{"id":"https://openalex.org/W4408816699","doi":"https://doi.org/10.1167/tvst.14.3.21","title":"Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease","display_name":"Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease","publication_year":2025,"publication_date":"2025-03-25","ids":{"openalex":"https://openalex.org/W4408816699","doi":"https://doi.org/10.1167/tvst.14.3.21","pmid":"https://pubmed.ncbi.nlm.nih.gov/40131299","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11951051"},"language":"en","primary_location":{"id":"doi:10.1167/tvst.14.3.21","doi":"https://doi.org/10.1167/tvst.14.3.21","is_oa":true,"landing_page_url":"https://doi.org/10.1167/tvst.14.3.21","pdf_url":null,"source":{"id":"https://openalex.org/S2764591444","display_name":"Translational Vision Science & Technology","issn_l":"2164-2591","issn":["2164-2591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315919","host_organization_name":"Association for Research in Vision and Ophthalmology","host_organization_lineage":["https://openalex.org/P4310315919"],"host_organization_lineage_names":["Association for Research in Vision and Ophthalmology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Vision Science & Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1167/tvst.14.3.21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045419036","display_name":"Sergio Li Calzi","orcid":"https://orcid.org/0000-0001-8963-1519","observed_orcids":["https://orcid.org/0000-0001-8963-1519"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Li Calzi","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058520182","display_name":"Ayaka Fujihashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayaka Fujihashi","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103111204","display_name":"Dibyendu Chakraborty","orcid":"https://orcid.org/0000-0003-3934-3249","observed_orcids":["https://orcid.org/0000-0003-3934-3249"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dibyendu Chakraborty","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116058605","display_name":"Yvonne Adu-Rutledge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne Adu-Rutledge","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058833186","display_name":"Ram Prasad","orcid":"https://orcid.org/0000-0002-1931-5040","observed_orcids":["https://orcid.org/0000-0002-1931-5040"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Prasad","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077447874","display_name":"Edgar L. Ready","orcid":"https://orcid.org/0009-0005-2576-2890","observed_orcids":["https://orcid.org/0009-0005-2576-2890"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edgar L. V. Ready","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033492637","display_name":"Sarbodeep Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarbodeep Paul","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072219087","display_name":"Srikanth Kakumanu","orcid":"https://orcid.org/0000-0003-3616-3517","observed_orcids":["https://orcid.org/0000-0003-3616-3517"]},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srikanth Kakumanu","raw_affiliation_strings":["Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA","institution_ids":["https://openalex.org/I133738476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103737538","display_name":"Xiaoping Qi","orcid":"https://orcid.org/0009-0009-6768-405X","observed_orcids":["https://orcid.org/0009-0009-6768-405X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Qi","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059483104","display_name":"Michael E. Boulton","orcid":"https://orcid.org/0000-0002-0796-1766","observed_orcids":["https://orcid.org/0000-0002-0796-1766"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Boulton","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083124580","display_name":"Alan J. Franklin","orcid":"https://orcid.org/0000-0002-3824-3265","observed_orcids":["https://orcid.org/0000-0002-3824-3265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan J. Franklin","raw_affiliation_strings":["ForwardVue Pharma, Mobile, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ForwardVue Pharma, Mobile, AL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bob H. Katz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bob H. Katz","raw_affiliation_strings":["ForwardVue Pharma, Mobile, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ForwardVue Pharma, Mobile, AL, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083537513","display_name":"Maria B. Grant","orcid":"https://orcid.org/0000-0002-6470-0255","observed_orcids":["https://orcid.org/0000-0002-6470-0255","https://orcid.org/0000-0002-3602-8844","https://orcid.org/0000-0001-8571-4827"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria B. Grant","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083537513"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.6997,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59026062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"14","issue":"3","first_page":"21","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carboxyamidotriazole","display_name":"carboxyamidotriazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.7599999904632568},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.968999981880188},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.5740000009536743},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":0.925000011920929},{"id":"https://openalex.org/keywords/vitreous-fluorophotometry","display_name":"vitreous fluorophotometry","score":0.8159999847412109},{"id":"https://openalex.org/keywords/retinal-toxicity","display_name":"retinal toxicity","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6074864864349365},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.5265985727310181},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4634331166744232},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4212172329425812},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.3475338816642761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1992630958557129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.086946040391922},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1167/tvst.14.3.21","doi":"https://doi.org/10.1167/tvst.14.3.21","is_oa":true,"landing_page_url":"https://doi.org/10.1167/tvst.14.3.21","pdf_url":null,"source":{"id":"https://openalex.org/S2764591444","display_name":"Translational Vision Science & Technology","issn_l":"2164-2591","issn":["2164-2591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315919","host_organization_name":"Association for Research in Vision and Ophthalmology","host_organization_lineage":["https://openalex.org/P4310315919"],"host_organization_lineage_names":["Association for Research in Vision and Ophthalmology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Vision Science & Technology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11951051","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11951051/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11951051/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Vis Sci Technol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:10762176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11951051","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40131299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40131299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational vision science & technology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1167/tvst.14.3.21","doi":"https://doi.org/10.1167/tvst.14.3.21","is_oa":true,"landing_page_url":"https://doi.org/10.1167/tvst.14.3.21","pdf_url":null,"source":{"id":"https://openalex.org/S2764591444","display_name":"Translational Vision Science & Technology","issn_l":"2164-2591","issn":["2164-2591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315919","host_organization_name":"Association for Research in Vision and Ophthalmology","host_organization_lineage":["https://openalex.org/P4310315919"],"host_organization_lineage_names":["Association for Research in Vision and Ophthalmology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Vision Science & Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1441903723","display_name":null,"funder_award_id":"EY035539","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7586896607","display_name":"Cholesterol homeostasis in pathogenesis of DR","funder_award_id":"R01EY025383","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000862124","display_name":"ACE2 on gut barrier dysfunction and BRB disruption","funder_award_id":"R01EY032753","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000873022","display_name":"UAB Core Grant for Vision Research","funder_award_id":"P30EY003039","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000873685","display_name":"Brain-gut-retina axis in diabetic retinopathy","funder_award_id":"R01EY033620","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000891314","display_name":"RXR-based therapy for diabetic retinopathy","funder_award_id":"R01EY035539","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000914414","display_name":"Hematopoietic cell mobilization from distinct bone marrow compartments following retinal injury","funder_award_id":"R01EY012601","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408816699.pdf","grobid_xml":"https://content.openalex.org/works/W4408816699.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1534389636","https://openalex.org/W1560522926","https://openalex.org/W1640752252","https://openalex.org/W1874193881","https://openalex.org/W1939876877","https://openalex.org/W1997930612","https://openalex.org/W2015524859","https://openalex.org/W2028063907","https://openalex.org/W2029864279","https://openalex.org/W2054580627","https://openalex.org/W2074159963","https://openalex.org/W2083043469","https://openalex.org/W2091486028","https://openalex.org/W2101970615","https://openalex.org/W2121617556","https://openalex.org/W2123130682","https://openalex.org/W2124083444","https://openalex.org/W2161487737","https://openalex.org/W2216902666","https://openalex.org/W2412434883","https://openalex.org/W2551371378","https://openalex.org/W2572738486","https://openalex.org/W2580337785","https://openalex.org/W2741201879","https://openalex.org/W2800324940","https://openalex.org/W3110284464","https://openalex.org/W3121972677","https://openalex.org/W4220792018","https://openalex.org/W4293576555","https://openalex.org/W6675408374"],"related_works":["https://openalex.org/W2074159963","https://openalex.org/W7095315298","https://openalex.org/W2091486028","https://openalex.org/W2989685719","https://openalex.org/W2737926042","https://openalex.org/W2002326417","https://openalex.org/W4416542982","https://openalex.org/W2080657339","https://openalex.org/W2915735863","https://openalex.org/W148946959"],"abstract_inverted_index":{"Purpose:":[0],"We":[1],"evaluated":[2],"the":[3,18,137,150,153,189,197,206,217],"safety":[4],"and":[5,25,75,119,124,131,141,170,191,242,249],"bioactivity":[6],"of":[7,21,34,42,57,114,149,155,165,186],"carboxyamidotriazole":[8],"(CAI)":[9],"using":[10],"two":[11],"approaches,":[12],"a":[13,31,50,234,259],"polymeric":[14],"CAI-PLGA":[15,105],"nanoemulsion":[16],"in":[17,30,188,224,229,247],"mouse":[19],"model":[20,33],"choroidal":[22,160],"neovascularization":[23,213],"(CNV)":[24],"CAI-loaded":[26],"bioresorbable":[27,237],"intravitreal":[28,55,98,106],"implant":[29,193,208,238],"rabbit":[32,250],"vascular":[35],"leakage.":[36],"Methods:":[37],"Mice":[38],"underwent":[39,95,128],"laser":[40],"rupture":[41],"Bruch's":[43],"membrane":[44],"to":[45,163,178,196],"induce":[46],"CNV":[47],"followed":[48],"by":[49],"single":[51],"(2":[52],"\u00b5L":[53],"volume)":[54],"injection":[56,148],"either":[58,96],"vehicle":[59],"(n":[60],"=":[61],"11);":[62],"CAI":[63,83,192,207,228,254],"nanoparticles":[64,84],"(0.5":[65],"\u00b5g,":[66,68,70],"1":[67,156],"2":[69],"400":[71],"nM,":[72,74],"800":[73],"1.6":[76],"\u00b5M,":[77],"respectively);":[78],"aflibercept":[79,88,100,190,218],"10":[80,89],"\u00b5g;":[81],"or":[82,104,232],"(1":[85],"\u00b5g)":[86],"+":[87],"\u00b5g.":[90],"New":[91],"Zealand":[92],"white":[93],"rabbits":[94,138],"sham":[97,198],"injection,":[99,103],"500":[101],"\u00b5g":[102,157],"implant.":[107],"Vascular":[108],"leakage":[109],"was":[110,176,222],"induced":[111],"with":[112,216,264],"injections":[113],"VEGF":[115],"on":[116,167,172,200],"days":[117,122],"23":[118],"53.":[120],"On":[121,134,203],"30":[123],"60,":[125,136,205],"all":[126],"groups":[127,194],"vitreous":[129],"fluorophotometry":[130,181],"fundus":[132],"imaging.":[133],"day":[135,168,173,201,204],"were":[139,144],"euthanized,":[140],"their":[142],"eyes":[143],"enucleated.":[145],"Results:":[146],"Intravitreal":[147],"CAI-Nano":[151],"at":[152],"dose":[154],"significantly":[158,183,211],"decreased":[159],"neovascular":[161],"volume,":[162],"25%":[164],"saline":[166],"7":[169],"30%":[171],"14,":[174],"which":[175],"comparable":[177],"aflibercept.":[179],"Vitreous":[180],"revealed":[182],"lower":[184],"levels":[185],"fluorescein":[187],"compared":[195,215],"group":[199,209],"30.":[202],"showed":[210,239],"reduced":[212],"as":[214,233,258],"groups.":[219],"No":[220],"toxicity":[221,246],"observed":[223],"any":[225],"group.":[226],"Conclusions:":[227],"nanoparticle":[230],"formulation":[231],"sustained":[235,260],"release":[236,261],"potent":[240],"efficacy":[241],"caused":[243],"no":[244],"retinal":[245],"murine":[248],"models.":[251],"Translational":[252],"Significance:":[253],"demonstrates":[255],"strong":[256],"potential":[257],"anti-angiogenic":[262],"therapy":[263],"effective":[265],"long-term":[266],"durability.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-03-26T00:00:00"}