{"id":"https://openalex.org/W4408553793","doi":"https://doi.org/10.1136/jitc-2024-010572","title":"Nivolumab adjuvant to chemo-radiation in localized muscle-invasive urothelial cancer: primary analysis of a multicenter, single-arm, phase II, investigator-initiated trial (NEXT)","display_name":"Nivolumab adjuvant to chemo-radiation in localized muscle-invasive urothelial cancer: primary analysis of a multicenter, single-arm, phase II, investigator-initiated trial (NEXT)","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4408553793","doi":"https://doi.org/10.1136/jitc-2024-010572","pmid":"https://pubmed.ncbi.nlm.nih.gov/40102029","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11927433"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2024-010572","doi":"https://doi.org/10.1136/jitc-2024-010572","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-010572","pdf_url":"https://jitc.bmj.com/content/13/3/e010572.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/13/3/e010572.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031760297","display_name":"Gliceida Galarza Fortuna","orcid":"https://orcid.org/0000-0002-1084-953X","observed_orcids":["https://orcid.org/0000-0002-1084-953X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gliceida M. Galarza Fortuna","raw_affiliation_strings":["University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":"https://orcid.org/0000-0002-1084-953X","affiliations":[{"raw_affiliation_string":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112560159","display_name":"Daniel Grass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Grass","raw_affiliation_strings":["Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022744341","display_name":"Benjamin Louis Maughan","orcid":"https://orcid.org/0000-0002-0010-8551","observed_orcids":["https://orcid.org/0000-0002-0010-8551"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin L Maughan","raw_affiliation_strings":["University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023152191","display_name":"Rohit Jain","orcid":"https://orcid.org/0000-0002-9295-9360","observed_orcids":["https://orcid.org/0000-0002-9295-9360"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohit K Jain","raw_affiliation_strings":["Department of Medical Oncology, Weill Cornell Medicine, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Weill Cornell Medicine, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090253469","display_name":"Christopher Dechet","orcid":"https://orcid.org/0000-0002-0534-6006","observed_orcids":["https://orcid.org/0000-0002-0534-6006"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Dechet","raw_affiliation_strings":["University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071754471","display_name":"Julia Beck","orcid":"https://orcid.org/0000-0002-4143-1363","observed_orcids":["https://orcid.org/0000-0002-4143-1363","https://orcid.org/0009-0007-8556-1075"]},"institutions":[{"id":"https://openalex.org/I4405281304","display_name":"Insight Molecular Diagnostics, Inc (United States)","ror":"https://ror.org/045weg456","country_code":"US","type":"company","lineage":["https://openalex.org/I4405281304"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Beck","raw_affiliation_strings":["Oncocyte Corporation, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncocyte Corporation, Irvine, California, USA","institution_ids":["https://openalex.org/I4405281304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110054563","display_name":"E. Sch\u00fcetz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281304","display_name":"Insight Molecular Diagnostics, Inc (United States)","ror":"https://ror.org/045weg456","country_code":"US","type":"company","lineage":["https://openalex.org/I4405281304"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekke Schuetz","raw_affiliation_strings":["Oncocyte Corporation, Irvine, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncocyte Corporation, Irvine, California, USA","institution_ids":["https://openalex.org/I4405281304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063526218","display_name":"Alejandro S\u00e1nchez","orcid":"https://orcid.org/0000-0002-9054-7346","observed_orcids":["https://orcid.org/0000-0002-9054-7346"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Sanchez","raw_affiliation_strings":["University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054836663","display_name":"Brock B. O'Neil","orcid":"https://orcid.org/0000-0002-1497-5824","observed_orcids":["https://orcid.org/0000-0002-1497-5824"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210148268","display_name":"University of Utah Health Care","ror":"https://ror.org/047s7ex42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brock O\u2019Neil","raw_affiliation_strings":["Department of Surgery, Division of Urology, University of Utah Health, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Urology, University of Utah Health, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I4210148268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087611807","display_name":"Michael Adam Poch","orcid":"https://orcid.org/0000-0001-7339-8978","observed_orcids":["https://orcid.org/0000-0001-7339-8978"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Poch","raw_affiliation_strings":["Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA","Immunology, Moffitt Cancer Center, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Immunology, Moffitt Cancer Center, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054735116","display_name":"Roger Li","orcid":"https://orcid.org/0000-0003-1274-7200","observed_orcids":["https://orcid.org/0000-0003-1274-7200"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger Li","raw_affiliation_strings":["Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057200744","display_name":"Shane A. J. Lloyd","orcid":"https://orcid.org/0000-0002-4235-7652","observed_orcids":["https://orcid.org/0000-0002-4235-7652"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane Lloyd","raw_affiliation_strings":["Department of Radiation Oncology, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040908498","display_name":"Jonathan David Tward","orcid":"https://orcid.org/0000-0001-7765-4473","observed_orcids":["https://orcid.org/0000-0001-7765-4473"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Tward","raw_affiliation_strings":["Department of Radiation Oncology, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070458204","display_name":"Tenzin Kunsang Phunrab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tenzin Phunrab","raw_affiliation_strings":["Department of Medical Oncology, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076648854","display_name":"Josiah Hawks","orcid":"https://orcid.org/0000-0001-9908-4598","observed_orcids":["https://orcid.org/0000-0001-9908-4598"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josiah Lyn Hawks","raw_affiliation_strings":["Research Compliance Office, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":"https://orcid.org/0000-0001-9908-4598","affiliations":[{"raw_affiliation_string":"Research Compliance Office, University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034103357","display_name":"Umang Swami","orcid":"https://orcid.org/0000-0003-3518-0411","observed_orcids":["https://orcid.org/0000-0003-3518-0411"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umang Swami","raw_affiliation_strings":["Department of Oncology, Huntsman Cancer Institute Cancer Hospital, Salt Lake City, Utah, USA"],"raw_orcid":"https://orcid.org/0000-0003-3518-0411","affiliations":[{"raw_affiliation_string":"Department of Oncology, Huntsman Cancer Institute Cancer Hospital, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082070319","display_name":"Kenneth M. Boucher","orcid":"https://orcid.org/0000-0003-2833-0127","observed_orcids":["https://orcid.org/0000-0003-2833-0127"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M Boucher","raw_affiliation_strings":["University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763587","display_name":"Neeraj Agarwal","orcid":"https://orcid.org/0000-0003-1076-0428","observed_orcids":["https://orcid.org/0000-0003-1076-0428","https://orcid.org/0000-0001-6574-8499"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neeraj Agarwal","raw_affiliation_strings":["Department of Medical Oncology, University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":"https://orcid.org/0000-0003-1076-0428","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013942253","display_name":"Sumati V. Gupta","orcid":"https://orcid.org/0000-0001-6271-0831","observed_orcids":["https://orcid.org/0000-0001-6271-0831"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sumati Gupta","raw_affiliation_strings":["University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA Sumati.Gupta@hci.utah.edu"],"raw_orcid":"https://orcid.org/0000-0001-6271-0831","affiliations":[{"raw_affiliation_string":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]},{"raw_affiliation_string":"University of Utah Health Huntsman Cancer Institute, Salt Lake City, Utah, USA Sumati.Gupta@hci.utah.edu","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013942253"],"corresponding_institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":4.4648,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.94432911,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"13","issue":"3","first_page":"e010572","last_page":"e010572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9290000200271606},{"id":"https://openalex.org/keywords/adjuvant-immunotherapy","display_name":"adjuvant immunotherapy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/failure-free-survival","display_name":"failure-free survival","score":0.9350000023841858},{"id":"https://openalex.org/keywords/high-risk-features","display_name":"high-risk features","score":0.6769999861717224},{"id":"https://openalex.org/keywords/plasma-cell-free-dna","display_name":"plasma cell-free DNA","score":0.7739999890327454},{"id":"https://openalex.org/keywords/copy-number-instability","display_name":"copy number instability","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.5950000286102295},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.7160000205039978},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9810000061988831},{"id":"https://openalex.org/keywords/recurrence-patterns","display_name":"recurrence patterns","score":0.4399999976158142},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6890000104904175},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8980753421783447},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.8388826251029968},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.7022005319595337},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6426342129707336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6169948577880859},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5875754356384277},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5778629779815674},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.507075309753418},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.4308548867702484},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.41310739517211914},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3693848252296448},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.343384325504303},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33573228120803833},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33378374576568604},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1902807652950287},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.1743001937866211}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059248","descriptor_name":"Chemoradiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/jitc-2024-010572","doi":"https://doi.org/10.1136/jitc-2024-010572","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-010572","pdf_url":"https://jitc.bmj.com/content/13/3/e010572.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmid:40102029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40102029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for immunotherapy of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11927433","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11927433/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:643c85c3b1ae407599a3903afdc214f9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/643c85c3b1ae407599a3903afdc214f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 13, Iss 3 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2024-010572","doi":"https://doi.org/10.1136/jitc-2024-010572","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-010572","pdf_url":"https://jitc.bmj.com/content/13/3/e010572.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1207220112","display_name":null,"funder_award_id":"1I01BX005765","funder_id":"https://openalex.org/F4320309842","funder_display_name":"Biomedical Laboratory Research and Development, VA Office of Research and Development"},{"id":"https://openalex.org/G4663591985","display_name":null,"funder_award_id":"I01 BX005765","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320309842","display_name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"},{"id":"https://openalex.org/F4320312218","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408553793.pdf","grobid_xml":"https://content.openalex.org/works/W4408553793.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W573831242","https://openalex.org/W1618447972","https://openalex.org/W1657226110","https://openalex.org/W1975918912","https://openalex.org/W2053900432","https://openalex.org/W2063504751","https://openalex.org/W2071749637","https://openalex.org/W2118328604","https://openalex.org/W2164361265","https://openalex.org/W2204690650","https://openalex.org/W2417757798","https://openalex.org/W2582671354","https://openalex.org/W2598988196","https://openalex.org/W2753065806","https://openalex.org/W2804853604","https://openalex.org/W2884251983","https://openalex.org/W2923057410","https://openalex.org/W2973000142","https://openalex.org/W3087464965","https://openalex.org/W3134944806","https://openalex.org/W3148827278","https://openalex.org/W3163995648","https://openalex.org/W3168935284","https://openalex.org/W3196810121","https://openalex.org/W4212805541","https://openalex.org/W4282980285","https://openalex.org/W4321614235","https://openalex.org/W4376272229","https://openalex.org/W4386031138","https://openalex.org/W4387859553","https://openalex.org/W4389861133","https://openalex.org/W4390946922","https://openalex.org/W4391303637","https://openalex.org/W4392498919","https://openalex.org/W4392982527","https://openalex.org/W4399259144","https://openalex.org/W4402548582","https://openalex.org/W4402565776","https://openalex.org/W4402565851"],"related_works":["https://openalex.org/W4391333767","https://openalex.org/W3163995648","https://openalex.org/W4410791548","https://openalex.org/W3172349060","https://openalex.org/W4415281041","https://openalex.org/W4212939704","https://openalex.org/W3134461649","https://openalex.org/W7223025862","https://openalex.org/W4411135001","https://openalex.org/W4403320624"],"abstract_inverted_index":{"BACKGROUND:":[0],"Muscle-invasive":[1],"urothelial":[2],"cancer":[3],"(UC)":[4],"has":[5],"a":[6,27,47,184],"high":[7,28],"risk":[8,29,212,306],"of":[9,30,56,82,87,113,187,247],"recurrence":[10],"after":[11],"definitive":[12],"treatment.":[13],"Nivolumab":[14,291],"adjuvant":[15,35,58,124,248,292],"to":[16,36,59,96,100,121,125,137,193,204,293],"radical":[17],"surgery":[18],"improves":[19],"disease-free":[20],"survival":[21,73,259],"in":[22,61,174,206,220,233,288,295],"patients":[23,62,106,141],"with":[24,26,63,102,179,198,208,230,256,261,310],"UC":[25,300],"recurrence;":[31],"however,":[32],"its":[33],"role":[34],"chemoradiation":[37],"therapy":[38],"(CRT)":[39],"is":[40,46,71,301],"unknown.":[41],"METHODS:":[42],"The":[43,68,127],"NEXT":[44],"trial":[45],"single-arm,":[48],"phase-2":[49],"study":[50],"evaluating":[51],"the":[52,244],"efficacy":[53],"and":[54,85,109,145,176,250,278,308,320],"tolerability":[55],"nivolumab":[57,114,249],"CRT":[60,294],"localized":[64,143,296],"or":[65,155,210,297],"locoregional":[66],"UC.":[67],"primary":[69],"endpoint":[70],"failure-free":[72],"(FFS)":[74],"at":[75,129,251],"2":[76,130],"years.":[77],"Secondary":[78],"endpoints":[79],"include":[80],"patterns":[81],"recurrence,":[83],"toxicity":[84],"quality":[86],"life":[88],"(QoL).":[89],"Plasma":[90,235],"cell-free":[91],"DNA":[92],"(cfDNA)":[93],"was":[94,132],"subjected":[95],"shallow":[97],"whole-genome":[98],"sequencing":[99],"correlate":[101],"outcomes.":[103],"RESULTS:":[104],"28":[105],"were":[107,254],"enrolled":[108],"received":[110],"480":[111],"mg":[112],"intravenously":[115],"every":[116],"4":[117,253],"weeks":[118],"for":[119,316,324],"up":[120],"12":[122],"cycles":[123],"CRT.":[126],"FFS":[128,186],"years":[131],"33.2%":[133],"(95%":[134,190,201],"CI":[135,191,202],"18.5%":[136],"59.6%).":[138],"Nine":[139],"(32%)":[140],"had":[142,148,153,183,226],"progression,":[144],"eight":[146],"(29%)":[147],"distant":[149],"progression.":[150,289],"25":[151],"(89%)":[152],"one":[154],"more":[156,211],"high-risk":[157,181],"features":[158,182,213],"(ie,":[159],"plasmacytoid":[160],"differentiation,":[161],"T4,":[162],"N+,":[163],"multiple":[164],"tumors,":[165],"tumors":[166],">5":[167],"cm,":[168],"residual":[169],"disease":[170],"before":[171,243],"CRT,":[172],"carcinoma":[173],"situ,":[175],"hydronephrosis).":[177],"Patients":[178],"\u22642":[180],"median":[185],"45.2":[188],"months":[189,200,266],"14.56":[192],"not":[194],"reached":[195],"(NR))":[196],"compared":[197,260],"8.2":[199],"7.1":[203],"NR)":[205],"those":[207],"three":[209],"(p=0.0024).":[214],"Nivolumab-associated":[215],"treatment-related":[216],"adverse":[217],"events":[218],"occurred":[219],"18":[221],"(64.3%)":[222],"patients,":[223],"only":[224],"3":[225,228],"grade":[227],"TRAEs,":[229],"significant":[231],"changes":[232,274],"QoL.":[234],"cfDNA":[236,312],"copy":[237,272],"number":[238,273],"instability":[239],"(CNI)":[240],"scores":[241,263],"\u226425":[242],"first":[245],"dose":[246],"cycle":[252],"associated":[255],"better":[257],"overall":[258],"CNI":[262],"\u226526":[264],"(49.6":[265],"vs":[267],"20.5":[268],"months,":[269],"p=0.0024).":[270],"Genome":[271],"indicated":[275],"chromatin":[276],"remodeling":[277],"tyrosine":[279],"kinase":[280],"pathways,":[281],"among":[282],"others,":[283],"as":[284],"oncogenic":[285],"drivers":[286],"implicated":[287],"CONCLUSION:":[290],"locally":[298],"advanced":[299],"well":[302],"tolerated.":[303],"Stratification":[304],"by":[305],"factors":[307],"correlation":[309],"plasma":[311],"analyses":[313],"generate":[314],"hypotheses":[315],"potential":[317],"patient":[318],"selection":[319],"putative":[321],"therapeutic":[322],"targets":[323],"future":[325],"study.":[326],"TRIAL":[327],"REGISTRATION":[328],"NUMBER:":[329],"NCT03171025.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-03-19T00:00:00"}