{"id":"https://openalex.org/W4408841908","doi":"https://doi.org/10.1021/acsnano.5c00433","title":"Unveiling the Assembly Transition of Diphenylalanine and Its Analogs: from Oligomer Equilibrium to Nanocluster Formation","display_name":"Unveiling the Assembly Transition of Diphenylalanine and Its Analogs: from Oligomer Equilibrium to Nanocluster Formation","publication_year":2025,"publication_date":"2025-03-26","ids":{"openalex":"https://openalex.org/W4408841908","doi":"https://doi.org/10.1021/acsnano.5c00433","pmid":"https://pubmed.ncbi.nlm.nih.gov/40134347"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.5c00433","doi":"https://doi.org/10.1021/acsnano.5c00433","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5c00433","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.dora.lib4ri.ch/psi/dload/psi:69261/PDF3/view","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Chang Liu","raw_affiliation_strings":["PSI","PSI Center for Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PSI","institution_ids":["https://openalex.org/I2802229908"]},{"raw_affiliation_string":"PSI Center for Life Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086125952","display_name":"Yoav Dan","orcid":"https://orcid.org/0000-0002-3683-0474","observed_orcids":["https://orcid.org/0000-0002-3683-0474"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yoav Dan","raw_affiliation_strings":["Department of Oral Biology, The Goldschleger School of Dental Medicine, Faculty of Medical & Health Sciences","Jan Koum Center for Nanoscience and Nanotechnology","Tel-Aviv University","The Center for Physics & Chemistry of Living Systems"],"raw_orcid":"https://orcid.org/0000-0002-3683-0474","affiliations":[{"raw_affiliation_string":"Department of Oral Biology, The Goldschleger School of Dental Medicine, Faculty of Medical & Health Sciences","institution_ids":[]},{"raw_affiliation_string":"Jan Koum Center for Nanoscience and Nanotechnology","institution_ids":[]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The Center for Physics & Chemistry of Living Systems","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ji Yun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ji Yun","raw_affiliation_strings":["Department of Biology","University of Bern"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology","institution_ids":[]},{"raw_affiliation_string":"University of Bern","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025739895","display_name":"Lihi Adler\u2010Abramovich","orcid":"https://orcid.org/0000-0003-3433-0625","observed_orcids":["https://orcid.org/0000-0003-3433-0625"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lihi Adler-Abramovich","raw_affiliation_strings":["Department of Oral Biology, The Goldschleger School of Dental Medicine, Faculty of Medical & Health Sciences","Jan Koum Center for Nanoscience and Nanotechnology","Tel-Aviv University","The Center for Physics & Chemistry of Living Systems"],"raw_orcid":"https://orcid.org/0000-0003-3433-0625","affiliations":[{"raw_affiliation_string":"Department of Oral Biology, The Goldschleger School of Dental Medicine, Faculty of Medical & Health Sciences","institution_ids":[]},{"raw_affiliation_string":"Jan Koum Center for Nanoscience and Nanotechnology","institution_ids":[]},{"raw_affiliation_string":"Tel-Aviv University","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The Center for Physics & Chemistry of Living Systems","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017067673","display_name":"Jinghui Luo","orcid":"https://orcid.org/0000-0002-7014-8153","observed_orcids":["https://orcid.org/0000-0002-7014-8153","https://orcid.org/0009-0002-5549-7520"]},"institutions":[{"id":"https://openalex.org/I2802229908","display_name":"Paul Scherrer Institute","ror":"https://ror.org/03eh3y714","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I2802229908"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jinghui Luo","raw_affiliation_strings":["PSI","PSI Center for Life Sciences"],"raw_orcid":"https://orcid.org/0000-0002-7014-8153","affiliations":[{"raw_affiliation_string":"PSI","institution_ids":["https://openalex.org/I2802229908"]},{"raw_affiliation_string":"PSI Center for Life Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017067673"],"corresponding_institution_ids":["https://openalex.org/I2802229908"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02073983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"13","first_page":"13250","last_page":"13263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diphenylalanine","display_name":"diphenylalanine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/peptide-self-assembly","display_name":"peptide self-assembly","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oligomerization-kinetics","display_name":"oligomerization kinetics","score":0.6430000066757202},{"id":"https://openalex.org/keywords/low-molecular-weight-oligomers","display_name":"low molecular weight oligomers","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nanocluster-formation","display_name":"nanocluster formation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/supramolecular-structure","display_name":"supramolecular structure","score":0.597000002861023},{"id":"https://openalex.org/keywords/secondary-structure","display_name":"secondary structure","score":0.5550000071525574},{"id":"https://openalex.org/keywords/mass-photometry","display_name":"mass photometry","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.8617365956306458},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5083093047142029},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.49949097633361816},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.45117515325546265},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3589811325073242},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.33022984862327576},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.32078349590301514},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.18816512823104858},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acsnano.5c00433","doi":"https://doi.org/10.1021/acsnano.5c00433","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5c00433","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:40134347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40134347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"},{"id":"pmh:oai:dora:psi_69261","doi":null,"is_oa":true,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:69261","pdf_url":"https://www.dora.lib4ri.ch/psi/dload/psi:69261/PDF3/view","source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Nano","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:doi:10.48620/87493","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/208905","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:dora:psi_69261","doi":null,"is_oa":true,"landing_page_url":"https://www.dora.lib4ri.ch/psi/item/psi:69261","pdf_url":"https://www.dora.lib4ri.ch/psi/dload/psi:69261/PDF3/view","source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Nano","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1057335504","display_name":"Effects of molecular glues on amyloid protein oligomerization and assembly for potential chemical degradation in the cellular machinery","funder_award_id":"10002967","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2446968241","display_name":"Structure determination of amyloid oligomer displayed on a functionally and structurally relevant scaffold","funder_award_id":"197626","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G377172898","display_name":"Multifunctional Personalized Self-Assembled Biomaterials for Bone Regeneration","funder_award_id":"948102","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G6108673378","display_name":null,"funder_award_id":"2422/24","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G79902365","display_name":null,"funder_award_id":"202106260035","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G8238088463","display_name":"Structure determination of Alzheimer and Parkinson associated oligomers in lipidic cubic phase","funder_award_id":"A20201759S","funder_id":"https://openalex.org/F4320308990","funder_display_name":"BrightFocus Foundation"}],"funders":[{"id":"https://openalex.org/F4320308990","display_name":"BrightFocus Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408841908.pdf","grobid_xml":"https://content.openalex.org/works/W4408841908.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1227630998","https://openalex.org/W1481393922","https://openalex.org/W1528511554","https://openalex.org/W1580458257","https://openalex.org/W1940710031","https://openalex.org/W1963805451","https://openalex.org/W1970248675","https://openalex.org/W1970874743","https://openalex.org/W1993527536","https://openalex.org/W1998991819","https://openalex.org/W2004546493","https://openalex.org/W2007593295","https://openalex.org/W2008146123","https://openalex.org/W2013455144","https://openalex.org/W2024420279","https://openalex.org/W2025607001","https://openalex.org/W2030683115","https://openalex.org/W2036227819","https://openalex.org/W2057038469","https://openalex.org/W2063118926","https://openalex.org/W2071306911","https://openalex.org/W2072327749","https://openalex.org/W2086145691","https://openalex.org/W2088090794","https://openalex.org/W2107290421","https://openalex.org/W2108058966","https://openalex.org/W2114648545","https://openalex.org/W2127407003","https://openalex.org/W2294780803","https://openalex.org/W2298216719","https://openalex.org/W2322972210","https://openalex.org/W2342925174","https://openalex.org/W2507241899","https://openalex.org/W2511181291","https://openalex.org/W2603399854","https://openalex.org/W2620672869","https://openalex.org/W2745090873","https://openalex.org/W2748622848","https://openalex.org/W2765546463","https://openalex.org/W2790899814","https://openalex.org/W2801084441","https://openalex.org/W2809560694","https://openalex.org/W2892075913","https://openalex.org/W2901324150","https://openalex.org/W2903318472","https://openalex.org/W2939512899","https://openalex.org/W2980466050","https://openalex.org/W3045914804","https://openalex.org/W3096298772","https://openalex.org/W3113311955","https://openalex.org/W3162034755","https://openalex.org/W3203844580","https://openalex.org/W3209616060","https://openalex.org/W4281751056","https://openalex.org/W4295498578","https://openalex.org/W4297243252","https://openalex.org/W4323348435","https://openalex.org/W4366084614","https://openalex.org/W4376224198","https://openalex.org/W4378071595","https://openalex.org/W4379619213","https://openalex.org/W4384523825","https://openalex.org/W4385564341","https://openalex.org/W4388465444","https://openalex.org/W4390098801","https://openalex.org/W4392489445","https://openalex.org/W4395005397","https://openalex.org/W4400870939"],"related_works":["https://openalex.org/W3029615903","https://openalex.org/W2292512574","https://openalex.org/W1829912350","https://openalex.org/W2383441779","https://openalex.org/W345422279","https://openalex.org/W2800250885","https://openalex.org/W2258142825","https://openalex.org/W2572847020","https://openalex.org/W2803925928","https://openalex.org/W2015435909"],"abstract_inverted_index":{"Peptide":[0],"self-assembly":[1],"is":[2,104,113],"fundamental":[3],"to":[4,139,151,173],"various":[5],"biological":[6],"processes":[7,205],"and":[8,14,46,54,68,92,119,128,165,185,243,255],"holds":[9],"significant":[10],"potential":[11],"for":[12,108,117,133,253],"nanotechnology":[13,254],"biomedical":[15,256],"applications.":[16,257],"Despite":[17],"progress":[18],"in":[19,73,158,225],"understanding":[20,220,248],"larger-scale":[21],"assemblies,":[22],"the":[23,37,41,56,82,89,102,105,111,114,126,141,147,159,175,202,207,226],"early":[24,83],"formation":[25,58,93,227],"of":[26,40,59,85,95,143,182,206,221,228,249],"low-molecular-weight":[27,96,229],"oligomers":[28,230],"remains":[29],"poorly":[30],"understood.":[31],"In":[32],"this":[33],"study,":[34],"we":[35,52,195],"investigate":[36],"aggregation":[38,160,204],"behavior":[39,91],"self-assembling":[42,209],"diphenylalanine":[43],"(FF)":[44],"peptide":[45,86,222],"its":[47],"analogs.":[48],"Utilizing":[49],"single-nanopore":[50],"analysis,":[51],"detected":[53],"characterized":[55],"low-molecular-oligomer":[57],"FF,":[60,109],"N":[61],"-":[62],"tert":[63],"-butoxycarbonyl-diphenylalanine":[64],"(BocFF),":[65],"fluorenylmethyloxycarbonyl-diphenylalanine":[66],"(FmocFF),":[67],"fluorenylmethyloxycarbonyl-pentafluoro-phenylalanine":[69],"(Fmoc-F":[70],"5":[71,121],"-Phe)":[72],"real":[74],"time.":[75],"This":[76,214],"approach":[77,216],"provided":[78],"detailed":[79,186],"insights":[80],"into":[81],"stages":[84],"self-assembly,":[87,223],"revealing":[88,146],"dynamic":[90],"kinetics":[94],"oligomeric":[97],"species.":[98],"Analysis":[99],"revealed":[100],"that":[101,200],"trimer":[103,129],"key":[106],"nucleus":[107,116],"while":[110],"dimer":[112,127],"primary":[115],"FmocFF":[118],"Fmoc-F":[120],"-Phe":[122],"aggregation,":[123],"whereas":[124],"both":[125],"serve":[130],"as":[131],"nuclei":[132],"BocFF.":[134],"Mass":[135],"photometry":[136],"was":[137],"employed":[138,172],"track":[140],"evolution":[142],"these":[144,193],"oligomers,":[145],"transition":[148],"from":[149],"low-":[150],"high-molecular-weight":[152],"species,":[153],"thereby":[154],"elucidating":[155],"intermediate":[156],"phases":[157],"process.":[161],"Transmission":[162],"electron":[163],"microscopy":[164],"Fourier":[166],"transform":[167],"infrared":[168],"spectroscopy":[169],"were":[170],"further":[171],"characterize":[174],"final":[176],"assembly":[177,241,251],"states,":[178],"offering":[179],"high-resolution":[180],"imaging":[181],"morphological":[183],"structures":[184],"information":[187],"on":[188,192,239],"secondary":[189],"structures.":[190,234],"Based":[191],"analyses,":[194],"constructed":[196],"a":[197,218],"comprehensive":[198],"graph":[199],"correlates":[201],"entire":[203],"tested":[208],"peptides":[210],"across":[211],"multiple":[212],"scales.":[213],"integrative":[215],"provides":[217],"holistic":[219],"particularly":[224],"toward":[231],"mature":[232],"supramolecular":[233],"These":[235],"findings":[236],"shed":[237],"light":[238],"their":[240,250],"pathways":[242,252],"structural":[244],"properties,":[245],"advancing":[246],"our":[247]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
