{"id":"https://openalex.org/W4408922360","doi":"https://doi.org/10.1007/s10787-025-01700-6","title":"Immunomodulatory properties of a methanolic extract of Ficus lyrata mitigate inflammation in Complete Freund\u2019s Adjuvant-induced arthritis","display_name":"Immunomodulatory properties of a methanolic extract of Ficus lyrata mitigate inflammation in Complete Freund\u2019s Adjuvant-induced arthritis","publication_year":2025,"publication_date":"2025-03-26","ids":{"openalex":"https://openalex.org/W4408922360","doi":"https://doi.org/10.1007/s10787-025-01700-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/40140117"},"language":"en","primary_location":{"id":"doi:10.1007/s10787-025-01700-6","doi":"https://doi.org/10.1007/s10787-025-01700-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10787-025-01700-6","pdf_url":null,"source":{"id":"https://openalex.org/S77466329","display_name":"Inflammopharmacology","issn_l":"0925-4692","issn":["0925-4692","1568-5608"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113903779","display_name":"Anam Iftikhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Anam Iftikhar","raw_affiliation_strings":["University College of Pharmacy, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College of Pharmacy, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631559","display_name":"Mohammad Saleem","orcid":"https://orcid.org/0000-0001-5064-1584","observed_orcids":["https://orcid.org/0000-0001-5064-1584"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Mohammad Saleem","raw_affiliation_strings":["University College of Pharmacy, University of the Punjab, Lahore, Pakistan. saleem2978@hotmail.com"],"raw_orcid":"https://orcid.org/0000-0001-5064-1584","affiliations":[{"raw_affiliation_string":"University College of Pharmacy, University of the Punjab, Lahore, Pakistan. saleem2978@hotmail.com","institution_ids":["https://openalex.org/I172780181"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Syed Atif Raza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Syed Atif Raza","raw_affiliation_strings":["University College of Pharmacy, University of the Punjab, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College of Pharmacy, University of the Punjab, Lahore, Pakistan","institution_ids":["https://openalex.org/I172780181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050863147","display_name":"Adrian A. Achuthan","orcid":"https://orcid.org/0000-0003-3640-2338","observed_orcids":["https://orcid.org/0000-0003-3640-2338"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adrian Achuthan","raw_affiliation_strings":["Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, 3050, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, 3050, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003231470","display_name":"Rodney Brian Luwor","orcid":"https://orcid.org/0000-0002-3020-4245","observed_orcids":["https://orcid.org/0000-0002-3020-4245"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I149672521","display_name":"Federation University","ror":"https://ror.org/05qbzwv83","country_code":"AU","type":"education","lineage":["https://openalex.org/I149672521"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210107908","display_name":"Ballarat Health Services","ror":"https://ror.org/01jmjwt28","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210107908","https://openalex.org/I4388446407"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rodney Luwor","raw_affiliation_strings":["Dept of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, 3050, Australia","Federation University, Ballarat, VIC, 3350, Australia","Fiona Elsey Cancer Research Institute, Ballarat, VIC, 3350, Australia","Pukou District, Huagene Institute, Kecheng Science and Technology Park, Nanjing, 211806, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, 3050, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595"]},{"raw_affiliation_string":"Federation University, Ballarat, VIC, 3350, Australia","institution_ids":["https://openalex.org/I149672521"]},{"raw_affiliation_string":"Fiona Elsey Cancer Research Institute, Ballarat, VIC, 3350, Australia","institution_ids":["https://openalex.org/I4210107908"]},{"raw_affiliation_string":"Pukou District, Huagene Institute, Kecheng Science and Technology Park, Nanjing, 211806, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103985585","display_name":"Taha Muhammad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taha Muhammad","raw_affiliation_strings":["Shalamar Medical and Dental College, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shalamar Medical and Dental College, Lahore, Pakistan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102505545","display_name":"Umair Majeed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Umair Majeed","raw_affiliation_strings":["University of Karachi, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Karachi, Karachi, Pakistan","institution_ids":["https://openalex.org/I193670377"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101631559"],"corresponding_institution_ids":["https://openalex.org/I172780181"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.2977,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.75860224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":"4","first_page":"1921","last_page":"1934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13422","display_name":"Phytochemistry and biological activities of Ficus species","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13422","display_name":"Phytochemistry and biological activities of Ficus species","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ficus-lyrata","display_name":"Ficus lyrata","score":1.0},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.8880000114440918},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/anti-arthritic-activity","display_name":"anti-arthritic activity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/complete-freund-s-adjuvant-induced-arthritis","display_name":"complete Freund's adjuvant-induced arthritis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/carrageenan-induced-edema","display_name":"carrageenan-induced edema","score":0.8939999938011169},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.7419999837875366},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.859000027179718},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8130000233650208},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7229999899864197},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7070000171661377},{"id":"https://openalex.org/keywords/bone-erosion","display_name":"bone erosion","score":0.7289999723434448},{"id":"https://openalex.org/keywords/pannus-formation","display_name":"pannus formation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/methotrexate-comparison","display_name":"methotrexate comparison","score":0.7179999947547913},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.7005147933959961},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6952034831047058},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5611588954925537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.538735568523407},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5027024745941162},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.45478522777557373},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4503275156021118},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.4401226043701172},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.43023619055747986},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33759093284606934},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3325311541557312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2747272849082947},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13959231972694397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1260843575000763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005620","descriptor_name":"Freund's Adjuvant","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D030681","descriptor_name":"Ficus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10787-025-01700-6","doi":"https://doi.org/10.1007/s10787-025-01700-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10787-025-01700-6","pdf_url":null,"source":{"id":"https://openalex.org/S77466329","display_name":"Inflammopharmacology","issn_l":"0925-4692","issn":["0925-4692","1568-5608"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"journal-article"},{"id":"pmid:40140117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40140117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1991021622","https://openalex.org/W2010802338","https://openalex.org/W2012198083","https://openalex.org/W2035699049","https://openalex.org/W2045558389","https://openalex.org/W2078624814","https://openalex.org/W2079067931","https://openalex.org/W2093731034","https://openalex.org/W2094156327","https://openalex.org/W2099559204","https://openalex.org/W2100260684","https://openalex.org/W2106668238","https://openalex.org/W2118767323","https://openalex.org/W2140535402","https://openalex.org/W2148658155","https://openalex.org/W2162192155","https://openalex.org/W2273452210","https://openalex.org/W2341082996","https://openalex.org/W2464371645","https://openalex.org/W2528225935","https://openalex.org/W2608454940","https://openalex.org/W2771472591","https://openalex.org/W2792738411","https://openalex.org/W2795502752","https://openalex.org/W2887291408","https://openalex.org/W2936013463","https://openalex.org/W2943575556","https://openalex.org/W2965903541","https://openalex.org/W2990558578","https://openalex.org/W2991394131","https://openalex.org/W3002498794","https://openalex.org/W3004273376","https://openalex.org/W3010003321","https://openalex.org/W3012401407","https://openalex.org/W3016830390","https://openalex.org/W3047315048","https://openalex.org/W3085095620","https://openalex.org/W3092945653","https://openalex.org/W3116205427","https://openalex.org/W3131645162","https://openalex.org/W3180882235","https://openalex.org/W3192507134","https://openalex.org/W3200061127","https://openalex.org/W3200742722","https://openalex.org/W4210968471","https://openalex.org/W4214581218","https://openalex.org/W4224213710","https://openalex.org/W4226201544","https://openalex.org/W4232642069","https://openalex.org/W4304695608","https://openalex.org/W4362649391","https://openalex.org/W4362732775","https://openalex.org/W4363651570","https://openalex.org/W4366602975","https://openalex.org/W4368252294","https://openalex.org/W4376602505","https://openalex.org/W4382726518","https://openalex.org/W4385606470","https://openalex.org/W4389285323","https://openalex.org/W4390745911","https://openalex.org/W4394891914","https://openalex.org/W7162862243"],"related_works":["https://openalex.org/W3176692165","https://openalex.org/W4405086995","https://openalex.org/W2156791937","https://openalex.org/W7163276786","https://openalex.org/W7212430991","https://openalex.org/W4205349435","https://openalex.org/W4405650213","https://openalex.org/W7154735752","https://openalex.org/W7095620504","https://openalex.org/W4225985492"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-03-28T00:00:00"}
