{"id":"https://openalex.org/W4408564018","doi":"https://doi.org/10.1371/journal.pntd.0012914","title":"Comprehensive analysis of intervention and control studies for the computational identification of dengue biomarker genes","display_name":"Comprehensive analysis of intervention and control studies for the computational identification of dengue biomarker genes","publication_year":2025,"publication_date":"2025-03-18","ids":{"openalex":"https://openalex.org/W4408564018","doi":"https://doi.org/10.1371/journal.pntd.0012914","pmid":"https://pubmed.ncbi.nlm.nih.gov/40100920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11918421"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0012914","doi":"https://doi.org/10.1371/journal.pntd.0012914","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0012914","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4408564018"],"child_works_count":9,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pntd.0012914","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113360792","display_name":"Jibon Kumar Paul","orcid":"https://orcid.org/0009-0008-7258-9113","observed_orcids":["https://orcid.org/0009-0008-7258-9113"]},"institutions":[{"id":"https://openalex.org/I133190216","display_name":"Shahjalal University of Science and Technology","ror":"https://ror.org/05hm0vv72","country_code":"BD","type":"education","lineage":["https://openalex.org/I133190216"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Jibon Kumar Paul","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh","institution_ids":["https://openalex.org/I133190216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096858261","display_name":"Mahir Azmal","orcid":"https://orcid.org/0009-0003-8937-0613","observed_orcids":["https://orcid.org/0009-0003-8937-0613"]},"institutions":[{"id":"https://openalex.org/I133190216","display_name":"Shahjalal University of Science and Technology","ror":"https://ror.org/05hm0vv72","country_code":"BD","type":"education","lineage":["https://openalex.org/I133190216"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mahir Azmal","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh","institution_ids":["https://openalex.org/I133190216"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tasnim Alam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133190216","display_name":"Shahjalal University of Science and Technology","ror":"https://ror.org/05hm0vv72","country_code":"BD","type":"education","lineage":["https://openalex.org/I133190216"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Tasnim Alam","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh","institution_ids":["https://openalex.org/I133190216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106884292","display_name":"Omar Faruk Talukder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133190216","display_name":"Shahjalal University of Science and Technology","ror":"https://ror.org/05hm0vv72","country_code":"BD","type":"education","lineage":["https://openalex.org/I133190216"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Omar Faruk Talukder","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh","institution_ids":["https://openalex.org/I133190216"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081002324","display_name":"Ajit Ghosh","orcid":"https://orcid.org/0000-0001-9045-3916","observed_orcids":["https://orcid.org/0000-0001-9045-3916"]},"institutions":[{"id":"https://openalex.org/I133190216","display_name":"Shahjalal University of Science and Technology","ror":"https://ror.org/05hm0vv72","country_code":"BD","type":"education","lineage":["https://openalex.org/I133190216"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Ajit Ghosh","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh"],"raw_orcid":"https://orcid.org/0000-0001-9045-3916","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh","institution_ids":["https://openalex.org/I133190216"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081002324"],"corresponding_institution_ids":["https://openalex.org/I133190216"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":5.4601,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.95796659,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"19","issue":"3","first_page":"e0012914","last_page":"e0012914"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dengue-virus","display_name":"dengue virus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/biomarker-genes","display_name":"biomarker genes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9559999704360962},{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.902999997138977},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bub1","display_name":"BUB1","score":0.871999979019165},{"id":"https://openalex.org/keywords/bub3","display_name":"Bub3","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cyclin-b2","display_name":"CCNB2","score":0.5659999847412109},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.5809999704360962},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.7829999923706055},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6570000052452087},{"id":"https://openalex.org/keywords/aedes-aegypti","display_name":"Aedes aegypti","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8472481966018677},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.7086093425750732},{"id":"https://openalex.org/C2780391303","wikidata":"https://www.wikidata.org/wiki/Q17853888","display_name":"BUB1","level":5,"score":0.593054473400116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5918501615524292},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.45310068130493164},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3930369019508362},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36980634927749634},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35433250665664673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3300638794898987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1742033064365387},{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000330","descriptor_name":"Aedes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pntd.0012914","doi":"https://doi.org/10.1371/journal.pntd.0012914","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0012914","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11918421","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11918421/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11918421/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmid:40100920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40100920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7786b556128e4bca8850f5357805a130","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7786b556128e4bca8850f5357805a130","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 19, Iss 3, p e0012914 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0012914","doi":"https://doi.org/10.1371/journal.pntd.0012914","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0012914","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324793","display_name":"Shahjalal University of Science and Technology","ror":"https://ror.org/05hm0vv72"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408564018.pdf","grobid_xml":"https://content.openalex.org/works/W4408564018.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1534341432","https://openalex.org/W1594451942","https://openalex.org/W1595441435","https://openalex.org/W1975852576","https://openalex.org/W1983499787","https://openalex.org/W1983907306","https://openalex.org/W1990315216","https://openalex.org/W1997999342","https://openalex.org/W2008472008","https://openalex.org/W2013644996","https://openalex.org/W2040603998","https://openalex.org/W2042479028","https://openalex.org/W2043352558","https://openalex.org/W2046121796","https://openalex.org/W2057093156","https://openalex.org/W2062879743","https://openalex.org/W2071892880","https://openalex.org/W2089528674","https://openalex.org/W2119733227","https://openalex.org/W2121679759","https://openalex.org/W2121722272","https://openalex.org/W2127036378","https://openalex.org/W2127864764","https://openalex.org/W2134392597","https://openalex.org/W2152900318","https://openalex.org/W2153560607","https://openalex.org/W2283435117","https://openalex.org/W2528672224","https://openalex.org/W2554298913","https://openalex.org/W2758814317","https://openalex.org/W2893000446","https://openalex.org/W2910150654","https://openalex.org/W2922169587","https://openalex.org/W2997529346","https://openalex.org/W3039953668","https://openalex.org/W3047070782","https://openalex.org/W3091670099","https://openalex.org/W3108814108","https://openalex.org/W3136485825","https://openalex.org/W3142274976","https://openalex.org/W3161315738","https://openalex.org/W3174941558","https://openalex.org/W3188545396","https://openalex.org/W3196645117","https://openalex.org/W3207679345","https://openalex.org/W3210673675","https://openalex.org/W4211002680","https://openalex.org/W4220793594","https://openalex.org/W4225632128","https://openalex.org/W4240900279","https://openalex.org/W4289522310","https://openalex.org/W4308834893","https://openalex.org/W4313367091","https://openalex.org/W4313644174","https://openalex.org/W4318473522","https://openalex.org/W4321254023","https://openalex.org/W4322217009","https://openalex.org/W4366828609","https://openalex.org/W4379179468","https://openalex.org/W4379207369","https://openalex.org/W4380083828","https://openalex.org/W4383105306","https://openalex.org/W4385325777","https://openalex.org/W4385555467","https://openalex.org/W4387454021","https://openalex.org/W4387638846","https://openalex.org/W4393114141","https://openalex.org/W4397022209"],"related_works":["https://openalex.org/W3188545396","https://openalex.org/W4407061960","https://openalex.org/W4403369450","https://openalex.org/W4416855337","https://openalex.org/W4321254023","https://openalex.org/W3185342163","https://openalex.org/W4416946893","https://openalex.org/W4289522310","https://openalex.org/W4414908554","https://openalex.org/W4403990528"],"abstract_inverted_index":{"Dengue":[0,25,250,263],"fever,":[1,26],"caused":[2],"by":[3,49],"the":[4,35,50,98,123,164,199,209,245,259,290,296],"dengue":[5,93,115],"virus":[6,251],"(DENV),":[7],"presents":[8],"a":[9,107],"significant":[10,21,166],"global":[11],"health":[12],"concern,":[13],"with":[14,136,205],"millions":[15],"of":[16,62,91,100,110,295],"cases":[17],"reported":[18,140],"annually.":[19],"Despite":[20],"progress":[22],"in":[23,41,55,83,114,172,231,238,244],"understanding":[24],"effective":[27],"prognosis":[28],"and":[29,39,78,142,160,181,192,213,224,235,273,284],"treatment":[30],"remain":[31],"elusive":[32],"due":[33,96],"to":[34,71,97,208,228,249],"complex":[36],"clinical":[37,102],"presentations":[38],"limitations":[40],"current":[42],"diagnostic":[43,84],"methods.":[44],"The":[45],"virus,":[46,210],"transmitted":[47],"primarily":[48],"Aedes":[51],"aegypti":[52],"mosquito,":[53],"exists":[54],"four":[56],"closely":[57],"related":[58],"forms,":[59],"each":[60],"capable":[61],"causing":[63],"flu-like":[64],"symptoms":[65],"ranging":[66],"from":[67,122],"mild":[68],"febrile":[69],"illness":[70],"severe":[72,92],"manifestations":[73],"such":[74,176,219,270],"as":[75,177,220,271,278],"plasma":[76],"leakage":[77],"hemorrhagic":[79],"fever.":[80],"Although":[81],"advancements":[82],"techniques":[85],"have":[86,236],"been":[87],"made,":[88],"early":[89,282],"detection":[90],"remains":[94],"difficult":[95],"complexity":[99],"its":[101],"presentations.":[103],"This":[104,253],"study":[105,254],"conducted":[106],"comprehensive":[108],"analysis":[109,196],"differential":[111],"gene":[112],"expression":[113],"fever":[116,264],"patients":[117],"using":[118],"multiple":[119],"microarray":[120],"datasets":[121],"NCBI":[124],"GEO":[125],"database.":[126],"Through":[127],"bioinformatics":[128],"approaches,":[129],"163":[130],"potential":[131,279],"biomarker":[132],"genes":[133,169,201,218,269],"were":[134,162,202],"identified,":[135],"some":[137],"overlapping":[138],"previously":[139],"biomarkers":[141,280],"others":[143],"representing":[144],"novel":[145,256],"candidates.":[146],"Notably,":[147],"AURKA,":[148,221],"BUB1,":[149,222],"BUB1B,":[150],"BUB3,":[151,223],"CCNA2,":[152],"CCNB2,":[153],"CDC6,":[154],"CDK1,":[155],"CENPE,":[156],"EXO1,":[157],"NEK2,":[158],"ZWINT,":[159],"STAT1":[161],"among":[163],"most":[165],"biomarkers.":[167],"These":[168],"are":[170,186,226],"involved":[171,230],"critical":[173],"cellular":[174],"processes,":[175],"cell":[178,190,211,232],"cycle":[179,233],"regulation":[180,234],"mitotic":[182],"checkpoint":[183],"control,":[184],"which":[185],"essential":[187],"for":[188,281,286,292],"immune":[189,206,247],"function":[191],"response.":[193],"Functional":[194],"enrichment":[195],"revealed":[197],"that":[198,275],"dysregulated":[200],"predominantly":[203],"associated":[204],"response":[207,248],"division,":[212],"RNA":[214],"processing.":[215],"Key":[216],"regulatory":[217,268],"CDK1":[225,274],"found":[227],"be":[229],"roles":[237],"immune-related":[239],"pathways,":[240],"underscoring":[241],"their":[242],"importance":[243],"host":[246],"infection.":[252],"provides":[255],"insights":[257],"into":[258],"molecular":[260],"mechanisms":[261],"underlying":[262],"pathogenesis,":[265],"highlighting":[266],"key":[267],"AURKA":[272],"could":[276],"serve":[277],"diagnosis":[283],"targets":[285],"therapeutic":[287],"intervention,":[288],"paving":[289],"way":[291],"improved":[293],"management":[294],"disease.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2025-03-19T00:00:00"}