{"id":"https://openalex.org/W4408884673","doi":"https://doi.org/10.1002/alz.14367","title":"Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries","display_name":"Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4408884673","doi":"https://doi.org/10.1002/alz.14367","pmid":"https://pubmed.ncbi.nlm.nih.gov/38645114","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030471"},"language":"en","primary_location":{"id":"doi:10.1002/alz.14367","doi":"https://doi.org/10.1002/alz.14367","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.14367","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14367","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14367","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089163662","display_name":"Anthony J. Griswold","orcid":"https://orcid.org/0000-0003-1925-7810","observed_orcids":["https://orcid.org/0000-0003-1925-7810"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony J. Griswold","raw_affiliation_strings":["Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030847656","display_name":"Farid Rajabli","orcid":"https://orcid.org/0000-0001-5229-7254","observed_orcids":["https://orcid.org/0000-0001-5229-7254"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farid Rajabli","raw_affiliation_strings":["Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012761829","display_name":"Tianjie Gu","orcid":"https://orcid.org/0009-0003-8525-5220","observed_orcids":["https://orcid.org/0009-0003-8525-5220"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianjie Gu","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015795110","display_name":"Jamie Arvizu","orcid":"https://orcid.org/0009-0004-8733-160X","observed_orcids":["https://orcid.org/0009-0004-8733-160X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Arvizu","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075903136","display_name":"Charles G. Golightly","orcid":"https://orcid.org/0000-0001-6256-9153","observed_orcids":["https://orcid.org/0000-0001-6256-9153"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles G. Golightly","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032798711","display_name":"Patrice L. Whitehead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrice L. Whitehead","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040175506","display_name":"Kara L. Hamilton\u2010Nelson","orcid":"https://orcid.org/0000-0003-3748-7193","observed_orcids":["https://orcid.org/0000-0003-3748-7193"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara L. Hamilton\u2010Nelson","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109439277","display_name":"Larry Deon Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry D. Adams","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jose J. Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose J. Sanchez","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075700154","display_name":"Pedro Ramon Mena","orcid":"https://orcid.org/0000-0003-2150-2977","observed_orcids":["https://orcid.org/0000-0003-2150-2977"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro R. Mena","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061338695","display_name":"Takiyah D. Starks","orcid":"https://orcid.org/0000-0001-7267-3480","observed_orcids":["https://orcid.org/0000-0001-7267-3480"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takiyah D. Starks","raw_affiliation_strings":["Maya Angelou Center for Health Equity Wake Forest University Winston\u2010Salem North Carolina USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maya Angelou Center for Health Equity Wake Forest University Winston\u2010Salem North Carolina USA","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023899730","display_name":"Maryenela Illanes\u2010Manrique","orcid":"https://orcid.org/0000-0002-3098-0981","observed_orcids":["https://orcid.org/0000-0002-3098-0981"]},"institutions":[{"id":"https://openalex.org/I4387153184","display_name":"Instituto Nacional de Ciencias Neurol\u00f3gicas","ror":"https://ror.org/00hmkqz52","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4210149555","https://openalex.org/I4387153184"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Maryenela Illanes\u2010Manrique","raw_affiliation_strings":["Neurogenetics Research Center Instituto Nacional de Ciencias Neurologicas Lima Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Research Center Instituto Nacional de Ciencias Neurologicas Lima Peru","institution_ids":["https://openalex.org/I4387153184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009968156","display_name":"Concepcion Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201879955","display_name":"Central University of the Caribbean","ror":"https://ror.org/01rpmzy83","country_code":"PR","type":"education","lineage":["https://openalex.org/I201879955"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Concepcion Silva","raw_affiliation_strings":["Department of Internal Medicine Universidad Central Del Caribe Bayam\u00f3n Puerto Rico USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Universidad Central Del Caribe Bayam\u00f3n Puerto Rico USA","institution_ids":["https://openalex.org/I201879955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066140517","display_name":"William S. Bush","orcid":"https://orcid.org/0000-0002-9729-6519","observed_orcids":["https://orcid.org/0000-0002-9729-6519"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S. Bush","raw_affiliation_strings":["Cleveland Institute for Computational Biology Case Western Reserve University Cleveland Ohio USA","Department of Population & Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Institute for Computational Biology Case Western Reserve University Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Population & Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039221620","display_name":"Michael L. Cuccaro","orcid":"https://orcid.org/0000-0003-4769-0785","observed_orcids":["https://orcid.org/0000-0003-4769-0785"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Cuccaro","raw_affiliation_strings":["Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039717261","display_name":"Jeffery M. Vance","orcid":"https://orcid.org/0000-0003-3815-8199","observed_orcids":["https://orcid.org/0000-0003-3815-8199"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery M. Vance","raw_affiliation_strings":["Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000059029","display_name":"Mario Cornejo\u2010Olivas","orcid":"https://orcid.org/0000-0001-6313-5680","observed_orcids":["https://orcid.org/0000-0001-6313-5680"]},"institutions":[{"id":"https://openalex.org/I4387153184","display_name":"Instituto Nacional de Ciencias Neurol\u00f3gicas","ror":"https://ror.org/00hmkqz52","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4210149555","https://openalex.org/I4387153184"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Mario R. Cornejo\u2010Olivas","raw_affiliation_strings":["Neurogenetics Research Center Instituto Nacional de Ciencias Neurologicas Lima Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Research Center Instituto Nacional de Ciencias Neurologicas Lima Peru","institution_ids":["https://openalex.org/I4387153184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060686570","display_name":"Briseida E. Feliciano\u2010Astacio","orcid":"https://orcid.org/0000-0003-4747-8928","observed_orcids":["https://orcid.org/0000-0003-4747-8928"]},"institutions":[{"id":"https://openalex.org/I201879955","display_name":"Central University of the Caribbean","ror":"https://ror.org/01rpmzy83","country_code":"PR","type":"education","lineage":["https://openalex.org/I201879955"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Briseida E. Feliciano\u2010Astacio","raw_affiliation_strings":["Department of Internal Medicine Universidad Central Del Caribe Bayam\u00f3n Puerto Rico USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Universidad Central Del Caribe Bayam\u00f3n Puerto Rico USA","institution_ids":["https://openalex.org/I201879955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032846688","display_name":"Goldie S. Byrd","orcid":"https://orcid.org/0000-0003-1057-0261","observed_orcids":["https://orcid.org/0000-0003-1057-0261"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Goldie S. Byrd","raw_affiliation_strings":["Maya Angelou Center for Health Equity Wake Forest University Winston\u2010Salem North Carolina USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maya Angelou Center for Health Equity Wake Forest University Winston\u2010Salem North Carolina USA","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020855307","display_name":"Gary W. Beecham","orcid":"https://orcid.org/0000-0002-7061-6332","observed_orcids":["https://orcid.org/0000-0002-7061-6332"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary W. Beecham","raw_affiliation_strings":["Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020266650","display_name":"Jonathan L. Haines","orcid":"https://orcid.org/0000-0002-4351-4728","observed_orcids":["https://orcid.org/0000-0002-4351-4728"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan L. Haines","raw_affiliation_strings":["Cleveland Institute for Computational Biology Case Western Reserve University Cleveland Ohio USA","Department of Population & Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Institute for Computational Biology Case Western Reserve University Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Population & Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069324665","display_name":"Margaret Ann Pericak\u2010Vance","orcid":"https://orcid.org/0000-0001-7283-8804","observed_orcids":["https://orcid.org/0000-0001-7283-8804","https://orcid.org/0000-0002-3309-1303"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Pericak\u2010Vance","raw_affiliation_strings":["Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T Macdonald Foundation Department of Human Genetics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089163662"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":{"value":4200,"currency":"USD","value_usd":4200},"fwci":5.9683,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.96707233,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"21","issue":"3","first_page":"e14367","last_page":"e14367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8475358486175537},{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.7396060824394226},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5668331384658813},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5001945495605469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49822139739990234},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4759352207183838},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.44953209161758423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4073338806629181},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.350810706615448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29013675451278687},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27005231380462646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2403496503829956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2386370301246643},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.19905292987823486},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.07808992266654968}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1002/alz.14367","doi":"https://doi.org/10.1002/alz.14367","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.14367","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14367","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},{"id":"doi:10.1101/2024.04.10.24305617","doi":"https://doi.org/10.1101/2024.04.10.24305617","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.04.10.24305617","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/04/12/2024.04.10.24305617.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11936763","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11936763","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement","raw_type":"Text"},{"id":"pmid:38645114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38645114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Preprint"},{"id":"pmid:40133765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40133765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia : the journal of the Alzheimer's Association","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11030471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030471","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11030471/pdf/nihpp-2024.04.10.24305617v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/alz.14367","doi":"https://doi.org/10.1002/alz.14367","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.14367","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14367","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1338552347","display_name":"Genomic, Epigenomic, and Transcriptomic Mechanisms of Contributing to Alzheimer's Disease Risk in Diverse Ancestral Populations","funder_award_id":"RF1AG070935","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3834659764","display_name":"Neuroanatomical associations with the factor structure underlying neuropsychiatric symptoms in Alzheimer's disease","funder_award_id":"R01AG062268","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4485214244","display_name":"Replication and Extension of ADSP Discoveries in African-Americans","funder_award_id":"U01AG052410","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5219604940","display_name":"Whole Genome Sequencing in Ethnically Diverse Cohorts for the ADSP Follow-Up Study (FUS)","funder_award_id":"U01AG057659","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5893835595","display_name":"Additional Sequencing Cohorts for the Alzheimer's Disease Sequencing Project","funder_award_id":"U01AG062943","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7389159272","display_name":"Using RDoC Negative and Positive Valence Paradigms to Investigate the Mechanisms of Neuropsychiatric Symptoms (NPS) in Alzheimer's Disease and Related Dementias","funder_award_id":"R01MH120794","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G787256302","display_name":"The Origins of Alzheimer Disease in Individuals of African Ancestry","funder_award_id":"R56AG072547","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000269964","display_name":null,"funder_award_id":"AG074865","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000273041","display_name":null,"funder_award_id":"AG072547","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000861639","display_name":"Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic Ancestry","funder_award_id":"R01AG070864","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000864943","display_name":"The Origins of Alzheimer Disease in African Americans","funder_award_id":"R01AG072547","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000885427","display_name":"Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American Ancestries","funder_award_id":"U01AG084545","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000889615","display_name":"Genetic and neuroanatomical basis of neuropsychiatric symptoms in Alzheimer's disease in populations of diverse ancestry","funder_award_id":"U01AG079850","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000895417","display_name":"Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)","funder_award_id":"U19AG074865","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000909230","display_name":"Genomic, Epigenomic, and Transcriptomic Mechanisms of Contributing to Alzheimer's Disease Risk in Diverse Ancestral Populations","funder_award_id":"R01AG070935","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408884673.pdf","grobid_xml":"https://content.openalex.org/works/W4408884673.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W573909598","https://openalex.org/W1499597724","https://openalex.org/W1596841969","https://openalex.org/W1970424036","https://openalex.org/W1981802311","https://openalex.org/W1991411120","https://openalex.org/W1996506645","https://openalex.org/W2006617902","https://openalex.org/W2007317410","https://openalex.org/W2020692998","https://openalex.org/W2033295623","https://openalex.org/W2044447672","https://openalex.org/W2056008497","https://openalex.org/W2083390520","https://openalex.org/W2091858036","https://openalex.org/W2102213696","https://openalex.org/W2115017507","https://openalex.org/W2119444539","https://openalex.org/W2129990146","https://openalex.org/W2131228118","https://openalex.org/W2159267296","https://openalex.org/W2161341842","https://openalex.org/W2165840723","https://openalex.org/W2170087560","https://openalex.org/W2171439968","https://openalex.org/W2172079354","https://openalex.org/W2254509181","https://openalex.org/W2550934658","https://openalex.org/W2582524520","https://openalex.org/W2774486220","https://openalex.org/W2790742207","https://openalex.org/W2886870891","https://openalex.org/W2902034093","https://openalex.org/W2906702113","https://openalex.org/W2916749909","https://openalex.org/W2922534626","https://openalex.org/W2962685339","https://openalex.org/W2966365568","https://openalex.org/W2973037195","https://openalex.org/W2999417355","https://openalex.org/W3009441391","https://openalex.org/W3018431352","https://openalex.org/W3045997188","https://openalex.org/W3106852472","https://openalex.org/W3126187484","https://openalex.org/W3146983201","https://openalex.org/W3215097377","https://openalex.org/W4200292595","https://openalex.org/W4230063602","https://openalex.org/W4241726394","https://openalex.org/W4242839013","https://openalex.org/W4251246996","https://openalex.org/W4293828794","https://openalex.org/W4295107480","https://openalex.org/W4324309277","https://openalex.org/W4385878323","https://openalex.org/W4390640632"],"related_works":["https://openalex.org/W4406209993","https://openalex.org/W4390199813","https://openalex.org/W4312086548","https://openalex.org/W4416076874","https://openalex.org/W4221046843","https://openalex.org/W4405984776","https://openalex.org/W4411078080","https://openalex.org/W4405889468","https://openalex.org/W4206765709","https://openalex.org/W7161536575"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Plasma":[1,170,189,199],"phosphorylated":[2,190],"threonine":[3],"181":[4],"of":[5,20,34,45,75,91,151,165],"tau":[6,191],"(pTau181)":[7],"and":[8,17,53,59,66,70,83,142,154,179],"amyloid":[9],"beta":[10],"(A\u03b2)":[11],"are":[12],"biomarkers":[13,63,78,167,171],"for":[14,126,168],"differential":[15],"diagnosis":[16,68],"preclinical":[18],"detection":[19],"Alzheimer":[21],"disease":[22],"(AD).":[23],"Given":[24],"differences":[25],"in":[26,62,174,194,196,202],"AD":[27,128,195],"risk":[28,153],"across":[29,87,131,185],"diverse":[30,46,146,162,187,203],"populations,":[31],"the":[32,71,76,112,115,186],"generalizability":[33],"existing":[35,208],"biomarker":[36,125,143,200],"data":[37,144],"is":[38,129,160],"not":[39],"assured.":[40],"METHODS:":[41],"In":[42],"2086":[43],"individuals":[44,147],"genetic":[47,132,152],"ancestries":[48],"(African":[49],"American,":[50],"Caribbean":[51,177],"Hispanic,":[52],"Peruvian),":[54],"we":[55],"measured":[56],"plasma":[57,124,166],"pTau181":[58,82,92,103,121],"A\u03b242/A\u03b240.":[60],"Differences":[61],"between":[64,118],"cohorts":[65,204],"clinical":[67,127,156],"groups":[69],"potential":[72],"discriminative":[73],"performance":[74],"two":[77],"were":[79,85,93,172,183],"assessed.":[80],"RESULTS:":[81],"A\u03b242/A\u03b240":[84,98],"consistent":[86,184],"cohorts.":[88,119,188,198],"Higher":[89],"levels":[90,182],"associated":[94],"with":[95,207],"AD,":[96],"while":[97],"had":[99,104],"minimal":[100],"differences.":[101],"Correspondingly,":[102],"a":[105,123,161],"greater":[106],"predictive":[107,136],"value":[108,137],"than":[109],"A\u03b242/A\u03b240;":[110],"however,":[111],"area":[113],"under":[114],"curve":[116],"differed":[117],"DISCUSSION:":[120],"as":[122],"generalizable":[130],"ancestries,":[133],"but":[134],"its":[135],"may":[138],"vary.":[139],"Combining":[140],"genomic":[141],"from":[145],"will":[148],"increase":[149],"understanding":[150],"refine":[155],"diagnoses.":[157],"HIGHLIGHTS:":[158],"This":[159],"ancestry":[163],"study":[164],"AD.":[169],"assessed":[173],"African":[175],"Americans,":[176],"Hispanics,":[178],"Peruvians.":[180],"Biomarker":[181],"was":[192],"higher":[193],"all":[197],"findings":[201],"largely":[205],"generalize":[206],"European":[209],"studies.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2025-03-27T00:00:00"}