{"id":"https://openalex.org/W4408804641","doi":"https://doi.org/10.1002/advs.202413375","title":"Role of Testosterone Signaling in Microglia: A Potential Role for Sex\u2010Related Differences in Alzheimer's Disease","display_name":"Role of Testosterone Signaling in Microglia: A Potential Role for Sex\u2010Related Differences in Alzheimer's Disease","publication_year":2025,"publication_date":"2025-03-24","ids":{"openalex":"https://openalex.org/W4408804641","doi":"https://doi.org/10.1002/advs.202413375","pmid":"https://pubmed.ncbi.nlm.nih.gov/40125707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12097063"},"language":"en","primary_location":{"id":"doi:10.1002/advs.202413375","doi":"https://doi.org/10.1002/advs.202413375","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202413375","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.202413375","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100931322","display_name":"Haiyan Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haiyan Du","raw_affiliation_strings":["Department of Cell Biology, Aging Science, and Pharmacology Division of Oral Biological Sciences Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Aging Science, and Pharmacology Division of Oral Biological Sciences Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082577947","display_name":"Akiko Mizokami","orcid":"https://orcid.org/0000-0002-7490-5190","observed_orcids":["https://orcid.org/0000-0002-7490-5190"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akiko Mizokami","raw_affiliation_strings":["OBT Research Center Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan"],"raw_orcid":"https://orcid.org/0000-0002-7490-5190","affiliations":[{"raw_affiliation_string":"OBT Research Center Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068392270","display_name":"Junjun Ni","orcid":"https://orcid.org/0000-0001-8486-8146","observed_orcids":["https://orcid.org/0000-0001-8486-8146"]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjun Ni","raw_affiliation_strings":["Key Laboratory of Molecular Medicine and Biotherapy Department of Biology School of Life Science Beijing Institute of Technology  Beijing 100081 China"],"raw_orcid":"https://orcid.org/0000-0001-8486-8146","affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Medicine and Biotherapy Department of Biology School of Life Science Beijing Institute of Technology  Beijing 100081 China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012887882","display_name":"Si-Meng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125839683","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I125839683","https://openalex.org/I890469752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Simeng Zhang","raw_affiliation_strings":["Key Laboratory of Molecular Medicine and Biotherapy Department of Biology School of Life Science Beijing Institute of Technology  Beijing 100081 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Medicine and Biotherapy Department of Biology School of Life Science Beijing Institute of Technology  Beijing 100081 China","institution_ids":["https://openalex.org/I125839683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059111388","display_name":"Yosuke Yamawaki","orcid":"https://orcid.org/0000-0002-7247-8295","observed_orcids":["https://orcid.org/0000-0002-7247-8295"]},"institutions":[{"id":"https://openalex.org/I2802008203","display_name":"Daiichi University of Pharmacy","ror":"https://ror.org/03jvvjr23","country_code":"JP","type":"education","lineage":["https://openalex.org/I2802008203"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Yamawaki","raw_affiliation_strings":["Department of Advanced Pharmacology Daiichi University of Pharmacy  22\u20101 Tamagawa\u2010cho, Minami\u2010ku Fukuoka 815\u20108511 Japan"],"raw_orcid":"https://orcid.org/0000-0002-7247-8295","affiliations":[{"raw_affiliation_string":"Department of Advanced Pharmacology Daiichi University of Pharmacy  22\u20101 Tamagawa\u2010cho, Minami\u2010ku Fukuoka 815\u20108511 Japan","institution_ids":["https://openalex.org/I2802008203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052718987","display_name":"Tomomi Sano","orcid":"https://orcid.org/0000-0001-8342-0315","observed_orcids":["https://orcid.org/0000-0001-8342-0315"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Sano","raw_affiliation_strings":["Department of Cell Biology, Aging Science, and Pharmacology Division of Oral Biological Sciences Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan"],"raw_orcid":"https://orcid.org/0000-0001-8342-0315","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Aging Science, and Pharmacology Division of Oral Biological Sciences Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008014053","display_name":"Eijiro Jimi","orcid":"https://orcid.org/0000-0003-3616-5299","observed_orcids":["https://orcid.org/0000-0003-3616-5299"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eijiro Jimi","raw_affiliation_strings":["Laboratory of Molecular and Cellular Biochemistry Division of Oral Biological Sciences Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan","OBT Research Center Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Cellular Biochemistry Division of Oral Biological Sciences Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"OBT Research Center Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102110009","display_name":"Isei Tanida","orcid":"https://orcid.org/0000-0001-8999-3990","observed_orcids":["https://orcid.org/0000-0001-8999-3990"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isei Tanida","raw_affiliation_strings":["Department of Cellular and Molecular Neuropathology Juntendo University Graduate School of Medicine  Tokyo 113\u20108421 Japan"],"raw_orcid":"https://orcid.org/0000-0001-8999-3990","affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Neuropathology Juntendo University Graduate School of Medicine  Tokyo 113\u20108421 Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069538468","display_name":"Takashi Kanematsu","orcid":"https://orcid.org/0000-0001-8592-0831","observed_orcids":["https://orcid.org/0000-0001-8592-0831"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Kanematsu","raw_affiliation_strings":["Department of Cell Biology, Aging Science, and Pharmacology Division of Oral Biological Sciences Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Aging Science, and Pharmacology Division of Oral Biological Sciences Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka 812\u20108582 Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069538468","https://openalex.org/A5082577947"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":3.0485,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.91932046,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"19","first_page":"e2413375","last_page":"e2413375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.31130000948905945,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7710000276565552},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.8999999761581421},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.996999979019165},{"id":"https://openalex.org/keywords/gprc6a","display_name":"GPRC6A","score":0.9810000061988831},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9430000185966492},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.8579999804496765},{"id":"https://openalex.org/keywords/orchiectomy","display_name":"orchiectomy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/testosterone-supplementation","display_name":"testosterone supplementation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8781270980834961},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7704452276229858},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6376993656158447},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5864219665527344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5337439775466919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5069060921669006},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.449362188577652},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4239952564239502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38832101225852966},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3764881491661072},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34678757190704346},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34050941467285156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31045567989349365},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1895153820514679},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1760495901107788},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07903912663459778}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/advs.202413375","doi":"https://doi.org/10.1002/advs.202413375","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202413375","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12097063","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12097063/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12097063/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmid:40125707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40125707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bf50bd8718e5465085e0b846d4485d76","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bf50bd8718e5465085e0b846d4485d76","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Science, Vol 12, Iss 19, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/advs.202413375","doi":"https://doi.org/10.1002/advs.202413375","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202413375","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1853357194","display_name":null,"funder_award_id":"JP23KJ1699","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3629652617","display_name":"Functional analysis of M2 macrophages regulating chronic inflammation in tissue","funder_award_id":"24K12872","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4757638445","display_name":"\u6027\u5dee\u304b\u3089\u89e3\u304d\u660e\u304b\u3059\u65b0\u305f\u306a\u8a8d\u77e5\u75c7\u5236\u5fa1\u6a5f\u69cb","funder_award_id":"22K09904","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6352584081","display_name":"The role of testosterone signaling in microglia: a potential role for sex differences in Alzheimer's Disease","funder_award_id":"23KJ1699","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6724624590","display_name":"Research for elucidating mechanism of stress vulnerability mediated by adipokine-evoked microglial activation in the obesity","funder_award_id":"21K11588","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6870427673","display_name":"Functional analysis of a new anti-cancer molecule that promotes anti-tumor immune responses","funder_award_id":"21K09817","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8991950087","display_name":"\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6a5f\u80fd\u3092\u5236\u5fa1\u3059\u308bmiRNA\u3092\u5fdc\u7528\u3057\u305f\u65b0\u898f\u6b6f\u5468\u75c5\u6cbb\u7642\u85ac\u306e\u958b\u767a","funder_award_id":"23K09119","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408804641.pdf","grobid_xml":"https://content.openalex.org/works/W4408804641.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W126188432","https://openalex.org/W1527938810","https://openalex.org/W1576427485","https://openalex.org/W1874568289","https://openalex.org/W1985759934","https://openalex.org/W2002636911","https://openalex.org/W2042197302","https://openalex.org/W2051218719","https://openalex.org/W2059959955","https://openalex.org/W2060878195","https://openalex.org/W2061573441","https://openalex.org/W2062817877","https://openalex.org/W2070167771","https://openalex.org/W2091678590","https://openalex.org/W2099588975","https://openalex.org/W2104259759","https://openalex.org/W2128433581","https://openalex.org/W2130325075","https://openalex.org/W2131266318","https://openalex.org/W2132960194","https://openalex.org/W2146124002","https://openalex.org/W2161695527","https://openalex.org/W2170644095","https://openalex.org/W2174940789","https://openalex.org/W2323322844","https://openalex.org/W2329336071","https://openalex.org/W2566160175","https://openalex.org/W2751377372","https://openalex.org/W2771826181","https://openalex.org/W2801136562","https://openalex.org/W2808882111","https://openalex.org/W2809030012","https://openalex.org/W2885498250","https://openalex.org/W2890429382","https://openalex.org/W2924596877","https://openalex.org/W2977622316","https://openalex.org/W2996255187","https://openalex.org/W3002574430","https://openalex.org/W3047818817","https://openalex.org/W3099635178","https://openalex.org/W3173194636","https://openalex.org/W3190631166","https://openalex.org/W3204225629","https://openalex.org/W4205611269","https://openalex.org/W4313828769","https://openalex.org/W4378212353","https://openalex.org/W4386306372","https://openalex.org/W4388082182","https://openalex.org/W4392059707","https://openalex.org/W4396803604","https://openalex.org/W4407143018"],"related_works":["https://openalex.org/W4390653477","https://openalex.org/W7146120412","https://openalex.org/W4407143018","https://openalex.org/W2021381523","https://openalex.org/W4401503854","https://openalex.org/W1972278675","https://openalex.org/W2754110860","https://openalex.org/W3185293139","https://openalex.org/W30428193","https://openalex.org/W3112500535"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,44,90,110,117,136,142,160],"less":[4,169],"prevalent":[5],"in":[6,9,39,56,60,70,98,114,128,144,148,152,163,166,181,189,198],"men":[7,164],"than":[8,165],"women,":[10,167],"although":[11],"mechanisms":[12],"remain":[13],"unclear.":[14],"Microglia":[15],"degrade":[16],"aggregated":[17],"amyloid":[18],"\u03b2":[19],"(A\u03b2)":[20],"through":[21],"the":[22,129],"lysosomal":[23],"system,":[24],"including":[25],"autophagy.":[26],"G":[27],"protein-coupled":[28],"receptor":[29],"family":[30],"C":[31],"group":[32],"6":[33],"member":[34],"A":[35],"(GPRC6A),":[36],"predominantly":[37],"expressed":[38],"mouse":[40],"microglial":[41],"MG6":[42,71],"cells,":[43],"a":[45],"primary":[46],"mediator":[47],"of":[48,85,95,131,172],"testosterone":[49,124,141,185],"signaling.":[50],"This":[51],"study":[52],"examines":[53],"testosterone's":[54],"role":[55],"modulating":[57],"A\u03b2-induced":[58,64,187],"autophagy":[59,65,113,188],"microglia.":[61,149],"Testosterone":[62],"promotes":[63],"leading":[66],"to":[67,193,196],"A\u03b2":[68,107,146,150,173],"clearance":[69,108,147],"cells":[72],"by":[73,92,119,123,138],"suppressing":[74],"extracellular":[75],"signal-regulated":[76],"kinase":[77],"(ERK)":[78],"phosphorylation":[79,127],"and":[80,116],"subsequently":[81],"inhibiting":[82],"mammalian":[83],"target":[84],"rapamycin":[86],"(mTOR)":[87],"activation,":[88],"which":[89],"abrogated":[91],"shRNA":[93],"knockdown":[94],"GPRC6A.":[96],"In":[97,183],"vivo":[99],"experiments":[100],"with":[101,112,158,168,174],"male":[102,132],"5xFAD":[103],"AD":[104,133,159,197],"model":[105,134],"mice,":[106],"activity":[109,180],"associated":[111],"microglia":[115],"reduced":[118],"orchiectomy,":[120],"but":[121],"restored":[122],"supplementation.":[125],"ERK":[126],"brains":[130],"mice":[135],"upregulated":[137],"orchiectomy.":[139],"Therefore,":[140],"involved":[143],"autophagy-mediated":[145],"accumulation":[151],"human":[153],"brain":[154],"samples":[155],"from":[156],"patients":[157],"significantly":[161],"lower":[162,194],"pronounced":[170],"colocalization":[171],"p62":[175],"aggregates,":[176],"suggesting":[177],"enhanced":[178],"autophagic":[179],"men.":[182,199],"conclusion,":[184],"enhances":[186],"microglia,":[190],"possibly":[191],"contributing":[192],"susceptibility":[195]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-03-25T00:00:00"}
