{"id":"https://openalex.org/W4408838804","doi":"https://doi.org/10.3389/fmicb.2025.1564675","title":"Advances in the study of the correlation between balanoposthitis and skin microecology","display_name":"Advances in the study of the correlation between balanoposthitis and skin microecology","publication_year":2025,"publication_date":"2025-03-26","ids":{"openalex":"https://openalex.org/W4408838804","doi":"https://doi.org/10.3389/fmicb.2025.1564675","pmid":"https://pubmed.ncbi.nlm.nih.gov/40207153","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11978672"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2025.1564675","doi":"https://doi.org/10.3389/fmicb.2025.1564675","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2025.1564675","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fmicb.2025.1564675","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100420890","display_name":"Mingyue Wang","orcid":"https://orcid.org/0000-0001-8317-3414","observed_orcids":["https://orcid.org/0000-0001-8317-3414","https://orcid.org/0009-0004-3893-5255"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyue Wang","raw_affiliation_strings":["Department of Dermatology, The First Hospital of China Medical University, Shenyang, China","Key Laboratory of Immunodermatology, Ministry of Education and NHC; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","Key Laboratory of Immunodermatology, Ministry of Education and NHC","National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I4210140515"]},{"raw_affiliation_string":"Key Laboratory of Immunodermatology, Ministry of Education and NHC; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Immunodermatology, Ministry of Education and NHC","institution_ids":[]},{"raw_affiliation_string":"National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xinghua Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinghua Gao","raw_affiliation_strings":["Department of Dermatology, The First Hospital of China Medical University, Shenyang, China","Key Laboratory of Immunodermatology, Ministry of Education and NHC; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","Key Laboratory of Immunodermatology, Ministry of Education and NHC","National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I4210140515"]},{"raw_affiliation_string":"Key Laboratory of Immunodermatology, Ministry of Education and NHC; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Immunodermatology, Ministry of Education and NHC","institution_ids":[]},{"raw_affiliation_string":"National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Department of Dermatology, The First Hospital of China Medical University, Shenyang, China","Key Laboratory of Immunodermatology, Ministry of Education and NHC; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","Key Laboratory of Immunodermatology, Ministry of Education and NHC","National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I4210140515"]},{"raw_affiliation_string":"Key Laboratory of Immunodermatology, Ministry of Education and NHC; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Immunodermatology, Ministry of Education and NHC","institution_ids":[]},{"raw_affiliation_string":"National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100425554"],"corresponding_institution_ids":["https://openalex.org/I4210140515"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.5944,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.51137847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1564675","last_page":"1564675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/balanoposthitis","display_name":"balanoposthitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glans-penis","display_name":"glans penis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/foreskin","display_name":"prepuce","score":0.9940000176429749},{"id":"https://openalex.org/keywords/microbial-colonization","display_name":"microbial colonization","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/intertrigo","display_name":"intertrigo","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/immune-mechanisms","display_name":"immune mechanisms","score":0.746999979019165},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2781140480","wikidata":"https://www.wikidata.org/wiki/Q673203","display_name":"Foreskin","level":3,"score":0.8516358137130737},{"id":"https://openalex.org/C120667501","wikidata":"https://www.wikidata.org/wiki/Q6839493","display_name":"Microecology","level":2,"score":0.7843328714370728},{"id":"https://openalex.org/C2778598218","wikidata":"https://www.wikidata.org/wiki/Q650891","display_name":"Glans penis","level":3,"score":0.7704657912254333},{"id":"https://openalex.org/C2777050469","wikidata":"https://www.wikidata.org/wiki/Q14290107","display_name":"Glans","level":3,"score":0.6045603156089783},{"id":"https://openalex.org/C2777786686","wikidata":"https://www.wikidata.org/wiki/Q58","display_name":"Penis","level":2,"score":0.5282175540924072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5018148422241211},{"id":"https://openalex.org/C2778426668","wikidata":"https://www.wikidata.org/wiki/Q1138584","display_name":"Balanitis","level":2,"score":0.4956573247909546},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.4173037111759186},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.38765841722488403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31983423233032227},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20250940322875977},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.15716779232025146},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.08502763509750366},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2025.1564675","doi":"https://doi.org/10.3389/fmicb.2025.1564675","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2025.1564675","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11978672","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11978672","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:40207153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40207153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bfbda960cbac48fb9f9b224cce33d624","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bfbda960cbac48fb9f9b224cce33d624","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2025.1564675","doi":"https://doi.org/10.3389/fmicb.2025.1564675","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2025.1564675","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W71214579","https://openalex.org/W103510145","https://openalex.org/W1594460566","https://openalex.org/W1602925213","https://openalex.org/W1848055118","https://openalex.org/W1975731555","https://openalex.org/W2001009396","https://openalex.org/W2001624282","https://openalex.org/W2013527817","https://openalex.org/W2020932661","https://openalex.org/W2026507301","https://openalex.org/W2038797605","https://openalex.org/W2047774330","https://openalex.org/W2053198704","https://openalex.org/W2055897950","https://openalex.org/W2068814873","https://openalex.org/W2071329285","https://openalex.org/W2092116660","https://openalex.org/W2099990988","https://openalex.org/W2144740366","https://openalex.org/W2151757727","https://openalex.org/W2162723913","https://openalex.org/W2162912997","https://openalex.org/W2163903854","https://openalex.org/W2165531896","https://openalex.org/W2315722591","https://openalex.org/W2351380634","https://openalex.org/W2429273920","https://openalex.org/W2438569264","https://openalex.org/W2611402155","https://openalex.org/W2619587583","https://openalex.org/W2619772777","https://openalex.org/W2772832352","https://openalex.org/W2773553976","https://openalex.org/W2775169685","https://openalex.org/W2784164089","https://openalex.org/W2891073947","https://openalex.org/W2900880727","https://openalex.org/W2901011713","https://openalex.org/W2922000444","https://openalex.org/W2941716972","https://openalex.org/W2954115740","https://openalex.org/W2971411759","https://openalex.org/W3019824560","https://openalex.org/W3026123551","https://openalex.org/W3036138712","https://openalex.org/W3044139359","https://openalex.org/W3089889830","https://openalex.org/W3122621164","https://openalex.org/W3165346279","https://openalex.org/W4213276602","https://openalex.org/W4225854602","https://openalex.org/W4290852280","https://openalex.org/W4309721947","https://openalex.org/W4321097255","https://openalex.org/W4323905477","https://openalex.org/W4328047993","https://openalex.org/W4363651026","https://openalex.org/W4381598640","https://openalex.org/W4386874130","https://openalex.org/W4388408565","https://openalex.org/W4390571346","https://openalex.org/W4392184770","https://openalex.org/W4393226884","https://openalex.org/W4399594088","https://openalex.org/W4401640695"],"related_works":["https://openalex.org/W3166804993","https://openalex.org/W3165346279","https://openalex.org/W4390507497","https://openalex.org/W4388239125","https://openalex.org/W1968786597","https://openalex.org/W4387351492","https://openalex.org/W4256170798","https://openalex.org/W105027352","https://openalex.org/W7223103767","https://openalex.org/W4240970258"],"abstract_inverted_index":{"Balanoposthitis":[0],"is":[1,14],"a":[2,51,97],"common":[3],"heterogeneous":[4],"skin":[5,36,93],"condition":[6],"involving":[7],"the":[8,39,44,59,86,100],"glans":[9,40,65],"penis":[10,41,66],"and":[11,13,30,35,64,92,95],"prepuce,":[12],"seen":[15],"from":[16],"infancy":[17],"to":[18],"old":[19],"age.":[20],"Its":[21],"predisposing":[22],"factors":[23],"are":[24,67],"intertrigo,":[25],"lengthy":[26],"foreskin,":[27],"localized":[28],"irritation,":[29],"mucosal":[31],"injury.":[32],"The":[33],"itching":[34],"inflammation":[37],"at":[38],"seriously":[42],"affects":[43],"quality":[45],"of":[46,48,53,78,88,103],"life":[47],"patients.":[49],"As":[50],"result":[52],"advances":[54],"in":[55,106],"high-throughput":[56],"sequencing":[57],"technology,":[58],"prepuce":[60],"microbial":[61],"colonization":[62],"patterns":[63],"now":[68],"known":[69],"better.":[70],"Previous":[71],"studies":[72],"have":[73],"shown":[74],"that":[75],"an":[76],"imbalance":[77],"flora":[79],"can":[80],"cause":[81],"balanoposthitis.":[82,107],"This":[83],"article":[84],"summarizes":[85],"progress":[87],"research":[89],"on":[90],"balanoposthitis":[91],"microecology,":[94],"provides":[96],"direction":[98],"for":[99],"subsequent":[101],"exploration":[102],"immunological":[104],"mechanisms":[105]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-26T00:00:00"}