{"id":"https://openalex.org/W4408776959","doi":"https://doi.org/10.1016/j.labinv.2024.102782","title":"551 Computational Analysis of Digitized Pre-Treatment Biopsies of Rectal Adenocarcinomas Identifies Tumor Microenvironment Features Associated with Response to Chemoradiation","display_name":"551 Computational Analysis of Digitized Pre-Treatment Biopsies of Rectal Adenocarcinomas Identifies Tumor Microenvironment Features Associated with Response to Chemoradiation","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4408776959","doi":"https://doi.org/10.1016/j.labinv.2024.102782"},"language":"en","primary_location":{"id":"doi:10.1016/j.labinv.2024.102782","doi":"https://doi.org/10.1016/j.labinv.2024.102782","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.labinv.2024.102782","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.labinv.2024.102782","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041149368","display_name":"Charlems Alvarez\u2010Jimenez","orcid":"https://orcid.org/0000-0001-7100-6387","observed_orcids":["https://orcid.org/0000-0001-7100-6387"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlems Alvarez-Jimenez","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049321736","display_name":"Murad Labbad","orcid":"https://orcid.org/0009-0006-9403-2266","observed_orcids":["https://orcid.org/0009-0006-9403-2266"]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murad Labbad","raw_affiliation_strings":["University of Toledo Medical Center, Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo Medical Center, Toledo, OH","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116770521","display_name":"Mario Quica\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Quicana","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066777585","display_name":"Emily F. Steinhagen","orcid":"https://orcid.org/0000-0002-1155-6624","observed_orcids":["https://orcid.org/0000-0002-1155-6624"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Steinhagen","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103047354","display_name":"Joseph E. Willis","orcid":"https://orcid.org/0000-0003-1782-886X","observed_orcids":["https://orcid.org/0000-0003-1782-886X"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Willis","raw_affiliation_strings":["University Hospitals Cleveland Medical Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Cleveland Medical Center, Cleveland, OH","institution_ids":["https://openalex.org/I4210108791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016940872","display_name":"Satish E. Viswanath","orcid":"https://orcid.org/0000-0003-4550-8337","observed_orcids":["https://orcid.org/0000-0003-4550-8337"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satish Viswanath","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05563421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"3","first_page":"102782","last_page":"102782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.25459998846054077,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.08160000294446945,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-adenocarcinoma","display_name":"rectal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chemoradiation-response","display_name":"chemoradiation response","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pre-treatment-biopsy","display_name":"pre-treatment biopsy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"digital pathology","score":0.5789999961853027},{"id":"https://openalex.org/keywords/computational-analysis","display_name":"computational analysis","score":0.48100000619888306},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5403509140014648},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.49034571647644043},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4805636703968048},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4248712360858917},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4221653938293457},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2591642737388611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2270069420337677},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12205073237419128}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.labinv.2024.102782","doi":"https://doi.org/10.1016/j.labinv.2024.102782","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.labinv.2024.102782","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.labinv.2024.102782","doi":"https://doi.org/10.1016/j.labinv.2024.102782","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.labinv.2024.102782","pdf_url":null,"source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7140129778","https://openalex.org/W2793492939","https://openalex.org/W7214405592","https://openalex.org/W4210888554","https://openalex.org/W6949424410","https://openalex.org/W1043072229","https://openalex.org/W3129030142","https://openalex.org/W4402044226","https://openalex.org/W6889741551","https://openalex.org/W7108364481"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2025-03-24T00:00:00"}
