{"id":"https://openalex.org/W4408772139","doi":"https://doi.org/10.7759/cureus.81069","title":"Effect of Isolating the Periosteum With a Resorbable Barrier Membrane on Neoangiogenesis in Guided Bone Regeneration: An Experimental Study","display_name":"Effect of Isolating the Periosteum With a Resorbable Barrier Membrane on Neoangiogenesis in Guided Bone Regeneration: An Experimental Study","publication_year":2025,"publication_date":"2025-03-24","ids":{"openalex":"https://openalex.org/W4408772139","doi":"https://doi.org/10.7759/cureus.81069","pmid":"https://pubmed.ncbi.nlm.nih.gov/40271309"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.81069","doi":"https://doi.org/10.7759/cureus.81069","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.81069","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.7759/cureus.81069","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075092522","display_name":"Danai Anna Papavasileiou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Danai Anna Papavasileiou","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Dental School, National and Kapodistrian University of Athens, Athens, GRC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Dental School, National and Kapodistrian University of Athens, Athens, GRC","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078963326","display_name":"Minas D. Leventis","orcid":"https://orcid.org/0000-0002-0873-0767","observed_orcids":["https://orcid.org/0000-0002-0873-0767"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Minas Leventis","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Dental School, National and Kapodistrian University of Athens, Athens, GRC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Dental School, National and Kapodistrian University of Athens, Athens, GRC","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Georgios Agrogiannis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Agrogiannis","raw_affiliation_strings":["1st Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, GRC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, GRC","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108529232","display_name":"Demos G. Kalyvas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Demos Kalyvas","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Dental School, National and Kapodistrian University of Athens, Athens, GRC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Dental School, National and Kapodistrian University of Athens, Athens, GRC","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":null,"apc_paid":null,"fwci":0.8789,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70146687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"17","issue":"3","first_page":"e81069","last_page":"e81069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guided-bone-regeneration","display_name":"guided bone regeneration","score":0.984000027179718},{"id":"https://openalex.org/keywords/neoangiogenesis","display_name":"neoangiogenesis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/resorbable-barrier-membrane","display_name":"resorbable barrier membrane","score":0.871999979019165},{"id":"https://openalex.org/keywords/collagen-fleece","display_name":"collagen fleece","score":0.9660000205039978},{"id":"https://openalex.org/keywords/deproteinized-bovine-bone-mineral","display_name":"deproteinized bovine bone mineral","score":0.9309999942779541},{"id":"https://openalex.org/keywords/bone-grafting","display_name":"bone grafting","score":0.5130000114440918},{"id":"https://openalex.org/keywords/calvarial-defect","display_name":"calvarial defect","score":0.8330000042915344},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.5569999814033508},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.46799999475479126},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.9108819961547852},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.8883111476898193},{"id":"https://openalex.org/C2775965322","wikidata":"https://www.wikidata.org/wiki/Q4863605","display_name":"Barrier membrane","level":3,"score":0.7856670618057251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6400823593139648},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4587751626968384},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.4356825351715088},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.42854657769203186},{"id":"https://openalex.org/C2779464278","wikidata":"https://www.wikidata.org/wiki/Q7317735","display_name":"Revascularization","level":3,"score":0.4190353751182556},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3718068599700928},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.31367945671081543},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12674939632415771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11841323971748352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09583362936973572},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.81069","doi":"https://doi.org/10.7759/cureus.81069","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.81069","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:40271309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40271309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12016391","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12016391","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.81069","doi":"https://doi.org/10.7759/cureus.81069","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.81069","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W85781814","https://openalex.org/W1655460658","https://openalex.org/W1987573834","https://openalex.org/W1997081753","https://openalex.org/W2003054685","https://openalex.org/W2010383360","https://openalex.org/W2011834806","https://openalex.org/W2024559570","https://openalex.org/W2025422403","https://openalex.org/W2027221841","https://openalex.org/W2030696265","https://openalex.org/W2036301144","https://openalex.org/W2038635691","https://openalex.org/W2038925074","https://openalex.org/W2047298158","https://openalex.org/W2063732100","https://openalex.org/W2081014102","https://openalex.org/W2101682146","https://openalex.org/W2102763606","https://openalex.org/W2112110053","https://openalex.org/W2163314917","https://openalex.org/W2166703442","https://openalex.org/W2185989244","https://openalex.org/W2246756881","https://openalex.org/W2318781482","https://openalex.org/W2411109183","https://openalex.org/W2516328293","https://openalex.org/W2735731356","https://openalex.org/W3180638439","https://openalex.org/W4320482660"],"related_works":["https://openalex.org/W4399571809","https://openalex.org/W2068709160","https://openalex.org/W4248110529","https://openalex.org/W1988392248","https://openalex.org/W2049635965","https://openalex.org/W2023407333","https://openalex.org/W2013984707","https://openalex.org/W2002155230","https://openalex.org/W3032763713","https://openalex.org/W2468943226"],"abstract_inverted_index":{"Introduction":[0],"In":[1],"guided":[2],"bone":[3,8,21,29,65,83,88,115,136,221,262],"regeneration,":[4],"the":[5,18,44,48,57,60,124,127,162,210,233,239],"use":[6],"of":[7,20,24,59,70,80,126,212,235,255,276],"substitutes":[9],"protected":[10],"by":[11,167],"resorbable":[12,94,152,267,281],"barrier":[13,53,95,283],"membranes":[14],"is":[15,36],"suggested":[16],"for":[17,40,238,272],"treatment":[19],"defects.":[22],"Sprouting":[23],"vessels":[25,237],"from":[26,47],"surrounding":[27],"local":[28],"and":[30,90,129,191,201,203,249],"periosteum":[31,50],"into":[32,185],"such":[33],"regenerated":[34],"areas":[35],"an":[37],"important":[38],"factor":[39],"osteogenesis.":[41],"However,":[42],"isolating":[43],"grafted":[45,146],"area":[46],"overlying":[49],"with":[51,86,92,132,150,264],"a":[52,77,87,93,98,133,151,168,228,261,265,273,280],"membrane":[54,96,154],"may":[55],"affect":[56],"revascularization":[58],"site,":[61],"thus":[62],"compromising":[63],"new":[64],"formation.":[66],"Aim":[67],"The":[68,181,253],"aim":[69],"this":[71,256],"experimental":[72],"study":[73,187,257],"was":[74,148,165,227],"to":[75,279],"perform":[76],"comparative":[78],"evaluation":[79],"neoangiogenesis":[81,277],"in":[82,119,123,232],"defects":[84,116],"filled":[85,131],"graft":[89,263],"covered":[91,149,166],"or":[97],"collagen":[99,153,169,172,240,282],"fleece.":[100],"Method":[101],"Eighteen":[102],"2.5-3.5":[103],"kg":[104],"weighing":[105],"New":[106],"Zealand":[107],"white":[108],"rabbits":[109,182],"were":[110,121,183,199,206],"used.":[111],"Two":[112],"circular":[113],"bicortical":[114],"(8":[117],"mm":[118],"diameter)":[120],"created":[122],"calvaria":[125],"animals":[128],"subsequently":[130],"deproteinized":[134],"bovine":[135],"mineral":[137],"([DBBM];":[138],"Bio-Oss\u00ae,":[139],"Geistlich":[140,156],"Pharma":[141,157],"AG,":[142],"Wolhusen,":[143],"Switzerland).":[144],"One":[145],"defect":[147],"(Bio-Guide\u00ae,":[155],"AG)":[158],"(group":[159,179],"A),":[160],"while":[161],"other":[163],"site":[164],"fleece":[170,241],"(Jason\u00ae":[171],"fleece,":[173],"Botiss":[174],"Biomaterials":[175],"GmbH,":[176],"Zossen,":[177],"Germany)":[178],"B).":[180],"divided":[184],"three":[186],"groups":[188],"(7,":[189,247],"14,":[190,248],"28":[192,224,250],"days),":[193],"each":[194],"containing":[195],"six":[196],"animals.":[197],"Specimens":[198],"taken,":[200],"histological":[202],"immunohistological":[204],"analyses":[205],"carried":[207],"out":[208],"concerning":[209],"number":[211,234],"newly":[213],"formed":[214],"vessels.":[215],"Results":[216],"All":[217],"specimens":[218],"showed":[219],"uneventful":[220],"formation":[222],"at":[223,243],"days.":[225],"There":[226],"statistically":[229],"significant":[230],"difference":[231],"blood":[236],"group":[242],"all":[244],"time":[245],"periods":[246],"days).":[251],"Conclusions":[252],"results":[254],"indicate":[258],"that":[259],"covering":[260],"quickly":[266],"biomaterial":[268],"(collagen":[269],"fleece)":[270],"allows":[271],"greater":[274],"degree":[275],"compared":[278],"membrane.":[284]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
