{"id":"https://openalex.org/W4408918641","doi":"https://doi.org/10.21522/tijph.2013.13.01.art079","title":"Therapeutic Applications of Fluorides in Dental and Medical Diseases-A Systematic Review","display_name":"Therapeutic Applications of Fluorides in Dental and Medical Diseases-A Systematic Review","publication_year":2025,"publication_date":"2025-03-28","ids":{"openalex":"https://openalex.org/W4408918641","doi":"https://doi.org/10.21522/tijph.2013.13.01.art079"},"language":"en","primary_location":{"id":"doi:10.21522/tijph.2013.13.01.art079","doi":"https://doi.org/10.21522/tijph.2013.13.01.art079","is_oa":true,"landing_page_url":"https://doi.org/10.21522/tijph.2013.13.01.art079","pdf_url":null,"source":{"id":"https://openalex.org/S4393918755","display_name":"Texila international journal of public health","issn_l":"2309-6470","issn":["2309-6470","2520-3134"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Texila International Journal of Public Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.21522/tijph.2013.13.01.art079","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017344802","display_name":"Sirigala Lavanya","orcid":"https://orcid.org/0009-0000-8462-1696","observed_orcids":["https://orcid.org/0009-0000-8462-1696"]},"institutions":[{"id":"https://openalex.org/I4405274550","display_name":"Government Dental College and Hospital Vijayawada","ror":"https://ror.org/01xvj1x75","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405274550"]},{"id":"https://openalex.org/I85461943","display_name":"Saveetha University","ror":"https://ror.org/0034me914","country_code":"IN","type":"education","lineage":["https://openalex.org/I85461943"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sirigala Lavanya","raw_affiliation_strings":["Department of Oral Pathology, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India & Department of Oral Pathology, Saveetha Dental College and Hospital, Saveetha University of Medical Sciences, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India & Department of Oral Pathology, Saveetha Dental College and Hospital, Saveetha University of Medical Sciences, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4405274550","https://openalex.org/I85461943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037936347","display_name":"Hema Shree K","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85461943","display_name":"Saveetha University","ror":"https://ror.org/0034me914","country_code":"IN","type":"education","lineage":["https://openalex.org/I85461943"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Hemashree","raw_affiliation_strings":["Department of Oral Pathology, Saveetha Dental College and Hospital, Saveetha University of Medical Sciences, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, Saveetha Dental College and Hospital, Saveetha University of Medical Sciences, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I85461943"]}]},{"author_position":"last","author":{"id":null,"display_name":"Prathiba Ramani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85461943","display_name":"Saveetha University","ror":"https://ror.org/0034me914","country_code":"IN","type":"education","lineage":["https://openalex.org/I85461943"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prathiba Ramani","raw_affiliation_strings":["Department of Oral Pathology, Saveetha Dental College and Hospital, Saveetha University of Medical Sciences, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, Saveetha Dental College and Hospital, Saveetha University of Medical Sciences, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I85461943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7921,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64406988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"13","issue":"1","first_page":"841","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11969","display_name":"Fluoride Effects and Removal","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoride","display_name":"fluoride","score":0.6520000100135803},{"id":"https://openalex.org/keywords/dental-caries-prevention","display_name":"dental caries prevention","score":0.8629999756813049},{"id":"https://openalex.org/keywords/silver-diamine-fluoride","display_name":"silver diamine fluoride","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sodium-fluoride-varnish","display_name":"sodium fluoride varnish","score":0.9399999976158142},{"id":"https://openalex.org/keywords/orthodontic-patients","display_name":"orthodontic patients","score":0.6439999938011169},{"id":"https://openalex.org/keywords/enamel-erosion","display_name":"enamel erosion","score":0.7680000066757202},{"id":"https://openalex.org/keywords/sodium-hyaluronate","display_name":"sodium hyaluronate","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gingival-health","display_name":"gingival health","score":0.9580000042915344},{"id":"https://openalex.org/keywords/otosclerosis","display_name":"otosclerosis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/osteosclerosis","display_name":"osteosclerosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.6909999847412109},{"id":"https://openalex.org/keywords/fluoride-mouthwash","display_name":"fluoride mouthwash","score":0.45899999141693115},{"id":"https://openalex.org/keywords/fluoride-toothpaste","display_name":"fluoride toothpaste","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4741643965244293},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.42683878540992737}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21522/tijph.2013.13.01.art079","doi":"https://doi.org/10.21522/tijph.2013.13.01.art079","is_oa":true,"landing_page_url":"https://doi.org/10.21522/tijph.2013.13.01.art079","pdf_url":null,"source":{"id":"https://openalex.org/S4393918755","display_name":"Texila international journal of public health","issn_l":"2309-6470","issn":["2309-6470","2520-3134"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Texila International Journal of Public Health","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21522/tijph.2013.13.01.art079","doi":"https://doi.org/10.21522/tijph.2013.13.01.art079","is_oa":true,"landing_page_url":"https://doi.org/10.21522/tijph.2013.13.01.art079","pdf_url":null,"source":{"id":"https://openalex.org/S4393918755","display_name":"Texila international journal of public health","issn_l":"2309-6470","issn":["2309-6470","2520-3134"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Texila International Journal of Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410442101","https://openalex.org/W4414156356","https://openalex.org/W4414005942","https://openalex.org/W2157287448","https://openalex.org/W4405419081","https://openalex.org/W4389866318","https://openalex.org/W4392303777","https://openalex.org/W7141776984","https://openalex.org/W7222825972","https://openalex.org/W4250647456"],"abstract_inverted_index":{"A":[0,34],"systematic":[1,79],"review":[2,80],"was":[3,41,89],"conducted":[4],"to":[5,43,191,238],"evaluate":[6],"the":[7,157],"therapeutic":[8,86],"applications":[9,165],"of":[10,32,36],"fluoride,":[11],"focusing":[12],"on":[13,57,84,147,162],"dental":[14,96,148,200],"and":[15,30,39,52,65,75,94,106,118,166,180,198,201,215,223,229,244],"medical":[16,170],"uses.":[17,87],"Searches":[18],"were":[19,184],"performed":[20],"across":[21,186],"five":[22],"major":[23],"databases:":[24],"PubMed,":[25],"Embase,":[26],"Cochrane":[27],"Library,":[28],"Scopus,":[29],"Web":[31],"Science.":[33],"combination":[35],"MeSH":[37],"terms":[38],"keywords":[40],"used":[42],"cover":[44],"four":[45],"domains:":[46],"Fluorides,":[47],"Dental":[48],"Therapeutics,":[49,51],"Medical":[50],"Outcomes.":[53],"Inclusion":[54],"criteria":[55,69],"focused":[56],"human":[58],"studies":[59,83,142],"published":[60],"in":[61,92,123,176,196,207,220,248],"English":[62],"between":[63],"2000":[64],"2024,":[66],"while":[67,126],"exclusion":[68],"eliminated":[70],"non-human":[71],"studies,":[72],"irrelevant":[73],"topics,":[74],"grey":[76],"literature.":[77],"This":[78],"analyzed":[81],"34":[82],"fluoride's":[85,163],"Fluoride":[88,188],"consistently":[90],"effective":[91,130],"preventing":[93,197],"managing":[95],"caries,":[97],"with":[98,136],"combinations":[99],"like":[100,178],"38%":[101],"silver":[102],"diamine":[103],"fluoride":[104,109,137,172,206],"(SDF)":[105],"5%":[107],"sodium":[108],"(NaF)":[110],"varnish":[111],"showing":[112],"higher":[113],"efficacy.":[114],"High-fluoride":[115],"mouth":[116],"rinses":[117],"toothpaste":[119],"reduced":[120],"demineralized":[121],"lesions":[122],"orthodontic":[124],"patients,":[125],"Arg-NaF":[127],"varnishes":[128],"are":[129],"against":[131],"enamel":[132,216],"erosion.":[133,217],"Sodium":[134],"hyaluronate":[135],"improved":[138],"gingival":[139],"health.":[140],"Some":[141],"noted":[143],"potential":[144],"negative":[145],"effects":[146,175,243],"materials,":[149],"such":[150],"as":[151],"reducing":[152],"sealant":[153],"bond":[154],"strength,":[155],"highlighting":[156],"need":[158],"for":[159],"further":[160],"research":[161,235],"broader":[164],"material":[167],"interactions.":[168],"In":[169],"contexts,":[171],"demonstrated":[173],"stabilizing":[174,226],"conditions":[177],"otosclerosis":[179],"osteoporosis,":[181],"though":[182],"findings":[183],"inconsistent":[185],"studies.":[187],"is":[189,236],"observed":[190],"have":[192],"a":[193],"positive":[194],"role":[195],"treating":[199],"bone":[202,231],"diseases.":[203],"Studies":[204],"showed":[205],"specific":[208],"doses":[209],"could":[210],"enhance":[211],"tooth":[212],"caries":[213],"resistance":[214],"Fluorides":[218],"act":[219],"controlling":[221],"osteosclerosis":[222],"osteoporosis":[224],"by":[225],"disease":[227],"progression":[228],"improving":[230],"density.":[232],"However,":[233],"more":[234],"needed":[237],"fully":[239],"understand":[240],"its":[241,246],"long-term":[242],"optimize":[245],"use":[247],"both":[249],"fields.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-03-28T00:00:00"}
