{"id":"https://openalex.org/W4408791663","doi":"https://doi.org/10.3390/v17040455","title":"Predictors of Unfavorable Outcomes in COVID-19-Related Sepsis: A Prospective Cohort Study","display_name":"Predictors of Unfavorable Outcomes in COVID-19-Related Sepsis: A Prospective Cohort Study","publication_year":2025,"publication_date":"2025-03-21","ids":{"openalex":"https://openalex.org/W4408791663","doi":"https://doi.org/10.3390/v17040455","pmid":"https://pubmed.ncbi.nlm.nih.gov/40284898"},"language":"en","primary_location":{"id":"doi:10.3390/v17040455","doi":"https://doi.org/10.3390/v17040455","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v17040455","pdf_url":null,"source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/v17040455","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026045228","display_name":"Diana-Maria Mateescu","orcid":"https://orcid.org/0009-0009-4951-1702","observed_orcids":["https://orcid.org/0009-0009-4951-1702"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Diana-Maria Mateescu","raw_affiliation_strings":["Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":"https://orcid.org/0009-0009-4951-1702","affiliations":[{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119829838","display_name":"Ioana-Georgiana Cotet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ioana Cotet","raw_affiliation_strings":["Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094236264","display_name":"Cristina Guse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cristina Guse","raw_affiliation_strings":["Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093108270","display_name":"C\u0103t\u0103lin Prodan-B\u0103rbulescu","orcid":"https://orcid.org/0000-0003-4348-5469","observed_orcids":["https://orcid.org/0000-0003-4348-5469"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Catalin Prodan-Barbulescu","raw_affiliation_strings":["Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":"https://orcid.org/0000-0003-4348-5469","affiliations":[{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089532322","display_name":"Norberth-Istvan Varga","orcid":"https://orcid.org/0009-0002-0320-6904","observed_orcids":["https://orcid.org/0009-0002-0320-6904"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Norberth-Istvan Varga","raw_affiliation_strings":["Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":"https://orcid.org/0009-0002-0320-6904","affiliations":[{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Doctoral School, Department of General Medicine, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026538626","display_name":"Stela Iurciuc","orcid":"https://orcid.org/0000-0003-3536-6099","observed_orcids":["https://orcid.org/0000-0003-3536-6099"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Stela Iurciuc","raw_affiliation_strings":["Cardiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Cardiology Department, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Cardiology Department, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria-Laura Craciun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Maria-Laura Craciun","raw_affiliation_strings":["Cardiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Cardiology Department, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Cardiology Department, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026536469","display_name":"Adrian Cosmin Ilie","orcid":"https://orcid.org/0000-0002-8533-4856","observed_orcids":["https://orcid.org/0000-0002-8533-4856"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Adrian-Cosmin Ilie","raw_affiliation_strings":["Department III Functional Sciences, Division of Public Health and Management, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Department III Functional Sciences, Division of Public Health and Management, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department III Functional Sciences, Division of Public Health and Management, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Department III Functional Sciences, Division of Public Health and Management, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107871097","display_name":"Alexandra Enache","orcid":"https://orcid.org/0000-0003-4425-5876","observed_orcids":["https://orcid.org/0000-0003-4425-5876"]},"institutions":[{"id":"https://openalex.org/I4210088791","display_name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara","ror":"https://ror.org/00afdp487","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210088791"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Alexandra Enache","raw_affiliation_strings":["Discipline of Forensic Medicine, Bioethics, Deontology and Medical Law, Department of Neuroscience, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Ethics and Human Identification Research Center, Department of Neuroscience, Discipline of Forensic Medicine, Bioethics, Deontology and Medical Law, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","Ethics and Human Identification Research Center, Department of Neuroscience, Discipline of Forensic Medicine, Bioethics, Deontology and Medical Law, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Forensic Medicine, Bioethics, Deontology and Medical Law, Department of Neuroscience, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Ethics and Human Identification Research Center, Department of Neuroscience, Discipline of Forensic Medicine, Bioethics, Deontology and Medical Law, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]},{"raw_affiliation_string":"Ethics and Human Identification Research Center, Department of Neuroscience, Discipline of Forensic Medicine, Bioethics, Deontology and Medical Law, \"Victor Babes\" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania","institution_ids":["https://openalex.org/I4210088791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026536469"],"corresponding_institution_ids":["https://openalex.org/I4210088791"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":6.3774,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.96927556,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"17","issue":"4","first_page":"455","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.23010000586509705,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.949999988079071},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.859000027179718},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pulmonary-involvement","display_name":"pulmonary involvement","score":0.6449999809265137},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.781000018119812},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.574999988079071},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8479718565940857},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.781815767288208},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6874791979789734},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6754286885261536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6603715419769287},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5510014295578003},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.49245724081993103},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.42672911286354065},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4177253842353821},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.416268914937973},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35368430614471436},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3050888180732727},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1763937771320343}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/v17040455","doi":"https://doi.org/10.3390/v17040455","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v17040455","pdf_url":null,"source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},{"id":"pmid:40284898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40284898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12031614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12031614","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:948d9ac990e14d2c981763841c49b4f3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/948d9ac990e14d2c981763841c49b4f3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses, Vol 17, Iss 4, p 455 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/v17040455","doi":"https://doi.org/10.3390/v17040455","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v17040455","pdf_url":null,"source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5899999737739563,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W2087203965","https://openalex.org/W2280404143","https://openalex.org/W2617620062","https://openalex.org/W2620581468","https://openalex.org/W2999693571","https://openalex.org/W3006882119","https://openalex.org/W3013444243","https://openalex.org/W3023936058","https://openalex.org/W3025110062","https://openalex.org/W3025768420","https://openalex.org/W3038308872","https://openalex.org/W3038638982","https://openalex.org/W3040075864","https://openalex.org/W3040395637","https://openalex.org/W3041275036","https://openalex.org/W3044208427","https://openalex.org/W3046496943","https://openalex.org/W3080244189","https://openalex.org/W3102206020","https://openalex.org/W3115059693","https://openalex.org/W3122971552","https://openalex.org/W3130433021","https://openalex.org/W3138775655","https://openalex.org/W3139864337","https://openalex.org/W3158873712","https://openalex.org/W3167752735","https://openalex.org/W3182386410","https://openalex.org/W3203604766","https://openalex.org/W4226000943","https://openalex.org/W4226216300","https://openalex.org/W4288047119","https://openalex.org/W4307388621","https://openalex.org/W4310482580","https://openalex.org/W4322740274","https://openalex.org/W4372333096","https://openalex.org/W4377093577","https://openalex.org/W4379514636","https://openalex.org/W4394923782","https://openalex.org/W4402311046","https://openalex.org/W6775900539","https://openalex.org/W6811242337"],"related_works":["https://openalex.org/W1581686323","https://openalex.org/W2963601472","https://openalex.org/W2408782992","https://openalex.org/W3030014144","https://openalex.org/W4383099252","https://openalex.org/W2034930488","https://openalex.org/W2105533052","https://openalex.org/W2594515381","https://openalex.org/W2441087844","https://openalex.org/W2042625557"],"abstract_inverted_index":{"Sepsis":[0],"is":[1],"a":[2,13,29,71,136,145],"leading":[3],"cause":[4],"of":[5,49,95,177,188],"mortality":[6],"in":[7,65,180,196],"critically":[8],"ill":[9],"patients,":[10],"arising":[11],"from":[12],"dysregulated":[14],"immune":[15],"response":[16],"to":[17,44,90,205],"infection.":[18],"While":[19],"traditionally":[20],"associated":[21,117],"with":[22,79,118],"bacterial":[23],"pathogens,":[24],"severe":[25,210],"COVID-19":[26,211],"can":[27],"induce":[28],"sepsis-like":[30],"syndrome,":[31],"characterized":[32],"by":[33,214],"systemic":[34],"inflammation,":[35],"endothelial":[36],"dysfunction,":[37,54],"and":[38,57,83,105,168,190],"coagulation":[39,53,191],"abnormalities.":[40],"This":[41],"study":[42,74],"aimed":[43],"assess":[45],"the":[46,92,186],"prognostic":[47],"value":[48],"age,":[50],"inflammatory":[51,189],"markers,":[52,192],"comorbidity":[55,194],"burden,":[56,195],"lung":[58,125,169],"involvement":[59,126,170],"on":[60,127,171],"computer":[61],"tomography":[62],"(CT)":[63],"scans":[64],"predicting":[66],"poor":[67,119,178],"outcomes.":[68,97,120],"We":[69],"conducted":[70],"prospective":[72,201],"cohort":[73],"including":[75],"163":[76],"patients":[77],"diagnosed":[78],"COVID-19-related":[80,181],"sepsis.":[81,182,215],"Univariate":[82],"multivariable":[84],"logistic":[85],"regression":[86],"analyses":[87],"were":[88,115],"performed":[89],"identify":[91],"independent":[93,175],"predictors":[94,176],"unfavorable":[96],"Higher":[98],"D-dimer":[99],"(OR:":[100,110,129],"1.417,":[101],"p":[102,112,131],"=":[103,113,132,151],"0.020)":[104],"C-reactive":[106],"protein":[107],"(CRP)":[108],"levels":[109],"1.010,":[111],"0.027)":[114],"independently":[116],"A":[121],"greater":[122],"than":[123],"50%":[124],"CT":[128,172],"1.774,":[130],"0.025)":[133],"was":[134],"also":[135],"significant":[137],"predictor.":[138],"The":[139],"Charleson":[140],"Comorbidity":[141],"Index":[142],"(CCI)":[143],"showed":[144],"strong":[146],"trend":[147],"toward":[148],"significance":[149,157],"(p":[150],"0.065),":[152],"while":[153],"age":[154],"lost":[155],"statistical":[156],"after":[158],"adjusting":[159],"for":[160,209],"comorbidities.":[161],"Our":[162],"findings":[163],"suggest":[164],"that":[165],"D-dimers,":[166],"CRP,":[167],"are":[173,203],"key":[174],"outcomes":[179],"These":[183],"results":[184],"emphasize":[185],"importance":[187],"alongside":[193],"early":[197],"risk":[198],"assessment.":[199],"Further":[200],"studies":[202],"warranted":[204],"refine":[206],"predictive":[207],"models":[208],"cases":[212],"complicated":[213]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}