{"id":"https://openalex.org/W4408709784","doi":"https://doi.org/10.1101/2025.03.20.644150","title":"A CRITICAL ROLE FOR NEUTRAL SPHINGOMYELINASE-2 IN DOXORUBICIN-INDUCED CARDIOTOXICITY","display_name":"A CRITICAL ROLE FOR NEUTRAL SPHINGOMYELINASE-2 IN DOXORUBICIN-INDUCED CARDIOTOXICITY","publication_year":2025,"publication_date":"2025-03-20","ids":{"openalex":"https://openalex.org/W4408709784","doi":"https://doi.org/10.1101/2025.03.20.644150","pmid":"https://pubmed.ncbi.nlm.nih.gov/40166217"},"language":"en","primary_location":{"id":"doi:10.1101/2025.03.20.644150","doi":"https://doi.org/10.1101/2025.03.20.644150","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.03.20.644150","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11957120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104158043","display_name":"Samia Mohammed","orcid":"https://orcid.org/0000-0001-7931-486X","observed_orcids":["https://orcid.org/0000-0001-7931-486X"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samia Mohammed","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Victoria Franzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Franzi","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103153603","display_name":"Yaping Jiang","orcid":"https://orcid.org/0000-0002-6614-0079","observed_orcids":["https://orcid.org/0000-0002-6614-0079"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ya-Ping Jiang","raw_affiliation_strings":["Department of Physiology and Biophysics, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020756003","display_name":"Fabiola Noelia Velazquez","orcid":"https://orcid.org/0000-0001-5692-848X","observed_orcids":["https://orcid.org/0000-0001-5692-848X"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabiola N. Velazquez","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Monica E. Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica E. Alexander","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Folnetti A. Alvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Folnetti A. Alvarez","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Danielle Lambadis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle Lambadis","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035958832","display_name":"Sam B Chiappone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam B. Chiappone","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077869193","display_name":"Anne G. Ostermeyer\u2010Fay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne G. Ostermeyer-Fay","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Brown University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Brown University","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028264204","display_name":"Leiqing Zhang","orcid":"https://orcid.org/0009-0009-6706-3069","observed_orcids":["https://orcid.org/0009-0009-6706-3069","https://orcid.org/0000-0002-9395-1862"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leiqing Zhang","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","MSKCC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"MSKCC","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079294911","display_name":"Achraf A. Shamseddine","orcid":"https://orcid.org/0000-0003-3686-5850","observed_orcids":["https://orcid.org/0000-0003-3686-5850"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Achraf A. Shamseddine","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Current address:","Department of Medicine, Stony Brook University, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Current address:","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053107030","display_name":"Daniel Canals","orcid":"https://orcid.org/0000-0002-9293-5123","observed_orcids":["https://orcid.org/0000-0002-9293-5123"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Canals","raw_affiliation_strings":["Biological Mass Spectrometry Center, Stony Brook University, Stony Brook, NY, USA","Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","College of Agriculture and Life Sciences, University of Arizona"],"raw_orcid":"https://orcid.org/0000-0002-9293-5123","affiliations":[{"raw_affiliation_string":"Biological Mass Spectrometry Center, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"College of Agriculture and Life Sciences, University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071695255","display_name":"Ashley J. Snider","orcid":"https://orcid.org/0000-0002-1515-4171","observed_orcids":["https://orcid.org/0000-0002-1515-4171"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4210109353","display_name":"Northport VA Medical Center","ror":"https://ror.org/01xtpc441","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109353"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley J. Snider","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","School of Nutritional Sciences and Wellness, College of Agriculture, Life and Environmental Sciences, University of Arizona, Tucson, AZ","Veteran Affairs Medical Center, Northport, NY, USA","Stony Brook University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"School of Nutritional Sciences and Wellness, College of Agriculture, Life and Environmental Sciences, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Veteran Affairs Medical Center, Northport, NY, USA","institution_ids":["https://openalex.org/I4210109353"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008203077","display_name":"Richard Z. Lin","orcid":"https://orcid.org/0000-0002-3967-0859","observed_orcids":["https://orcid.org/0000-0002-3967-0859"]},"institutions":[{"id":"https://openalex.org/I4210109353","display_name":"Northport VA Medical Center","ror":"https://ror.org/01xtpc441","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109353"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Z. Lin","raw_affiliation_strings":["Department of Physiology and Biophysics, Stony Brook University, NY, USA","Veteran Affairs Medical Center, Northport, NY, USA","Stony Brook University"],"raw_orcid":"https://orcid.org/0000-0002-3967-0859","affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Veteran Affairs Medical Center, Northport, NY, USA","institution_ids":["https://openalex.org/I4210109353"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090422329","display_name":"Yusuf Awni Hannun","orcid":"https://orcid.org/0000-0003-3349-3369","observed_orcids":["https://orcid.org/0000-0003-3349-3369"]},"institutions":[{"id":"https://openalex.org/I4210109353","display_name":"Northport VA Medical Center","ror":"https://ror.org/01xtpc441","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109353"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yusuf A. Hannun","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA","Veteran Affairs Medical Center, Northport, NY, USA","Stony Brook University"],"raw_orcid":"https://orcid.org/0000-0003-3349-3369","affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Veteran Affairs Medical Center, Northport, NY, USA","institution_ids":["https://openalex.org/I4210109353"]},{"raw_affiliation_string":"Stony Brook University","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020029085","display_name":"Christopher J. Clarke","orcid":"https://orcid.org/0000-0002-4855-522X","observed_orcids":["https://orcid.org/0000-0002-4855-522X"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher J. Clarke","raw_affiliation_strings":["Cancer Center, Stony Brook University, NY, USA","Department of Medicine, Stony Brook University, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4855-522X","affiliations":[{"raw_affiliation_string":"Cancer Center, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Medicine, Stony Brook University, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020029085"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutral-sphingomyelinase-2","display_name":"neutral sphingomyelinase 2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dusp4","display_name":"DUSP4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.5929999947547913},{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.9694499969482422},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7771395444869995},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6847570538520813},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5911024212837219},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.482501745223999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4810933768749237},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4399877190589905},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39548295736312866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34297889471054077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2977147400379181},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.29034164547920227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2557656764984131},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.03.20.644150","doi":"https://doi.org/10.1101/2025.03.20.644150","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.03.20.644150","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40166217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40166217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11957120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11957120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11957120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11957120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W20404323","https://openalex.org/W52847425","https://openalex.org/W1446970532","https://openalex.org/W1909616616","https://openalex.org/W1964007788","https://openalex.org/W1964342722","https://openalex.org/W1966929992","https://openalex.org/W1967394005","https://openalex.org/W1983953026","https://openalex.org/W1994315130","https://openalex.org/W1997306293","https://openalex.org/W2005513283","https://openalex.org/W2016254453","https://openalex.org/W2016470388","https://openalex.org/W2017729786","https://openalex.org/W2021776397","https://openalex.org/W2024751402","https://openalex.org/W2031476399","https://openalex.org/W2032389547","https://openalex.org/W2044450290","https://openalex.org/W2045955026","https://openalex.org/W2049108649","https://openalex.org/W2050036109","https://openalex.org/W2053547821","https://openalex.org/W2058152083","https://openalex.org/W2064177299","https://openalex.org/W2068444709","https://openalex.org/W2068499915","https://openalex.org/W2074934283","https://openalex.org/W2083318322","https://openalex.org/W2088250649","https://openalex.org/W2091238429","https://openalex.org/W2093805100","https://openalex.org/W2094580473","https://openalex.org/W2097105956","https://openalex.org/W2102299141","https://openalex.org/W2109775164","https://openalex.org/W2111032565","https://openalex.org/W2112357840","https://openalex.org/W2115507762","https://openalex.org/W2115764880","https://openalex.org/W2119043140","https://openalex.org/W2119764013","https://openalex.org/W2127830301","https://openalex.org/W2133349278","https://openalex.org/W2137227557","https://openalex.org/W2140182328","https://openalex.org/W2140818088","https://openalex.org/W2141347249","https://openalex.org/W2146035745","https://openalex.org/W2147382256","https://openalex.org/W2173735004","https://openalex.org/W2255975777","https://openalex.org/W2269172513","https://openalex.org/W2275702678","https://openalex.org/W2298001371","https://openalex.org/W2298838354","https://openalex.org/W2324138891","https://openalex.org/W2341883278","https://openalex.org/W2345356016","https://openalex.org/W2414529923","https://openalex.org/W2465957034","https://openalex.org/W2606289191","https://openalex.org/W2743877546","https://openalex.org/W2765824811","https://openalex.org/W2768617092","https://openalex.org/W2769383666","https://openalex.org/W2802257450","https://openalex.org/W2883721214","https://openalex.org/W2889063013","https://openalex.org/W2906118074","https://openalex.org/W2907094828","https://openalex.org/W2979656022","https://openalex.org/W2999210154","https://openalex.org/W3165721275","https://openalex.org/W3210801640","https://openalex.org/W3217033455","https://openalex.org/W4205972693","https://openalex.org/W4242409495","https://openalex.org/W4308293061","https://openalex.org/W4311670259","https://openalex.org/W4312052508","https://openalex.org/W4312083803","https://openalex.org/W4377043254","https://openalex.org/W4377221091","https://openalex.org/W4388595324","https://openalex.org/W4390050598","https://openalex.org/W4391138568","https://openalex.org/W4400562452","https://openalex.org/W4400738872","https://openalex.org/W4403814866","https://openalex.org/W4404483473"],"related_works":["https://openalex.org/W2094475704","https://openalex.org/W4388041187","https://openalex.org/W3011400996","https://openalex.org/W3030216814","https://openalex.org/W4323666172","https://openalex.org/W2143449387","https://openalex.org/W2056299406","https://openalex.org/W4390534911","https://openalex.org/W2738785033","https://openalex.org/W4385199638"],"abstract_inverted_index":{"ABSTRACT":[0],"Cardiotoxicity":[1],"is":[2,40,81],"a":[3,53,63,113,126,142],"major":[4],"side":[5],"effect":[6],"of":[7,56,67,78,116,144],"Doxorubicin":[8],"(Dox)":[9],"that":[10,74],"has":[11],"hampered":[12],"its":[13],"clinical":[14],"utility,":[15],"and":[16,72,88,102,105],"strategies":[17],"to":[18,28,124],"mitigate":[19],"this":[20,137],"cardiotoxicity":[21],"are":[22,26],"limited.":[23],"Sphingolipids":[24],"(SL)":[25],"central":[27],"the":[29,46,107,119],"chemotherapy":[30],"response":[31],"in":[32,37,69,75,100,103,118,131,134],"cancer":[33],"but":[34],"their":[35],"role":[36,127],"normal":[38,135],"tissue":[39],"less":[41],"clear.":[42],"Here,":[43],"we":[44],"identified":[45],"SL":[47,129],"enzyme":[48],"neutral":[49],"sphingomyelinase-2":[50],"(nSMase2)":[51],"as":[52,62,112,141],"critical":[54],"mediator":[55],"chronic":[57,84],"Dox-induced":[58,85,96],"cardiotoxicity,":[59],"establishing":[60],"nSMase2":[61,79,94,117,140],"key":[64],"downstream":[65],"effector":[66,115],"Dox":[68,120,132],"cardiomyocytes":[70],"(CM)":[71],"showing":[73],"vivo":[76,104],"loss":[77],"activity":[80],"protecting":[82],"against":[83],"cardiac":[86],"damage":[87],"dysfunction.":[89],"Biologically,":[90],"these":[91],"studies":[92],"link":[93],"with":[95],"CM":[97],"senescence":[98],"both":[99],"vitro":[101],"identify":[106],"dual":[108],"specificity":[109],"phosphatase":[110],"DUSP4":[111],"novel":[114],"response.":[121],"In":[122],"addition":[123],"cementing":[125],"for":[128,146],"metabolism":[130],"effects":[133],"tissue,":[136],"study":[138],"advances":[139],"target":[143],"interest":[145],"cardioprotection.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}