{"id":"https://openalex.org/W4408899604","doi":"https://doi.org/10.21037/apm-24-154","title":"Chronic chemotherapy-induced peripheral neuropathy: living with neuropathy during and after cancer treatments","display_name":"Chronic chemotherapy-induced peripheral neuropathy: living with neuropathy during and after cancer treatments","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4408899604","doi":"https://doi.org/10.21037/apm-24-154","pmid":"https://pubmed.ncbi.nlm.nih.gov/40211744"},"language":"en","primary_location":{"id":"doi:10.21037/apm-24-154","doi":"https://doi.org/10.21037/apm-24-154","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apm-24-154","pdf_url":null,"source":{"id":"https://openalex.org/S2764761676","display_name":"Annals of Palliative Medicine","issn_l":"2224-5820","issn":["2224-5820","2224-5839"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Palliative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/apm-24-154","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nur Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802074625","display_name":"Bridgeport Hospital","ror":"https://ror.org/000yct867","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802074625","https://openalex.org/I4210117499"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nur Rahman","raw_affiliation_strings":["Department of Internal Medicine, Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT, USA","institution_ids":["https://openalex.org/I2802074625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030631262","display_name":"Jasmine Singh Sukumar","orcid":"https://orcid.org/0000-0001-6994-8527","observed_orcids":["https://orcid.org/0000-0001-6994-8527"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmine Sukumar","raw_affiliation_strings":["Department of Breast Medical Oncology MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Medical Oncology MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086903918","display_name":"Maryam B. Lustberg","orcid":"https://orcid.org/0000-0001-8559-5645","observed_orcids":["https://orcid.org/0000-0001-8559-5645"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam B. Lustberg","raw_affiliation_strings":["Department of Breast Medical Oncology Yale Cancer Center, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Medical Oncology Yale Cancer Center, New Haven, CT, USA","institution_ids":["https://openalex.org/I2802730090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802074625"],"apc_list":null,"apc_paid":null,"fwci":8.2144,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.98282136,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"14","issue":"2","first_page":"196","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cancer-survivors","display_name":"cancer survivors","score":0.7400000095367432},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9610000252723694},{"id":"https://openalex.org/keywords/psychological-impact","display_name":"psychological impact","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.800000011920929},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7480000257492065},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.5600000023841858},{"id":"https://openalex.org/keywords/neuropathy-prevention","display_name":"neuropathy prevention","score":0.6620000004768372},{"id":"https://openalex.org/keywords/neuropathy-treatment","display_name":"neuropathy treatment","score":0.9539999961853027},{"id":"https://openalex.org/keywords/functional-status","display_name":"functional status","score":0.6349999904632568},{"id":"https://openalex.org/keywords/patient-experience","display_name":"patient experience","score":0.7020000219345093},{"id":"https://openalex.org/keywords/chemotherapy-induced-neurotoxicity","display_name":"chemotherapy-induced neurotoxicity","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9859904050827026},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.8357728719711304},{"id":"https://openalex.org/C2779289229","wikidata":"https://www.wikidata.org/wiki/Q17153857","display_name":"Chemotherapy-induced peripheral neuropathy","level":4,"score":0.7940772771835327},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6282185316085815},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5365737676620483},{"id":"https://openalex.org/C2983288658","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer chemotherapy","level":3,"score":0.4241715967655182},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3845757842063904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3760879337787628},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.14165830612182617},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08562919497489929}],"mesh":[{"descriptor_ui":"D000073116","descriptor_name":"Cancer Survivors","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21037/apm-24-154","doi":"https://doi.org/10.21037/apm-24-154","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apm-24-154","pdf_url":null,"source":{"id":"https://openalex.org/S2764761676","display_name":"Annals of Palliative Medicine","issn_l":"2224-5820","issn":["2224-5820","2224-5839"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Palliative Medicine","raw_type":"journal-article"},{"id":"pmid:40211744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40211744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of palliative medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/apm-24-154","doi":"https://doi.org/10.21037/apm-24-154","is_oa":true,"landing_page_url":"https://doi.org/10.21037/apm-24-154","pdf_url":null,"source":{"id":"https://openalex.org/S2764761676","display_name":"Annals of Palliative Medicine","issn_l":"2224-5820","issn":["2224-5820","2224-5839"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Palliative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2884870098","https://openalex.org/W4312210684","https://openalex.org/W2810254363","https://openalex.org/W862952031","https://openalex.org/W2613929012","https://openalex.org/W3011504162","https://openalex.org/W2360589500","https://openalex.org/W7161055500","https://openalex.org/W7165052080","https://openalex.org/W2788793264"],"abstract_inverted_index":{"Chemotherapy-induced":[0],"peripheral":[1,62],"neuropathy":[2],"(CIPN)":[3],"is":[4,59,78,169],"a":[5,204],"prevalent":[6],"and":[7,24,36,45,52,75,90,101,114,135,150,161,174,193,199,217],"often":[8],"debilitating":[9,182],"side":[10],"effect":[11],"faced":[12],"by":[13,61],"many":[14],"patients":[15,30,179],"undergoing":[16],"chemotherapy,":[17],"significantly":[18],"impacting":[19,48],"their":[20],"quality":[21,49,175,212],"of":[22,41,50,69,122,127,176,209,213],"life":[23,51,177],"functional":[25,218],"status.":[26,219],"Psychological":[27],"impact":[28,208],"in":[29,55,167,178],"with":[31,120,203],"CIPN":[32,58,128,139,168,210],"remains":[33],"widely":[34],"understudied":[35],"can":[37],"range":[38],"from":[39,86],"symptoms":[40,84],"sadness,":[42],"fear,":[43],"depression,":[44],"anxiety,":[46],"substantially":[47],"daily":[53],"functioning":[54],"cancer":[56],"survivors.":[57],"characterized":[60],"nerve":[63],"damage":[64],"due":[65],"to":[66,130,147,156],"neurotoxic":[67],"effects":[68],"chemotherapeutic":[70,99],"agents.":[71],"However,":[72],"the":[73,97,154,189,207],"pathophysiology":[74],"exact":[76],"mechanism":[77],"not":[79],"fully":[80],"understood.":[81],"Patients":[82],"experience":[83,216],"ranging":[85],"numbness,":[87],"tingling,":[88],"pain,":[89],"motor":[91],"dysfunction.":[92],"Various":[93],"clinical":[94,190],"factors":[95],"[e.g.,":[96],"specific":[98],"agents":[100],"dosing,":[102],"patient":[103,215],"characteristics":[104],"such":[105],"as":[106],"body":[107],"mass":[108],"index":[109],"(BMI),":[110],"age,":[111],"race,":[112],"genetics":[113],"co-morbid":[115],"conditions]":[116],"have":[117],"been":[118],"associated":[119],"risk":[121,195],"developing":[123],"CIPN.":[124],"The":[125],"prevalence":[126],"continues":[129],"increase;":[131],"however,":[132],"effective":[133],"preventive":[134,159],"treatment":[136,143],"strategies":[137,144,160,202],"for":[138,171],"remain":[140],"limited.":[141],"Current":[142],"are":[145],"limited":[146],"dose":[148],"adjustments":[149],"symptomatic":[151],"relief,":[152],"highlighting":[153],"need":[155],"identify":[157],"evidenced-based":[158],"well":[162],"beneficial":[163],"therapeutics.":[164],"Further":[165],"research":[166],"essential":[170],"improving":[172],"outcomes":[173],"experiencing":[180],"this":[181,185],"condition.":[183],"In":[184],"review,":[186],"we":[187],"examine":[188],"presentation,":[191],"incidence":[192],"prevalence,":[194],"factors,":[196],"diagnostic":[197],"evaluation,":[198],"current":[200],"preventive/treatment":[201],"focus":[205],"on":[206,211],"life,":[214]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-03-28T00:00:00"}