{"id":"https://openalex.org/W4408851156","doi":"https://doi.org/10.5772/intechopen.1009796","title":"Wolbachia: From Natural Variation to Genetic Engineering \u2013 Exploring Gene-Level Approaches for Next-Generation Dengue Control","display_name":"Wolbachia: From Natural Variation to Genetic Engineering \u2013 Exploring Gene-Level Approaches for Next-Generation Dengue Control","publication_year":2025,"publication_date":"2025-03-24","ids":{"openalex":"https://openalex.org/W4408851156","doi":"https://doi.org/10.5772/intechopen.1009796"},"language":"en","primary_location":{"id":"doi:10.5772/intechopen.1009796","doi":"https://doi.org/10.5772/intechopen.1009796","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.1009796","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Replication and Production","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4407544582","display_name":"Viral Replication and Production"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5772/intechopen.1009796","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107809161","display_name":"Iqra Mushtaq","orcid":"https://orcid.org/0000-0003-3610-586X","observed_orcids":["https://orcid.org/0000-0003-3610-586X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iqra Mushtaq","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ammara Chaudhry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ammara Chaudhry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025590991","display_name":"Muhammad Sajjad Sarwar","orcid":"https://orcid.org/0000-0002-6056-5906","observed_orcids":["https://orcid.org/0000-0002-6056-5906"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Muhammad Sajjad Sarwar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025590991"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7246,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.8094804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14053","display_name":"Dengue and Mosquito Control Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wolbachia","display_name":"Wolbachia","score":1.0},{"id":"https://openalex.org/keywords/dengue-control","display_name":"dengue control","score":0.8629999756813049},{"id":"https://openalex.org/keywords/aedes-aegypti","display_name":"Aedes aegypti","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mosquito-borne-viruses","display_name":"mosquito-borne viruses","score":0.503000020980835},{"id":"https://openalex.org/keywords/antiviral-mechanism","display_name":"antiviral mechanism","score":0.7739999890327454},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gene-drive","display_name":"gene drive","score":0.7239999771118164},{"id":"https://openalex.org/keywords/integrated-vector-management","display_name":"integrated vector management","score":0.6930000185966492},{"id":"https://openalex.org/keywords/insecticide-resistance","display_name":"insecticide resistance","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2779356413","wikidata":"https://www.wikidata.org/wiki/Q283526","display_name":"Wolbachia","level":3,"score":0.8872849941253662},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.7435448169708252},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.4933291971683502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34888753294944763},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3259790539741516},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.32463568449020386},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.28642237186431885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26796865463256836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1881970465183258},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11522531509399414},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5772/intechopen.1009796","doi":"https://doi.org/10.5772/intechopen.1009796","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.1009796","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Replication and Production","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.5772/intechopen.1009796","doi":"https://doi.org/10.5772/intechopen.1009796","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.1009796","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Replication and Production","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W1503212032","https://openalex.org/W1546964919","https://openalex.org/W1592352451","https://openalex.org/W1599389506","https://openalex.org/W1894874618","https://openalex.org/W1963710629","https://openalex.org/W1964717435","https://openalex.org/W1968774761","https://openalex.org/W1974046518","https://openalex.org/W1978933919","https://openalex.org/W1990863491","https://openalex.org/W1998312410","https://openalex.org/W1998504160","https://openalex.org/W2000414525","https://openalex.org/W2009246694","https://openalex.org/W2010188273","https://openalex.org/W2012819636","https://openalex.org/W2017971345","https://openalex.org/W2022870110","https://openalex.org/W2026369176","https://openalex.org/W2029593468","https://openalex.org/W2030942380","https://openalex.org/W2032451726","https://openalex.org/W2038357425","https://openalex.org/W2041602338","https://openalex.org/W2053184996","https://openalex.org/W2058647993","https://openalex.org/W2059914344","https://openalex.org/W2071986366","https://openalex.org/W2073727854","https://openalex.org/W2074607858","https://openalex.org/W2086729562","https://openalex.org/W2092133388","https://openalex.org/W2092911406","https://openalex.org/W2103438957","https://openalex.org/W2104024599","https://openalex.org/W2108367829","https://openalex.org/W2109666873","https://openalex.org/W2117672421","https://openalex.org/W2117855998","https://openalex.org/W2119001766","https://openalex.org/W2120118602","https://openalex.org/W2121527356","https://openalex.org/W2127359880","https://openalex.org/W2129254023","https://openalex.org/W2130263048","https://openalex.org/W2131112023","https://openalex.org/W2132582148","https://openalex.org/W2133250947","https://openalex.org/W2139568003","https://openalex.org/W2144906215","https://openalex.org/W2147199713","https://openalex.org/W2147402521","https://openalex.org/W2149765059","https://openalex.org/W2152112238","https://openalex.org/W2157982193","https://openalex.org/W2161135891","https://openalex.org/W2163412375","https://openalex.org/W2175374927","https://openalex.org/W2178187214","https://openalex.org/W2181243794","https://openalex.org/W2236625349","https://openalex.org/W2263233808","https://openalex.org/W2296845215","https://openalex.org/W2329113514","https://openalex.org/W2584730025","https://openalex.org/W2593335798","https://openalex.org/W2612679922","https://openalex.org/W2738161666","https://openalex.org/W2754511195","https://openalex.org/W2765596610","https://openalex.org/W2791412679","https://openalex.org/W2793982080","https://openalex.org/W2887559142","https://openalex.org/W2921581323","https://openalex.org/W2952094509","https://openalex.org/W2982043918","https://openalex.org/W2989624559","https://openalex.org/W3005081427","https://openalex.org/W3006509283","https://openalex.org/W3011384725","https://openalex.org/W3035470802","https://openalex.org/W3040411189","https://openalex.org/W3042765841","https://openalex.org/W3049708941","https://openalex.org/W3099407617","https://openalex.org/W3107755582","https://openalex.org/W3128142575","https://openalex.org/W3181394094","https://openalex.org/W3182114573","https://openalex.org/W3187027166","https://openalex.org/W4286485043","https://openalex.org/W4291021208","https://openalex.org/W4302288072","https://openalex.org/W4361293557","https://openalex.org/W4378782363","https://openalex.org/W4390056099","https://openalex.org/W4404638197"],"related_works":["https://openalex.org/W4406926869","https://openalex.org/W7164811634","https://openalex.org/W4256140328","https://openalex.org/W7161939429","https://openalex.org/W1221657869","https://openalex.org/W2098594887","https://openalex.org/W1972541583","https://openalex.org/W2761571099","https://openalex.org/W4402956073","https://openalex.org/W2727756598"],"abstract_inverted_index":{"Dengue":[0],"fever":[1],"poses":[2],"a":[3,46,135],"significant":[4],"global":[5,149],"health":[6],"challenge,":[7],"particularly":[8],"in":[9,31,53,65,106,123],"tropical":[10],"and":[11,28,73,93,126,142,157],"subtropical":[12],"regions.":[13],"Current":[14],"control":[15],"strategies,":[16],"heavily":[17],"reliant":[18],"on":[19],"vector":[20,140],"control,":[21],"face":[22],"limitations":[23],"due":[24],"to":[25,76,168],"insecticide":[26],"resistance":[27],"logistical":[29],"challenges":[30,121],"large":[32],"urban":[33],"areas.":[34],"This":[35,78],"book":[36],"chapter":[37,79],"explores":[38],"the":[39,57,71,81,100,111,127,148],"innovative":[40],"potential":[41,112,128],"of":[42,102,151],"Wolbachia":[43,51,172],"bacteria":[44],"as":[45,161],"biocontrol":[47],"agent":[48],"against":[49],"dengue.":[50],"infection":[52],"Aedes":[54],"aegypti":[55],"mosquitoes,":[56],"primary":[58],"dengue":[59,116,152],"vector,":[60],"has":[61],"demonstrated":[62],"promising":[63],"results":[64],"reducing":[66,147],"both":[67,89],"viral":[68,130],"replication":[69],"within":[70],"mosquito":[72],"onward":[74],"transmission":[75],"humans.":[77],"examines":[80],"complex":[82],"mechanisms":[83],"underlying":[84],"Wolbachia\u2019s":[85],"antiviral":[86],"effects,":[87,109],"including":[88],"immune":[90],"system":[91],"modulation":[92],"competition":[94],"for":[95,113,129,138,146],"host":[96],"cell":[97],"resources.":[98],"Furthermore,":[99],"role":[101],"gene":[103],"expression":[104],"changes":[105],"mediating":[107],"these":[108],"highlighting":[110],"long-term,":[114],"sustainable":[115],"suppression,":[117],"is":[118],"discussed.":[119],"While":[120],"remain":[122],"large-scale":[124],"implementation":[125],"evolution,":[131],"Wolbachia-based":[132],"interventions":[133],"offer":[134],"new":[136],"avenue":[137],"integrated":[139],"management":[141],"hold":[143],"considerable":[144],"promise":[145],"burden":[150],"fever.":[153],"Gene":[154],"drive":[155],"technology":[156],"thorough":[158],"testing,":[159],"such":[160],"analyzing":[162],"virus":[163],"sequences,":[164],"are":[165],"also":[166],"discussed":[167],"evaluate":[169],"how":[170],"well":[171],"works.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-26T00:00:00"}
