119457988","https://openalex.org/W3123231057","https://openalex.org/W3127560709","https://openalex.org/W3157389281","https://openalex.org/W3164127661","https://openalex.org/W3174527401","https://openalex.org/W3194272436","https://openalex.org/W3208022035","https://openalex.org/W3214770882","https://openalex.org/W3215721066","https://openalex.org/W4205494080","https://openalex.org/W4210307893","https://openalex.org/W4211161847","https://openalex.org/W4212978654","https://openalex.org/W4213362448","https://openalex.org/W4220654929","https://openalex.org/W4220700309","https://openalex.org/W4220945110","https://openalex.org/W4220992106","https://openalex.org/W4223438906","https://openalex.org/W4224277116","https://openalex.org/W4226243753","https://openalex.org/W4229030206","https://openalex.org/W4255256740","https://openalex.org/W4280604752","https://openalex.org/W4283639743","https://openalex.org/W4285177431","https://openalex.org/W4287922041","https://openalex.org/W4294311005","https://openalex.org/W4294324928","https://openalex.org/W4303476452","https://openalex.org/W4303579210","https://openalex.org/W4310956261","https://openalex.org/W4311202219","https://openalex.org/W4312067134","https://openalex.org/W4312433733","https://openalex.org/W4313417586","https://openalex.org/W4321254226","https://openalex.org/W4377940039","https://openalex.org/W4378217890","https://openalex.org/W4383873629","https://openalex.org/W4383894096","https://openalex.org/W4384818803","https://openalex.org/W4387041370","https://openalex.org/W4387911210","https://openalex.org/W4388098699","https://openalex.org/W4388722705","https://openalex.org/W4390412260","https://openalex.org/W4391123280","https://openalex.org/W4396704906","https://openalex.org/W4396707777","https://openalex.org/W4398765597","https://openalex.org/W4399439006","https://openalex.org/W4401218296","https://openalex.org/W4401798821","https://openalex.org/W4402144143","https://openalex.org/W4404328876","https://openalex.org/W4404544368","https://openalex.org/W4404863735","https://openalex.org/W4405646449","https://openalex.org/W6809787381"],"related_works":["https://openalex.org/W2306343806","https://openalex.org/W4291633109","https://openalex.org/W7162008543","https://openalex.org/W6946247981","https://openalex.org/W4412185119","https://openalex.org/W4387845098","https://openalex.org/W7125514820","https://openalex.org/W2750437639","https://openalex.org/W3031417063","https://openalex.org/W4396905601"],"abstract_inverted_index":{"Cerebral":[0],"small":[1],"vessel":[2],"disease":[3],"(cSVD)":[4],"is":[5,86],"a":[6],"common":[7],"cause":[8],"of":[9,33,45,58,96,99,105,154,181,183],"stroke":[10],"and":[11,16,39,56,64,79,129,132,137,173,186,191],"dementia.":[12],"Ageing,":[13],"hypertension,":[14],"hyperglycaemia,":[15],"smoking":[17],"make":[18],"up":[19],"the":[20,31,43,50,53,59,179],"biggest":[21],"risk":[22],"factors":[23],"for":[24,91,107,122],"cSVD.":[25,151,196],"They":[26],"individually":[27],"or":[28,94],"collectively":[29],"increase":[30],"levels":[32],"reactive":[34],"oxygen":[35],"species,":[36],"pro-inflammatory":[37],"cytokines":[38],"matrix":[40],"metalloproteinases,":[41],"decrease":[42],"bioavailability":[44],"nitric":[46],"oxide,":[47],"and,":[48],"in":[49,81,114],"process,":[51],"compromise":[52],"structural":[54],"integrity":[55],"function":[57,136],"vascular":[60],"endothelium,":[61],"blood-brain":[62,138],"barrier,":[63],"brain":[65],"parenchyma.":[66],"These":[67],"then":[68],"appear":[69],"as":[70,108,110],"white":[71],"matter":[72],"hyperintensities,":[73],"enlarged":[74],"perivascular":[75],"spaces,":[76],"cerebral":[77,82],"microbleeds,":[78],"atrophy":[80],"imaging.":[83],"As":[84],"there":[85],"currently":[87],"no":[88],"curative":[89],"therapy":[90],"cSVD,":[92],"prevention":[93],"delay":[95],"cSVD":[97],"remains":[98],"particular":[100],"importance":[101],"to":[102,150,195],"preserve":[103],"quality":[104],"life":[106],"long":[109],"possible.":[111],"Bearing":[112],"that":[113],"mind,":[115],"this":[116],"review":[117,177],"explores":[118],"whether":[119,144],"drugs":[120,155],"used":[121],"other":[123],"neurovascular":[124],"conditions":[125],"may":[126,147],"prevent":[127],"neuroinflammation":[128],"oxidative":[130],"damage":[131],"effectively":[133],"maintain":[134],"endothelial":[135],"barrier":[139],"integrity.":[140],"It":[141],"also":[142],"examines":[143],"potential":[145],"benefits":[146],"be":[148],"extended":[149],"The":[152],"list":[153],"includes":[156],"anti-anginal":[157],"drugs,":[158,167,172],"acetylcholine":[159],"esterase":[160],"inhibitors,":[161,165,169],"\u03b2-hydroxy":[162],"\u03b2-methylglutaryl-CoA":[163],"reductase":[164],"lithium":[166],"phosphodiesterase":[168],"oral":[170],"antihyperglycaemic":[171],"tetracycline":[174],"antibiotics.":[175],"This":[176],"discusses":[178],"mechanisms":[180],"action":[182],"these":[184],"agents":[185],"critically":[187],"evaluates":[188],"preclinical,":[189],"translational,":[190],"clinical":[192],"research":[193],"pertaining":[194]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-03-28T00:00:00"}