{"id":"https://openalex.org/W4408928635","doi":"https://doi.org/10.3390/w17070993","title":"Metabolomic Analysis of Both Microcystin-Producing and Microcystin-Free Microcystis aeruginosa Strains in Response to Exogenous Microcystin Exposure","display_name":"Metabolomic Analysis of Both Microcystin-Producing and Microcystin-Free Microcystis aeruginosa Strains in Response to Exogenous Microcystin Exposure","publication_year":2025,"publication_date":"2025-03-28","ids":{"openalex":"https://openalex.org/W4408928635","doi":"https://doi.org/10.3390/w17070993"},"language":"en","primary_location":{"id":"doi:10.3390/w17070993","doi":"https://doi.org/10.3390/w17070993","is_oa":true,"landing_page_url":"https://doi.org/10.3390/w17070993","pdf_url":null,"source":{"id":"https://openalex.org/S134216166","display_name":"Water","issn_l":"2073-4441","issn":["2073-4441"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Water","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/w17070993","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045870162","display_name":"Lijuan Cai","orcid":"https://orcid.org/0000-0003-1248-1422","observed_orcids":["https://orcid.org/0000-0003-1248-1422"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Cai","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","College of Life Sciences, Linyi University, Linyi 276000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"College of Life Sciences, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418340","display_name":"Chen Chen","orcid":"https://orcid.org/0000-0001-5145-8212","observed_orcids":["https://orcid.org/0000-0001-5145-8212"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["College of Life Sciences, Linyi University, Linyi 276000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061335554","display_name":"Bingqing Wang","orcid":"https://orcid.org/0000-0002-3803-8413","observed_orcids":["https://orcid.org/0000-0002-3803-8413"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingqing Wang","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","College of Life Sciences, Linyi University, Linyi 276000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"College of Life Sciences, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guoao Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoao Xie","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","College of Life Sciences, Linyi University, Linyi 276000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"College of Life Sciences, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408118","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0002-6047-1221","observed_orcids":["https://orcid.org/0000-0002-6047-1221"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baicai Wang","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","College of Life Sciences, Linyi University, Linyi 276000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"College of Life Sciences, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101329880","display_name":"Xiuling Li","orcid":"https://orcid.org/0000-0001-6119-4396","observed_orcids":["https://orcid.org/0000-0001-6119-4396"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiuling Li","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","College of Life Sciences, Linyi University, Linyi 276000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"College of Life Sciences, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100688146","display_name":"Wenxia Wang","orcid":"https://orcid.org/0000-0001-9485-5963","observed_orcids":["https://orcid.org/0000-0001-9485-5963"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134482","display_name":"Nanjing Institute of Geography and Limnology","ror":"https://ror.org/03k6r8t20","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134482"]},{"id":"https://openalex.org/I4391768240","display_name":"State Key Laboratory of Lake Science and Environment","ror":"https://ror.org/02aez6s57","country_code":null,"type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134482","https://openalex.org/I4391768240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxia Wang","raw_affiliation_strings":["College of Life Sciences, Linyi University, Linyi 276000, China","State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Linyi University, Linyi 276000, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134482","https://openalex.org/I4391768240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101329880"],"corresponding_institution_ids":["https://openalex.org/I15823474"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":1.161,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72925645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"17","issue":"7","first_page":"993","last_page":"993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcystis-aeruginosa","display_name":"Microcystis aeruginosa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microcystins","display_name":"microcystins","score":0.8420000076293945},{"id":"https://openalex.org/keywords/microcystin-lr","display_name":"microcystin-LR","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cyanobacterial-blooms","display_name":"cyanobacterial blooms","score":0.8289999961853027},{"id":"https://openalex.org/keywords/photosystem-ii","display_name":"photosystem II","score":0.6169999837875366},{"id":"https://openalex.org/keywords/photosynthetic-efficiency","display_name":"photosynthetic efficiency","score":0.7979999780654907},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9679999947547913},{"id":"https://openalex.org/keywords/arginine-biosynthesis","display_name":"arginine biosynthesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cyanotoxin-production","display_name":"cyanotoxin production","score":0.5170000195503235},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2781226839","wikidata":"https://www.wikidata.org/wiki/Q424720","display_name":"Microcystin","level":4,"score":0.9799261093139648},{"id":"https://openalex.org/C2779651202","wikidata":"https://www.wikidata.org/wiki/Q3555762","display_name":"Microcystis aeruginosa","level":4,"score":0.8700344562530518},{"id":"https://openalex.org/C2776056151","wikidata":"https://www.wikidata.org/wiki/Q309928","display_name":"Microcystis","level":4,"score":0.7337256073951721},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6096444129943848},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5005283355712891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.449226975440979},{"id":"https://openalex.org/C2780299475","wikidata":"https://www.wikidata.org/wiki/Q6839436","display_name":"Microcystin-LR","level":4,"score":0.4486192464828491},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3322913646697998},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.2917846739292145},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.21416324377059937},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09005671739578247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.044900983572006226}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/w17070993","doi":"https://doi.org/10.3390/w17070993","is_oa":true,"landing_page_url":"https://doi.org/10.3390/w17070993","pdf_url":null,"source":{"id":"https://openalex.org/S134216166","display_name":"Water","issn_l":"2073-4441","issn":["2073-4441"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Water","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/w17070993","doi":"https://doi.org/10.3390/w17070993","is_oa":true,"landing_page_url":"https://doi.org/10.3390/w17070993","pdf_url":null,"source":{"id":"https://openalex.org/S134216166","display_name":"Water","issn_l":"2073-4441","issn":["2073-4441"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Water","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1003993110","display_name":null,"funder_award_id":"32101373","funder_id":"https://openalex.org/F4320326891","funder_display_name":"State Key Laboratory of Lake Science and Environment"},{"id":"https://openalex.org/G189744342","display_name":null,"funder_award_id":"2024KJG059","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2995930044","display_name":null,"funder_award_id":"2022SKL017","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4417480069","display_name":null,"funder_award_id":"801KF2022-6","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5423818815","display_name":null,"funder_award_id":"32101373","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G777056051","display_name":null,"funder_award_id":"2024KJG059","funder_id":"https://openalex.org/F4320326891","funder_display_name":"State Key Laboratory of Lake Science and Environment"},{"id":"https://openalex.org/G886705929","display_name":null,"funder_award_id":"801KF2022-6","funder_id":"https://openalex.org/F4320326891","funder_display_name":"State Key Laboratory of Lake Science and Environment"},{"id":"https://openalex.org/G915811699","display_name":null,"funder_award_id":"2022SKL017","funder_id":"https://openalex.org/F4320326891","funder_display_name":"State Key Laboratory of Lake Science and Environment"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326891","display_name":"State Key Laboratory of Lake Science and Environment","ror":"https://ror.org/02aez6s57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W110994974","https://openalex.org/W1966940352","https://openalex.org/W1972102945","https://openalex.org/W1972984739","https://openalex.org/W1990839717","https://openalex.org/W2002443116","https://openalex.org/W2023430273","https://openalex.org/W2027834425","https://openalex.org/W2048727140","https://openalex.org/W2076674873","https://openalex.org/W2080767706","https://openalex.org/W2122667452","https://openalex.org/W2153822751","https://openalex.org/W2270452767","https://openalex.org/W2461054230","https://openalex.org/W2604962875","https://openalex.org/W2767683865","https://openalex.org/W2793750578","https://openalex.org/W2803037618","https://openalex.org/W2804242150","https://openalex.org/W2890145921","https://openalex.org/W2890866143","https://openalex.org/W2897785246","https://openalex.org/W2946011243","https://openalex.org/W2948372178","https://openalex.org/W2982170767","https://openalex.org/W2989651218","https://openalex.org/W3001058185","https://openalex.org/W3010857758","https://openalex.org/W3096085012","https://openalex.org/W3096447557","https://openalex.org/W3112834061","https://openalex.org/W3129163402","https://openalex.org/W3159063033","https://openalex.org/W3184148372","https://openalex.org/W3186932444","https://openalex.org/W3205885620","https://openalex.org/W3215201787","https://openalex.org/W4229082395","https://openalex.org/W4297121413","https://openalex.org/W4307771777","https://openalex.org/W4311498703","https://openalex.org/W4317436806","https://openalex.org/W4317726036","https://openalex.org/W4362663877","https://openalex.org/W4380758718","https://openalex.org/W4383498050","https://openalex.org/W4394617228","https://openalex.org/W4394726240","https://openalex.org/W4396991535","https://openalex.org/W4400370912"],"related_works":["https://openalex.org/W2049728267","https://openalex.org/W2494943576","https://openalex.org/W2560551869","https://openalex.org/W3145079205","https://openalex.org/W2349040535","https://openalex.org/W1988289665","https://openalex.org/W2073556641","https://openalex.org/W3180285984","https://openalex.org/W2156388564","https://openalex.org/W2392684654"],"abstract_inverted_index":{"Microcystis":[0],"aeruginosa":[1,36,186],"(M.":[2],"aeruginosa),":[3],"a":[4,76,84,90,155],"key":[5],"species":[6],"in":[7,26,65,79,87,93,124,184],"cyanobacterial":[8],"blooms,":[9],"is":[10],"notably":[11],"concerning":[12],"due":[13],"to":[14,37,39,121,127,145,169],"its":[15],"production":[16],"of":[17,29,34,114,136,161,193],"harmful":[18],"microcystins":[19],"(MCs).":[20],"In":[21,130],"this":[22],"study,":[23],"the":[24,27,40,134,159,164,173,189],"differences":[25],"ability":[28],"MC-producing":[30,73,128],"and":[31,61,89,106,187,191],"MC-free":[32,95,125,148],"strains":[33,74,96],"M.":[35,66,185],"respond":[38],"exogenous":[41],"MCs":[42],"(MC-LR)":[43],"were":[44],"compared.":[45],"The":[46,111],"results":[47],"showed":[48,75,97,178],"that":[49,179],"at":[50,116],"higher":[51,117],"concentrations,":[52],"MC-LR":[53,70,115,132,150,180],"affected":[54],"cell":[55,57,80,98],"morphology,":[56],"growth,":[58],"photosynthetic":[59],"efficiency,":[60],"induced":[62],"oxidative":[63],"stress":[64],"aeruginosa.":[67],"Under":[68],"high":[69],"concentration":[71],"exposure,":[72],"14.7%":[77],"reduction":[78],"density,":[81],"accompanied":[82],"by":[83,101,109,139],"32%":[85],"elevation":[86],"Vj":[88,103],"63.1%":[91],"decline":[92],"FV/FM.":[94],"density":[99],"decreasing":[100],"22.5%,":[102],"increasing":[104],"2-fold,":[105],"FV/FM":[107],"dropping":[108],"69.5%.":[110],"inhibitory":[112],"effect":[113],"concentrations":[118],"was":[119],"found":[120],"be":[122],"stronger":[123],"compared":[126],"strains.":[129],"addition,":[131],"reduced":[133],"efficiency":[135],"photosystem":[137],"II":[138],"blocking":[140],"electron":[141],"transfer":[142],"from":[143,172],"QA":[144],"QB;":[146],"for":[147],"strains,":[149],"may":[151],"have":[152],"acted":[153],"as":[154],"signaling":[156],"molecule":[157],"affecting":[158],"targeting":[160],"QB":[162,170],"on":[163],"D1":[165],"protein,":[166],"thus":[167,188],"leading":[168],"detachment":[171],"protein":[174],"complex.":[175],"Metabolomics":[176],"analysis":[177],"affects":[181],"arginine":[182],"synthesis":[183,190],"release":[192],"MCs.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}