{"id":"https://openalex.org/W4408564117","doi":"https://doi.org/10.1371/journal.pone.0319866","title":"Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons","display_name":"Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons","publication_year":2025,"publication_date":"2025-03-18","ids":{"openalex":"https://openalex.org/W4408564117","doi":"https://doi.org/10.1371/journal.pone.0319866","pmid":"https://pubmed.ncbi.nlm.nih.gov/40100917"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0319866","doi":"https://doi.org/10.1371/journal.pone.0319866","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0319866","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pone.0319866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090881726","display_name":"Nadine Thau\u2010Habermann","orcid":"https://orcid.org/0000-0002-2518-5019","observed_orcids":["https://orcid.org/0000-0002-2518-5019"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nadine Thau-Habermann","raw_affiliation_strings":["Department of Neurology, Hannover Medical School, Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2518-5019","affiliations":[{"raw_affiliation_string":"Department of Neurology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067359867","display_name":"Thomas Gschwendtberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Gschwendtberger","raw_affiliation_strings":["Department of Neurology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Colin Bodemer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Colin Bodemer","raw_affiliation_strings":["Department of Neurology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005633849","display_name":"Susanne Petri","orcid":"https://orcid.org/0000-0002-9783-8584","observed_orcids":["https://orcid.org/0000-0002-9783-8584"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Petri","raw_affiliation_strings":["Center for Systems Neuroscience (ZSN), Hannover, Germany","Department of Neurology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Neuroscience (ZSN), Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090881726"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.2953,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52237129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"20","issue":"3","first_page":"e0319866","last_page":"e0319866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parthenolide","display_name":"parthenolide","score":1.0},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6629999876022339},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.9629999995231628},{"id":"https://openalex.org/keywords/sod1","display_name":"SOD1","score":0.6660000085830688},{"id":"https://openalex.org/keywords/feverfew","display_name":"feverfew","score":0.8709999918937683},{"id":"https://openalex.org/keywords/microglial-phenotype","display_name":"microglial phenotype","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.796999990940094},{"id":"https://openalex.org/keywords/drug-candidates","display_name":"drug candidates","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8646566867828369},{"id":"https://openalex.org/C2780321935","wikidata":"https://www.wikidata.org/wiki/Q2662393","display_name":"Parthenolide","level":3,"score":0.8537487983703613},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8510741591453552},{"id":"https://openalex.org/C2908656565","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrocytosis","level":3,"score":0.8222128748893738},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7514116764068604},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.6084986329078674},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5960093140602112},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.5488265156745911},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.4859546422958374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48270487785339355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33671432733535767},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.30030515789985657},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25189208984375},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2199876308441162},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20498067140579224},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14675113558769226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0319866","doi":"https://doi.org/10.1371/journal.pone.0319866","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0319866","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:40100917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40100917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11918366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11918366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:abba4d3bc57f4bd6b6544a3f3737e425","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/abba4d3bc57f4bd6b6544a3f3737e425","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 20, Iss 3, p e0319866 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0319866","doi":"https://doi.org/10.1371/journal.pone.0319866","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0319866","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W18768637","https://openalex.org/W750226549","https://openalex.org/W1534148228","https://openalex.org/W1619588441","https://openalex.org/W1768846296","https://openalex.org/W1815163311","https://openalex.org/W1821242108","https://openalex.org/W1930450098","https://openalex.org/W1974280918","https://openalex.org/W1981329326","https://openalex.org/W1983982834","https://openalex.org/W1987138690","https://openalex.org/W1987577991","https://openalex.org/W1988491332","https://openalex.org/W1993988048","https://openalex.org/W1998109179","https://openalex.org/W2002526073","https://openalex.org/W2004653738","https://openalex.org/W2042938039","https://openalex.org/W2046508329","https://openalex.org/W2047462308","https://openalex.org/W2047532953","https://openalex.org/W2049919805","https://openalex.org/W2051387942","https://openalex.org/W2052859130","https://openalex.org/W2054876142","https://openalex.org/W2057039052","https://openalex.org/W2058742494","https://openalex.org/W2058973529","https://openalex.org/W2060121813","https://openalex.org/W2069893872","https://openalex.org/W2074661552","https://openalex.org/W2077477270","https://openalex.org/W2079516818","https://openalex.org/W2081680109","https://openalex.org/W2084566588","https://openalex.org/W2088324108","https://openalex.org/W2094100748","https://openalex.org/W2096386031","https://openalex.org/W2099671775","https://openalex.org/W2101321540","https://openalex.org/W2102653758","https://openalex.org/W2107282184","https://openalex.org/W2107768418","https://openalex.org/W2111027979","https://openalex.org/W2113107925","https://openalex.org/W2123779560","https://openalex.org/W2128833728","https://openalex.org/W2142288092","https://openalex.org/W2147180300","https://openalex.org/W2160188170","https://openalex.org/W2162983960","https://openalex.org/W2331152426","https://openalex.org/W2418432696","https://openalex.org/W2542406710","https://openalex.org/W2567699986","https://openalex.org/W2572710398","https://openalex.org/W2583124396","https://openalex.org/W2754829423","https://openalex.org/W2765155499","https://openalex.org/W2789730644","https://openalex.org/W2790138775","https://openalex.org/W2808916408","https://openalex.org/W2811102541","https://openalex.org/W2885883285","https://openalex.org/W2892730226","https://openalex.org/W2910657247","https://openalex.org/W2911503339","https://openalex.org/W2914008502","https://openalex.org/W2974865755","https://openalex.org/W2990713260","https://openalex.org/W3004705495","https://openalex.org/W3005495743","https://openalex.org/W3018565400","https://openalex.org/W3043016915","https://openalex.org/W3044057346","https://openalex.org/W3046216659","https://openalex.org/W3047765583","https://openalex.org/W3081311131","https://openalex.org/W3090922258","https://openalex.org/W3092059918","https://openalex.org/W3128695211","https://openalex.org/W3133511892","https://openalex.org/W3135599050","https://openalex.org/W3149315539","https://openalex.org/W3156835970","https://openalex.org/W3165773751","https://openalex.org/W3213369655","https://openalex.org/W4220875431","https://openalex.org/W4223598393","https://openalex.org/W4224997527","https://openalex.org/W4292674255","https://openalex.org/W4317036968","https://openalex.org/W4323666795","https://openalex.org/W4360864248","https://openalex.org/W4362661893","https://openalex.org/W4376269600","https://openalex.org/W4386032099","https://openalex.org/W4386945518","https://openalex.org/W4387096099","https://openalex.org/W4402871010"],"related_works":["https://openalex.org/W2148585034","https://openalex.org/W1964746292","https://openalex.org/W1084638677","https://openalex.org/W1979599881","https://openalex.org/W2043985705","https://openalex.org/W2363886610","https://openalex.org/W2883678860","https://openalex.org/W2134362363","https://openalex.org/W2087355574","https://openalex.org/W2381638252"],"abstract_inverted_index":{"Over":[0],"the":[1,5,12,34,46,50],"last":[2],"twenty":[3],"years,":[4],"role":[6],"of":[7,14,22,49,77,92,168],"microgliosis":[8],"and":[9,24,27,82,98,121],"astrocytosis":[10],"in":[11,33,89],"pathophysiology":[13],"neurodegenerative":[15,93],"diseases":[16,94],"has":[17,29,71,109,146,157],"increasingly":[18],"been":[19,30,72],"recognized.":[20],"Dysregulation":[21],"microglial":[23,80],"astrocyte":[25],"properties":[26],"function":[28],"described":[31],"also":[32,145],"fatal":[35],"degenerative":[36],"motor":[37,152,164],"neuron":[38],"disease":[39,97],"amyotrophic":[40],"lateral":[41],"sclerosis":[42],"(ALS).":[43],"Microglia":[44],"cells,":[45,117],"immune":[47],"cells":[48],"nervous":[51],"system,":[52],"can":[53],"either":[54],"have":[55],"an":[56,147],"immunonegative":[57],"neurotoxic":[58],"or":[59],"immunopositive":[60],"neuroprotective":[61,129],"phenotype.":[62],"The":[63,166],"feverfew":[64],"plant":[65],"(Tanacetum":[66],"parthenium)":[67],"derived":[68],"compound":[69],"parthenolide":[70],"found":[73],"to":[74,105,125,135,173],"be":[75],"capable":[76],"interfering":[78],"with":[79],"phenotype":[81],"properties.":[83],"Positive":[84],"treatment":[85],"effects":[86],"were":[87,103,133],"shown":[88],"animal":[90],"models":[91],"like":[95],"Alzheimer's":[96],"Parkinson's":[99],"disease.":[100],"Now":[101],"we":[102,132],"able":[104,134],"show":[106,136],"that":[107,137],"PTL":[108,155,175],"a":[110,127,177],"modulating":[111],"effect":[112,142,160],"on":[113,143,151,161],"primary":[114,163],"mouse":[115],"microglia":[116],"both":[118],"wild":[119],"type":[120],"SOD1,":[122],"causing":[123],"them":[124],"adopt":[126],"more":[128],"potential.":[130],"Furthermore,":[131],"PTL,":[138],"through":[139],"its":[140],"positive":[141,149],"microglia,":[144],"indirect":[148],"impact":[150],"neurons,":[153],"although":[154],"itself":[156],"no":[158],"direct":[159],"these":[162],"neurons.":[165],"results":[167],"our":[169],"study":[170],"give":[171],"reason":[172],"consider":[174],"as":[176],"drug":[178],"candidate":[179],"for":[180],"ALS.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
